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| | SUB0010 | Putative septum formation initiator protein. (123 aa) |
| | SUB0017 | Rod shape-determining protein MreC. (272 aa) |
| | SUB0018 | Putative membrane protein. (166 aa) |
| | SUB0019 | Putative amidase. (425 aa) |
| | SUB0048 | Putative amidase. (362 aa) |
| | pbp1B | Putative penicillin-binding protein 1B. (772 aa) |
| | SUB0144 | Putative Mga-like regulatory protein. (499 aa) |
| | SUB0150 | Conserved hypothetical protein. (416 aa) |
| | galE | UDP-glucose 4-epimerase (pseudogene); HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase family, score 9e-139. (118 aa) |
| | SUB0279 | Type I restriction-modification system M protein. (516 aa) |
| | SUB0282 | Type I restriction-modification system S protein (pseudogene); Subunit R is required for both nuclease and ATPase activities, but not for modification. (1031 aa) |
| | SUB0283 | Conserved hypothetical protein. (55 aa) |
| | rpoE | Putative DNA-directed RNA polymerase, delta subunit; Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling; Belongs to the RpoE family. (188 aa) |
| | SUB0335 | Conserved hypothetical protein. (38 aa) |
| | SUB0338 | Putative membrane protein. (633 aa) |
| | mecA | Adapter protein MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. (252 aa) |
| | rgpG | Putative glycosyl transferase. (385 aa) |
| | SUB0342 | Putative exported protein. (118 aa) |
| | sufC | Putative ABC transporter, ATP-binding protein. (256 aa) |
| | sufD | Conserved hypothetical protein; In S. thermophilus sufD mutant displayed increased sensitivity to superoxide radicals compared to the wild type. SufD is likely to play a major role in oxidative stress defense, possibly resulting from its role in [Fe-S] cluster assembly and/or repair. (423 aa) |
| | csdB | Putative cysteine desulfurase; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. (408 aa) |
| | iscU | NifU-like protein; In S. thermophilus iscU mutant displayed increased sensitivity to superoxide radicals compared to the wild type. IscU is likely to play a major role in oxidative stress defense, possibly resulting from its role in [Fe-S] cluster assembly and/or repair. (149 aa) |
| | sufB | Conserved hypothetical protein. (472 aa) |
| | SUB0350 | Putative D-alanyl-D-alanine carboxypeptidase; Belongs to the peptidase S11 family. (400 aa) |
| | SUB0351 | Putative D-alanyl-D-alanine carboxypeptidase; Belongs to the peptidase S11 family. (416 aa) |
| | SUB0377 | Conserved hypothetical protein. (177 aa) |
| | murC | UDP-N-acetylmuramate--alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (444 aa) |
| | SUB0399 | Putative exported protein. (79 aa) |
| | murE | UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-dia minopimelate ligase; Catalyzes the addition of L-lysine to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan; Belongs to the MurCDEF family. MurE subfamily. (482 aa) |
| | SUB0426 | Putative polysaccharide biosynthesis protein. (545 aa) |
| | gcaD | Bifunctional GlmU protein [includes: UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferas [...] (458 aa) |
| | SUB0547 | Conserved hypothetical protein. (335 aa) |
| | SUB0576 | Putative membrane protein. (91 aa) |
| | SUB0598 | Glycosyl hydrolases family protein. (280 aa) |
| | ftsW | Putative cell division protein; Belongs to the SEDS family. (424 aa) |
| | murN | Putative peptidoglycan branched peptide synthesis protein. (410 aa) |
| | murM | Putative peptidoglycan pentaglycine interpeptide biosynthesis protein. (407 aa) |
| | SUB0608 | Haloacid dehalogenase-like hydrolase. (269 aa) |
| | SUB0609 | Putative phosphohydrolase. (433 aa) |
| | SUB0610 | Conserved hypothetical protein. (132 aa) |
| | ftsE | Putative cell division ATP-binding protein; Part of the ABC transporter FtsEX involved in cellular division. (230 aa) |
| | ftsX | Putative cell division protein; Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation. Belongs to the ABC-4 integral membrane protein family. FtsX subfamily. (309 aa) |
| | SUB0647 | Putative peptidoglycan biosynthesis protein; Belongs to the SEDS family. (404 aa) |
| | ezrA | Septation ring formation regulator; Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization; Belongs to the EzrA family. (574 aa) |
| | murA1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (423 aa) |
| | SUB0684 | Putative neutral zinc metallopeptidase. (304 aa) |
| | addB | Putative ATP-dependent exonuclease subunit B; The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' -> 3' nuclease activity; Belongs to the helicase family. AddB/RexB type 2 subfamily. (1086 aa) |
| | addA | Putative ATP-dependent exonuclease subunit A; The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities; Belongs to the helicase family. AddA subfamily. (1220 aa) |
| | SUB0687 | Putative aminotransferase. (376 aa) |
| | SUB0693 | Conserved hypothetical protein. (112 aa) |
| | SUB0708 | Putative ferredoxin. (65 aa) |
| | SUB0709 | Putative membrane protein. (169 aa) |
| | SUB0714 | Putative sulfatase. (732 aa) |
