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| | bioH | Unannotated protein; The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters. (256 aa) |
| | thiH | Unannotated protein. (377 aa) |
| | metF | Unannotated protein; Belongs to the methylenetetrahydrofolate reductase family. (296 aa) |
| | metB | Unannotated protein. (386 aa) |
| | metJ | Unannotated protein; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family. (105 aa) |
| | fpr | Unannotated protein. (248 aa) |
| | yihT | Unannotated protein; Cleaves 6-deoxy-6-sulfo-D-fructose 1-phosphate (SFP) to form dihydroxyacetone phosphate (DHAP) and 3-sulfolactaldehyde (SLA). Belongs to the aldolase LacD family. (295 aa) |
| | yihU | Unannotated protein; Reduces 3-sulfolactaldehyde (SLA) to 2,3-dihydroxypropane 1- sulfonate (DHPS); Belongs to the HIBADH-related family. 3-sulfolactaldehyde reductase subfamily. (292 aa) |
| | rbsK_1 | Unannotated protein; Belongs to the carbohydrate kinase PfkB family. (267 aa) |
| | metE | Unannotated protein; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (753 aa) |
| | metR | Unannotated protein; Belongs to the LysR transcriptional regulatory family. (317 aa) |
| | yigL | Unannotated protein. (266 aa) |
| | cyaY | Unannotated protein; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. (106 aa) |
| | BZ172_10920 | Unannotated protein. (202 aa) |
| | cysE_4 | Unannotated protein; Belongs to the transferase hexapeptide repeat family. (273 aa) |
| | BZ172_09535 | Unannotated protein. (45 aa) |
| | gor | Unannotated protein. (450 aa) |
| | ggt | Unannotated protein. (499 aa) |
| | asd | Unannotated protein; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (367 aa) |
| | gntY | Unannotated protein; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. (191 aa) |
| | accC | Unannotated protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa) |
| | sspA | Unannotated protein; Belongs to the GST superfamily. (212 aa) |
| | BZ172_07975 | Unannotated protein; Belongs to the BolA/IbaG family. (89 aa) |
| | yhaM | Unannotated protein; Belongs to the UPF0597 family. (436 aa) |
| | GCA_000283715_03686 | Unannotated protein. (337 aa) |
| | gsp_2 | Unannotated protein. (386 aa) |
| | BZ172_06795 | Unannotated protein. (395 aa) |
| | yghU | Unannotated protein. (288 aa) |
| | gsp_1 | Unannotated protein. (619 aa) |
| | gshB | Unannotated protein; Belongs to the prokaryotic GSH synthase family. (316 aa) |
| | metK | Unannotated protein; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (384 aa) |
| | ygfH | Unannotated protein. (492 aa) |
| | csdE | Unannotated protein. (147 aa) |
| | csdA_1 | Unannotated protein. (401 aa) |
| | cysJ | Unannotated protein; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component. Belongs to the NADPH-dependent sulphite reductase flavoprotein subunit CysJ family. In the N-terminal section; belongs to the flavodoxin family. (599 aa) |
| | cysI | Unannotated protein; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (570 aa) |
| | cysH | Unannotated protein; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. (244 aa) |
| | cysD | Unannotated protein. (302 aa) |
| | cysN | Unannotated protein; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (475 aa) |
| | cysC | Unannotated protein; Catalyzes the synthesis of activated sulfate. (201 aa) |
| | gshA | Unannotated protein; Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily. (518 aa) |
| | yfhO | Unannotated protein; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur and selenium atoms from cysteine and selenocysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. Also functions as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate. (404 aa) |
| | iscU | Unannotated protein; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. (128 aa) |
| | iscA | Unannotated protein; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system TrxA/TrxB. (107 aa) |
| | hscB | Unannotated protein; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. (171 aa) |
| | hscA | Unannotated protein; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU. (616 aa) |
| | iscX | Unannotated protein. (66 aa) |
| | sseA | Unannotated protein. (281 aa) |
| | cysM | Unannotated protein; Belongs to the cysteine synthase/cystathionine beta- synthase family. (303 aa) |
| | BZ172_02930 | Unannotated protein; Belongs to the cysteine synthase/cystathionine beta- synthase family. (323 aa) |
| | cysZ | Unannotated protein; High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway; Belongs to the CysZ family. (253 aa) |
| | accD | Unannotated protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (304 aa) |
| | yfcG | Unannotated protein; Belongs to the GST superfamily. (215 aa) |
| | yfcF | Unannotated protein. (214 aa) |
