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| | ilvE | Unannotated protein; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (309 aa) |
| | thrA | Unannotated protein; In the C-terminal section; belongs to the homoserine dehydrogenase family. (820 aa) |
| | thrB | Unannotated protein; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (310 aa) |
| | thrC | Unannotated protein. (428 aa) |
| | BZ172_15740 | Unannotated protein; Belongs to the ribF family. (313 aa) |
| | dapB | Unannotated protein; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (273 aa) |
| | carA | Unannotated protein; Belongs to the CarA family. (382 aa) |
| | carB | Unannotated protein; Belongs to the CarB family. (1073 aa) |
| | folA | Unannotated protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (196 aa) |
| | pdxA | Unannotated protein; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (329 aa) |
| | leuD | Unannotated protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (201 aa) |
| | leuC | Unannotated protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (466 aa) |
| | leuB | Unannotated protein; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (363 aa) |
| | leuA | Unannotated protein; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (523 aa) |
| | ilvI | Unannotated protein. (574 aa) |
| | ilvH | Unannotated protein. (163 aa) |
| | BZ172_16315 | Unannotated protein; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (178 aa) |
| | panD | Unannotated protein; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (126 aa) |
| | panC | Unannotated protein; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (283 aa) |
| | panB | Unannotated protein; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (264 aa) |
| | folK | Unannotated protein. (159 aa) |
| | mtnN | Unannotated protein; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation. Belongs to the PNP/UDP phosphorylase [...] (232 aa) |
| | dapD | Unannotated protein; Belongs to the transferase hexapeptide repeat family. (274 aa) |
| | fabZ | Unannotated protein; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (151 aa) |
| | accA | Unannotated protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (319 aa) |
| | dkgB | Unannotated protein. (267 aa) |
| | gpt | Unannotated protein; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (152 aa) |
| | proB | Unannotated protein; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (367 aa) |
| | proA | Unannotated protein; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (417 aa) |
| | BZ172_17485 | Unannotated protein. (289 aa) |
| | proC | Unannotated protein; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (269 aa) |
| | aroL | Unannotated protein; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate. (174 aa) |
| | aroM | Unannotated protein. (225 aa) |
| | acpH | Unannotated protein; Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP; Belongs to the AcpH family. (193 aa) |
| | queA | Unannotated protein; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (356 aa) |
| | tgt | Unannotated protein; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. [...] (375 aa) |
| | ribD | Unannotated protein; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (367 aa) |
| | ribE_1 | Unannotated protein; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. (156 aa) |
| | thiL | Unannotated protein; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (325 aa) |
| | dxs | Unannotated protein; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (620 aa) |
| | thiI | Unannotated protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (482 aa) |
| | panE | Unannotated protein; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (303 aa) |
| | queC | Unannotated protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (231 aa) |
| | cof | Unannotated protein; Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5- hydroxymethylpyrimidine phosphate (HMP-P). (272 aa) |
| | apt | Unannotated protein; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (183 aa) |
| | folD | Unannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (288 aa) |
| | lipA | Unannotated protein; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (321 aa) |
| | cobC_2 | Unannotated protein; Belongs to the phosphoglycerate mutase family. (174 aa) |
| | ubiF | Unannotated protein. (391 aa) |
| | asnB | Unannotated protein. (554 aa) |
| | nadA_1 | Unannotated protein; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (297 aa) |
| | BZ172_19725 | Unannotated protein. (45 aa) |
| | aroG | Unannotated protein; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (350 aa) |
| | gpmA | Unannotated protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (250 aa) |
| | queH | Unannotated protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). (221 aa) |
| | bioA | Unannotated protein; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (429 aa) |
| | bioB | Unannotated protein; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (346 aa) |
| | bioF | Unannotated protein; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (384 aa) |
| | bioC | Unannotated protein; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. (251 aa) |
| | bioD | Unannotated protein; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. Belongs to the dethiobiotin synthetase family. (222 aa) |
| | trpD2 | Unannotated protein. (320 aa) |
| | supH | Unannotated protein. (271 aa) |
| | ybjI | Unannotated protein. (271 aa) |
| | BZ172_20685 | Unannotated protein. (476 aa) |
| | serS | Unannotated protein; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (430 aa) |
