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| | nnrD | Unannotated protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epim [...] (510 aa) |
| | purA | Unannotated protein; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (432 aa) |
| | cpdB | Unannotated protein; Belongs to the 5'-nucleotidase family. (647 aa) |
| | cysQ | Unannotated protein; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family. (246 aa) |
| | nrdG | Unannotated protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. (154 aa) |
| | pyrI | Unannotated protein; Involved in allosteric regulation of aspartate carbamoyltransferase. (153 aa) |
| | pyrB | Unannotated protein; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (311 aa) |
| | BZ172_15080 | Unannotated protein. (326 aa) |
| | deoC | Unannotated protein; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily. (259 aa) |
| | deoB | Unannotated protein; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (407 aa) |
| | nadR | Unannotated protein. (410 aa) |
| | yjjX | Unannotated protein; Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. (173 aa) |
| | cobC_1 | Unannotated protein; Belongs to the phosphoglycerate mutase family. GpmB subfamily. (215 aa) |
| | spaL | Unannotated protein; Required for surface presentation of invasion plasmid antigens. Probable catalytic subunit of a protein translocase. Required for invasion and for secretion of the three IPA proteins (By similarity). (430 aa) |
| | ushA-2 | Unannotated protein; Belongs to the 5'-nucleotidase family. (539 aa) |
| | lpxM-2 | Unannotated protein; Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)- lipid A. (314 aa) |
| | cmk | Unannotated protein. (227 aa) |
| | pykA | Unannotated protein; Belongs to the pyruvate kinase family. (480 aa) |
| | lpxK | Unannotated protein; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (328 aa) |
| | pncB | Unannotated protein; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (400 aa) |
| | pyrD | Unannotated protein; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (336 aa) |
| | appA_2 | Unannotated protein. (432 aa) |
| | clsC | Unannotated protein; Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) from phosphatidylglycerol (PG) and phosphatidylethanolamine (PE); Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsC sub-subfamily. (493 aa) |
| | lpxL | Unannotated protein; Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A). (306 aa) |
| | pyrC | Unannotated protein; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (348 aa) |
| | BZ172_22315 | Unannotated protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes 7- methyl-GTP (m(7)GTP). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids; Belongs to the Maf family. YceF subfamily. (207 aa) |
| | plsX | Unannotated protein; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (346 aa) |
| | tmk | Unannotated protein; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (213 aa) |
| | thiK | Unannotated protein; Catalyzes the phosphorylation of thiamine to thiamine phosphate. (274 aa) |
| | purB | Unannotated protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (456 aa) |
| | nadC | Unannotated protein; Belongs to the NadC/ModD family. (297 aa) |
| | pgsA | Unannotated protein; This protein catalyzes the committed step to the synthesis of the acidic phospholipids; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (182 aa) |
| | BZ172_23265 | Unannotated protein. (57 aa) |
| | lpxM | Unannotated protein; Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)- lipid A. (323 aa) |
| | BZ172_27860 | Unannotated protein. (617 aa) |
| | pgpB | Unannotated protein. (254 aa) |
| | pyrF | Unannotated protein; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (265 aa) |
| | ydcK | Unannotated protein. (326 aa) |
| | ygaD_2 | Unannotated protein; Belongs to the CinA family. (172 aa) |
| | add | Unannotated protein; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (333 aa) |
| | pdxY | Unannotated protein; Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP. (286 aa) |
| | pdxH | Unannotated protein; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (218 aa) |
| | purR | Unannotated protein; Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression. (341 aa) |
| | pykF | Unannotated protein; Belongs to the pyruvate kinase family. (470 aa) |
| | nadE | Unannotated protein; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. (275 aa) |
| | ynjF_2 | Unannotated protein; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (91 aa) |
| | pncA | Unannotated protein. (213 aa) |
| | nudL | Unannotated protein; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives. (192 aa) |
| | purT | Unannotated protein; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (392 aa) |
