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prpR prpR prpB prpB prpC prpC prpD prpD prpE prpE STY1110 STY1110 adh adh STY1493 STY1493 pduL pduL STY2262 STY2262 STY2567 STY2567 STY2568 STY2568 eutD eutD tdcD tdcD STY3830 STY3830 STY4116 STY4116 STY4401 STY4401 STY4402 STY4402 STY4403 STY4403 STY4471 STY4471 STY4472 STY4472 acs acs
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
prpRSimilar to Salmonella typhimurium propionate catabolism operon regulatory protein. propionate catabolism operon regulatory protein SW:PRPR_SALTY () (541 aa) fasta scores: E(): 0, 98.9% id in 541 aa, and to Escherichia coli propionate catabolism operon regulatory protein prpR SW:PRPR_ECOLI (P77743) (528 aa) fasta scores: E(): 0, 79.8% id in 530 aa; Fasta hit to YGAA_ECOLI (529 aa), 33% identity in 509 aa overlap; Orthologue of E. coli PRPR_ECOLI; Fasta hit to PRPR_ECOLI (528 aa), 80% identity in 530 aa overlap. (541 aa)
prpBPutative carboxyvinyl-carboxyphosphonate phosphorylmutase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. (295 aa)
prpCMethylcitrate synthase; Similar to Salmonella typhimurium methylcitrate synthase SW:CISZ_SALTY () (389 aa) fasta scores: E(): 0, 98.7% id in 389 aa, and to Escherichia coli methylcitrate synthase prpC SW:CISZ_ECOLI (P31660; P77217) (389 aa) fasta scores: E(): 0, 96.1% id in 388 aa; Fasta hit to CISY_ECOLI (427 aa), 32% identity in 369 aa overlap; Orthologue of E. coli CISZ_ECOLI; Fasta hit to CISZ_ECOLI (389 aa), 96% identity in 388 aa overlap. (389 aa)
prpDPrpD protein; Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the dehydration of 2-methylcitrate (2-MC) to yield the cis isomer of 2- methyl-aconitate. Could also catalyze the dehydration of citrate and the hydration of cis-aconitate; Belongs to the PrpD family. (483 aa)
prpEPrpE protein; Similar to Salmonella typhimurium prpe protein SW:PRPE_SALTY () (640 aa) fasta scores: E(): 0, 98.6% id in 621 aa, and to Escherichia coli PrpE protein prpE SW:PRPE_ECOLI (P77495) (628 aa) fasta scores: E(): 0, 89.5% id in 628 aa; Fasta hit to ACSA_ECOLI (652 aa), 38% identity in 638 aa overlap; Orthologue of E. coli PRPE_ECOLI; Fasta hit to PRPE_ECOLI (628 aa), 90% identity in 628 aa overlap. (628 aa)
STY1110Similar to Gallus gallus acylphosphatase, muscle type isozyme SW:ACYM_CHICK (P07031) fasta scores: E(): 6.1e-08, 39.5% id in 86 aa; Orthologue of E. coli ACYP_ECOLI; Fasta hit to ACYP_ECOLI (92 aa), 78% identity in 92 aa overlap. (93 aa)
adhAlcohol dehydrogenase; Similar to Escherichia coli aldehyde-alcohol dehydrogenase [includes: alcohol dehydrogenase adhE or ana SW:ADHE_ECOLI (P17547) (890 aa) fasta scores: E(): 0, 97.3% id in 892 aa; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (892 aa)
STY1493Alcohol dehydrogenase; Fasta hit to ADH3_ECOLI (369 aa), 32% identity in 373 aa overlap; Orthologue of E. coli ADHP_ECOLI; Fasta hit to ADHP_ECOLI (336 aa), 93% identity in 335 aa overlap. (336 aa)
pduLConserved hypothetical protein; Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate. (210 aa)
STY2262Putative propionate kinase; Similar to Salmonella typhimurium probable propionate kinase SW:PDUW_SALTY (P74879; Q9XDM5) (404 aa) fasta scores: E(): 0, 99.3% id in 404 aa; Fasta hit to ACKA_ECOLI (400 aa), 44% identity in 396 aa overlap; Paralogue of E. coli yhaA (TDCD_ECOLI); Fasta hit to TDCD_ECOLI (402 aa), 44% identity in 400 aa overlap. (404 aa)
