(12 nodes) Base excision repair, and Mutator MutT-like network (Shigella sonnei)

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second shell of interactors

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proteins of unknown 3D structure

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Your Input:
	mutT	Unannotated protein; Belongs to the Nudix hydrolase family. (129 aa)
	sfsA	Unannotated protein; Binds to DNA non-specifically. Could be a regulatory factor involved in maltose metabolism. (234 aa)
	ligT	Unannotated protein; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. (176 aa)
	xth	Unannotated protein. (268 aa)
	nth	Unannotated protein; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (211 aa)
	alkA	Unannotated protein. (282 aa)
	nfo	Unannotated protein; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. (285 aa)
	ada	Unannotated protein. (354 aa)
	ung	Unannotated protein; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (229 aa)
	mutY	Unannotated protein; Adenine glycosylase active on G-A mispairs. (350 aa)
	mutM	Unannotated protein; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (269 aa)
	BZ172_30220	Unannotated protein. (153 aa)

Your Current Organism:

Shigella sonnei

NCBI taxonomy Id: 216599
Other names: S. sonnei 53G, Shigella sonnei 53G, Shigella sonnei str. 53G

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BZ172_30220	ada	GCA_000283715_05323	GCA_000283715_02567	Unannotated protein.	Unannotated protein.	0.588
BZ172_30220	alkA	GCA_000283715_05323	GCA_000283715_02407	Unannotated protein.	Unannotated protein.	0.494
ada	BZ172_30220	GCA_000283715_02567	GCA_000283715_05323	Unannotated protein.	Unannotated protein.	0.588
ada	alkA	GCA_000283715_02567	GCA_000283715_02407	Unannotated protein.	Unannotated protein.	0.958
ada	nth	GCA_000283715_02567	GCA_000283715_01710	Unannotated protein.	Unannotated protein; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.	0.433
ada	xth	GCA_000283715_02567	GCA_000283715_01529	Unannotated protein.	Unannotated protein.	0.463
alkA	BZ172_30220	GCA_000283715_02407	GCA_000283715_05323	Unannotated protein.	Unannotated protein.	0.494
alkA	ada	GCA_000283715_02407	GCA_000283715_02567	Unannotated protein.	Unannotated protein.	0.958
alkA	nfo	GCA_000283715_02407	GCA_000283715_02505	Unannotated protein.	Unannotated protein; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin.	0.494
alkA	nth	GCA_000283715_02407	GCA_000283715_01710	Unannotated protein.	Unannotated protein; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.	0.471
alkA	xth	GCA_000283715_02407	GCA_000283715_01529	Unannotated protein.	Unannotated protein.	0.889
ligT	sfsA	GCA_000283715_00161	GCA_000283715_00160	Unannotated protein; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family.	Unannotated protein; Binds to DNA non-specifically. Could be a regulatory factor involved in maltose metabolism.	0.809
mutM	mutT	GCA_000283715_04229	GCA_000283715_00107	Unannotated protein; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.	Unannotated protein; Belongs to the Nudix hydrolase family.	0.551
mutM	mutY	GCA_000283715_04229	GCA_000283715_03535	Unannotated protein; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.	Unannotated protein; Adenine glycosylase active on G-A mispairs.	0.531
mutM	nfo	GCA_000283715_04229	GCA_000283715_02505	Unannotated protein; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.	Unannotated protein; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin.	0.489
mutM	nth	GCA_000283715_04229	GCA_000283715_01710	Unannotated protein; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.	Unannotated protein; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.	0.578
mutT	mutM	GCA_000283715_00107	GCA_000283715_04229	Unannotated protein; Belongs to the Nudix hydrolase family.	Unannotated protein; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.	0.551
mutT	mutY	GCA_000283715_00107	GCA_000283715_03535	Unannotated protein; Belongs to the Nudix hydrolase family.	Unannotated protein; Adenine glycosylase active on G-A mispairs.	0.684
mutY	mutM	GCA_000283715_03535	GCA_000283715_04229	Unannotated protein; Adenine glycosylase active on G-A mispairs.	Unannotated protein; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.	0.531
mutY	mutT	GCA_000283715_03535	GCA_000283715_00107	Unannotated protein; Adenine glycosylase active on G-A mispairs.	Unannotated protein; Belongs to the Nudix hydrolase family.	0.684