| | zwf | Unannotated protein; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (491 aa) |
| | grxC | Unannotated protein; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. (83 aa) |
| | gpsA | Unannotated protein; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (339 aa) |
| | eptB | Unannotated protein. (563 aa) |
| | glmU_1 | Unannotated protein; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (456 aa) |
| | atpC | Unannotated protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. (139 aa) |
| | atpD | Unannotated protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (460 aa) |
| | atpG | Unannotated protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (287 aa) |
| | atpA | Unannotated protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (513 aa) |
| | atpH | Unannotated protein; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (177 aa) |
| | atpF | Unannotated protein; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (156 aa) |
| | atpE | Unannotated protein; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (79 aa) |
| | atpB | Unannotated protein; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (271 aa) |
| | gppA | Unannotated protein; Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities. (494 aa) |
| | cyaA | Unannotated protein; Belongs to the adenylyl cyclase class-1 family. (848 aa) |
| | udp | Unannotated protein; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family. (253 aa) |
| | mobB | Unannotated protein. (175 aa) |
| | mobA | Unannotated protein; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family. (194 aa) |
| | fdhD | Unannotated protein; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (277 aa) |
| | pfkA | Unannotated protein; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (320 aa) |
| | cdh | Unannotated protein. (251 aa) |
| | tpiA | Unannotated protein; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (255 aa) |
| | glpK | Unannotated protein; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. (503 aa) |
| | coaA | Unannotated protein. (308 aa) |
| | thiG | Unannotated protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (256 aa) |
| | thiS | Unannotated protein. (66 aa) |
| | thiF_2 | Unannotated protein. (251 aa) |
| | thiE | Unannotated protein; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (211 aa) |
| | thiC | Unannotated protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (631 aa) |
| | nudC | Unannotated protein; Belongs to the Nudix hydrolase family. NudC subfamily. (257 aa) |
| | purD | Unannotated protein. (429 aa) |
| | purH | Unannotated protein. (529 aa) |
| | pgi | Unannotated protein; Belongs to the GPI family. (549 aa) |
| | plsB | Unannotated protein; Belongs to the GPAT/DAPAT family. (807 aa) |
| | dgkA | Unannotated protein; Recycling of diacylglycerol produced during the turnover of membrane phospholipid. (122 aa) |
| | GCA_000283715_04793 | Unannotated protein. (66 aa) |
| | phnP | Unannotated protein. (252 aa) |
| | phnO | Unannotated protein. (144 aa) |
| | phnN | Unannotated protein; Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP). (185 aa) |
| | phnM | Unannotated protein. (378 aa) |
| | phnL | Unannotated protein. (226 aa) |
| | phnK | Unannotated protein. (252 aa) |
| | phnJ | Unannotated protein; Catalyzes the breakage of the C-P bond in alpha-D-ribose 1- methylphosphonate 5-phosphate (PRPn) forming alpha-D-ribose. Belongs to the PhnJ family. (281 aa) |
| | phnI | Unannotated protein. (354 aa) |
| | phnH | Unannotated protein. (194 aa) |
| | lpxC | Unannotated protein; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (305 aa) |
| | coaE | Unannotated protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (206 aa) |
| | guaC | Unannotated protein; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (347 aa) |
| | phnG | Unannotated protein. (150 aa) |
| | BZ172_13910 | Unannotated protein. (120 aa) |
| | tal2 | Unannotated protein; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (317 aa) |
| | mog | Unannotated protein. (195 aa) |
| | BZ172_15740 | Unannotated protein; Belongs to the ribF family. (313 aa) |
| | ispH | Unannotated protein; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. (316 aa) |
| | carA | Unannotated protein; Belongs to the CarA family. (382 aa) |
| | carB | Unannotated protein; Belongs to the CarB family. (1073 aa) |
| | pdxA | Unannotated protein; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (329 aa) |
| | araD | Unannotated protein; Involved in the degradation of L-arabinose. Catalyzes the interconversion of L-ribulose 5-phosphate (LRu5P) and D-xylulose 5- phosphate (D-Xu5P) via a retroaldol/aldol mechanism (carbon-carbon bond cleavage analogous to a class II aldolase reaction). (231 aa) |
| | araA | Unannotated protein; Catalyzes the conversion of L-arabinose to L-ribulose. (500 aa) |
