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| | hisI-2 | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (137 aa) |
| | A7J50_0033 | Galactonate dehydratase; Pfam:pfam13378 Enolase C-terminal domain-like. (382 aa) |
| | cysQ | 3'(2'),5'-bisphosphate nucleotidase; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family. (278 aa) |
| | fbp | Fructose-1,6-bisphosphatase class 1; Pfam:pfam00316 Fructose-1-6-bisphosphatase; Belongs to the FBPase class 1 family. (336 aa) |
| | hisI | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (130 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (163 aa) |
| | selO | Hypothetical protein; Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation). Belongs to the SELO family. (487 aa) |
| | glnE | Bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of [...] (979 aa) |
| | A7J50_0492 | Phosphoserine phosphatase; Pfam:pfam13740 ACT domain. (404 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (429 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (310 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (212 aa) |
| | A7J50_0904 | Hypoxanthine-guanine phosphoribosyltransferase; Pfam:pfam00156 Phosphoribosyl transferase domain. (185 aa) |
| | murE | UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (487 aa) |
| | rnt | Ribonuclease T; Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis. (223 aa) |
| | lysS | Pfam:pfam00152 tRNA synthetases class II (D, K and N); Belongs to the class-II aminoacyl-tRNA synthetase family. (500 aa) |
| | ppc | Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (881 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (344 aa) |
| | uppS | UDP pyrophosphate synthase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. (251 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (429 aa) |
| | A7J50_1626 | Hypothetical protein; Pfam:pfam02776 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Belongs to the TPP enzyme family. (541 aa) |
| | A7J50_1705 | Phosphatase/phosphohexomutase-like protein; Pfam:pfam13419 Haloacid dehalogenase-like hydrolase. (202 aa) |
| | kdpB | Potassium-transporting ATPase subunit B; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. (685 aa) |
| | A7J50_1859 | Pfam:pfam06189 5'-nucleotidase. (305 aa) |
| | A7J50_1890 | Deoxyguanosinetriphosphate triphosphohydrolase. (443 aa) |
| | A7J50_1928 | Pfam:pfam00224 Pyruvate kinase, barrel domain; Belongs to the pyruvate kinase family. (471 aa) |
| | A7J50_1932 | Glyoxylate carboligase; Pfam:pfam02776 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Belongs to the TPP enzyme family. (591 aa) |
| | sucC | Succinyl-CoA ligase [ADP-forming] subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (404 aa) |
| | kdpB-2 | Potassium-transporting ATPase subunit B; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. (692 aa) |
| | selD | Selenophosphate synthetase; Synthesizes selenophosphate from selenide and ATP. (344 aa) |
| | A7J50_2160 | Pfam:pfam01131 DNA topoisomerase. (652 aa) |
| | A7J50_2200 | Decarboxylase; Pfam:pfam02776 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Belongs to the TPP enzyme family. (535 aa) |
| | A7J50_2326 | Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (895 aa) |
| | A7J50_2352 | DNA repair nucleotidyltransferase; Pfam:pfam00817 impB/mucB/samB family. (471 aa) |
| | rnhA | Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (150 aa) |
| | A7J50_2417 | Pyruvate dehydrogenase; Pfam:pfam02775 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Belongs to the TPP enzyme family. (574 aa) |
| | A7J50_2470 | Putative thiamine pyrophosphate-dependent protein; Pfam:pfam02775 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Belongs to the TPP enzyme family. (643 aa) |
| | nudC | NADH pyrophosphatase; Pfam:pfam00293 NUDIX domain; Belongs to the Nudix hydrolase family. NudC subfamily. (277 aa) |
| | A7J50_2680 | Mandelate racemase; Pfam:pfam13378 Enolase C-terminal domain-like; Belongs to the mandelate racemase/muconate lactonizing enzyme family. (405 aa) |
| | A7J50_2687 | LpxA family transferase. (205 aa) |
| | A7J50_2774 | Pfam:pfam02878 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I. (547 aa) |
| | A7J50_2796 | Hypothetical protein; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (547 aa) |
| | A7J50_2850 | Oxaloacetate decarboxylase; Catalyzes the decarboxylation of oxaloacetate into pyruvate. Seems to play a role in maintaining cellular concentrations of bicarbonate and pyruvate; Belongs to the isocitrate lyase family. Oxaloacetate decarboxylase subfamily. (289 aa) |
| | A7J50_2884 | Serine/threonine protein kinase; Pfam:pfam06745 KaiC. (472 aa) |
