(28 nodes) DNA integrity checkpoint signaling network (Aquilegia coerulea)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A2G5C136	CDT1_C domain-containing protein. (215 aa)
	A0A2G5C9C1	Uncharacterized protein. (224 aa)
	A0A2G5CLS9	Cell division control protein; Belongs to the CDC6/cdc18 family. (524 aa)
	A0A2G5CQ37	Uncharacterized protein. (358 aa)
	A0A2G5CRY5	Uncharacterized protein. (304 aa)
	A0A2G5CT40	Uncharacterized protein. (1189 aa)
	A0A2G5CVY2	Uncharacterized protein. (525 aa)
	A0A2G5CXP5	CDT1 domain-containing protein. (590 aa)
	A0A2G5CYV2	CDT1 domain-containing protein. (564 aa)
	A0A2G5D7Z5	Uncharacterized protein. (1476 aa)
	A0A2G5DRP4	Uncharacterized protein. (172 aa)
	A0A2G5DVM9	Uncharacterized protein. (1077 aa)
	A0A2G5DVR1	AAA domain-containing protein. (1447 aa)
	A0A2G5DWP0	Uncharacterized protein. (342 aa)
	A0A2G5DYJ7	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (813 aa)
	A0A2G5E068	Uncharacterized protein. (1004 aa)
	A0A2G5EAU2	Uncharacterized protein. (123 aa)
	A0A2G5ED01	ERCC4 domain-containing protein. (678 aa)
	A0A2G5EHN2	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (816 aa)
	A0A2G5EI65	Uncharacterized protein. (617 aa)
	A0A2G5EMI0	Checkpoint protein; Belongs to the HUS1 family. (317 aa)
	A0A2G5ESL0	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (752 aa)
	A0A2G5EZ67	AAA domain-containing protein. (437 aa)
	A0A2G5EZ70	Cdc6_C domain-containing protein. (88 aa)
	A0A2G5F0R3	Uncharacterized protein. (459 aa)
	A0A2G5F1A9	WD_REPEATS_REGION domain-containing protein. (371 aa)
	A0A2G5F6K3	NAC domain-containing protein. (495 aa)
	A0A2G5F7X6	CCHC-type domain-containing protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (303 aa)

Your Current Organism:

Aquilegia coerulea

NCBI taxonomy Id: 218851
Other names: A. coerulea, Aquilegia caerulea, Rocky Mountain columbine

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A2G5C136	A0A2G5C9C1	CDT1_C domain-containing protein.	Uncharacterized protein.	0.465
A0A2G5C136	A0A2G5CLS9	CDT1_C domain-containing protein.	Cell division control protein; Belongs to the CDC6/cdc18 family.	0.966
A0A2G5C136	A0A2G5CT40	CDT1_C domain-containing protein.	Uncharacterized protein.	0.552
A0A2G5C136	A0A2G5DRP4	CDT1_C domain-containing protein.	Uncharacterized protein.	0.465
A0A2G5C136	A0A2G5DYJ7	CDT1_C domain-containing protein.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.970
A0A2G5C136	A0A2G5EAU2	CDT1_C domain-containing protein.	Uncharacterized protein.	0.465
A0A2G5C136	A0A2G5EHN2	CDT1_C domain-containing protein.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.970
A0A2G5C136	A0A2G5EI65	CDT1_C domain-containing protein.	Uncharacterized protein.	0.441
A0A2G5C136	A0A2G5ESL0	CDT1_C domain-containing protein.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.970
A0A2G5C136	A0A2G5EZ67	CDT1_C domain-containing protein.	AAA domain-containing protein.	0.966
A0A2G5C136	A0A2G5EZ70	CDT1_C domain-containing protein.	Cdc6_C domain-containing protein.	0.971
A0A2G5C136	A0A2G5F1A9	CDT1_C domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.465
A0A2G5C136	A0A2G5F7X6	CDT1_C domain-containing protein.	CCHC-type domain-containing protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	0.701
A0A2G5C9C1	A0A2G5C136	Uncharacterized protein.	CDT1_C domain-containing protein.	0.465
A0A2G5C9C1	A0A2G5CLS9	Uncharacterized protein.	Cell division control protein; Belongs to the CDC6/cdc18 family.	0.504
A0A2G5C9C1	A0A2G5CXP5	Uncharacterized protein.	CDT1 domain-containing protein.	0.465
A0A2G5C9C1	A0A2G5CYV2	Uncharacterized protein.	CDT1 domain-containing protein.	0.465
A0A2G5C9C1	A0A2G5EZ67	Uncharacterized protein.	AAA domain-containing protein.	0.504
A0A2G5C9C1	A0A2G5EZ70	Uncharacterized protein.	Cdc6_C domain-containing protein.	0.504
A0A2G5CLS9	A0A2G5C136	Cell division control protein; Belongs to the CDC6/cdc18 family.	CDT1_C domain-containing protein.	0.966