(19 nodes) p53-Independent DNA Damage Response network (Aquilegia coerulea)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A2G5E646	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family. (224 aa)
	A0A2G5E723	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family. (273 aa)
	A0A2G5EJ62	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (261 aa)
	A0A2G5EKA3	26S proteasome non-ATPase regulatory subunit 1 homolog; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (1007 aa)
	A0A2G5ERE0	Uncharacterized protein. (1806 aa)
	A0A2G5ENN2	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (249 aa)
	A0A2G5C4D0	Ubiquitin-like domain-containing protein. (128 aa)
	A0A2G5C6D0	Uncharacterized protein. (331 aa)
	A0A2G5C907	PI31_Prot_N domain-containing protein. (295 aa)
	A0A2G5C9P2	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (249 aa)
	A0A2G5EYJ5	Ubiquitin-like domain-containing protein. (156 aa)
	A0A2G5CA05	Uncharacterized protein. (201 aa)
	A0A2G5CZ84	Uncharacterized protein. (520 aa)
	A0A2G5D537	PI31_Prot_N domain-containing protein. (302 aa)
	A0A2G5D9F8	26S proteasome non-ATPase regulatory subunit 1 homolog; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (1009 aa)
	A0A2G5DK67	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (261 aa)
	A0A2G5DKA5	Uncharacterized protein. (234 aa)
	A0A2G5F1J1	Ubiquitin-like domain-containing protein. (157 aa)
	A0A2G5E1Q0	Uncharacterized protein. (129 aa)

Your Current Organism:

Aquilegia coerulea

NCBI taxonomy Id: 218851
Other names: A. coerulea, Aquilegia caerulea, Rocky Mountain columbine

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A2G5C4D0	A0A2G5C6D0	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.919
A0A2G5C4D0	A0A2G5C907	Ubiquitin-like domain-containing protein.	PI31_Prot_N domain-containing protein.	0.633
A0A2G5C4D0	A0A2G5C9P2	Ubiquitin-like domain-containing protein.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.912
A0A2G5C4D0	A0A2G5CA05	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.917
A0A2G5C4D0	A0A2G5CZ84	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.967
A0A2G5C4D0	A0A2G5D537	Ubiquitin-like domain-containing protein.	PI31_Prot_N domain-containing protein.	0.633
A0A2G5C4D0	A0A2G5D9F8	Ubiquitin-like domain-containing protein.	26S proteasome non-ATPase regulatory subunit 1 homolog; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.	0.919
A0A2G5C4D0	A0A2G5DK67	Ubiquitin-like domain-containing protein.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.925
A0A2G5C4D0	A0A2G5DKA5	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.921
A0A2G5C4D0	A0A2G5E1Q0	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.921
A0A2G5C4D0	A0A2G5E646	Ubiquitin-like domain-containing protein.	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	0.938
A0A2G5C4D0	A0A2G5E723	Ubiquitin-like domain-containing protein.	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	0.917
A0A2G5C4D0	A0A2G5EJ62	Ubiquitin-like domain-containing protein.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.925
A0A2G5C4D0	A0A2G5EKA3	Ubiquitin-like domain-containing protein.	26S proteasome non-ATPase regulatory subunit 1 homolog; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.	0.919
A0A2G5C4D0	A0A2G5ENN2	Ubiquitin-like domain-containing protein.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.912
A0A2G5C4D0	A0A2G5ERE0	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.638
A0A2G5C6D0	A0A2G5C4D0	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.919
A0A2G5C6D0	A0A2G5C907	Uncharacterized protein.	PI31_Prot_N domain-containing protein.	0.553
A0A2G5C6D0	A0A2G5C9P2	Uncharacterized protein.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.962
A0A2G5C6D0	A0A2G5CA05	Uncharacterized protein.	Uncharacterized protein.	0.959