| | serC | Unannotated protein; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (362 aa) |
| | aroA | Unannotated protein; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (427 aa) |
| | fabA | Unannotated protein; Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E- (2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length. (208 aa) |
| | mgsA | Unannotated protein; Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. (152 aa) |
| | putA | Unannotated protein; Oxidizes proline to glutamate for use as a carbon and nitrogen source; Belongs to the aldehyde dehydrogenase family. In the N-terminal section; belongs to the proline dehydrogenase family. (1320 aa) |
| | ycdW | Unannotated protein; Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. (312 aa) |
| | lpxL | Unannotated protein; Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A). (306 aa) |
| | plsX | Unannotated protein; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (346 aa) |
| | fabH | Unannotated protein; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (317 aa) |
| | fabD | Unannotated protein. (309 aa) |
| | fabG_1 | Unannotated protein; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (244 aa) |
| | acpP | Unannotated protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (78 aa) |
| | fabF | Unannotated protein; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (413 aa) |
| | pabC | Unannotated protein. (269 aa) |
| | thiK | Unannotated protein; Catalyzes the phosphorylation of thiamine to thiamine phosphate. (274 aa) |
| | BZ172_23405 | Unannotated protein. (169 aa) |
| | lpxM | Unannotated protein; Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)- lipid A. (323 aa) |
| | sdaA | Unannotated protein; Belongs to the iron-sulfur dependent L-serine dehydratase family. (454 aa) |
| | selD | Unannotated protein; Synthesizes selenophosphate from selenide and ATP. (347 aa) |
| | astC | Unannotated protein; Catalyzes the transamination of N(2)-succinylornithine and alpha-ketoglutarate into N(2)-succinylglutamate semialdehyde and glutamate. Can also act as an acetylornithine aminotransferase. Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. AstC subfamily. (406 aa) |
| | aroH | Unannotated protein; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (348 aa) |
| | ppsA | Unannotated protein; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (792 aa) |
| | aroD | Unannotated protein; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (252 aa) |
| | ydiB | Unannotated protein; The actual biological function of YdiB remains unclear, nor is it known whether 3-dehydroshikimate or quinate represents the natural substrate. Catalyzes the reversible NAD-dependent reduction of both 3-dehydroshikimate (DHSA) and 3-dehydroquinate to yield shikimate (SA) and quinate, respectively. It can use both NAD or NADP for catalysis, however it has higher catalytic efficiency with NAD. (288 aa) |
| | ydiI | Unannotated protein; Catalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA). (136 aa) |
| | ribE_2 | Unannotated protein. (213 aa) |
| | pdxH | Unannotated protein; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (218 aa) |
| | pdxY | Unannotated protein; Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP. (286 aa) |
| | ydfG | Unannotated protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (248 aa) |
| | bioD2 | Unannotated protein; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. Belongs to the dethiobiotin synthetase family. (231 aa) |
| | ydgC | Unannotated protein. (111 aa) |
| | fabI | Unannotated protein. (262 aa) |
| | ribA | Unannotated protein; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate. (196 aa) |
| | btuR | Unannotated protein; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. (196 aa) |
| | trpE | Unannotated protein. (520 aa) |
| | trpD | Unannotated protein; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (531 aa) |
| | trpF | Unannotated protein; Belongs to the TrpC family. (452 aa) |
| | trpB | Unannotated protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (397 aa) |
| | trpA | Unannotated protein; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (268 aa) |
| | kdsA | Unannotated protein; Belongs to the KdsA family. (284 aa) |
| | yedP | Unannotated protein. (271 aa) |
| | cobT_2 | Unannotated protein; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). Belongs to the CobT family. (359 aa) |
| | cobS_2 | Unannotated protein; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (247 aa) |
| | BZ172_00210 | Unannotated protein; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. (181 aa) |
| | BZ172_00215 | Unannotated protein. (145 aa) |
| | yvqK | Unannotated protein; Belongs to the Cob(I)alamin adenosyltransferase family. (335 aa) |
| | hisG | Unannotated protein; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. (299 aa) |
| | hisD | Unannotated protein; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (434 aa) |
| | hisC | Unannotated protein; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (356 aa) |
| | hisB | Unannotated protein; In the N-terminal section; belongs to the histidinol- phosphatase family. (355 aa) |
| | hisH | Unannotated protein; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (196 aa) |
| | hisA | Unannotated protein. (245 aa) |
| | hisF | Unannotated protein; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (258 aa) |
| | hisIE | Unannotated protein; In the N-terminal section; belongs to the PRA-CH family. (203 aa) |
| | ugd | Unannotated protein. (388 aa) |
| | cysE_1 | Unannotated protein; Belongs to the transferase hexapeptide repeat family. (162 aa) |