STY2567Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (400 aa)
STY2568Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (714 aa)
eutDPutative phosphate acyltransferase; Similar to Salmonella typhimurium ethanolamine utilization protein EutD eutD or eutI SW:EUTD_SALTY (P41790) (338 aa) fasta scores: E(): 0, 98.8% id in 338 aa. Similar to phosphate acetyltransferases e.g. Clostridium acetobutylicum phosphate acetyltransferase pta SW:PTA_CLOAB (P71103) (333 aa) fasta scores: E(): 0, 38.1% id in 331 aa; Orthologue of E. coli eutI (EUTD_ECOLI); Fasta hit to EUTD_ECOLI (338 aa), 89% identity in 338 aa overlap. (338 aa)
tdcDPropionate kinase; Catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. (402 aa)
STY3830Similar to several alcohol dehydrogenases e.g. Bacillus methanolicus NAD-dependent methanol dehydrogenase MdH SW:MEDH_BACMT (P31005) (380 aa) fasta scores: E(): 0, 44.4% id in 378 aa; Fasta hit to EUTG_ECOLI (395 aa), 40% identity in 377 aa overlap; Fasta hit to FUCO_ECOLI (383 aa), 43% identity in 383 aa overlap. (382 aa)
STY4116Aldehyde dehydrogenase B; Fasta hit to ALDA_ECOLI (478 aa), 33% identity in 478 aa overlap; Fasta hit to FEAB_ECOLI (499 aa), 34% identity in 481 aa overlap; Fasta hit to YNEI_ECOLI (462 aa), 31% identity in 465 aa overlap; Fasta hit to DHAB_ECOLI (489 aa), 38% identity in 478 aa overlap; Fasta hit to DHAL_ECOLI (495 aa), 40% identity in 481 aa overlap; Fasta hit to YDCW_ECOLI (474 aa), 35% identity in 481 aa overlap; Fasta hit to GABD_ECOLI (482 aa), 34% identity in 485 aa overlap; Orthologue of E. coli aldB (ALDB_ECOLI); Fasta hit to ALDB_ECOLI (512 aa), 96% identity in 512 aa overla [...] (512 aa)
STY4401Similar to Escherichia coli malate synthase A AceB SW:MASY_ECOLI (P08997) (533 aa) fasta scores: E(): 0, 90.8% id in 533 aa, and to Myxococcus xanthus malate synthase mls SW:MASY_MYXXA (P95329) (541 aa) fasta scores: E(): 0, 56.2% id in 511 aa. (533 aa)
STY4402Isocitrate lyase; Similar to Escherichia coli isocitrate lyase AceA SW:ACEA_ECOLI (P05313) (434 aa) fasta scores: E(): 0, 95.6% id in 434 aa, and to Vibrio cholerae isocitrate lyase VC0736 TR:Q9KTZ4 (EMBL:AE004159) (437 aa) fasta scores: E(): 0, 79.4% id in 433 aa. (434 aa)
STY4403Isocitrate dehydrogenase kinase/phosphatase; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation. (593 aa)
STY4471Sodium:solute symporter family protein; Transports acetate; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (549 aa)
STY4472Putative membrane protein; Similar to Escherichia coli hypothetical 11.7 kDa protein in soxR-acs intergenic region YjcH SW:YJCH_ECOLI (P32706) (104 aa) fasta scores: E(): 0, 89.3% id in 103 aa, and to Pseudomonas aeruginosa conserved hypothetical protein PA3235 TR:AAG06623 (EMBL:AE004746) (103 aa) fasta scores: E(): 2.7e-20, 59.8% id in 102 aa. Predicted hydrophobic membrane spanning domains, integral membrane protein. (104 aa)
acsAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (652 aa)
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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