STRINGSTRING
SUB0695 SUB0695 SUB0699 SUB0699 pyrB pyrB carA carA SUB0753 SUB0753 clpX clpX folK folK SUB0822 SUB0822 radC radC prsA2 prsA2 guaC guaC SUB0901 SUB0901 SUB0923 SUB0923 dpfB dpfB coaC coaC SUB0973 SUB0973 pcrA pcrA pfk pfk dnaE dnaE hasB2 hasB2 SUB1032 SUB1032 SUB1036 SUB1036 uvrC uvrC SUB1073 SUB1073 pdhC pdhC rnj rnj alsS alsS uvrB uvrB SUB1162 SUB1162 uidA uidA dnaH dnaH SUB1225 SUB1225 SUB1227 SUB1227 SUB1234 SUB1234 SUB1243 SUB1243 SUB1252 SUB1252 xseB xseB xseA xseA rpoZ rpoZ gmk gmk nadE nadE glpO glpO glyS glyS glyQ glyQ trmB trmB accA accA accD accD accC accC fabE fabE recG recG uvrA uvrA recD2 recD2 SUB1584 SUB1584 SUB1592 SUB1592 SUB1612 SUB1612 SUB1619 SUB1619 rnj-2 rnj-2 SUB1784 SUB1784 ruvA ruvA SUB1774 SUB1774 ndh ndh SUB1737 SUB1737 hasB1 hasB1 gpsA gpsA rnpA rnpA rnmV rnmV dppC dppC dnaN dnaN prsA1 prsA1 ruvB ruvB rpoA rpoA rpoB rpoB rpoC rpoC SUB0134 SUB0134 SUB0141 SUB0141 SUB0177 SUB0177 ppk ppk SUB0279 SUB0279 SUB0314 SUB0314 SUB0324 SUB0324 mutS mutS rpoE rpoE iscU iscU SUB0385 SUB0385 holB holB dgk dgk SUB0538 SUB0538 SUB0539 SUB0539 eno eno glgB glgB glgC glgC SUB0663 SUB0663 epuA epuA addB addB addA addA dnaG dnaG rpoD rpoD
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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SUB0695Putative rhamnosyltransferase. (384 aa)
SUB0699Putative glycosyl transferase. (590 aa)
pyrBAspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (309 aa)
carACarbamoyl-phosphate synthase small chain; Belongs to the CarA family. (366 aa)
SUB0753Conserved hypothetical protein. (173 aa)
clpXATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (409 aa)
folK2-amino-4-hydroxy-6-hydroxymethyldihydropteridi ne pyrophosphokinase. (168 aa)
SUB0822Response regulator protein. (227 aa)
radCDNA repair protein RadC; Belongs to the UPF0758 family. (226 aa)
prsA2Putative ribose-phosphate pyrophosphokinase 2; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (323 aa)
guaCGMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. (327 aa)
SUB0901Conserved hypothetical protein. (151 aa)
SUB0923Putative DNA-binding protein. (224 aa)
dpfBPutative pantothenate metabolism flavoprotein. (228 aa)
coaCPutative phosphopantothenoylcysteine decarboxylase. (181 aa)
SUB0973Conserved hypothetical protein. (198 aa)
pcrAPutative ATP-dependent DNA helicase. (755 aa)
pfk6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (337 aa)
dnaEDNA polymerase III alpha subunit. (1034 aa)
hasB2UDP-glucose 6-dehydrogenase 2; Similar to SUB1696, 58.293% identity (59.900% ungapped) in 410 aa overlap (3-411:2-401). (411 aa)
SUB1032Hypothetical protein. (406 aa)
SUB1036Putative galacturonic acid acetylase (fragment); Probable gene remnant. Similar to an internal region of Streptococcus pneumoniae Cap1F galacturonic acid acetylase UniProt:P96477_STRPN (EMBL:SPZ83335) (183 aa) fasta scores: E()=1e-06, 38.889% id in 72 aa. (364 aa)
uvrCUvrABC system protein C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (591 aa)
SUB1073Carboxymuconolactone decarboxylase family protein. (107 aa)
pdhCDihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (471 aa)
rnjMetallo-beta-lactamase superfamily protein; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. (554 aa)
alsSAcetolactate synthase; Belongs to the TPP enzyme family. (558 aa)
uvrBUvrABC system protein B (UvrB protein); The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits [...] (663 aa)
SUB1162Conserved hypothetical protein. (117 aa)
uidAPutative beta-glucuronidase; Belongs to the glycosyl hydrolase 2 family. (596 aa)
dnaHDNA polymerase III subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (555 aa)
SUB1225Putative ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (719 aa)
SUB1227Putative ribonucleoside-diphosphate reductase beta chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (319 aa)
SUB1234Haloacid dehalogenase-like hydrolase. (213 aa)
SUB1243Putative DNA polymerase III delta subunit. (346 aa)
SUB1252Hypothetical protein; Possible pseudogene, N-terminus contains hydrophobic residues that are part of possible N-terminal signal sequence. Extention of the CDS by 7 residues, and frameshift at a poly A hexamer generates possible alternative tranlational start site. (230 aa)
xseBPutative exodeoxyribonuclease VII small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (71 aa)
xseAPutative exodeoxyribonuclease VII large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (442 aa)
rpoZDNA-directed RNA polymerase omega chain; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (105 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (208 aa)
nadENH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (274 aa)
glpOAlpha-glycerophosphate oxidase. (609 aa)
glySglycyl-tRNA synthetase beta chain. (679 aa)
glyQglycyl-tRNA synthetase alpha chain. (305 aa)
trmBtRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (211 aa)
accAAcetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (256 aa)
accDAcetyl-coenzyme A carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (288 aa)
accCBiotin carboxylase subunit of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (454 aa)
fabEBiotin carboxyl carrier protein of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (155 aa)
recGATP-dependent DNA helicase; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (671 aa)
uvrAUvrABC system protein A (UvrA protein); The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (940 aa)
recD2Conserved hypothetical protein; DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity; Belongs to the RecD family. RecD-like subfamily. (807 aa)
SUB1584Putative carboxylase subunit. (463 aa)
SUB1592Putative decarboxylase gamma chain. (135 aa)
SUB1612Putative exonuclease. (196 aa)
SUB1619Conserved hypothetical protein; Belongs to the UPF0356 family. (76 aa)
rnj-2Metallo-beta-lactamase superfamily protein; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. (560 aa)
SUB1784Putative exported protein; CDS contains coiled-coiled domains, residues 45 to 140. (169 aa)
ruvAHolliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (197 aa)
SUB1774Conserved hypothetical protein; Belongs to the UPF0473 family. (101 aa)
ndhNADH dehydrogenase. (510 aa)
SUB1737Putative exported protein. (545 aa)
hasB1UDP-glucose 6-dehydrogenase 1; Similar to SUB1027, 58.293% identity (59.900% ungapped) in 410 aa overlap (2-401:3-411). (401 aa)
gpsAGlycerol-3-phosphate dehydrogenase [NAD(P)+]; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (338 aa)
rnpARibonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. (119 aa)
rnmVConserved hypothetical protein; Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step. (195 aa)
dppCDi-tripeptide transporter permease protein. (343 aa)
dnaNDNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...] (378 aa)
prsA1Ribose-phosphate pyrophosphokinase 1; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (319 aa)
ruvBHolliday junction DNA helicase, subunit B; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (334 aa)
rpoADNA-directed RNA polymerase alpha chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (312 aa)
rpoBDNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1188 aa)
rpoCDNA-directed RNA polymerase beta' chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1212 aa)
SUB0134Putative tRNA-binding protein; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (208 aa)
SUB0141Putative deoxyadenosine kinase protein. (213 aa)
SUB0177RNA polymerase sigma factor protein; Possible alternative translational start site; Belongs to the sigma-70 factor family. ECF subfamily. (179 aa)
ppkPolyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). (707 aa)
SUB0279Type I restriction-modification system M protein. (516 aa)
SUB0314Conserved hypothetical protein. (281 aa)
SUB0324Haloacid dehalogenase-like hydrolase. (233 aa)
mutSDNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (847 aa)
rpoEPutative DNA-directed RNA polymerase, delta subunit; Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling; Belongs to the RpoE family. (188 aa)
iscUNifU-like protein; In S. thermophilus iscU mutant displayed increased sensitivity to superoxide radicals compared to the wild type. IscU is likely to play a major role in oxidative stress defense, possibly resulting from its role in [Fe-S] cluster assembly and/or repair. (149 aa)
SUB0385Putative helicase. (1029 aa)
holBPutative DNA polymerase III, delta' subunit. (291 aa)
dgkDiacylglycerol kinase. (134 aa)
SUB0538Putative glycosyltransferase. (332 aa)
SUB0539Putative glycosyltransferase. (444 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (435 aa)
glgB1,4-alpha-glucan branching enzyme; Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position; Belongs to the glycosyl hydrolase 13 family. GlgB subfamily. (625 aa)
glgCGlucose-1-phosphate adenylyltransferase; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc; Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. (379 aa)
SUB0663Putative glycogen biosynthesis protein. (377 aa)
epuAPutative competence associated protein. (62 aa)
addBPutative ATP-dependent exonuclease subunit B; The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' -> 3' nuclease activity; Belongs to the helicase family. AddB/RexB type 2 subfamily. (1086 aa)
addAPutative ATP-dependent exonuclease subunit A; The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities; Belongs to the helicase family. AddA subfamily. (1220 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (603 aa)
rpoDRNA polymerase sigma factor RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (369 aa)
Your Current Organism:
Streptococcus uberis
NCBI taxonomy Id: 218495
Other names: S. uberis 0140J, Streptococcus uberis 0140J, Streptococcus uberis str. 0140J
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