| | thiD | Unannotated protein. (266 aa) |
| | thiM | Unannotated protein; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (262 aa) |
| | ubiG | Unannotated protein; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family. (240 aa) |
| | menE | Unannotated protein; Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA); Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily. (451 aa) |
| | menC | Unannotated protein; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). (320 aa) |
| | menB | Unannotated protein; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA). (285 aa) |
| | menH | Unannotated protein; Catalyzes a proton abstraction reaction that results in 2,5- elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6- hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). (252 aa) |
| | menD | Unannotated protein; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Belongs to the TPP enzyme family. MenD subfamily. (556 aa) |
| | ubiX | Unannotated protein; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (189 aa) |
| | folC | Unannotated protein; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. (422 aa) |
| | accD | Unannotated protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (304 aa) |
| | usg | Unannotated protein; Belongs to the aspartate-semialdehyde dehydrogenase family. (337 aa) |
| | pdxB | Unannotated protein; Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate. (378 aa) |
| | fabB | Unannotated protein; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (406 aa) |
| | aroC | Unannotated protein; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (361 aa) |
| | ddg | Unannotated protein; Catalyzes the transfer of palmitoleate from palmitoleoyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (palmitoleoyl)-lipid IV(A); Belongs to the LpxL/LpxM/LpxP family. LpxP subfamily. (306 aa) |
| | cysZ | Unannotated protein; High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway; Belongs to the CysZ family. (253 aa) |
| | BZ172_02930 | Unannotated protein; Belongs to the cysteine synthase/cystathionine beta- synthase family. (323 aa) |
| | pdxK | Unannotated protein; B6-vitamer kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxine (PN), pyridoxal (PL), and pyridoxamine (PM), forming their respective 5'-phosphorylated esters, i.e. PNP, PLP and PMP. (283 aa) |
| | cysM | Unannotated protein; Belongs to the cysteine synthase/cystathionine beta- synthase family. (303 aa) |
| | eutT | Unannotated protein. (267 aa) |
| | dapE | Unannotated protein; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (375 aa) |
| | purC | Unannotated protein; Belongs to the SAICAR synthetase family. (237 aa) |
| | dapA | Unannotated protein; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (292 aa) |
| | glyA | Unannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa) |
| | acpS | Unannotated protein; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (126 aa) |
| | pdxJ | Unannotated protein; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (243 aa) |
| | ratA | Unannotated protein. (149 aa) |
| | aroF | Unannotated protein; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (356 aa) |
| | tyrA | Unannotated protein. (373 aa) |
| | pheA | Unannotated protein. (386 aa) |
| | cysI | Unannotated protein; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (570 aa) |
| | cysJ | Unannotated protein; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component. Belongs to the NADPH-dependent sulphite reductase flavoprotein subunit CysJ family. In the N-terminal section; belongs to the flavodoxin family. (599 aa) |
| | sscR | Unannotated protein. (121 aa) |
| | queE | Unannotated protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (223 aa) |
| | queF | Unannotated protein; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). (282 aa) |
| | BZ172_05590 | Unannotated protein; Belongs to the iron-sulfur dependent L-serine dehydratase family. (455 aa) |
| | argA | Unannotated protein; Belongs to the acetyltransferase family. ArgA subfamily. (443 aa) |
| | lysA | Unannotated protein; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (420 aa) |
| | lysR | Unannotated protein; Belongs to the LysR transcriptional regulatory family. (311 aa) |
| | BZ172_05985 | Unannotated protein. (292 aa) |
| | ygeW | Unannotated protein; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (395 aa) |
| | ygeX | Unannotated protein. (398 aa) |
| | preT_3 | Unannotated protein. (1032 aa) |
| | hcrA_2 | Unannotated protein. (979 aa) |
| | visC | Unannotated protein. (400 aa) |
| | ubiH | Unannotated protein. (392 aa) |
| | serA | Unannotated protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (410 aa) |
| | epd | Unannotated protein; Catalyzes the NAD-dependent conversion of D-erythrose 4- phosphate to 4-phosphoerythronate. (339 aa) |
| | dkgA | Unannotated protein. (275 aa) |
| | ribB | Unannotated protein; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. (217 aa) |
| | yqiC | Unannotated protein. (96 aa) |
| | folB | Unannotated protein; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (122 aa) |
| | tdcG | Unannotated protein; Belongs to the iron-sulfur dependent L-serine dehydratase family. (454 aa) |
| | BZ172_07790 | Unannotated protein. (174 aa) |
| | yhbU | Unannotated protein. (331 aa) |
| | yhbV | Unannotated protein. (292 aa) |
| | argG | Unannotated protein; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (447 aa) |
| | folP_2 | Unannotated protein; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (282 aa) |
| | BZ172_08095 | Unannotated protein. (1517 aa) |
| | gltD_1 | Unannotated protein. (472 aa) |
