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BZ172_15595 BZ172_15595 GCA_000283715_00007 GCA_000283715_00007 nhaA nhaA kefC kefC BZ172_15995 BZ172_15995 fhuA fhuA fhuC fhuC fhuD fhuD lacY_1 lacY_1 pcaK pcaK cyoD cyoD cyoC cyoC cyoB cyoB cyoA cyoA amt amt fepA fepA fepC fepC entS entS kdpC kdpC kdpB kdpB kdpA kdpA dtpD dtpD BZ172_19610 BZ172_19610 zitB zitB ybhF_2 ybhF_2 putP putP ycdN ycdN efeO efeO GCA_000283715_01165 GCA_000283715_01165 nhaB nhaB cvrA cvrA znuC znuC mntP mntP tppB tppB pntB pntB pntA pntA fecA_2 fecA_2 zntB zntB BZ172_28005 BZ172_28005 fliI fliI yohM yohM fruA fruA setB setB ccmA ccmA lacY_2 lacY_2 hcaT hcaT BZ172_03845 BZ172_03845 fucP fucP lplT lplT nupG nupG nanT nanT panF panF trkA trkA kefB kefB feoB feoB nikB nikB nikC nikC nikD nikD nikE nikE dtpB dtpB BZ172_09575 BZ172_09575 gltS gltS atpC atpC atpD atpD atpG atpG atpA atpA atpH atpH atpF atpF atpE atpE atpB atpB trkD trkD corA corA trkH trkH BZ172_12625 BZ172_12625 kdgT kdgT BZ172_12945 BZ172_12945 sthA sthA pNaS pNaS gltP gltP yjdL yjdL mgtA mgtA fecA_1 fecA_1 spaL spaL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BZ172_15595Unannotated protein. (297 aa)
GCA_000283715_00007Unannotated protein. (179 aa)
nhaAUnannotated protein; Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons; Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family. (388 aa)
kefCUnannotated protein; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. (620 aa)
BZ172_15995Unannotated protein. (365 aa)
fhuAUnannotated protein. (729 aa)
fhuCUnannotated protein. (265 aa)
fhuDUnannotated protein. (296 aa)
lacY_1Unannotated protein. (98 aa)
pcaKUnannotated protein. (403 aa)
cyoDUnannotated protein. (109 aa)
cyoCUnannotated protein. (204 aa)
cyoBUnannotated protein; Belongs to the heme-copper respiratory oxidase family. (663 aa)
cyoAUnannotated protein. (315 aa)
amtUnannotated protein. (428 aa)
fepAUnannotated protein. (746 aa)
fepCUnannotated protein. (271 aa)
entSUnannotated protein; Component of an export pathway for enterobactin. Belongs to the major facilitator superfamily. EntS (TC 2.A.1.38) family. (416 aa)
kdpCUnannotated protein; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex. (190 aa)
kdpBUnannotated protein; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. (682 aa)
kdpAUnannotated protein; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane. (557 aa)
dtpDUnannotated protein; Probable proton-dependent permease that transports dipeptides; Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpD subfamily. (493 aa)
BZ172_19610Unannotated protein. (638 aa)
zitBUnannotated protein; Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. (313 aa)
ybhF_2Unannotated protein. (578 aa)
putPUnannotated protein; Catalyzes the sodium-dependent uptake of extracellular L- proline; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (502 aa)
ycdNUnannotated protein. (276 aa)
efeOUnannotated protein. (375 aa)
GCA_000283715_01165Unannotated protein. (729 aa)
nhaBUnannotated protein; Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons; Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter family. (513 aa)
cvrAUnannotated protein; K(+)/H(+) antiporter that extrudes potassium in exchange for external protons and maintains the internal concentration of potassium under toxic levels; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. NhaP2 subfamily. (578 aa)
znuCUnannotated protein; Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Zinc importer (TC 3.A.1.15.5) family. (251 aa)
mntPUnannotated protein; Probably functions as a manganese efflux pump. Belongs to the MntP (TC 9.B.29) family. (188 aa)
tppBUnannotated protein; Proton-dependent permease that transports di- and tripeptides; Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpA subfamily. (500 aa)
pntBUnannotated protein; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. (462 aa)
pntAUnannotated protein; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the AlaDH/PNT family. (510 aa)
fecA_2Unannotated protein. (700 aa)
zntBUnannotated protein; Mediates efflux of zinc ions; Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family. (327 aa)
BZ172_28005Unannotated protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family. (251 aa)
