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| | trpG | Anthranilate synthase component II TrpG; Involved in biosynthesis of tryptophan (at the first step). supposed tetramer of two-components I and two-components II: component I TrpE) catalyzes the formation of anthranilate using ammonia rather than glutamine. (228 aa) |
| | thyA_1 | Thymidylate synthase, ThyA_1; Involved in deoxyribonucleotide biosynthesis. provides the sole de novo source of dTMP for dana biosynthesis [catalytic activity: 5,10- methylenetetrahydrofolate + dump = dihydrofolate + dTMP]. (316 aa) |
| | MMAR_0100 | 4-hydroxybenzoate synthetase (chorismate lyase). (199 aa) |
| | glyA2 | Serine hydroxymethyltransferase GlyA2; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (425 aa) |
| | gcvH_1 | Glycine cleavage system H protein GcvH_1; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (134 aa) |
| | gcvT_1 | Aminomethyltransferase GcvT_1ne; The glycine cleavage system catalyzes the degradation of glycine. (375 aa) |
| | gcvB_1 | Glycine dehydrogenase GcvB_1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (961 aa) |
| | ilvD | Dihydroxy-acid dehydratase IlvD; Involved in valine and isoleucine biosynthesis (at the fourth step) [catalytic activity: 2,3-dihydroxy-3- methylbutanoate = 3-methyl-2- oxobutanoate + H(2)O]; Belongs to the IlvD/Edd family. (564 aa) |
| | dcd | Deoxycytidine triphosphate deaminase, Dcd; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. (190 aa) |
| | aspC | Aspartate aminotransferase AspC; Involved in glutamate biosynthesis [catalytic activity: l-aspartate + 2-oxoglutarate = oxaloacetate + L- glutamate]. (429 aa) |
| | MMAR_0644 | Monooxygenase; Function unknown, probably involved in cellular metabolism; Belongs to the globin family. (393 aa) |
| | pyrE | Orotate phosphoribosyltransferase PyrE; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (179 aa) |
| | purA | Adenylosuccinate synthetase PurA; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (432 aa) |
| | purT | Formate-dependent phosphoribosylglycinamide formyltransferase PurT; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate. Belongs to the PurK/PurT family. (445 aa) |
| | mrsA | Phosphomannomutase, MrsA; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. (445 aa) |
| | glmS | Glucosamine-fructose-6-phosphate aminotransferase, GlmS; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (625 aa) |
| | guaB2 | Inosine-5'-monophosphate (imp) dehydrogenase, GuaB2; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (532 aa) |
| | guaB3 | Inosine-5'-monophosphate (imp) dehydrogenase, GuaB3; Catalyses the first reaction unique to GMP biosynthesis [catalytic activity: inosine 5'-phosphate + NAD(+) + H(2)O = xanthosine 5'-phosphate + NADH]. (375 aa) |
| | guaA | GMP synthase, GuaA; Catalyzes the synthesis of GMP from XMP. (525 aa) |
| | folD | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (281 aa) |
| | nagA | N-acetylglucosamine-6-phosphate deacetylase NagA; Involved in N-acetyl glucosamine utilization pathway [catalytic activity: N-acetyl-D-glucosamine 6- phosphate + H(2)O = D-glucosamine 6-phosphate + acetate]. (388 aa) |
| | sugI | Sugar-transport integral membrane protein SugI; Thought to be involved in transport of sugar across the membrane. responsible for the translocation of the substrate across the membrane; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (449 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase ATPase subunit PurK (air carboxylase) (AirC); Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (404 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase catalytic subunit PurE (air carboxylase) (AirC); Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (171 aa) |
| | tmk | Thymidylate kinase Tmk; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (217 aa) |
| | MMAR_1303 | Conserved hypothetical protein; Function unknown, but contains amidophosphoribosyltransferase domain. (211 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase AroA; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (431 aa) |
| | MMAR_1321 | Conserved hypothetical protein; Belongs to the SOS response-associated peptidase family. (260 aa) |
