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A7J50_0112 A7J50_0112 A7J50_0534 A7J50_0534 A7J50_0599 A7J50_0599 A7J50_0600 A7J50_0600 A7J50_0658 A7J50_0658 A7J50_0659 A7J50_0659 A7J50_0768 A7J50_0768 A7J50_1126 A7J50_1126 accA accA A7J50_2074 A7J50_2074 A7J50_2199 A7J50_2199 A7J50_2949 A7J50_2949 ackA ackA A7J50_2977 A7J50_2977 A7J50_2979 A7J50_2979 A7J50_3333 A7J50_3333 A7J50_3369 A7J50_3369 A7J50_3452 A7J50_3452 accD accD A7J50_3910 A7J50_3910 aceK aceK acsA acsA A7J50_4872 A7J50_4872 A7J50_4947 A7J50_4947 A7J50_4948 A7J50_4948 acsA-2 acsA-2 glcB glcB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
A7J50_0112Pfam:pfam13336 Acetyl-CoA hydrolase/transferase C-terminal domain. (497 aa)
A7J50_0534Pfam:pfam00171 Aldehyde dehydrogenase family; Belongs to the aldehyde dehydrogenase family. (496 aa)
A7J50_0599acetyl-CoA carboxylase biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (453 aa)
A7J50_0600acetyl-CoA carboxylase biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (152 aa)
A7J50_0658Pfam:pfam00202 Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (449 aa)
A7J50_0659Pfam:pfam00171 Aldehyde dehydrogenase family. (497 aa)
A7J50_0768Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (699 aa)
A7J50_1126Pfam:pfam00202 Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (464 aa)
accAacetyl-CoA carboxylase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (315 aa)
A7J50_2074Pfam:pfam00171 Aldehyde dehydrogenase family; Belongs to the aldehyde dehydrogenase family. (471 aa)
A7J50_2199acyl-CoA synthetase; Pfam:pfam13549 ATP-grasp domain. (702 aa)
A7J50_2949Hypothetical protein; Pfam:pfam00583 Acetyltransferase (GNAT) family. (189 aa)
ackAPropionate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (404 aa)
A7J50_2977acetyl-CoA acetyltransferase; Pfam:pfam00108 Thiolase, N-terminal domain; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
A7J50_2979Pfam:pfam00501 AMP-binding enzyme. (549 aa)
A7J50_3333methylmalonyl-CoA decarboxylase; Pfam:pfam00378 Enoyl-CoA hydratase/isomerase family; Belongs to the enoyl-CoA hydratase/isomerase family. (260 aa)
A7J50_3369Pfam:pfam00171 Aldehyde dehydrogenase family. (499 aa)
A7J50_3452Pfam:pfam00463 Isocitrate lyase family. (441 aa)
accDacetyl-CoA carboxylase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (306 aa)
A7J50_3910methylmalonyl-CoA epimerase; Pfam:pfam13669 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily. (151 aa)
aceKIsocitrate dehydrogenase; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation. (569 aa)
acsAacetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (651 aa)
A7J50_4872Pfam:pfam00202 Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (416 aa)
A7J50_49473-hydroxyisobutyrate dehydrogenase; Pfam:pfam03446 NAD binding domain of 6-phosphogluconate dehydrogenase; Belongs to the HIBADH-related family. (295 aa)
A7J50_4948Pfam:pfam00171 Aldehyde dehydrogenase family. (505 aa)
acsA-2acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (645 aa)
glcBMalate synthase; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (725 aa)
Your Current Organism:
Pseudomonas antarctica
NCBI taxonomy Id: 219572
Other names: CCUG 49625, DSM 15318, LMG 22709, LMG:22709, MTCC 4992, Pseudomonas antarctica Reddy et al. 2004, strain CMS 35
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