fliIUnannotated protein. (457 aa)
yohMUnannotated protein; Efflux system for nickel and cobalt. (274 aa)
fruAUnannotated protein. (563 aa)
setBUnannotated protein. (393 aa)
ccmAUnannotated protein; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. (205 aa)
lacY_2Unannotated protein. (415 aa)
hcaTUnannotated protein. (379 aa)
BZ172_03845Unannotated protein. (258 aa)
fucPUnannotated protein. (438 aa)
lplTUnannotated protein; Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell; Belongs to the major facilitator superfamily. LplT (TC 2.A.1.42) family. (397 aa)
nupGUnannotated protein; Broad-specificity transporter of purine and pyrimidine nucleosides. Driven by a proton motive force; Belongs to the major facilitator superfamily. Nucleoside:H(+) symporter (NHS) (TC 2.A.1.10) family. (418 aa)
nanTUnannotated protein; Catalyzes the proton-dependent transport of sialic acid. Belongs to the major facilitator superfamily. Sialate:H(+) symporter (SHS) (TC 2.A.1.12) family. (496 aa)
panFUnannotated protein; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (483 aa)
trkAUnannotated protein. (458 aa)
kefBUnannotated protein; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. (601 aa)
feoBUnannotated protein; Probable transporter of a GTP-driven Fe(2+) uptake system. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family. (773 aa)
nikBUnannotated protein. (314 aa)
nikCUnannotated protein. (277 aa)
nikDUnannotated protein; Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Nickel importer (TC 3.A.1.5.3) family. (254 aa)
nikEUnannotated protein; Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Nickel importer (TC 3.A.1.5.3) family. (268 aa)
dtpBUnannotated protein; Proton-dependent permease that transports di- and tripeptides; Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpB subfamily. (489 aa)
BZ172_09575Unannotated protein. (732 aa)
gltSUnannotated protein; Catalyzes the sodium-dependent transport of glutamate. Belongs to the glutamate:Na(+) symporter (ESS) (TC 2.A.27) family. (401 aa)
atpCUnannotated protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. (139 aa)
atpDUnannotated protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (460 aa)
atpGUnannotated protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (287 aa)
atpAUnannotated protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (513 aa)
atpHUnannotated protein; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (177 aa)
atpFUnannotated protein; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (156 aa)
atpEUnannotated protein; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (79 aa)
atpBUnannotated protein; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (271 aa)
trkDUnannotated protein; Responsible for the low-affinity transport of potassium into the cell, with the probable concomitant uptake of protons (symport system); Belongs to the HAK/KUP transporter (TC 2.A.72) family. (622 aa)
corAUnannotated protein; Mediates influx of magnesium ions. Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family. (316 aa)
trkHUnannotated protein; Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA; Belongs to the TrkH potassium transport family. (483 aa)
BZ172_12625Unannotated protein. (483 aa)
kdgTUnannotated protein; The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system. Belongs to the KdgT transporter family. (327 aa)
BZ172_12945Unannotated protein. (359 aa)
sthAUnannotated protein; Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (466 aa)
pNaSUnannotated protein. (543 aa)
gltPUnannotated protein; Catalyzes the proton-dependent transport of glutamate and aspartate; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. GltP subfamily. (437 aa)
yjdLUnannotated protein. (485 aa)
mgtAUnannotated protein. (898 aa)
fecA_1Unannotated protein. (774 aa)
spaLUnannotated protein; Required for surface presentation of invasion plasmid antigens. Probable catalytic subunit of a protein translocase. Required for invasion and for secretion of the three IPA proteins (By similarity). (430 aa)
Your Current Organism:
Shigella sonnei
NCBI taxonomy Id: 216599
Other names: S. sonnei 53G, Shigella sonnei 53G, Shigella sonnei str. 53G
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