(79 nodes) Double-strand break repair via homologous recombination network (Aquilegia coerulea)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	A0A2G5CE99	Rad21_Rec8_N domain-containing protein. (852 aa)
	A0A2G5EAN9	DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (211 aa)
	A0A2G5E6E3	Uncharacterized protein. (1010 aa)
	A0A2G5E676	Rad21_Rec8 domain-containing protein. (445 aa)
	A0A2G5E427	DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Unwinds duplex DNA. Component of the meiotic recombination pathway. Seems to play a role in mediating chromosome homology search, chromosome pairing and synapsis at early stages and probably chromosome crossing-over at later stages in meiosis. Probably is involved in the repair of meiotic double strand breaks (DBSs) and in homologous recombination; Belongs to the RecA family. RAD51 subfamily. (339 aa)
	A0A2G5E3M3	ERCC4 domain-containing protein. (1248 aa)
	A0A2G5E2T1	RECA_2 domain-containing protein. (349 aa)
	A0A2G5DYC8	Uncharacterized protein. (497 aa)
	A0A2G5ECK2	Uncharacterized protein; Belongs to the nucleosome assembly protein (NAP) family. (71 aa)
	A0A2G5ECL9	Uncharacterized protein. (591 aa)
	A0A2G5ED01	ERCC4 domain-containing protein. (678 aa)
	A0A2G5ED88	SMC_N domain-containing protein. (1044 aa)
	A0A2G5EFK6	Uncharacterized protein. (367 aa)
	A0A2G5EGA2	Uncharacterized protein. (1063 aa)
	A0A2G5EKZ5	Uncharacterized protein. (925 aa)
	A0A2G5EMI0	Checkpoint protein; Belongs to the HUS1 family. (317 aa)
	A0A2G5EN12	DNA helicase; Belongs to the MCM family. (861 aa)
	A0A2G5EP27	Uncharacterized protein; Belongs to the nucleosome assembly protein (NAP) family. (274 aa)
	A0A2G5ES81	DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (211 aa)
	A0A2G5EUH1	RECA_2 domain-containing protein. (298 aa)
	A0A2G5EV10	Tower domain-containing protein. (1185 aa)
	A0A2G5EV80	Structure-specific endonuclease subunit SLX1 homolog; Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA; Belongs to the SLX1 family. (467 aa)
	A0A2G5EVE1	Uncharacterized protein. (388 aa)
	A0A2G5EZL5	Uncharacterized protein. (83 aa)
	A0A2G5F0E9	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (859 aa)
	A0A2G5F0S8	DNA polymerase. (1819 aa)
	A0A2G5F0X8	WD_REPEATS_REGION domain-containing protein. (762 aa)
	A0A2G5F242	Uncharacterized protein. (81 aa)
	A0A2G5DXU9	GIY-YIG domain-containing protein. (182 aa)
	A0A2G5DVJ1	Uncharacterized protein. (1484 aa)
	A0A2G5DU58	Uncharacterized protein. (237 aa)
	A0A2G5DI32	Replication protein A subunit; Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses. (637 aa)
	A0A2G5ECG7	Rad21_Rec8 domain-containing protein. (585 aa)
	A0A2G5F3U9	Uncharacterized protein; Belongs to the nucleosome assembly protein (NAP) family. (268 aa)
	A0A2G5F4T9	Uncharacterized protein. (141 aa)
	A0A2G5F4V7	Sister chromatid cohesion protein. (1601 aa)
	A0A2G5F5E8	Replication protein A subunit; Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses. (623 aa)
	A0A2G5F6P9	Uncharacterized protein. (189 aa)
	A0A2G5F8K9	Uncharacterized protein; Belongs to the nucleosome assembly protein (NAP) family. (382 aa)
	A0A2G5FAR8	Uncharacterized protein. (184 aa)
	A0A2G5FAS7	Uncharacterized protein. (2406 aa)
	A0A2G5FCH2	Replication protein A subunit; Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses. (896 aa)
	A0A2G5C2W5	TP6A_N domain-containing protein. (367 aa)
	A0A2G5C3Y0	Uncharacterized protein. (96 aa)
	A0A2G5C4B4	Uncharacterized protein. (247 aa)
	A0A2G5C5I8	Uncharacterized protein. (1578 aa)
	A0A2G5C5W0	RPA_C domain-containing protein. (302 aa)
	A0A2G5C893	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (638 aa)
	A0A2G5C962	DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (230 aa)
	A0A2G5C9P0	Uncharacterized protein. (658 aa)
	A0A2G5DI13	Replication protein A subunit; Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses. (637 aa)
	A0A2G5DE91	Uncharacterized protein. (1327 aa)
	A0A2G5DE78	WD_REPEATS_REGION domain-containing protein. (499 aa)
	A0A2G5DDD3	DNA helicase; Belongs to the MCM family. (771 aa)
	A0A2G5DC35	RECA_2 domain-containing protein. (320 aa)
	A0A2G5DC22	Uncharacterized protein. (625 aa)
	A0A2G5DBM6	Uncharacterized protein. (1231 aa)
	A0A2G5DAG5	Uncharacterized protein. (75 aa)
	A0A2G5DAD2	Uncharacterized protein. (108 aa)
	A0A2G5D681	RECA_2 domain-containing protein. (369 aa)
	A0A2G5D5X9	RECA_2 domain-containing protein. (320 aa)
	A0A2G5D534	Uncharacterized protein. (137 aa)
	A0A2G5D413	Serine/threonine-protein phosphatase. (308 aa)
	A0A2G5CYE4	Uncharacterized protein. (634 aa)
	A0A2G5CWJ2	SMC_N domain-containing protein. (1058 aa)
	A0A2G5CVY2	Uncharacterized protein. (525 aa)
	A0A2G5CV16	SP-RING-type domain-containing protein. (247 aa)
	A0A2G5CTY4	Uncharacterized protein. (408 aa)
	A0A2G5CRM2	DUF1767 domain-containing protein. (743 aa)
	A0A2G5CQR7	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (716 aa)
	A0A2G5CQQ0	OB domain-containing protein. (314 aa)
	A0A2G5CP46	SWIM-type domain-containing protein. (132 aa)
	A0A2G5CK41	Uncharacterized protein; Belongs to the RecA family. (343 aa)
	A0A2G5CJ87	Uncharacterized protein. (1087 aa)
	A0A2G5CI20	Protein kinase domain-containing protein. (1091 aa)
	A0A2G5CH13	Uncharacterized protein. (1001 aa)
	A0A2G5CG68	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (729 aa)
	A0A2G5CEB0	Rad21_Rec8 domain-containing protein. (38 aa)
	A0A2G5CB55	zf-RING-like domain-containing protein. (329 aa)