| | araB | Unannotated protein. (566 aa) |
| | gpmM | Unannotated protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (514 aa) |
| | coaD | Unannotated protein; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (159 aa) |
| | dfp | Unannotated protein; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (406 aa) |
| | dut | Unannotated protein; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (152 aa) |
| | pyrE | Unannotated protein; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (213 aa) |
| | gmk | Unannotated protein; Essential for recycling GMP and indirectly, cGMP. (207 aa) |
| | spoT | Unannotated protein; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (702 aa) |
| | glpD | Unannotated protein; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (501 aa) |
| | nudE | Unannotated protein. (186 aa) |
| | rpe | Unannotated protein; Belongs to the ribulose-phosphate 3-epimerase family. (225 aa) |
| | GCA_000283715_03944 | Unannotated protein. (129 aa) |
| | GCA_000283715_03943 | Unannotated protein. (249 aa) |
| | accC | Unannotated protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa) |
| | maf1 | Unannotated protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. (197 aa) |
| | BZ172_06610 | Unannotated protein. (167 aa) |
| | plsY | Unannotated protein; Catalyzes the transfer of an acyl group from acyl-ACP to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme can also utilize acyl-CoA as fatty acyl donor, but not acyl- PO(4); Belongs to the PlsY family. (205 aa) |
| | nudF | Unannotated protein. (209 aa) |
| | plsC | Unannotated protein; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (245 aa) |
| | BZ172_06690 | Unannotated protein. (230 aa) |
| | BZ172_07220 | Unannotated protein. (232 aa) |
| | yghR_2 | Unannotated protein. (252 aa) |
| | BZ172_07290 | Unannotated protein. (1171 aa) |
| | rdgB | Unannotated protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (197 aa) |
| | yqgE | Unannotated protein; Belongs to the UPF0301 (AlgH) family. (211 aa) |
| | tktA | Unannotated protein; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (663 aa) |
| | epd | Unannotated protein; Catalyzes the NAD-dependent conversion of D-erythrose 4- phosphate to 4-phosphoerythronate. (339 aa) |
| | pgk | Unannotated protein; Belongs to the phosphoglycerate kinase family. (387 aa) |
| | fbaA | Unannotated protein; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (359 aa) |
| | ygfH | Unannotated protein. (492 aa) |
| | rpiA | Unannotated protein; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (219 aa) |
| | psd | Unannotated protein; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (322 aa) |
| | idi | Unannotated protein; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). (182 aa) |
| | BZ172_06035 | Unannotated protein. (192 aa) |
| | aas | Unannotated protein; Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1; In the C-terminal section; belongs to the ATP-dependent AMP-binding enzyme family. (719 aa) |
| | thyA_2 | Unannotated protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa) |
| | relA | Unannotated protein; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (744 aa) |
| | mazG | Unannotated protein. (263 aa) |
| | pyrG | Unannotated protein; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (545 aa) |
| | eno | Unannotated protein; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (432 aa) |
| | ispD | Unannotated protein; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. (236 aa) |
| | ispF | Unannotated protein; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (159 aa) |
| | surE | Unannotated protein; Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. (253 aa) |
| | BZ172_05160 | Unannotated protein. (117 aa) |
| | ygaD_1 | Unannotated protein; Belongs to the CinA family. (165 aa) |
| | nrdF | Unannotated protein; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (319 aa) |
| | ppnK | Unannotated protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (292 aa) |
| | pssA | Unannotated protein. (451 aa) |
| | nadB_1 | Unannotated protein. (313 aa) |
| | nadB_2 | Unannotated protein. (235 aa) |
| | GCA_000283715_02983 | Unannotated protein. (684 aa) |
| | yfhB | Unannotated protein. (211 aa) |
| | purL | Unannotated protein; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1295 aa) |
| | suhB | Unannotated protein; Belongs to the inositol monophosphatase superfamily. (267 aa) |
| | ndk | Unannotated protein; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (143 aa) |
| | ispG | Unannotated protein; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (372 aa) |
| | guaB | Unannotated protein; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (488 aa) |
| | guaA | Unannotated protein; Catalyzes the synthesis of GMP from XMP. (525 aa) |