| | MMAR_1433 | Domain identity with XerD and XerC integrases, DNA breaking-rejoining enzymes, n- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination of chromosomal replication, and stable plasmid inheritance; Belongs to the 'phage' integrase family. (359 aa) |
| | MMAR_1511 | Monophosphatase; Function unknown, involved in cellular metabolism. (262 aa) |
| | MMAR_1512 | Conserved hypothetical membrane protein. (111 aa) |
| | MMAR_1560 | Conserved hypothetical protein; Function unknown but contains tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain. (326 aa) |
| | ilvB1 | Acetolactate synthase (large subunit) IlvB1; Involved in valine and isoleucine biosynthesis (at the first step) [catalytic activity: 2-acetolactate + CO(2) = 2 pyruvate]. (618 aa) |
| | ilvN | Acetolactate synthase (small subunit) IlvN; Involved in valine and isoleucine biosynthesis (at the first step) [catalytic activity: 2-acetolactate + CO(2) = 2-pyruvate]. (169 aa) |
| | ilvC | Ketol-acid reductoisomerase IlvC; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (343 aa) |
| | leuB | 3-isopropylmalate dehydrogenase LeuB; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (339 aa) |
| | leuC | 3-isopropylmalate dehydratase (large subunit) LeuC; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (473 aa) |
| | leuD | 3-isopropylmalate dehydratase (small subunit) LeuD; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (198 aa) |
| | purU | Formyltetrahydrofolate deformylase PurU; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (298 aa) |
| | aroG_1 | 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase AroG_1; Involved in chorismate biosynthesis; Belongs to the class-II DAHP synthase family. (471 aa) |
| | dapB | Dihydrodipicolinate reductase DapB; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (245 aa) |
| | thyA | Thymidylate synthase ThyA; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (266 aa) |
| | dfrA | Dihydrofolate reductase DfrA; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (165 aa) |
| | MMAR_1958 | Conserved hypothetical protein. (404 aa) |
| | hsdM | Implicated in methylation of DNA. component of type I restriction/modification system. it is possible that the M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues in complementary strands of bipartite DNA recognition sequence. (484 aa) |
| | hsdS | Type I restriction/modification system specificity determinant HsdS (S protein); Implicated in restriction/modification of DNA. component of type I restriction/modification system. it is thought that the M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues in complementary strands of bipartite DNA recognition sequence. (361 aa) |
| | thyX | Thymidylate synthase ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (250 aa) |
| | dapA | Dihydrodipicolinate synthase DapA; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (300 aa) |
| | MMAR_1968 | Acetyltransferase; Function unknown, domain identity to ArgA, N- acetylglutamate synthase and related acetyltransferases suggests a role in amino acid transport and metabolism; Belongs to the acetyltransferase family. (174 aa) |
| | dapF | Diaminopimelate epimerase DapF; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (290 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase DutT; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (154 aa) |
| | apt | Adenine phosphoribosyltransferase, Apt; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (184 aa) |
| | dapA_1 | Dihydrodipicolinate synthase DapA_1; Involved in biosynthesis of diaminopimelate and lysine from aspartate semialdehyde (at the first step) [catalytic activity: l-aspartate 4-semialdehyde + pyruvate = dihydrodipicolinate + 2 H(2)O]; Belongs to the DapA family. (296 aa) |
| | aroE | Shikimate 5-dehydrogenase AroE; Possibly involved at the fourth step in the biosynthesis of chorismate within the biosynthesis of aromatic amino acids (the shikimate pathway) [catalytic activity: shikimate + NADP(+) = 5-dehydroshikimate + NADPH]; Belongs to the shikimate dehydrogenase family. (277 aa) |
| | aroF | Chorismate synthase AroF; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (407 aa) |
| | aroK | Shikimate kinase AroK; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (184 aa) |
