17 items (Streptococcus uberis) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Your Input:
	dnaN	DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...] (378 aa)
	SUB0136	Putative single stranded DNA-binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. (132 aa)
	polC	DNA polymerase III PolC-type; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (1465 aa)
	holB	Putative DNA polymerase III, delta' subunit. (291 aa)
	lig	DNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (652 aa)
	pcrA	Putative ATP-dependent DNA helicase. (755 aa)
	dnaE	DNA polymerase III alpha subunit. (1034 aa)
	SUB1129	Putative single-stranded-DNA-specific exonuclease. (743 aa)
	dnaH	DNA polymerase III subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (555 aa)
	SUB1243	Putative DNA polymerase III delta subunit. (346 aa)
	xseB	Putative exodeoxyribonuclease VII small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (71 aa)
	xseA	Putative exodeoxyribonuclease VII large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (442 aa)
	ssb	Single strand binding protein (SSB); Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. (163 aa)
	mutS2	Putative DNA mismatch repair protein; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (777 aa)
	SUB1612	Putative exonuclease. (196 aa)
	mutL	DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (660 aa)
	mutS	DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (847 aa)

Your Current Organism:

Streptococcus uberis

NCBI taxonomy Id: 218495
Other names: S. uberis 0140J, Streptococcus uberis 0140J, Streptococcus uberis str. 0140J

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SUB0136	SUB1129	SUB0136	SUB1129	Putative single stranded DNA-binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.	Putative single-stranded-DNA-specific exonuclease.	0.678
SUB0136	dnaE	SUB0136	SUB1002	Putative single stranded DNA-binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.	DNA polymerase III alpha subunit.	0.739
SUB0136	dnaH	SUB0136	SUB1214	Putative single stranded DNA-binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.	DNA polymerase III subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.	0.696
SUB0136	ssb	SUB0136	SUB1556	Putative single stranded DNA-binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.	Single strand binding protein (SSB); Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.	0.909
SUB1129	SUB0136	SUB1129	SUB0136	Putative single-stranded-DNA-specific exonuclease.	Putative single stranded DNA-binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.	0.678
SUB1129	SUB1243	SUB1129	SUB1243	Putative single-stranded-DNA-specific exonuclease.	Putative DNA polymerase III delta subunit.	0.521
SUB1129	SUB1612	SUB1129	SUB1612	Putative single-stranded-DNA-specific exonuclease.	Putative exonuclease.	0.456
SUB1129	dnaE	SUB1129	SUB1002	Putative single-stranded-DNA-specific exonuclease.	DNA polymerase III alpha subunit.	0.503
SUB1129	dnaH	SUB1129	SUB1214	Putative single-stranded-DNA-specific exonuclease.	DNA polymerase III subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.	0.553
SUB1129	dnaN	SUB1129	SUB0002	Putative single-stranded-DNA-specific exonuclease.	DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...]	0.606
SUB1129	lig	SUB1129	SUB0658	Putative single-stranded-DNA-specific exonuclease.	DNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.	0.637
SUB1129	mutL	SUB1129	SUB1783	Putative single-stranded-DNA-specific exonuclease.	DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.	0.661
SUB1129	mutS	SUB1129	SUB1786	Putative single-stranded-DNA-specific exonuclease.	DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.	0.661
SUB1129	mutS2	SUB1129	SUB1560	Putative single-stranded-DNA-specific exonuclease.	Putative DNA mismatch repair protein; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.	0.608
SUB1129	pcrA	SUB1129	SUB0986	Putative single-stranded-DNA-specific exonuclease.	Putative ATP-dependent DNA helicase.	0.627
SUB1129	polC	SUB1129	SUB0257	Putative single-stranded-DNA-specific exonuclease.	DNA polymerase III PolC-type; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.	0.424
SUB1129	ssb	SUB1129	SUB1556	Putative single-stranded-DNA-specific exonuclease.	Single strand binding protein (SSB); Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.	0.567
SUB1129	xseA	SUB1129	SUB1276	Putative single-stranded-DNA-specific exonuclease.	Putative exodeoxyribonuclease VII large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family.	0.743
SUB1129	xseB	SUB1129	SUB1275	Putative single-stranded-DNA-specific exonuclease.	Putative exodeoxyribonuclease VII small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family.	0.666
SUB1243	SUB1129	SUB1243	SUB1129	Putative DNA polymerase III delta subunit.	Putative single-stranded-DNA-specific exonuclease.	0.521