| | ppk | Unannotated protein; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. (688 aa) |
| | purN | Unannotated protein; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (212 aa) |
| | purM | Unannotated protein. (345 aa) |
| | upp | Unannotated protein; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (208 aa) |
| | purC | Unannotated protein; Belongs to the SAICAR synthetase family. (237 aa) |
| | GCA_000283715_02871 | Unannotated protein. (32 aa) |
| | nudK | Unannotated protein. (132 aa) |
| | tktB | Unannotated protein; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (667 aa) |
| | tal1 | Unannotated protein; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (316 aa) |
| | pdxK | Unannotated protein; B6-vitamer kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxine (PN), pyridoxal (PL), and pyridoxamine (PM), forming their respective 5'-phosphorylated esters, i.e. PNP, PLP and PMP. (283 aa) |
| | glk | Unannotated protein; Belongs to the bacterial glucokinase family. (321 aa) |
| | ddg | Unannotated protein; Catalyzes the transfer of palmitoleate from palmitoleoyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (palmitoleoyl)-lipid IV(A); Belongs to the LpxL/LpxM/LpxP family. LpxP subfamily. (306 aa) |
| | accD | Unannotated protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (304 aa) |
| | purF | Unannotated protein; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (505 aa) |
| | yfcD | Unannotated protein. (180 aa) |
| | pta | Unannotated protein; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (714 aa) |
| | ackA | Unannotated protein; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (400 aa) |
| | yfbR | Unannotated protein; Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates. (199 aa) |
| | arnF | Unannotated protein; Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane; Belongs to the ArnF family. (128 aa) |
| | arnE | Unannotated protein; Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane; Belongs to the ArnE family. (111 aa) |
| | arnT | Unannotated protein; Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. Belongs to the glycosyltransferase 83 family. (550 aa) |
| | arnD | Unannotated protein; Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; Belongs to the polysaccharide deacetylase family. ArnD deformylase subfamily. (296 aa) |
| | arnA | Unannotated protein; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; In the N-terminal section; belongs to the Fmt family. UDP- L-Ara4N formyltransferase subfamily. (660 aa) |
| | aceE | Unannotated protein; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (887 aa) |
| | aceF | Unannotated protein; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (630 aa) |
| | BZ172_16315 | Unannotated protein; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (178 aa) |
| | dgt_2 | Unannotated protein; dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs. (286 aa) |
| | BZ172_16605 | Unannotated protein. (211 aa) |
| | BZ172_16630 | Unannotated protein. (270 aa) |
| | pyrH | Unannotated protein; Catalyzes the reversible phosphorylation of UMP to UDP. (241 aa) |
| | dxr | Unannotated protein; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP). (398 aa) |
| | BZ172_16690 | Unannotated protein; Belongs to the CDS family. (249 aa) |
| | lpxD | Unannotated protein; Catalyzes the N-acylation of UDP-3-O- (hydroxytetradecanoyl)glucosamine using 3-hydroxytetradecanoyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell; Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (341 aa) |
| | fabZ | Unannotated protein; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (151 aa) |
| | lpxA | Unannotated protein; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (262 aa) |
| | lpxB | Unannotated protein; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (382 aa) |
| | accA | Unannotated protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (319 aa) |
| | arnC | Unannotated protein; Catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. (322 aa) |
| | arnB | Unannotated protein; Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; Belongs to the DegT/DnrJ/EryC1 family. ArnB subfamily. (385 aa) |
| | yfaY | Unannotated protein; Belongs to the CinA family. (400 aa) |
| | glpB | Unannotated protein; Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor. (419 aa) |
| | glpA | Unannotated protein; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (542 aa) |
| | nrdB_2 | Unannotated protein. (376 aa) |
| | napA | Unannotated protein; Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite. (828 aa) |
| | yeiU | Unannotated protein; Involved in the modification of the lipid A domain of lipopolysaccharides (LPS). Transfers a phosphate group from undecaprenyl pyrophosphate (C55-PP) to lipid A to form lipid A 1- diphosphate. Contributes to the recycling of undecaprenyl phosphate (C55-P); Belongs to the LpxT phosphotransferase family. (237 aa) |