| | aroB | 3-dehydroquinate synthase AroB; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (362 aa) |
| | aroD | 3-dehydroquinate dehydratase AroD; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (146 aa) |
| | MMAR_2184 | Amino acid decarboxylase; Function unknown. could be an ornithine/arginine/lysine decarboxylase involved in the biosynthesis of spermidine from arginine. (943 aa) |
| | pyrR | Pyrimidine operon regulatory protein PyrR; Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines. (187 aa) |
| | pyrB | Aspartate carbamoyltransferase PyrB; Involved in pyrimidine biosynthesis (second step) [catalytic activity : carbamoyl phosphate + l-aspartate = phosphate + N-carbamoyl-L-aspartate]; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (320 aa) |
| | pyrC | Dihydroorotase PyrC; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (430 aa) |
| | MMAR_2197 | Secreted protein. (173 aa) |
| | carA | Carbamoyl-phosphate synthase small chain CarA; Involved in both arginine and pyrimidine biosynthesis [catalytic activity : 2 ATP + L-glutamine + CO(2) + H(2)O = 2 ADP + phosphate + glutamate + carbamoyl phosphate]; Belongs to the CarA family. (375 aa) |
| | carB | Carbamoyl-phosphate synthase large chain CarB; Involved in both arginine and pyrimidine biosynthesis [catalytic activity : 2 ATP + L-glutamine + CO(2) + H(2)O = 2 ADP + phosphate + glutamate + carbamoyl phosphate.]; Belongs to the CarB family. (1145 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase PyrF; Involved in the biosynthesis of pyrimidines [catalytic activity : orotidine 5'-phosphate = ump + CO(2)]; Belongs to the OMP decarboxylase family. Type 2 subfamily. (278 aa) |
| | gmk | Guanylate kinase Gmk; Essential for recycling GMP and indirectly, cGMP. (197 aa) |
| | aroB_2 | 3-dehydroquinate synthase AroB_2; Involved at the second step in the biosynthesis of chorismate within the biosynthesis of aromatic amino acids (the shikimate pathway) [catalytic activity: 7-phospho-3- deoxy-arabino-heptulosonate = 3-dehydroquinate + orthophosphate]. (360 aa) |
| | ilvA | Threonine dehydratase IlvA; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (426 aa) |
| | hisD | Histidinol dehydrogenase HisD; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (447 aa) |
| | hisC1 | Histidinol-phosphate aminotransferase HisC1; Histidine biosynthesis (eighth step) [catalytic activity : L-histidinol-phosphate + 2-oxoglutarate = 3- (imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate]; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (382 aa) |
| | hisB | Imidazole glycerol-phosphate dehydratase HisB; Histidine biosynthesis (seventh step) [catalytic activity : D-erythro-1-(imidazol-4-yl)glycerol 3- phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H(2)O]. (210 aa) |
| | hisH | Amidotransferase HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (210 aa) |
| | hisA | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA; Involved in both the histidine and tryptophan biosynthetic pathways; Belongs to the HisA/HisF family. (249 aa) |
| | hisF | Cyclase HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (261 aa) |
| | hisI | phosphoribosyl-AMP 1,6 cyclohydrolase HisI; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (111 aa) |
| | trpE | Anthranilate synthase component I TrpE; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high con [...] (512 aa) |
| | trpC | Indole-3-glycerol phosphate synthase TrpC; Tryptophan biosynthesis pathway (fourth step) [catalytic activity : 1-(2-carboxyphenylamino)-1-deoxy-D- ribulose 5-phosphate = 1-(indol-3-YL)glycerol 3-phosphate + CO(2) + H(2)O.]; Belongs to the TrpC family. (272 aa) |
| | trpB | Tryptophan synthase, beta subunit TrpB; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (425 aa) |
| | trpA | Tryptophan synthase, alpha subunit TrpA; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (269 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase ArgC; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (350 aa) |
| | argJ | Glutamate N-acetyltransferase ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (404 aa) |
| | argB | Acetylglutamate kinase ArgB; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (293 aa) |
