(20 nodes) Signal transduction response regulator, C-terminal effector network (Mycobacterium marinum)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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Predicted Interactions

gene neighborhood

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Your Input:
	MMAR_0085	Transcriptional regulatory protein; Contains N-term ATPase domain and C-term DNA- binding domain; may be involved in regulation of transcription. (914 aa)
	MMAR_0123	Transcriptional regulatory protein (LuxR- family); Involved in transcriptional mechanism. (1117 aa)
	MMAR_0132	Response regulator of a two-component regulatory system involved in transcriptional regulatory mechanism. has domain homology to CitB, a response regulator containing a CheY-like receiver domain and an HTH DNA- binding domain. (220 aa)
	MMAR_0520	Transcriptional regulatory protein; Could be involved in transcriptional mechanism. (383 aa)
	MMAR_0612	Transcriptional regulatory protein; Involved in transcriptional mechanism. (817 aa)
	regX3	Transcriptional regulatory protein part of the two-component regulatory system RegX3/SenX3. (227 aa)
	embR_2	Transcriptional regulatory protein EmbR_2; Involved in transcriptional mechanism. thought to regulate the biosynthesis of the mycobacterial cell wall arabinan and resistance to ethambutol (Emb; dextro-2,2'- (ethylenediimino)-di-1-butanol), regulating EmbA and EmbB. (276 aa)
	MMAR_1324	Conserved hypothetical membrane protein; May be involved in regulation. (909 aa)
	devR	Regulator part of the two-component regulatory system DevR/DevS. controls HspX\|Acr expression. (216 aa)
	MMAR_1825	Transcriptional regulatory protein; Involved in transcriptional mechanism. (266 aa)
	MMAR_2876	Conserved hypothetical regulatory protein; Function unknown but weak domain identity with two- component response regulators. (395 aa)
	MMAR_2962	Transcriptional regulatory protein; Involved in transcriptional mechanism. (1078 aa)
	MMAR_3480	Regulator part of a two-component regulatory system. (217 aa)
	embR_1	Transcriptional regulatory protein EmbR_1; Involved in transcriptional mechanism. thought to regulate the biosynthesis of the mycobacterial cell wall arabinan and resistance to ethambutol (Emb; dextro-2,2'- (ethylenediimino)-di-1-butanol), regulating EmbA and EmbB. (379 aa)
	MMAR_3930	Conserved hypothetical regulatory protein. (76 aa)
	embR	Transcriptional regulatory protein EmbR; Involved in transcriptional mechanism. thought to regulate the biosynthesis of the mycobacterial cell wall arabinan and resistance to ethambutol (Emb; dextro-2,2'- (ethylenediimino)-di-1-butanol), regulating EmbA and EmbB. (386 aa)
	trcR	Sensor part of the two-component regulatory system TrcS/TrcR. involved in transcriptional autoactivation: TrcR activates its own expression by interacting with the AT-rich sequence of the TrcR promoter. (254 aa)
	narL	Nitrate/nitrite response regulator protein NarL. (216 aa)
	MMAR_4865	Transcriptional regulatory protein; Involved in transcriptional mechanism. (264 aa)
	phoP	Involved in transcriptional mechanism. part of the two-component regulatory system PhoP/PhoQ. this protein is thought to be a positive regulator for the phosphate regulon, required for intracellular growth. transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited. (240 aa)

Your Current Organism:

Mycobacterium marinum

NCBI taxonomy Id: 216594
Other names: M. marinum M, Mycobacterium marinum M, Mycobacterium marinum str. M, Mycobacterium marinum strain M

