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lacZ lacZ lacI lacI BZ172_17320 BZ172_17320 yiaJ yiaJ mhpA mhpA mhpB mhpB BZ172_17510 BZ172_17510 mhpD_2 mhpD_2 mhpF mhpF mhpE mhpE hcr hcr ybjW ybjW ophA1 ophA1 GCA_000283715_01424 GCA_000283715_01424 antA antA hcaA1 hcaA1 hcaA2 hcaA2 hcaC hcaC hcaB hcaB hcaD hcaD hmp hmp norV norV norW norW nirB nirB nirD nirD fpr fpr nsrR nsrR ytfE ytfE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
lacZUnannotated protein; Belongs to the glycosyl hydrolase 2 family. (1024 aa)
lacIUnannotated protein. (363 aa)
BZ172_17320Unannotated protein. (160 aa)
yiaJUnannotated protein. (109 aa)
mhpAUnannotated protein; Catalyzes the insertion of one atom of molecular oxygen into position 2 of the phenyl ring of 3-(3-hydroxyphenyl)propionate (3-HPP) and hydroxycinnamic acid (3HCI). (554 aa)
mhpBUnannotated protein; Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3-dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2-hydroxy-6- ketononatrienedioate, respectively; Belongs to the LigB/MhpB extradiol dioxygenase family. (314 aa)
BZ172_17510Unannotated protein. (288 aa)
mhpD_2Unannotated protein; Catalyzes the conversion of 2-hydroxypentadienoic acid (enolic form of 2-oxopent-4-enoate) to 4-hydroxy-2-ketopentanoic acid. Belongs to the hydratase/decarboxylase family. MhpD subfamily. (269 aa)
mhpFUnannotated protein; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. (316 aa)
mhpEUnannotated protein; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. (337 aa)
hcrUnannotated protein. (322 aa)
ybjWUnannotated protein; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. (550 aa)
ophA1Unannotated protein; Converts carnitine to trimethylamine and malic semialdehyde. (191 aa)
GCA_000283715_01424Unannotated protein. (111 aa)
antAUnannotated protein; Converts carnitine to trimethylamine and malic semialdehyde. (374 aa)
hcaA1Unannotated protein; Part of the multicomponent 3-phenylpropionate dioxygenase. Converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3- phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid- dihydrodiol (CI-dihydrodiol), respectively; Belongs to the bacterial ring-hydroxylating dioxygenase alpha subunit family. (453 aa)
hcaA2Unannotated protein; Part of the multicomponent 3-phenylpropionate dioxygenase. Converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3- phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid- dihydrodiol (CI-dihydrodiol), respectively. (172 aa)
hcaCUnannotated protein; Part of the multicomponent 3-phenylpropionate dioxygenase, that converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid- dihydrodiol (CI-dihydrodiol), respectively. This protein seems to be a 2Fe-2S ferredoxin. (106 aa)
hcaBUnannotated protein; Converts 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol) into 3-(2,3- dihydroxylphenyl)propanoic acid (DHPP) and 2,3-dihydroxicinnamic acid (DHCI), respectively; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (270 aa)
hcaDUnannotated protein; Part of the multicomponent 3-phenylpropionate dioxygenase, that converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid- dihydrodiol (CI-dihydrodiol), respectively. (400 aa)
hmpUnannotated protein; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress; Belongs to the globin family. Two-domain flavohemoproteins subfamily. (396 aa)
norVUnannotated protein; Anaerobic nitric oxide reductase; uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center; electrons enter from the NorW at rubredoxin and are transferred sequentially to the FMN center and the di-iron center. Also able to function as an aerobic oxygen reductase; In the N-terminal section; belongs to the zinc metallo- hydrolase group 3 family. (479 aa)
norWUnannotated protein; One of at least two accessory proteins for anaerobic nitric oxide (NO) reductase. Reduces the rubredoxin moiety of NO reductase. (377 aa)
nirBUnannotated protein; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (847 aa)
nirDUnannotated protein. (108 aa)
fprUnannotated protein. (248 aa)
nsrRUnannotated protein; Nitric oxide-sensitive repressor of genes involved in protecting the cell against nitrosative stress. May require iron for activity. (141 aa)
ytfEUnannotated protein; Di-iron-containing protein involved in the repair of iron- sulfur clusters damaged by oxidative and nitrosative stress conditions. (220 aa)
Your Current Organism:
Shigella sonnei
NCBI taxonomy Id: 216599
Other names: S. sonnei 53G, Shigella sonnei 53G, Shigella sonnei str. 53G
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