| | argD | Acetylornithine aminotransferase ArgD; Arginine biosynthesis (fourth step) [catalytic activity :N2-acetyl-L-ornithine + 2-oxoglutarate = N- acetyl-L-glutamate 5-semialdehyde + L-glutamate]; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (396 aa) |
| | argF | Ornithine carbamoyltransferase, anabolic ArgF; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (308 aa) |
| | argR | Arginine repressor ArgR; Regulates arginine biosynthesis genes. (166 aa) |
| | argG | Argininosuccinate synthase ArgG; Arginine biosynthesis [catalytic activity : ATP + l- citrulline + l-aspartate = AMP + diphosphate + l- argininosuccinate]; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (398 aa) |
| | argH | Argininosuccinate lyase ArgH; Arginine biosynthesis (last step) [catalytic activity : n-(L-arginino)succinate = fumarate + l- arginine]. (470 aa) |
| | gcvH | Glycine cleavage system H protein GcvH; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (134 aa) |
| | gcvB | Glycine dehydrogenase GcvB; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (945 aa) |
| | guaB1 | Inosine-5'-monophosphate dehydrogenase GuaB1; Involved in GMP biosynthesis [catalytic activity: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'- phosphate + NADH]. (478 aa) |
| | MMAR_2773 | Conserved secreted protein; Catalyzes the Claisen rearrangement of chorismate to prephenate. (202 aa) |
| | hisG | ATP phosphoribosyltransferase HisG; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. (286 aa) |
| | hisE | phosphoribosyl-AMP pyrophosphatase HisE; Thought to be involved in histidine biosynthesis. (93 aa) |
| | pyrD | Dihydroorotate dehydrogenase PyrD; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (360 aa) |
| | aroG | 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase AroG; Involved in chorismate biosynthesis; Belongs to the class-II DAHP synthase family. (462 aa) |
| | trpD | Anthranilate phosphoribosyltransferase TrpD; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (367 aa) |
| | ilvE | Branched-chain amino acid transaminase IlvE; Thought to catalyze the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine [catalytic activity: L- leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L- glutamate]. (368 aa) |
| | gcvT | Aminomethyltransferase GcvT; The glycine cleavage system catalyzes the degradation of glycine. (367 aa) |
| | MMAR_3409 | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate. (336 aa) |
| | ndkA | Nucleoside diphosphate kinase NdkA; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (136 aa) |
| | MMAR_4040 | Ham1-related NTPase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (203 aa) |
| | thrB | Homoserine kinase ThrB; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (314 aa) |
| | thrC | Threonine synthase ThrC; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (360 aa) |
| | thrA | Homoserine dehydrogenase ThrA; Involved in the conversion of l-aspartate to homoserine (third step). homoserine participates in the biosynthesis of threonine and then isoleucine and in the biosynthesis of methionine [catalytic activity : L- homoserine + NAD(P)(+) = l-aspartate 4-semialdehyde + NAD(P)H.]. (441 aa) |
| | lysA | Diaminopimelate decarboxylase LysA; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (472 aa) |
| | dapE | Succinyl-diaminopimelate desuccinylase DapE; Involved in lysine biosynthesis [catalytic activity: N-succinyl-LL-2,6-diaminoheptanedioate + H2O = succinate + LL-2,6-diaminoheptanedioate]. (354 aa) |
| | dapD | Transferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (314 aa) |
| | MMAR_4273 | Aminotransferase; Function unknown, probably involved in cellular metabolism. (365 aa) |
| | glyA1 | Serine hydroxymethyltransferase 1 GlyA1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (426 aa) |
| | MMAR_4464 | Conserved hypothetical protein. (366 aa) |
| | glmU | UDP-N-acetylglucosamine pyrophosphorylase GlmU; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. (492 aa) |
| | prsA | Ribose-phosphate pyrophosphokinase PrsA; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (326 aa) |
| | MMAR_4469 | Arsenate reductase; Belongs to the ArsC family. (122 aa) |
| | lpqT | Conserved lipoprotein LpqT. (218 aa) |
| | pabD | Para-aminobenzoate synthase component, PabD; Catalyzes the biosynthesis of 4-amino-4- deoxychorismate (adc) from chorismate and glutamine. (437 aa) |