| | folE | Unannotated protein. (222 aa) |
| | thiM | Unannotated protein; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (262 aa) |
| | thiD | Unannotated protein. (266 aa) |
| | fbaB | Unannotated protein. (350 aa) |
| | gatY | Unannotated protein; Catalytic subunit of the tagatose-1,6-bisphosphate aldolase GatYZ, which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6-bisphosphate (TBP). Requires GatZ subunit for full activity and stability. Is involved in the catabolism of galactitol. (284 aa) |
| | gatZ_2 | Unannotated protein. (159 aa) |
| | gatZ_1 | Unannotated protein. (266 aa) |
| | yegS | Unannotated protein; Probably phosphorylates lipids; the in vivo substrate is unknown; Belongs to the diacylglycerol/lipid kinase family. YegS lipid kinase subfamily. (299 aa) |
| | udk | Unannotated protein. (213 aa) |
| | dcd | Unannotated protein; Catalyzes the deamination of dCTP to dUTP. (193 aa) |
| | gnd | Unannotated protein; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (468 aa) |
| | amn | Unannotated protein; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations. (484 aa) |
| | fliI | Unannotated protein. (457 aa) |
| | prs | Unannotated protein; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (337 aa) |
| | ipk | Unannotated protein; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol; Belongs to the GHMP kinase family. IspE subfamily. (283 aa) |
| | purU | Unannotated protein; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (280 aa) |
| | BZ172_28225 | Unannotated protein. (314 aa) |
| | tdk | Unannotated protein. (205 aa) |
| | cls | Unannotated protein; Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. (486 aa) |
| | yciA | Unannotated protein. (132 aa) |
| | yaeR | Unannotated protein. (129 aa) |
| | gmhA | Unannotated protein; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate. (192 aa) |
| | gpt | Unannotated protein; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (152 aa) |
| | thiL | Unannotated protein; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (325 aa) |
| | pgpA | Unannotated protein; Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). (172 aa) |
| | dxs | Unannotated protein; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (620 aa) |
| | thiI | Unannotated protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (482 aa) |
| | tesB | Unannotated protein. (286 aa) |
| | apt | Unannotated protein; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (183 aa) |
| | adk | Unannotated protein; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (214 aa) |
| | ushA | Unannotated protein; Belongs to the 5'-nucleotidase family. (550 aa) |
| | folD | Unannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (288 aa) |
| | lpxH | Unannotated protein; Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (240 aa) |
| | purE | Unannotated protein; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (169 aa) |
| | purK | Unannotated protein; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (355 aa) |
| | uspG | Unannotated protein. (142 aa) |
| | BZ172_18945 | Unannotated protein. (510 aa) |
| | citE | Unannotated protein; Belongs to the HpcH/HpaI aldolase family. (302 aa) |
| | citD | Unannotated protein; Covalent carrier of the coenzyme of citrate lyase. (98 aa) |
| | pagP | Unannotated protein; Transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors. (160 aa) |
| | nadD | Unannotated protein; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (213 aa) |
| | corC | Unannotated protein. (292 aa) |
| | sucB | Unannotated protein; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (405 aa) |
| | nadA_1 | Unannotated protein; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (297 aa) |
| | BZ172_19725 | Unannotated protein. (45 aa) |
| | gpmA | Unannotated protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (250 aa) |
| | pgl | Unannotated protein; Catalyzes the hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate. (331 aa) |
| | moaA | Unannotated protein; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (329 aa) |
| | moaB | Unannotated protein; May be involved in the biosynthesis of molybdopterin. Belongs to the MoaB/Mog family. (170 aa) |
| | moaC | Unannotated protein; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (161 aa) |
| | moaD | Unannotated protein. (81 aa) |
| | moaE | Unannotated protein. (150 aa) |
| | ybhO | Unannotated protein; Catalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. (413 aa) |
| | moeB | Unannotated protein. (249 aa) |
| | moeA | Unannotated protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (411 aa) |
| | grxA | Unannotated protein. (85 aa) |
