STRINGSTRING
mraZ mraZ mraW mraW ftsL ftsL ftsI ftsI murE murE murF murF mraY mraY murD murD ftsW ftsW murG murG murC murC ddl_1 ddl_1 ftsQ ftsQ ftsA ftsA ftsZ ftsZ BZ172_16880 BZ172_16880 ddl_2 ddl_2 ybeD ybeD BZ172_19070 BZ172_19070 rlpA rlpA mrdB mrdB mrdA mrdA rlmH rlmH ybeB ybeB GCA_000283715_00878 GCA_000283715_00878 yceG yceG ycfH ycfH minE minE minD_2 minD_2 minC minC dadA dadA dadX dadX dacD dacD BZ172_03040 BZ172_03040 rodZ rodZ amiC amiC nlpD_1 nlpD_1 dacB dacB murA murA mtgA mtgA yhbL yhbL hemZ hemZ tldD tldD BZ172_08250 BZ172_08250 cafA cafA maf1 maf1 lytS lytS mreC mreC mreB mreB mrcA mrcA murB murB alr alr amiB amiB pmbA pmbA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mraZUnannotated protein; Negatively regulates its own expression and that of the subsequent genes in the proximal part of the division and cell wall (dcw) gene cluster. Acts by binding directly to DNA. May also regulate the expression of genes outside the dcw cluster. (152 aa)
mraWUnannotated protein; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (313 aa)
ftsLUnannotated protein; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. (121 aa)
ftsIUnannotated protein; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. (588 aa)
murEUnannotated protein; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (497 aa)
murFUnannotated protein; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (452 aa)
mraYUnannotated protein; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (360 aa)
murDUnannotated protein; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (438 aa)
ftsWUnannotated protein; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. (414 aa)
murGUnannotated protein; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (355 aa)
murCUnannotated protein; Cell wall formation; Belongs to the MurCDEF family. (491 aa)
ddl_1Unannotated protein; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (306 aa)
ftsQUnannotated protein; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. (276 aa)
ftsAUnannotated protein; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. (420 aa)
ftsZUnannotated protein; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (383 aa)
BZ172_16880Unannotated protein. (406 aa)
ddl_2Unannotated protein; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (364 aa)
ybeDUnannotated protein; Belongs to the UPF0250 family. (87 aa)
BZ172_19070Unannotated protein; Belongs to the peptidase S11 family. (427 aa)
rlpAUnannotated protein; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. (362 aa)
mrdBUnannotated protein; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. (370 aa)
mrdAUnannotated protein; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. (633 aa)
rlmHUnannotated protein; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family. (155 aa)
ybeBUnannotated protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. (105 aa)
GCA_000283715_00878Unannotated protein. (400 aa)
yceGUnannotated protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. (340 aa)
ycfHUnannotated protein. (265 aa)
minEUnannotated protein; Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell. (88 aa)
minD_2Unannotated protein. (270 aa)
minCUnannotated protein; Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization; Belongs to the MinC family. (231 aa)
dadAUnannotated protein; Oxidative deamination of D-amino acids. (432 aa)
dadXUnannotated protein; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (356 aa)
dacDUnannotated protein; Belongs to the peptidase S11 family. (388 aa)
BZ172_03040Unannotated protein. (289 aa)
rodZUnannotated protein; Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis. (337 aa)
amiCUnannotated protein. (417 aa)
nlpD_1Unannotated protein. (251 aa)
dacBUnannotated protein. (477 aa)
murAUnannotated protein; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (419 aa)
mtgAUnannotated protein; Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors; Belongs to the glycosyltransferase 51 family. (242 aa)
yhbLUnannotated protein; Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate; Belongs to the peptidase C56 family. (217 aa)
hemZUnannotated protein. (309 aa)
tldDUnannotated protein. (481 aa)
BZ172_08250Unannotated protein. (1266 aa)
cafAUnannotated protein. (489 aa)
maf1Unannotated protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. (197 aa)
lytSUnannotated protein; Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins. Belongs to the MreD family. (162 aa)
mreCUnannotated protein. (367 aa)
mreBUnannotated protein. (347 aa)
mrcAUnannotated protein. (850 aa)
murBUnannotated protein; Cell wall formation. (342 aa)
alrUnannotated protein; Catalyzes the interconversion of L-alanine and D-alanine. (359 aa)
amiBUnannotated protein. (445 aa)
pmbAUnannotated protein. (450 aa)
Your Current Organism:
Shigella sonnei
NCBI taxonomy Id: 216599
Other names: S. sonnei 53G, Shigella sonnei 53G, Shigella sonnei str. 53G
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