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A7J50_0112 A7J50_0112 pckA pckA A7J50_0448 A7J50_0448 A7J50_0449 A7J50_0449 fumC fumC mqo mqo A7J50_1666 A7J50_1666 mqo-2 mqo-2 A7J50_1949 A7J50_1949 A7J50_1950 A7J50_1950 A7J50_1951 A7J50_1951 A7J50_1952 A7J50_1952 A7J50_1953 A7J50_1953 A7J50_1954 A7J50_1954 A7J50_1955 A7J50_1955 A7J50_1956 A7J50_1956 sucC sucC sucD sucD A7J50_3192 A7J50_3192 A7J50_3443 A7J50_3443 A7J50_3444 A7J50_3444 A7J50_3622 A7J50_3622 fumC-2 fumC-2 A7J50_4721 A7J50_4721 A7J50_5805 A7J50_5805 A7J50_5806 A7J50_5806
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
A7J50_0112Pfam:pfam13336 Acetyl-CoA hydrolase/transferase C-terminal domain. (497 aa)
pckAPhosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. (513 aa)
A7J50_0448Dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (548 aa)
A7J50_0449Pyruvate dehydrogenase; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (881 aa)
fumCFumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (458 aa)
mqoPfam:pfam06039 Malate:quinone oxidoreductase (Mqo). (502 aa)
A7J50_1666Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (913 aa)
mqo-2Pfam:pfam06039 Malate:quinone oxidoreductase (Mqo). (551 aa)
A7J50_1949Pfam:pfam00285 Citrate synthase; Belongs to the citrate synthase family. (429 aa)
A7J50_1950Pfam:pfam01127 Succinate dehydrogenase/Fumarate reductase transmembrane subunit. (124 aa)
A7J50_1951Succinate dehydrogenase, hydrophobic membrane anchor protein; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (122 aa)
A7J50_1952Succinate dehydrogenase; Pfam:pfam00890 FAD binding domain; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (590 aa)
A7J50_1953Succinate dehydrogenase, iron-sulfur protein; Pfam:pfam13085 2Fe-2S iron-sulfur cluster binding domain. (234 aa)
A7J50_19542-oxoglutarate dehydrogenase E1; Pfam:pfam02779 Transketolase, pyrimidine binding domain. (943 aa)
A7J50_1955Dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (408 aa)
A7J50_1956Dihydrolipoyl dehydrogenase; Pfam:pfam07992 Pyridine nucleotide-disulphide oxidoreductase. (478 aa)
sucCSuccinyl-CoA ligase [ADP-forming] subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (404 aa)
sucDSuccinyl-CoA ligase [ADP-forming] subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (293 aa)
A7J50_3192Pfam:pfam06434 Aconitate hydratase 2 N-terminus; Belongs to the aconitase/IPM isomerase family. (874 aa)
A7J50_3443Pfam:pfam00180 Isocitrate/isopropylmalate dehydrogenase. (418 aa)
A7J50_3444Pfam:pfam03971 Monomeric isocitrate dehydrogenase; Belongs to the monomeric-type IDH family. (741 aa)
A7J50_3622Dihydrolipoamide dehydrogenase; Pfam:pfam07992 Pyridine nucleotide-disulphide oxidoreductase. (459 aa)
fumC-2Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (462 aa)
A7J50_4721Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (507 aa)
A7J50_5805Pfam:pfam02436 Conserved carboxylase domain. (602 aa)
A7J50_5806Biotin carboxylase; Pfam:pfam02786 Carbamoyl-phosphate synthase L chain, ATP binding domain. (471 aa)
Your Current Organism:
Pseudomonas antarctica
NCBI taxonomy Id: 219572
Other names: CCUG 49625, DSM 15318, LMG 22709, LMG:22709, MTCC 4992, Pseudomonas antarctica Reddy et al. 2004, strain CMS 35
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