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| | BPSY_0010 | Pyruvate oxidase; Belongs to the TPP enzyme family. (615 aa) |
| | BPSY_0014 | Acetolactate synthase small subunit. (184 aa) |
| | BPSY_0015 | Acetolactate synthase large subunit. (644 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (348 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (226 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (467 aa) |
| | BPSY_0152 | RpiR family transcriptional regulator. (347 aa) |
| | BPSY_0153 | Aminotransferase. (416 aa) |
| | BPSY_0190 | Pyruvate oxidase, PoxB; Belongs to the TPP enzyme family. (581 aa) |
| | BPSY_0309 | Hypothetical protein. (216 aa) |
| | BPSY_0310 | Bifunctional acetaldehyde-CoA/alcohol dehydrogenase. (299 aa) |
| | BPSY_0494 | Threonine dehydratase. (421 aa) |
| | BPSY_0562 | 4-aminobutyrate transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (453 aa) |
| | BPSY_0563 | NAD binding domain-containing protein. (283 aa) |
| | BPSY_0564 | Amino acid permease. (462 aa) |
| | BPSY_0565 | Carbon-nitrogen hydrolase. (315 aa) |
| | BPSY_0566 | PucR-like transcriptional regulator. (528 aa) |
| | BPSY_0567 | AldH Aldehyde dehydrogenase (NAD(P)+). (450 aa) |
| | BPSY_0620 | Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (918 aa) |
| | BPSY_0621 | Hypothetical protein. (532 aa) |
| | BPSY_0631 | Glutamine amidotransferase class-I. (216 aa) |
| | BPSY_0656 | O-acetylhomoserine aminocarboxypropyltransferase. (439 aa) |
| | BPSY_0657 | CoA-binding domain-containing protein. (193 aa) |
| | BPSY_0670 | ferredoxin/ferredoxin-NADP reductase. (487 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (350 aa) |
| | BPSY_0801 | Ammonium transporter. (428 aa) |
| | BPSY_0802 | Nitrogen regulatory protein N-II; Belongs to the P(II) protein family. (112 aa) |
| | BPSY_0803 | protein-PII. (604 aa) |
| | BPSY_0827 | Aspartate kinase; Belongs to the aspartokinase family. (254 aa) |
| | BPSY_0828 | Aspartate kinase. (190 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (356 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (635 aa) |
| | BPSY_0846 | Putative intracellular protease/amidase. (182 aa) |
| | BPSY_0847 | Fumarylacetoacetate (FAA) hydrolase. (275 aa) |
| | BPSY_0862 | Chorismate mutase TyrA. (143 aa) |
| | metAA | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (352 aa) |
| | BPSY_0906 | Endoribonuclease L-PSP. (131 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (521 aa) |
| | BPSY_0916 | Homoserine dehydrogenase. (437 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (366 aa) |
| | BPSY_0922 | Succinyl-diaminopimelate desuccinylase. (413 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (377 aa) |
| | BPSY_0928 | Aspartate aminotransferase. (406 aa) |
| | BPSY_0973 | MTA/SAH nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (243 aa) |
| | mscL | Large-conductance mechanosensitive channel; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. (167 aa) |
| | BPSY_0990 | Cystathionine gamma lyase. (408 aa) |
| | hisC | Histidinol-phosphate transaminase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (365 aa) |
| | BPSY_1000 | Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (108 aa) |
| | BPSY_1001 | N-succinyldiaminopimelate aminotransferase. (381 aa) |
| | BPSY_1012 | Aldehyde-alcohol dehydrogenase 2; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (915 aa) |
| | serC | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (397 aa) |
| | BPSY_1148 | Glycerate kinase; Belongs to the glycerate kinase type-1 family. (414 aa) |
| | BPSY_1182 | Citrate synthase I; Belongs to the citrate synthase family. (429 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (324 aa) |
| | BPSY_1206 | Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (448 aa) |
| | BPSY_1207 | Cystathionine beta-synthase. (337 aa) |
| | BPSY_1208 | Cystathionine gamma-synthase. (391 aa) |
| | luxS | LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (162 aa) |
| | BPSY_1273 | Class I and II aminotransferase. (437 aa) |
| | BPSY_1290 | L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (359 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (617 aa) |
| | metK | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (402 aa) |