| | pta | Unannotated protein; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (714 aa) |
| | ackA | Unannotated protein; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (400 aa) |
| | minD_3 | Unannotated protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (369 aa) |
| | thiM | Unannotated protein; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (262 aa) |
| | thiD | Unannotated protein. (266 aa) |
| | cysE_1 | Unannotated protein; Belongs to the transferase hexapeptide repeat family. (162 aa) |
| | BZ172_28300 | Unannotated protein; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (238 aa) |
| | yciA | Unannotated protein. (132 aa) |
| | fabI | Unannotated protein. (262 aa) |
| | gstB | Unannotated protein. (205 aa) |
| | bioD2 | Unannotated protein; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. Belongs to the dethiobiotin synthetase family. (231 aa) |
| | gstA | Unannotated protein. (45 aa) |
| | BZ172_24930 | Unannotated protein. (150 aa) |
| | grxD | Unannotated protein; Belongs to the glutaredoxin family. Monothiol subfamily. (115 aa) |
| | sufE | Unannotated protein; Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L- alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process; Belongs to the SufE family. (138 aa) |
| | sufS | Unannotated protein; Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L- selenocysteine. Selenocysteine lyase activity is however unsure in vivo. (406 aa) |
| | sufD | Unannotated protein. (423 aa) |
| | sufC | Unannotated protein. (248 aa) |
| | ynhE | Unannotated protein. (495 aa) |
| | sufA | Unannotated protein; Belongs to the HesB/IscA family. (122 aa) |
| | ynjE | Unannotated protein. (435 aa) |
| | thiK | Unannotated protein; Catalyzes the phosphorylation of thiamine to thiamine phosphate. (274 aa) |
| | grxB | Unannotated protein. (215 aa) |
| | yliJ | Unannotated protein; Belongs to the GST superfamily. (192 aa) |
| | bioD | Unannotated protein; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. Belongs to the dethiobiotin synthetase family. (222 aa) |
| | bioC | Unannotated protein; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. (251 aa) |
| | bioF | Unannotated protein; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (384 aa) |
| | bioB | Unannotated protein; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (346 aa) |
| | bioA | Unannotated protein; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (429 aa) |
| | sucB | Unannotated protein; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (405 aa) |
| | lipA | Unannotated protein; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (321 aa) |
| | citD | Unannotated protein; Covalent carrier of the coenzyme of citrate lyase. (98 aa) |
| | citE | Unannotated protein; Belongs to the HpcH/HpaI aldolase family. (302 aa) |
| | BZ172_18945 | Unannotated protein. (510 aa) |
| | folD | Unannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (288 aa) |
| | tesB | Unannotated protein. (286 aa) |
| | cof | Unannotated protein; Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5- hydroxymethylpyrimidine phosphate (HMP-P). (272 aa) |
| | thiI | Unannotated protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (482 aa) |
| | dxs | Unannotated protein; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (620 aa) |
| | iolS | Unannotated protein. (324 aa) |
| | thiL | Unannotated protein; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (325 aa) |
| | tauD | Unannotated protein. (283 aa) |
| | yaeR | Unannotated protein. (129 aa) |
| | accA | Unannotated protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (319 aa) |
| | mtnN | Unannotated protein; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation. Belongs to the PNP/UDP phosphorylase [...] (232 aa) |
| | yadR | Unannotated protein; Required for insertion of 4Fe-4S clusters for at least IspG. (114 aa) |
| | cysQ | Unannotated protein; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family. (246 aa) |
| | yjfC | Unannotated protein. (387 aa) |
| | BZ172_13910 | Unannotated protein. (120 aa) |
| | BZ172_13820 | Unannotated protein. (661 aa) |
| | GCA_000283715_04793 | Unannotated protein. (66 aa) |
| | metH | Unannotated protein; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1227 aa) |
| | metA | Unannotated protein; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. (309 aa) |
| | thiC | Unannotated protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (631 aa) |
| | thiE | Unannotated protein; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (211 aa) |
| | thiF_2 | Unannotated protein. (251 aa) |
| | thiS | Unannotated protein. (66 aa) |
| | thiG | Unannotated protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (256 aa) |
