STRINGSTRING
A7J50_0264 A7J50_0264 A7J50_0332 A7J50_0332 A7J50_0409 A7J50_0409 A7J50_0412 A7J50_0412 A7J50_0422 A7J50_0422 A7J50_0424 A7J50_0424 A7J50_0425 A7J50_0425 A7J50_0427 A7J50_0427 A7J50_0541 A7J50_0541 A7J50_0599 A7J50_0599 A7J50_0600 A7J50_0600 A7J50_0635 A7J50_0635 A7J50_0636 A7J50_0636 A7J50_0658 A7J50_0658 fabZ fabZ accA accA A7J50_1522 A7J50_1522 A7J50_1570 A7J50_1570 fabV fabV A7J50_1858 A7J50_1858 A7J50_1970 A7J50_1970 fabA fabA A7J50_2033 A7J50_2033 A7J50_2187 A7J50_2187 A7J50_2438 A7J50_2438 A7J50_2439 A7J50_2439 A7J50_2579 A7J50_2579 A7J50_2580 A7J50_2580 A7J50_2850 A7J50_2850 A7J50_3202 A7J50_3202 A7J50_3272 A7J50_3272 A7J50_3273 A7J50_3273 A7J50_3310 A7J50_3310 A7J50_3338 A7J50_3338 A7J50_3340 A7J50_3340 A7J50_3551 A7J50_3551 accD accD A7J50_3935 A7J50_3935 A7J50_4009 A7J50_4009 A7J50_4072 A7J50_4072 A7J50_4130 A7J50_4130 A7J50_4221 A7J50_4221 prpB prpB A7J50_4337 A7J50_4337 A7J50_4454 A7J50_4454 A7J50_4467 A7J50_4467 A7J50_4468 A7J50_4468 acpP acpP A7J50_4470 A7J50_4470 A7J50_4471 A7J50_4471 plsX plsX A7J50_4602 A7J50_4602 A7J50_4697 A7J50_4697 panB panB panC panC A7J50_5047 A7J50_5047 A7J50_5082 A7J50_5082 lipA lipA A7J50_5287 A7J50_5287 bioD bioD bioC bioC A7J50_5345 A7J50_5345 bioF bioF bioB bioB bioA bioA A7J50_5467 A7J50_5467 A7J50_5470 A7J50_5470 mdcC mdcC A7J50_5515 A7J50_5515 A7J50_5580 A7J50_5580 ubiC ubiC A7J50_5806 A7J50_5806
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
A7J50_0264Putative membrane protein; Pfam:pfam07377 Protein of unknown function (DUF1493). (209 aa)
A7J50_0332Chorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate. (178 aa)
A7J50_0409Pfam:pfam00109 Beta-ketoacyl synthase, N-terminal domain; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (408 aa)
A7J50_0412Pfam:pfam02801 Beta-ketoacyl synthase, C-terminal domain; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (388 aa)
A7J50_0422Pfam:pfam00501 AMP-binding enzyme. (556 aa)
A7J50_0424Acyl carrier protein; Pfam:pfam00550 Phosphopantetheine attachment site. (84 aa)
A7J50_0425Acyl carrier protein. (89 aa)
A7J50_0427Pfam:pfam13723 Beta-ketoacyl synthase, N-terminal domain. (209 aa)
A7J50_0541Putative amino acid oxidase; Pfam:pfam00106 short chain dehydrogenase. (254 aa)
A7J50_0599acetyl-CoA carboxylase biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (453 aa)
A7J50_0600acetyl-CoA carboxylase biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (152 aa)
A7J50_0635Acyl dehydratase; Pfam:pfam01575 MaoC like domain. (282 aa)
A7J50_0636Oxidoreductase; Pfam:pfam00106 short chain dehydrogenase. (450 aa)
A7J50_0658Pfam:pfam00202 Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (449 aa)
fabZ3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (146 aa)
accAacetyl-CoA carboxylase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (315 aa)
A7J50_1522ACP phosphodiesterase; Pfam:pfam04336 Protein of unknown function, DUF479. (194 aa)
A7J50_1570Urea carboxylase; Pfam:pfam02626 Allophanate hydrolase subunit 2. (1230 aa)
fabVtrans-2-enoyl-CoA reductase; Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon- carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP); Belongs to the TER reductase family. (397 aa)
A7J50_18582-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (321 aa)
A7J50_1970Pfam:pfam00109 Beta-ketoacyl synthase, N-terminal domain; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (406 aa)
fabA3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase; Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E- (2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length. (171 aa)
A7J50_2033NAD(P)H-quinone oxidoreductase; Pfam:pfam08240 Alcohol dehydrogenase GroES-like domain. (320 aa)
A7J50_2187Pfam:pfam00202 Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (439 aa)
A7J50_2438Putative non-ribosomal peptide synthetase; Pfam:pfam00501 AMP-binding enzyme. (4303 aa)
A7J50_2439Putative non-ribosomal peptide synthetase; Pfam:pfam00501 AMP-binding enzyme. (3778 aa)
A7J50_25793-ketoacyl-ACP reductase; Pfam:pfam00106 short chain dehydrogenase. (447 aa)
A7J50_2580Acyl dehydratase; Pfam:pfam01575 MaoC like domain. (300 aa)