| | A7J50_2925 | Protein kinase; Pfam:pfam06745 KaiC. (488 aa) |
| | ackA | Propionate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (404 aa) |
| | A7J50_2982 | Circadian clock protein KaiC; Pfam:pfam06745 KaiC. (500 aa) |
| | A7J50_3246 | COF family hydrolase; Pfam:pfam08282 haloacid dehalogenase-like hydrolase. (274 aa) |
| | A7J50_3357 | Pfam:pfam00920 Dehydratase family; Belongs to the IlvD/Edd family. (578 aa) |
| | ttcA | tRNA 2-thiocytidine biosynthesis protein TtcA; Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system. (274 aa) |
| | A7J50_3443 | Pfam:pfam00180 Isocitrate/isopropylmalate dehydrogenase. (418 aa) |
| | phnX | Phosphonoacetaldehyde hydrolase; Involved in phosphonate degradation; Belongs to the HAD-like hydrolase superfamily. PhnX family. (275 aa) |
| | pheT | phenylalanyl-tRNA synthetase; Pfam:pfam03483 B3/4 domain; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (792 aa) |
| | pheS | Phenylalanine--tRNA ligase alpha subunit; Pfam:pfam01409 tRNA synthetases class II core domain (F); Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (338 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (501 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (360 aa) |
| | A7J50_3892 | Protein kinase; Pfam:pfam06745 KaiC. (488 aa) |
| | A7J50_3922 | Glucarate dehydratase; Pfam:pfam13378 Enolase C-terminal domain-like. (444 aa) |
| | A7J50_4083 | Lipid kinase; Probably phosphorylates lipids; the in vivo substrate is unknown; Belongs to the diacylglycerol/lipid kinase family. YegS lipid kinase subfamily. (306 aa) |
| | A7J50_4313 | CmaX protein; Pfam:pfam01544 CorA-like Mg2+ transporter protein. (331 aa) |
| | prpB | Methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. (297 aa) |
| | rne | Ribonuclease E; Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. Belongs to the RNase E/G family. RNase E subfamily. (1060 aa) |
| | A7J50_4488 | Pfam:pfam01648 4'-phosphopantetheinyl transferase superfamily; Belongs to the P-Pant transferase superfamily. (238 aa) |
| | A7J50_4508 | Magnesium transporter; Acts as a magnesium transporter. (480 aa) |
| | A7J50_4558 | Pfam:pfam01544 CorA-like Mg2+ transporter protein. (340 aa) |
| | queE | 7-carboxy-7-deazaguanine synthase; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (215 aa) |
| | ruvC | Crossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (174 aa) |
| | A7J50_4718 | Pfam:pfam00224 Pyruvate kinase, barrel domain; Belongs to the pyruvate kinase family. (483 aa) |
| | dinB | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (352 aa) |
| | purT | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (393 aa) |
| | obg | GTPase CgtA; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. (407 aa) |
| | recB | Exodeoxyribonuclease V subunit beta; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and rep [...] (1224 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (338 aa) |
| | A7J50_4968 | Acetolactate synthase; Pfam:pfam02776 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain. (574 aa) |
| | pnp | Polyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (701 aa) |
| | glmM | Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. (445 aa) |
| | thiE | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (209 aa) |
| | ppa | Inorganic pyrophosphatase; Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions. (186 aa) |
| | dxs | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (632 aa) |
| | thiL | Thiamine monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (321 aa) |
| | ribB | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. (363 aa) |
| | rpoC | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1399 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (349 aa) |
| | pdxA | 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (329 aa) |
| | cca | 2',3'-cyclic phosphodiesterase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases. (409 aa) |
| | bioD | ATP-dependent dethiobiotin synthetase BioD; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (226 aa) |
| | srkA | Serine/threonine protein kinase; A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response. (324 aa) |
| | metK | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (423 aa) |
| | glmU | Glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (455 aa) |
| | ilvD | Pfam:pfam00920 Dehydratase family; Belongs to the IlvD/Edd family. (613 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (151 aa) |
| | A7J50_5720 | Pfam:pfam02878 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I. (465 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (214 aa) |
| | pdxY | Pyridoxamine kinase; Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP. (290 aa) |