| | arcA | Arginine deiminase ArcA; Arginine degradation [catalytic activity:L-arginine + H(2)O = l-citrulline + NH(3)]. (402 aa) |
| | purH | Bifunctional purine biosynthesis protein PurH; Involved in de novo purine biosynthesis (at the ninth and tenth steps) [catalytic activity 1: 10- formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4- imidazolecarboxamide = tetrahydrofolate + 5'- phosphoribosyl-5-formamido-4-imidazolecarboxamide] [catalytic activity 2: imp + H2O = 5-formamido-1-(5- phosphoribosyl)imidazole-4-carboxamide]. (523 aa) |
| | purN | 5'-phosphoribosylglycinamide formyltransferase PurN; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (215 aa) |
| | MMAR_4555 | Conserved hypothetical protein. (104 aa) |
| | MMAR_4678 | Aminotransferase; Function unknown, probably involved in cellular metabolism. (398 aa) |
| | pabC | Amino acid aminotransferase, PabC; class-IV of pyridoxal-phosphate-dependent aminotransferases. (296 aa) |
| | purM | 5'-phosphoribosyl-5-aminoimidazole synthetase, PurM; Involved in de novo purine biosynthesis (at the fifth step) [catalytic activity: ATP + 5'- phosphoribosylformylglycinamidine = ADP + phosphate + 5'- phosphoribosyl-5-aminoimidazole]. (367 aa) |
| | purF | Amidophosphoribosyltransferase, PurF; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (508 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase II, PurL; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to a [...] (765 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase I, PurQ; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to as [...] (224 aa) |
| | purS | Conserved protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammon [...] (81 aa) |
| | purC | Phosphoribosylaminoimidazole- succinocarboxamide synthase, PurC; Involved in de novo purine biosynthesis (at the seventh step) [catalytic activity: ATP + 1-(5- phosphoribosyl)-4-carboxy-5-aminoimidazole + l-aspartate = ADP + phosphate + 1-(5-phosphoribosyl)-4-(N-succino- carboxamide)-5-aminoimidazole]; Belongs to the SAICAR synthetase family. (297 aa) |
| | purB | Adenylosuccinate lyase, PurB; Involved in de novo purine biosynthesis (at the eight step) catalytic activity: 1-(5-phosphoribosyl)-4-(N- succino-carboxamide) -5-aminoimidazole = fumarate + 5'- phosphoribosyl-5-amino-4-imidazolecarboxamide (also catalyzes: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP); Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (475 aa) |
| | purD | Phosphoribosylamine-glycine ligase, PurD; Involved in de novo purine biosynthesis (at the second step) [catalytic activity: ATP + 5- phosphoribosylamine + glycine = ADP + phosphate + 5'- phosphoribosylglycinamide]; Belongs to the GARS family. (422 aa) |
| | serB | Phosphoserine phosphatase SerB; Phosphoserine + H(2)O <=> serine + phosphate. (285 aa) |
| | whiB4 | Transcriptional regulatory protein Whib-like WhiB4; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity). Plays a role in lipooligosaccharide (LOS) biosynthesis by regulating LOS gene expression; Belongs to the WhiB family. (116 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase Asd; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (352 aa) |
| | ask | Aspartate kinase Ask; Involved at the first step in the common biosynthetic pathway leading from asp to the cell wall precursor meso-diaminopimelate, to lys, to met, to ile and to the[catalytic activity: ATP + l-aspartate = ADP + 4- phospho-L-aspartate]. possibly acts in tetramer configuration, tetramer consisting of two alpha (catalytic activity) and two beta (function not known) chains; Belongs to the aspartokinase family. (421 aa) |
| | leuA | 2-isopropylmalate synthase LeuA; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (606 aa) |
| | tyrA | Prephenate dehydrogenase TyrA; Involved in tyrosine biosynthesis [catalytic activity: prephenate + NAD(+) = 4-hydroxyphenylpyruvate + CO(2) + NADH]. (319 aa) |
| | hisC2 | Histidinol-phosphate aminotransferase HisC2; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (361 aa) |
| | pheA | Prephenate dehydratase PheA; Involved in L-phenylalanine biosynthesis [catalytic activity: prephenate = phenylpyruvate + H(2)O + CO(2)]. (315 aa) |