A7J50_2850Oxaloacetate decarboxylase; Catalyzes the decarboxylation of oxaloacetate into pyruvate. Seems to play a role in maintaining cellular concentrations of bicarbonate and pyruvate; Belongs to the isocitrate lyase family. Oxaloacetate decarboxylase subfamily. (289 aa)
A7J50_3202Short-chain dehydrogenase; Pfam:pfam13561 Enoyl-(Acyl carrier protein) reductase. (255 aa)
A7J50_3272Pyoverdine non-ribosomal peptide synthetase; Pfam:pfam00501 AMP-binding enzyme. (3950 aa)
A7J50_3273Pyoverdine synthetase I; Pfam:pfam00501 AMP-binding enzyme. (4684 aa)
A7J50_3310Oxidoreductase; Pfam:pfam08240 Alcohol dehydrogenase GroES-like domain. (319 aa)
A7J50_3338Pfam:pfam00107 Zinc-binding dehydrogenase. (332 aa)
A7J50_3340Dimethylallyltransferase; Pfam:pfam13587 N-terminal domain of DJ-1_PfpI family. (225 aa)
A7J50_3551methylcrotonoyl-CoA carboxylase; Pfam:pfam01039 Carboxyl transferase domain. (535 aa)
accDacetyl-CoA carboxylase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (306 aa)
A7J50_3935NAD(P)H-quinone oxidoreductase; Pfam:pfam00107 Zinc-binding dehydrogenase. (326 aa)
A7J50_4009Long-chain acyl-CoA synthetase; Pfam:pfam00501 AMP-binding enzyme. (608 aa)
A7J50_4072methylcrotonoyl-CoA carboxylase; Pfam:pfam01039 Carboxyl transferase domain. (538 aa)
A7J50_4130beta-ketoacyl-ACP synthase; Pfam:pfam08541 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal. (309 aa)
A7J50_42213-oxoacyl-ACP synthase; Pfam:pfam08541 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal. (373 aa)
prpBMethylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. (297 aa)
A7J50_4337Aminodeoxychorismate synthase; Pfam:pfam00425 chorismate binding enzyme. (447 aa)
A7J50_4454Pfam:pfam08241 Methyltransferase domain. (242 aa)
A7J50_44674-amino-4-deoxychorismate lyase; Pfam:pfam01063 Aminotransferase class IV. (271 aa)
A7J50_44683-oxoacyl-ACP synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (414 aa)
acpPAcyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (78 aa)
A7J50_44703-ketoacyl-ACP reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (247 aa)
A7J50_4471ACP S-malonyltransferase; Pfam:pfam00698 Acyl transferase domain. (312 aa)
plsXPhosphate acyltransferase; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (326 aa)
A7J50_46023-hydroxybutyryl-CoA dehydratase; Pfam:pfam01575 MaoC like domain. (156 aa)
A7J50_46972-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (305 aa)
panB3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (266 aa)
panCPantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (283 aa)
A7J50_5047Pfam:pfam01817 Chorismate mutase type II. (101 aa)
A7J50_5082Pfam:pfam14696 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal. (633 aa)
lipALipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (341 aa)
A7J50_5287Phosphoglycolate phosphatase; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. (272 aa)
bioDATP-dependent dethiobiotin synthetase BioD; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (226 aa)
bioCmalonyl-CoA O-methyltransferase; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. (270 aa)
A7J50_5345Transporter; Pfam:pfam12697 Alpha/beta hydrolase family. (243 aa)
bioF8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (393 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (351 aa)
bioAAdenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (468 aa)
A7J50_5467Malonate decarboxylase subunit epsilon; Pfam:pfam00698 Acyl transferase domain. (299 aa)
A7J50_5470Malonate decarboxylase subunit beta; Pfam:pfam01039 Carboxyl transferase domain. (280 aa)
mdcCMalonate decarboxylase acyl carrier protein; Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism. (99 aa)
A7J50_5515Pfam:pfam12697 Alpha/beta hydrolase family. (332 aa)
A7J50_5580Pfam:pfam00202 Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (454 aa)
ubiCChorismate--pyruvate lyase; Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway; Belongs to the UbiC family. (187 aa)
A7J50_5806Biotin carboxylase; Pfam:pfam02786 Carbamoyl-phosphate synthase L chain, ATP binding domain. (471 aa)
Your Current Organism:
Pseudomonas antarctica
NCBI taxonomy Id: 219572
Other names: CCUG 49625, DSM 15318, LMG 22709, LMG:22709, MTCC 4992, Pseudomonas antarctica Reddy et al. 2004, strain CMS 35
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.