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MMAR_0085	MMAR_0123	MMAR_0085	MMAR_0123	Transcriptional regulatory protein; Contains N-term ATPase domain and C-term DNA- binding domain; may be involved in regulation of transcription.	Transcriptional regulatory protein (LuxR- family); Involved in transcriptional mechanism.	0.462
MMAR_0085	MMAR_0612	MMAR_0085	MMAR_0612	Transcriptional regulatory protein; Contains N-term ATPase domain and C-term DNA- binding domain; may be involved in regulation of transcription.	Transcriptional regulatory protein; Involved in transcriptional mechanism.	0.415
MMAR_0085	MMAR_1324	MMAR_0085	MMAR_1324	Transcriptional regulatory protein; Contains N-term ATPase domain and C-term DNA- binding domain; may be involved in regulation of transcription.	Conserved hypothetical membrane protein; May be involved in regulation.	0.831
MMAR_0085	MMAR_2962	MMAR_0085	MMAR_2962	Transcriptional regulatory protein; Contains N-term ATPase domain and C-term DNA- binding domain; may be involved in regulation of transcription.	Transcriptional regulatory protein; Involved in transcriptional mechanism.	0.462
MMAR_0123	MMAR_0085	MMAR_0123	MMAR_0085	Transcriptional regulatory protein (LuxR- family); Involved in transcriptional mechanism.	Transcriptional regulatory protein; Contains N-term ATPase domain and C-term DNA- binding domain; may be involved in regulation of transcription.	0.462
MMAR_0123	embR	MMAR_0123	MMAR_4155	Transcriptional regulatory protein (LuxR- family); Involved in transcriptional mechanism.	Transcriptional regulatory protein EmbR; Involved in transcriptional mechanism. thought to regulate the biosynthesis of the mycobacterial cell wall arabinan and resistance to ethambutol (Emb; dextro-2,2'- (ethylenediimino)-di-1-butanol), regulating EmbA and EmbB.	0.882
MMAR_0123	embR_1	MMAR_0123	MMAR_3545	Transcriptional regulatory protein (LuxR- family); Involved in transcriptional mechanism.	Transcriptional regulatory protein EmbR_1; Involved in transcriptional mechanism. thought to regulate the biosynthesis of the mycobacterial cell wall arabinan and resistance to ethambutol (Emb; dextro-2,2'- (ethylenediimino)-di-1-butanol), regulating EmbA and EmbB.	0.401
MMAR_0123	embR_2	MMAR_0123	MMAR_0930	Transcriptional regulatory protein (LuxR- family); Involved in transcriptional mechanism.	Transcriptional regulatory protein EmbR_2; Involved in transcriptional mechanism. thought to regulate the biosynthesis of the mycobacterial cell wall arabinan and resistance to ethambutol (Emb; dextro-2,2'- (ethylenediimino)-di-1-butanol), regulating EmbA and EmbB.	0.819
MMAR_0123	trcR	MMAR_0123	MMAR_4455	Transcriptional regulatory protein (LuxR- family); Involved in transcriptional mechanism.	Sensor part of the two-component regulatory system TrcS/TrcR. involved in transcriptional autoactivation: TrcR activates its own expression by interacting with the AT-rich sequence of the TrcR promoter.	0.680
MMAR_0132	MMAR_2876	MMAR_0132	MMAR_2876	Response regulator of a two-component regulatory system involved in transcriptional regulatory mechanism. has domain homology to CitB, a response regulator containing a CheY-like receiver domain and an HTH DNA- binding domain.	Conserved hypothetical regulatory protein; Function unknown but weak domain identity with two- component response regulators.	0.681
MMAR_0132	narL	MMAR_0132	MMAR_4782	Response regulator of a two-component regulatory system involved in transcriptional regulatory mechanism. has domain homology to CitB, a response regulator containing a CheY-like receiver domain and an HTH DNA- binding domain.	Nitrate/nitrite response regulator protein NarL.	0.924
MMAR_0612	MMAR_0085	MMAR_0612	MMAR_0085	Transcriptional regulatory protein; Involved in transcriptional mechanism.	Transcriptional regulatory protein; Contains N-term ATPase domain and C-term DNA- binding domain; may be involved in regulation of transcription.	0.415
MMAR_0612	MMAR_1324	MMAR_0612	MMAR_1324	Transcriptional regulatory protein; Involved in transcriptional mechanism.	Conserved hypothetical membrane protein; May be involved in regulation.	0.747
MMAR_0612	MMAR_2876	MMAR_0612	MMAR_2876	Transcriptional regulatory protein; Involved in transcriptional mechanism.	Conserved hypothetical regulatory protein; Function unknown but weak domain identity with two- component response regulators.	0.489
MMAR_0612	embR	MMAR_0612	MMAR_4155	Transcriptional regulatory protein; Involved in transcriptional mechanism.	Transcriptional regulatory protein EmbR; Involved in transcriptional mechanism. thought to regulate the biosynthesis of the mycobacterial cell wall arabinan and resistance to ethambutol (Emb; dextro-2,2'- (ethylenediimino)-di-1-butanol), regulating EmbA and EmbB.	0.571
MMAR_0612	embR_1	MMAR_0612	MMAR_3545	Transcriptional regulatory protein; Involved in transcriptional mechanism.	Transcriptional regulatory protein EmbR_1; Involved in transcriptional mechanism. thought to regulate the biosynthesis of the mycobacterial cell wall arabinan and resistance to ethambutol (Emb; dextro-2,2'- (ethylenediimino)-di-1-butanol), regulating EmbA and EmbB.	0.427
MMAR_0612	embR_2	MMAR_0612	MMAR_0930	Transcriptional regulatory protein; Involved in transcriptional mechanism.	Transcriptional regulatory protein EmbR_2; Involved in transcriptional mechanism. thought to regulate the biosynthesis of the mycobacterial cell wall arabinan and resistance to ethambutol (Emb; dextro-2,2'- (ethylenediimino)-di-1-butanol), regulating EmbA and EmbB.	0.446
MMAR_1324	MMAR_0085	MMAR_1324	MMAR_0085	Conserved hypothetical membrane protein; May be involved in regulation.	Transcriptional regulatory protein; Contains N-term ATPase domain and C-term DNA- binding domain; may be involved in regulation of transcription.	0.831
MMAR_1324	MMAR_0612	MMAR_1324	MMAR_0612	Conserved hypothetical membrane protein; May be involved in regulation.	Transcriptional regulatory protein; Involved in transcriptional mechanism.	0.747
MMAR_2876	MMAR_0132	MMAR_2876	MMAR_0132	Conserved hypothetical regulatory protein; Function unknown but weak domain identity with two- component response regulators.	Response regulator of a two-component regulatory system involved in transcriptional regulatory mechanism. has domain homology to CitB, a response regulator containing a CheY-like receiver domain and an HTH DNA- binding domain.	0.681