| | argR | Unannotated protein; Regulates arginine biosynthesis genes. (156 aa) |
| | accB | Unannotated protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (156 aa) |
| | accC | Unannotated protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa) |
| | aroE | Unannotated protein; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (272 aa) |
| | yheT | Unannotated protein. (340 aa) |
| | argD | Unannotated protein; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (406 aa) |
| | cysG | Unannotated protein; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. (457 aa) |
| | gph | Unannotated protein; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. (252 aa) |
| | aroB | Unannotated protein; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (362 aa) |
| | aroK | Unannotated protein; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (173 aa) |
| | pckA | Unannotated protein; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. (540 aa) |
| | bioH | Unannotated protein; The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters. (256 aa) |
| | asd | Unannotated protein; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (367 aa) |
| | yhhK | Unannotated protein; Controls both the activation and catalytic activity of PanD in a coenzyme A (CoA)-dependent fashion; Belongs to the PanZ/PanM family. (127 aa) |
| | yhhQ | Unannotated protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (221 aa) |
| | BZ172_09755 | Unannotated protein. (33 aa) |
| | ilvB | Unannotated protein. (562 aa) |
| | ilvN | Unannotated protein. (96 aa) |
| | BZ172_09535 | Unannotated protein. (45 aa) |
| | cysE_4 | Unannotated protein; Belongs to the transferase hexapeptide repeat family. (273 aa) |
| | asnA | Unannotated protein. (330 aa) |
| | ilvG | Unannotated protein. (548 aa) |
| | ilvM | Unannotated protein. (87 aa) |
| | ilvD | Unannotated protein; Belongs to the IlvD/Edd family. (616 aa) |
| | ilvA | Unannotated protein; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (514 aa) |
| | ilvC | Unannotated protein; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (491 aa) |
| | hemD | Unannotated protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (246 aa) |
| | dapF | Unannotated protein; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (274 aa) |
| | yigL | Unannotated protein. (266 aa) |
| | metR | Unannotated protein; Belongs to the LysR transcriptional regulatory family. (317 aa) |
| | metE | Unannotated protein; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (753 aa) |
| | ubiE | Unannotated protein; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). (251 aa) |
| | BZ172_12260 | Unannotated protein. (201 aa) |
| | ubiB | Unannotated protein; Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis. (546 aa) |
| | ubiD | Unannotated protein; Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis. (497 aa) |
| | glnA | Unannotated protein. (469 aa) |
| | tpiA | Unannotated protein; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (255 aa) |
| | BZ172_12770 | Unannotated protein. (373 aa) |
| | menA | Unannotated protein; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily. (308 aa) |
| | metJ | Unannotated protein; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family. (105 aa) |
| | metL | Unannotated protein; In the C-terminal section; belongs to the homoserine dehydrogenase family. (810 aa) |
| | metF | Unannotated protein; Belongs to the methylenetetrahydrofolate reductase family. (296 aa) |
| | argE | Unannotated protein. (383 aa) |
| | argC | Unannotated protein; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (334 aa) |
| | argB | Unannotated protein; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate. (257 aa) |
| | argH | Unannotated protein. (457 aa) |
| | fabR | Unannotated protein; Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer. (234 aa) |
| | thiH | Unannotated protein. (377 aa) |
| | thiG | Unannotated protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (256 aa) |
| | thiS | Unannotated protein. (66 aa) |
| | thiF_2 | Unannotated protein. (251 aa) |
| | thiE | Unannotated protein; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (211 aa) |
| | thiC | Unannotated protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (631 aa) |
| | metA | Unannotated protein; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. (309 aa) |
| | metH | Unannotated protein; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1227 aa) |
| | lysC | Unannotated protein; Belongs to the aspartokinase family. (449 aa) |
| | pgi | Unannotated protein; Belongs to the GPI family. (549 aa) |
| | ubiC | Unannotated protein; Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway. (165 aa) |
| | ubiA | Unannotated protein; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. (290 aa) |
| | alr | Unannotated protein; Catalyzes the interconversion of L-alanine and D-alanine. (359 aa) |
| | BZ172_13910 | Unannotated protein. (120 aa) |
| | yjeS | Unannotated protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. (379 aa) |
| | fbp | Unannotated protein; Belongs to the FBPase class 1 family. (332 aa) |
| | ridA | Unannotated protein. (128 aa) |
| | argI | Unannotated protein; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (334 aa) |
| | yjgM | Unannotated protein. (167 aa) |
| | serB | Unannotated protein. (322 aa) |
| | BZ172_30895 | Unannotated protein. (78 aa) |
| | lpxM-2 | Unannotated protein; Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)- lipid A. (314 aa) |
| | BZ172_30070 | Unannotated protein; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (437 aa) |
