(38 nodes) One carbon pool by folate network (Aquilegia coerulea)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	A0A2G5EHH7	Queuine tRNA-ribosyltransferase catalytic subunit 1; Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, formi [...] (396 aa)
	A0A2G5EK14	DHFR domain-containing protein. (411 aa)
	A0A2G5EVK0	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (594 aa)
	A0A2G5EVW2	HNHc domain-containing protein. (161 aa)
	A0A2G5EW04	Uncharacterized protein. (222 aa)
	A0A2G5EX31	Uncharacterized protein. (356 aa)
	A0A2G5F6T4	Uncharacterized protein. (368 aa)
	A0A2G5C4B1	Patatin; Lipolytic acyl hydrolase (LAH). Belongs to the patatin family. (1359 aa)
	A0A2G5C5U3	Rhodanese domain-containing protein. (466 aa)
	A0A2G5C9T9	Rhodanese domain-containing protein. (635 aa)
	A0A2G5CBY5	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (408 aa)
	A0A2G5CFW9	Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (469 aa)
	A0A2G5CGK5	Uncharacterized protein. (200 aa)
	A0A2G5CGT3	Uncharacterized protein. (196 aa)
	A0A2G5CT54	MGS domain-containing protein. (603 aa)
	A0A2G5CXI0	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (471 aa)
	A0A2G5D3R5	Uncharacterized protein. (365 aa)
	A0A2G5D4V7	Rhodanese domain-containing protein. (468 aa)
	A0A2G5DAM4	5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (239 aa)
	A0A2G5DAY1	Uncharacterized protein. (217 aa)
	A0A2G5DD67	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (532 aa)
	A0A2G5DHM6	Uncharacterized protein. (373 aa)
	A0A2G5DLQ2	Uncharacterized protein. (303 aa)
	A0A2G5DN40	FSH1 domain-containing protein. (249 aa)
	A0A2G5DR02	Formyl_trans_N domain-containing protein. (299 aa)
	A0A2G5DUM0	Queuine tRNA-ribosyltransferase accessory subunit 2; Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine); Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily. (473 aa)
	A0A2G5DVA8	Uncharacterized protein. (435 aa)
	A0A2G5DVK1	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (595 aa)
	A0A2G5DWH1	Uncharacterized protein. (374 aa)
	A0A2G5DYF7	Uncharacterized protein. (685 aa)
	A0A2G5E0H4	AAA domain-containing protein. (971 aa)
	A0A2G5E3G9	ACT domain-containing protein. (327 aa)
	A0A2G5E861	FSH1 domain-containing protein. (236 aa)
	A0A2G5E8N6	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (520 aa)
	A0A2G5EAI6	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. (523 aa)
	A0A2G5EED9	TIR domain-containing protein. (961 aa)
	A0A2G5EJA5	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. (543 aa)
	A0A2G5EJS2	Uncharacterized protein. (355 aa)

Your Current Organism:

Aquilegia coerulea

NCBI taxonomy Id: 218851
Other names: A. coerulea, Aquilegia caerulea, Rocky Mountain columbine

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A2G5C5U3	A0A2G5EAI6	Rhodanese domain-containing protein.	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	0.889
A0A2G5C5U3	A0A2G5EJA5	Rhodanese domain-containing protein.	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	0.889
A0A2G5C5U3	A0A2G5EK14	Rhodanese domain-containing protein.	DHFR domain-containing protein.	0.889
A0A2G5C9T9	A0A2G5EAI6	Rhodanese domain-containing protein.	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	0.889
A0A2G5C9T9	A0A2G5EJA5	Rhodanese domain-containing protein.	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	0.889
A0A2G5C9T9	A0A2G5EK14	Rhodanese domain-containing protein.	DHFR domain-containing protein.	0.889
A0A2G5CBY5	A0A2G5CGT3	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	Uncharacterized protein.	0.871
A0A2G5CBY5	A0A2G5CT54	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	MGS domain-containing protein.	0.940
A0A2G5CBY5	A0A2G5CXI0	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.963
A0A2G5CBY5	A0A2G5D3R5	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	Uncharacterized protein.	0.901
A0A2G5CBY5	A0A2G5DAY1	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	Uncharacterized protein.	0.871
A0A2G5CBY5	A0A2G5DD67	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.957
A0A2G5CBY5	A0A2G5DHM6	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	Uncharacterized protein.	0.871
A0A2G5CBY5	A0A2G5DLQ2	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	Uncharacterized protein.	0.871
A0A2G5CBY5	A0A2G5DR02	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	Formyl_trans_N domain-containing protein.	0.920
A0A2G5CBY5	A0A2G5DVK1	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.964
A0A2G5CBY5	A0A2G5DYF7	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	Uncharacterized protein.	0.950
A0A2G5CBY5	A0A2G5E3G9	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	ACT domain-containing protein.	0.920
A0A2G5CBY5	A0A2G5E8N6	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.954
A0A2G5CBY5	A0A2G5EAI6	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	0.955