STRINGSTRING
pbp1B pbp1B SUB0350 SUB0350 SUB0351 SUB0351 murC murC murE murE gcaD gcaD ftsW ftsW SUB0647 SUB0647 murA1 murA1 murB murB mnaA mnaA glmM glmM murZ murZ murF murF ddlA ddlA SUB1285 SUB1285 SUB1286 SUB1286 SUB1287 SUB1287 sepF sepF SUB1289 SUB1289 ftsZ ftsZ ftsA ftsA murG murG murD murD SUB1295 SUB1295 SUB1296 SUB1296 SUB1297 SUB1297 SUB1299 SUB1299 pbp1A pbp1A mraY mraY pbpX pbpX SUB1508 SUB1508 pbp2A pbp2A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pbp1BPutative penicillin-binding protein 1B. (772 aa)
SUB0350Putative D-alanyl-D-alanine carboxypeptidase; Belongs to the peptidase S11 family. (400 aa)
SUB0351Putative D-alanyl-D-alanine carboxypeptidase; Belongs to the peptidase S11 family. (416 aa)
murCUDP-N-acetylmuramate--alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (444 aa)
murEUDP-N-acetylmuramoylalanyl-D-glutamate--2,6-dia minopimelate ligase; Catalyzes the addition of L-lysine to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan; Belongs to the MurCDEF family. MurE subfamily. (482 aa)
gcaDBifunctional GlmU protein [includes: UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferas [...] (458 aa)
ftsWPutative cell division protein; Belongs to the SEDS family. (424 aa)
SUB0647Putative peptidoglycan biosynthesis protein; Belongs to the SEDS family. (404 aa)
murA1UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (423 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (303 aa)
mnaAUDP-N-acetylglucosamine 2-epimerase; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. (365 aa)
glmMConserved hypothetical protein (pseudogene); Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. (450 aa)
murZPutative sugar transporter (pseudogene); Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (419 aa)
murFPutative UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (456 aa)
ddlAD-alanine--D-alanine ligase; Cell wall formation. (348 aa)
SUB1285Putative cell-division protein DivIVA. (254 aa)
SUB1286Conserved hypothetical protein. (263 aa)
SUB1287Putative membrane protein. (85 aa)
sepFConserved hypothetical protein; Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA. (211 aa)
SUB1289Conserved hypothetical protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. (223 aa)
ftsZCell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (441 aa)
ftsAPutative cell division protein; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. (454 aa)
murGUndecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (358 aa)
murDUDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (453 aa)
SUB1295Putative membrane protein. (79 aa)
SUB1296BipA family GTPase. (613 aa)
SUB1297Putative membrane protein. (126 aa)
SUB1299Conserved hypothetical protein. (72 aa)
pbp1APutative penicillin-binding protein 1A. (739 aa)
mraYphospho-N-acetylmuramoyl-pentapeptide-transfera se; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (335 aa)
pbpXPutative penicillin binding protein 2x. (750 aa)
SUB1508Putative D-alanyl-D-alanine carboxypeptidase. (248 aa)
pbp2APenicillin-binding protein 2a. (774 aa)
Your Current Organism:
Streptococcus uberis
NCBI taxonomy Id: 218495
Other names: S. uberis 0140J, Streptococcus uberis 0140J, Streptococcus uberis str. 0140J
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.