| | SUB0718 | Conserved hypothetical protein; Belongs to the UPF0342 family. (112 aa) |
| | gor | Glutathione reductase. (449 aa) |
| | murB | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (303 aa) |
| | SUB0848 | Conserved hypothetical protein. (116 aa) |
| | SUB0973 | Conserved hypothetical protein. (198 aa) |
| | SUB1007 | Putative lipoprotein. (207 aa) |
| | mnaA | UDP-N-acetylglucosamine 2-epimerase; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. (365 aa) |
| | glmM | Conserved hypothetical protein (pseudogene); Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. (450 aa) |
| | SUB1091 | Putative exported protein. (318 aa) |
| | dacA | Putative membrane protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (281 aa) |
| | SUB1093 | Mur ligase family protein. (447 aa) |
| | SUB1094 | Conserved hypothetical protein. (262 aa) |
| | dltD | Putative D-alanyl-lipoteichoic acid biosynthesis protein. (421 aa) |
| | dltC | D-alanyl carrier protein; Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC- carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. (79 aa) |
| | dltB | Putative activated D-alanine transport protein; Could be involved in the transport of activated D-alanine through the membrane. (420 aa) |
| | dltA | D-alanine--poly(phosphoribitol) ligase subunit 1; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to [...] (512 aa) |
| | SUB1150 | Putative membrane protein. (44 aa) |
| | SUB1155 | Nicotinamide mononucleotide transporter. (232 aa) |
| | murZ | Putative sugar transporter (pseudogene); Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (419 aa) |
| | SUB1212 | Putative lipoprotein. (727 aa) |
| | prsA1-2 | Foldase protein PrsA 1 precursor; Plays a major role in protein secretion by helping the post- translocational extracellular folding of several secreted proteins. (314 aa) |
| | SUB1241 | Putative lipoprotein. (350 aa) |
| | SUB1252 | Hypothetical protein; Possible pseudogene, N-terminus contains hydrophobic residues that are part of possible N-terminal signal sequence. Extention of the CDS by 7 residues, and frameshift at a poly A hexamer generates possible alternative tranlational start site. (230 aa) |
| | prfC | Peptide chain release factor 3; Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily. (514 aa) |
| | SUB1254 | Putative membrane protein. (231 aa) |
| | murF | Putative UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (456 aa) |
| | SUB1256 | Putative membrane protein. (185 aa) |
| | ddlA | D-alanine--D-alanine ligase; Cell wall formation. (348 aa) |
| | SUB1285 | Putative cell-division protein DivIVA. (254 aa) |
| | SUB1286 | Conserved hypothetical protein. (263 aa) |
| | SUB1287 | Putative membrane protein. (85 aa) |
| | sepF | Conserved hypothetical protein; Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA. (211 aa) |
| | SUB1289 | Conserved hypothetical protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. (223 aa) |
| | ftsZ | Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (441 aa) |
| | ftsA | Putative cell division protein; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. (454 aa) |
| | divIB | Putative cell division protein; Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex; Belongs to the FtsQ/DivIB family. DivIB subfamily. (393 aa) |
| | murG | Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (358 aa) |
| | murD | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (453 aa) |
| | SUB1295 | Putative membrane protein. (79 aa) |
| | SUB1296 | BipA family GTPase. (613 aa) |
| | SUB1297 | Putative membrane protein. (126 aa) |
| | SUB1299 | Conserved hypothetical protein. (72 aa) |
| | gpsB | DivIVA protein; Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation. (107 aa) |
| | SUB1405 | Conserved hypothetical protein; Belongs to the UPF0398 family. (175 aa) |
| | recU | Putative recombination protein U homologue; Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation; Belongs to the RecU family. (202 aa) |
| | pbp1A | Putative penicillin-binding protein 1A. (739 aa) |
| | mraY | phospho-N-acetylmuramoyl-pentapeptide-transfera se; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (335 aa) |
| | pbpX | Putative penicillin binding protein 2x. (750 aa) |
| | SUB1438 | Isoprenylcysteine carboxyl methyltransferase (ICMT) family protein. (179 aa) |
| | SUB1508 | Putative D-alanyl-D-alanine carboxypeptidase. (248 aa) |
| | SUB1533 | Aldo/keto reductase family protein. (305 aa) |
| | recG | ATP-dependent DNA helicase; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (671 aa) |
| | alr | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (368 aa) |
| | acpS | Holo-[acyl-carrier protein] synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (118 aa) |
| | SUB1553 | Putative membrane protein. (221 aa) |
| | SUB1619 | Conserved hypothetical protein; Belongs to the UPF0356 family. (76 aa) |
| | SUB1635 | Putative membrane anchored protein. (878 aa) |
| | pbp2A | Penicillin-binding protein 2a. (774 aa) |
| | SUB1737 | Putative exported protein. (545 aa) |
| | SUB1738 | Putative dipeptidase. (498 aa) |