| | BPSY_1322 | Phosphoserine phosphatase. (213 aa) |
| | BPSY_1353 | Methyltransferase. (289 aa) |
| | BPSY_1361 | Aminotransferase. (441 aa) |
| | BPSY_1376 | Glutamine synthase. (478 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (318 aa) |
| | BPSY_1435 | Threonine synthase. (499 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (448 aa) |
| | BPSY_1458 | Malate permease. (318 aa) |
| | BPSY_1459 | Malate dehydrogenase. (550 aa) |
| | BPSY_1460 | LysR family transcriptional regulator; Belongs to the LysR transcriptional regulatory family. (294 aa) |
| | BPSY_1520 | Isocitrate dehydrogenase, NADP-dependent; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (405 aa) |
| | hisF | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (256 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (137 aa) |
| | trpE | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (521 aa) |
| | trpB | Bifunctional tryptophan synthase subunit beta/indole-3-glycerol phosphate synthase; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine; Belongs to the TrpC family. (698 aa) |
| | trpA | Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (300 aa) |
| | hisE | phosphoribosyl-ATP pyrophosphatase. (87 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (283 aa) |
| | sucD | succinyl-CoA synthetase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (306 aa) |
| | sucC | succinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (405 aa) |
| | BPSY_1606 | Shikimate 5-dehydrogenase. (309 aa) |
| | BPSY_1629 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (236 aa) |
| | metE | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (770 aa) |
| | BPSY_1638 | Glutamate synthase small chain GltD. (510 aa) |
| | BPSY_1639 | Glutamate synthase. (1523 aa) |
| | BPSY_1647 | Branched-chain-amino-acid transaminase. (375 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (151 aa) |
| | aroK | Bifunctional shikimate kinase/3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (548 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (397 aa) |
| | BPSY_1684 | Phosphate acetyltransferase. (558 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (408 aa) |
| | BPSY_1686 | Histidinol-phosphate phosphatase. (281 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (450 aa) |
| | BPSY_1751 | Aminotransferase. (419 aa) |
| | BPSY_1753 | Succinate-semialdehyde dehydrogenase. (463 aa) |
| | BPSY_1761 | Class IV superfamily aminotransferase. (317 aa) |
| | BPSY_1762 | O-acetylhomoserine (thiol)-lyase. (436 aa) |
| | BPSY_1768 | Succinate dehydrogenase flavoprotein subunit. (653 aa) |
| | BPSY_1769 | Succinate dehydrogenase/fumarate reductase. (339 aa) |
| | BPSY_1772 | Aspartate aminotransferase. (392 aa) |
| | trpD | Anthranilate phosphoribosyltransferase 1; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (353 aa) |
| | BPSY_1858 | Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (903 aa) |
| | BPSY_1873 | Prephenate dehydrogenase. (367 aa) |
| | BPSY_1874 | Prephenate dehydratase. (341 aa) |
| | BPSY_1948 | D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (398 aa) |
| | ldh | L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (320 aa) |
| | BPSY_1959 | Glutamine synthetase. (445 aa) |
| | hisA | Phosphoribosyl isomerase A. (241 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (217 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase; Histidine biosynthesis bifunctional protein HisB (histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase). (199 aa) |
| | hisC-2 | Histidinol-phosphate transaminase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (385 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (460 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (315 aa) |
| | BPSY_2039 | Aspartate ammonia-lyase. (499 aa) |
| | BPSY_2041 | Cystathionine beta-lyase. (395 aa) |
| | BPSY_2048 | Putative O-acetylhomoserine aminocarboxypropyltransferase. (435 aa) |
| | BPSY_2084 | Putative O-acetylhomoserine aminocarboxypropyltransferase. (436 aa) |
| | BPSY_2095 | 4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (441 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (296 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (248 aa) |
