STRINGSTRING
A7J50_3443 A7J50_3443 A7J50_3444 A7J50_3444 A7J50_3452 A7J50_3452 fumC-2 fumC-2 aceK aceK A7J50_4330 A7J50_4330 A7J50_4331 A7J50_4331 glcB glcB A7J50_5793 A7J50_5793 A7J50_1954 A7J50_1954 sucC sucC sucD sucD A7J50_1951 A7J50_1951 A7J50_1950 A7J50_1950 A7J50_1949 A7J50_1949 mqo-2 mqo-2 A7J50_1953 A7J50_1953 A7J50_1666 A7J50_1666 ppc ppc mqo mqo fumC fumC A7J50_2326 A7J50_2326 A7J50_3192 A7J50_3192
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
A7J50_3443Pfam:pfam00180 Isocitrate/isopropylmalate dehydrogenase. (418 aa)
A7J50_3444Pfam:pfam03971 Monomeric isocitrate dehydrogenase; Belongs to the monomeric-type IDH family. (741 aa)
A7J50_3452Pfam:pfam00463 Isocitrate lyase family. (441 aa)
fumC-2Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (462 aa)
aceKIsocitrate dehydrogenase; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation. (569 aa)
A7J50_4330Aconitate hydratase; Pfam:pfam00330 Aconitase family (aconitate hydratase). (864 aa)
A7J50_4331Pfam:pfam00285 Citrate synthase; Belongs to the citrate synthase family. (375 aa)
glcBMalate synthase; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (725 aa)
A7J50_5793Aspartate ammonia-lyase; Pfam:pfam00206 Lyase. (474 aa)
A7J50_19542-oxoglutarate dehydrogenase E1; Pfam:pfam02779 Transketolase, pyrimidine binding domain. (943 aa)
sucCSuccinyl-CoA ligase [ADP-forming] subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (404 aa)
sucDSuccinyl-CoA ligase [ADP-forming] subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (293 aa)
A7J50_1951Succinate dehydrogenase, hydrophobic membrane anchor protein; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (122 aa)
A7J50_1950Pfam:pfam01127 Succinate dehydrogenase/Fumarate reductase transmembrane subunit. (124 aa)
A7J50_1949Pfam:pfam00285 Citrate synthase; Belongs to the citrate synthase family. (429 aa)
mqo-2Pfam:pfam06039 Malate:quinone oxidoreductase (Mqo). (551 aa)
A7J50_1953Succinate dehydrogenase, iron-sulfur protein; Pfam:pfam13085 2Fe-2S iron-sulfur cluster binding domain. (234 aa)
A7J50_1666Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (913 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (881 aa)
mqoPfam:pfam06039 Malate:quinone oxidoreductase (Mqo). (502 aa)
fumCFumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (458 aa)
A7J50_2326Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (895 aa)
A7J50_3192Pfam:pfam06434 Aconitate hydratase 2 N-terminus; Belongs to the aconitase/IPM isomerase family. (874 aa)
Your Current Organism:
Pseudomonas antarctica
NCBI taxonomy Id: 219572
Other names: CCUG 49625, DSM 15318, LMG 22709, LMG:22709, MTCC 4992, Pseudomonas antarctica Reddy et al. 2004, strain CMS 35
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.