Your Current Organism:

Aquilegia coerulea

NCBI taxonomy Id: 218851
Other names: A. coerulea, Aquilegia caerulea, Rocky Mountain columbine

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A2G5C2W5	A0A2G5CK41	TP6A_N domain-containing protein.	Uncharacterized protein; Belongs to the RecA family.	0.730
A0A2G5C2W5	A0A2G5CRM2	TP6A_N domain-containing protein.	DUF1767 domain-containing protein.	0.406
A0A2G5C2W5	A0A2G5CVY2	TP6A_N domain-containing protein.	Uncharacterized protein.	0.413
A0A2G5C2W5	A0A2G5CWJ2	TP6A_N domain-containing protein.	SMC_N domain-containing protein.	0.447
A0A2G5C2W5	A0A2G5D681	TP6A_N domain-containing protein.	RECA_2 domain-containing protein.	0.479
A0A2G5C2W5	A0A2G5DVJ1	TP6A_N domain-containing protein.	Uncharacterized protein.	0.458
A0A2G5C2W5	A0A2G5E2T1	TP6A_N domain-containing protein.	RECA_2 domain-containing protein.	0.714
A0A2G5C2W5	A0A2G5E3M3	TP6A_N domain-containing protein.	ERCC4 domain-containing protein.	0.510
A0A2G5C2W5	A0A2G5E427	TP6A_N domain-containing protein.	DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Unwinds duplex DNA. Component of the meiotic recombination pathway. Seems to play a role in mediating chromosome homology search, chromosome pairing and synapsis at early stages and probably chromosome crossing-over at later stages in meiosis. Probably is involved in the repair of meiotic double strand breaks (DBSs) and in homologous recombination; Belongs to the RecA family. RAD51 subfamily.	0.642
A0A2G5C2W5	A0A2G5ED01	TP6A_N domain-containing protein.	ERCC4 domain-containing protein.	0.665
A0A2G5C2W5	A0A2G5ED88	TP6A_N domain-containing protein.	SMC_N domain-containing protein.	0.486
A0A2G5C2W5	A0A2G5EUH1	TP6A_N domain-containing protein.	RECA_2 domain-containing protein.	0.573
A0A2G5C3Y0	A0A2G5DE91	Uncharacterized protein.	Uncharacterized protein.	0.488
A0A2G5C5W0	A0A2G5C893	RPA_C domain-containing protein.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.884
A0A2G5C5W0	A0A2G5C962	RPA_C domain-containing protein.	DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family.	0.884
A0A2G5C5W0	A0A2G5CB55	RPA_C domain-containing protein.	zf-RING-like domain-containing protein.	0.412
A0A2G5C5W0	A0A2G5CG68	RPA_C domain-containing protein.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.884
A0A2G5C5W0	A0A2G5CH13	RPA_C domain-containing protein.	Uncharacterized protein.	0.665
A0A2G5C5W0	A0A2G5CI20	RPA_C domain-containing protein.	Protein kinase domain-containing protein.	0.812
A0A2G5C5W0	A0A2G5CK41	RPA_C domain-containing protein.	Uncharacterized protein; Belongs to the RecA family.	0.720