(24 nodes) RNA polymerase II, holoenzyme network (Aquilegia coerulea)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A2G5C2A9	Uncharacterized protein. (763 aa)
	A0A2G5C775	RPOLD domain-containing protein. (215 aa)
	A0A2G5CKT8	Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. (284 aa)
	A0A2G5CZV9	Uncharacterized protein. (386 aa)
	A0A2G5D3Y8	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (525 aa)
	A0A2G5D5X0	TFIIF_beta domain-containing protein. (297 aa)
	A0A2G5D7V7	HTH TFE/IIEalpha-type domain-containing protein. (472 aa)
	A0A2G5D817	RNA_pol_L_2 domain-containing protein. (116 aa)
	A0A2G5DJI8	Uncharacterized protein. (205 aa)
	A0A2G5DKJ0	RNA polymerase II transcription factor B subunit 2; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (452 aa)
	A0A2G5DME7	HTH TFE/IIEalpha-type domain-containing protein. (464 aa)
	A0A2G5DMW4	Helicase ATP-binding domain-containing protein. (793 aa)
	A0A2G5DNV2	General transcription factor IIH subunit. (427 aa)
	A0A2G5DP22	Uncharacterized protein. (51 aa)
	A0A2G5DT06	Uncharacterized protein. (303 aa)
	A0A2G5DW58	TFIIS N-terminal domain-containing protein. (360 aa)
	A0A2G5DWL1	RPOL4c domain-containing protein. (139 aa)
	A0A2G5E1G5	Uncharacterized protein. (144 aa)
	A0A2G5E2N0	Uncharacterized protein. (48 aa)
	A0A2G5E882	Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. (106 aa)
	A0A2G5EG07	Uncharacterized protein. (356 aa)
	A0A2G5EUL4	BSD domain-containing protein. (597 aa)
	A0A2G5EZH6	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (114 aa)
	A0A2G5FAW7	MAT1 domain-containing protein. (196 aa)

Your Current Organism:

Aquilegia coerulea

NCBI taxonomy Id: 218851
Other names: A. coerulea, Aquilegia caerulea, Rocky Mountain columbine

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A2G5C2A9	A0A2G5C775	Uncharacterized protein.	RPOLD domain-containing protein.	0.946
A0A2G5C2A9	A0A2G5CKT8	Uncharacterized protein.	Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.	0.985
A0A2G5C2A9	A0A2G5CZV9	Uncharacterized protein.	Uncharacterized protein.	0.947
A0A2G5C2A9	A0A2G5D3Y8	Uncharacterized protein.	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family.	0.981
A0A2G5C2A9	A0A2G5D5X0	Uncharacterized protein.	TFIIF_beta domain-containing protein.	0.964
A0A2G5C2A9	A0A2G5D7V7	Uncharacterized protein.	HTH TFE/IIEalpha-type domain-containing protein.	0.954
A0A2G5C2A9	A0A2G5D817	Uncharacterized protein.	RNA_pol_L_2 domain-containing protein.	0.972
A0A2G5C2A9	A0A2G5DJI8	Uncharacterized protein.	Uncharacterized protein.	0.926
A0A2G5C2A9	A0A2G5DKJ0	Uncharacterized protein.	RNA polymerase II transcription factor B subunit 2; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family.	0.960
A0A2G5C2A9	A0A2G5DME7	Uncharacterized protein.	HTH TFE/IIEalpha-type domain-containing protein.	0.954
A0A2G5C2A9	A0A2G5DMW4	Uncharacterized protein.	Helicase ATP-binding domain-containing protein.	0.986
A0A2G5C2A9	A0A2G5DNV2	Uncharacterized protein.	General transcription factor IIH subunit.	0.972
A0A2G5C2A9	A0A2G5DP22	Uncharacterized protein.	Uncharacterized protein.	0.926
A0A2G5C2A9	A0A2G5DT06	Uncharacterized protein.	Uncharacterized protein.	0.954
A0A2G5C2A9	A0A2G5DW58	Uncharacterized protein.	TFIIS N-terminal domain-containing protein.	0.933
A0A2G5C2A9	A0A2G5DWL1	Uncharacterized protein.	RPOL4c domain-containing protein.	0.978
A0A2G5C2A9	A0A2G5E1G5	Uncharacterized protein.	Uncharacterized protein.	0.948
A0A2G5C2A9	A0A2G5E2N0	Uncharacterized protein.	Uncharacterized protein.	0.980
A0A2G5C2A9	A0A2G5E882	Uncharacterized protein.	Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family.	0.972
A0A2G5C2A9	A0A2G5EG07	Uncharacterized protein.	Uncharacterized protein.	0.947