STRINGSTRING
STY0426 STY0426 STY0723 STY0723 STY1242 STY1242 STY1260 STY1260 STY1576 STY1576 STY1785 STY1785 manX manX STY1960 STY1960 STY1961 STY1961 STY2439 STY2439 STY2441 STY2441 STY2442 STY2442 STY2667 STY2667 STY2670 STY2670 STY2816 STY2816 STY3144 STY3144 STY3433 STY3433 STY3435 STY3435 STY3436 STY3436 STY3437 STY3437 STY3438 STY3438 ptsN ptsN STY3503 STY3503 STY3925 STY3925 STY4004 STY4004 STY4013 STY4013 STY4014 STY4014 STY4015 STY4015 STY4016 STY4016 STY4017 STY4017 STY4018 STY4018 STY4020 STY4020 STY4115 STY4115 STY4191 STY4191 STY4202 STY4202
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STY0426Similar to Escherichia coli hypothetical 32.5 kDa protein in arom-araj intergenic region yajF SW:YAJF_ECOLI (P23917; P75705; P71316) (302 aa) fasta scores: E(): 0, 87.7% id in 300 aa, and to Staphylococcus xylosus glucokinase glkA SW:GLK_STAXY (Q56198) (328 aa) fasta scores: E(): 3.6e-16, 28.4% id in 320 aa; Fasta hit to YCFX_ECOLI (303 aa), 39% identity in 298 aa overlap; Orthologue of E. coli yajF (YAJF_ECOLI); Fasta hit to YAJF_ECOLI (302 aa), 88% identity in 300 aa overlap. (302 aa)
STY0723Pts system, N-acetylglucosamine-specific IIABC component; Orthologue of E. coli nagE (PTAA_ECOLI); Fasta hit to PTAA_ECOLI (648 aa), 93% identity in 648 aa overlap. (650 aa)
STY1242PTS system, glucose-specific IIBC component; Fasta hit to PTOA_ECOLI (530 aa), 37% identity in 513 aa overlap; Orthologue of E. coli ptsG (PTGB_ECOLI); Fasta hit to PTGB_ECOLI (477 aa), 97% identity in 476 aa overlap. (477 aa)
STY1260Putative ROK-family protein; Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P. (302 aa)
STY1576Putative regulatory protein; Fasta hit to NAGC_ECOLI (406 aa), 40% identity in 385 aa overlap; Orthologue of E. coli mlc (MLC_ECOLI); Fasta hit to MLC_ECOLI (406 aa), 91% identity in 386 aa overlap. (386 aa)
STY17856-phosphofructokinase isozyme; Fasta hit to K1PF_ECOLI (312 aa), 31% identity in 311 aa overlap; Orthologue of E. coli pfkB (K6P2_ECOLI); Fasta hit to K6P2_ECOLI (309 aa), 93% identity in 308 aa overlap; Belongs to the carbohydrate kinase PfkB family. (310 aa)
manXSimilar to Escherichia coli PTS system, mannose-specific IIAB component SW:PTNA_ECOLI (P08186) (322 aa) fasta scores: E(): 0, 96.0% id in 322 aa. (322 aa)
STY1960Phosphotransferase enzyme II, C component; Orthologue of E. coli manY (PTNC_ECOLI); Fasta hit to PTNC_ECOLI (266 aa), 94% identity in 266 aa overlap. (266 aa)
STY1961Phosphotransferase enzyme II, D component; Fasta hit to PTPD_ECOLI (263 aa), 35% identity in 274 aa overlap; Orthologue of E. coli manZ (PTND_ECOLI); Fasta hit to PTND_ECOLI (286 aa), 93% identity in 282 aa overlap. (283 aa)
STY2439PTS system, fructose-specific IIBC component; Fasta hit to PTVB_ECOLI (485 aa), 34% identity in 478 aa overlap; Orthologue of E. coli fruA (PTFB_ECOLI); Fasta hit to PTFB_ECOLI (563 aa), 94% identity in 507 aa overlap. (562 aa)
STY24411-phosphofructokinase; Fasta hit to K6P2_ECOLI (309 aa), 31% identity in 310 aa overlap; Orthologue of E. coli fruK (K1PF_ECOLI); Fasta hit to K1PF_ECOLI (312 aa), 98% identity in 312 aa overlap; Belongs to the carbohydrate kinase PfkB family. (312 aa)
STY2442Pts system, fructose-specific IIA/FPR component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FruAB PTS system is involved in fructose transport. (376 aa)
STY2667Phosphocarrier protein HPr; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain. (85 aa)
STY2670Pts system, glucose-specific IIA component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II complex composed of PtsG and Crr is involved in glucose transport. (169 aa)
STY2816Putative PTS system IIBC component; Similar to Bacillus subtilis negative regulatory protein of SacY sacX or sacS SW:SACX_BACSU (P15400) (459 aa) fasta scores: E(): 0, 33.1% id in 472 aa and putative PTS components e.g. Bacillus halodurans putative PTS system, sucrose phosphotransferase enzyme II BC component BH3574 TR:Q9K700 (EMBL:AP001519) (453 aa) fasta scores: E(): 0, 47.4% id in 454 aa; Orthologue of E. coli P77272; Fasta hit to P77272 (474 aa), 39% identity in 470 aa overlap. (453 aa)
STY3144Phosphoenolpyruvate-protein phosphotransferase; Orthologue of E. coli ptsP (PT1P_ECOLI); Fasta hit to PT1P_ECOLI (748 aa), 95% identity in 748 aa overlap; Belongs to the PEP-utilizing enzyme family. (748 aa)
STY3433Similar to several Eukaryotic carbohydrate kinases e.g. Lycopersicon esculentum fructokinase fk or frk2 TR:Q42896 (EMBL:U62329) (328 aa) fasta scores: E(): 2.2e-22, 29.0% id in 317 aa. (315 aa)
STY3435Tagatose-bisphosphate aldolase; Catalytic subunit of the tagatose-1,6-bisphosphate aldolase GatYZ, which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6-bisphosphate (TBP). Requires GatZ subunit for full activity and stability. Is involved in the catabolism of galactitol. (284 aa)
STY3436Possible carbohydrate kinase; Similar to Bacillus subtilis 1-phosphofructokinase fruk or fruB SW:K1PF_BACSU (O31714) (303 aa) fasta scores: E(): 9.9e-28, 31.8% id in 305 aa; Belongs to the carbohydrate kinase PfkB family. (304 aa)
STY3437Similar to Escherichia coli PTS system, fructose-like-1 IIBC component FrvB SW:PTVB_ECOLI (P32154) (485 aa) fasta scores: E(): 0, 32.4% id in 475 aa. Note, like the example given, the predicted product of this CDS contains only one hydrophilic IIB domain. Contains possible membrane spanning hydrophobic domains; Fasta hit to PTVB_ECOLI (485 aa), 32% identity in 474 aa overlap; Paralogue of E. coli fruA (PTFB_ECOLI); Fasta hit to PTFB_ECOLI (563 aa), 42% identity in 471 aa overlap. (475 aa)
STY3438This CDS is similar to the phosphotransferase enzyme IIA and HPr (phosphoryl carrier protein) domains of PTF family sugar transport proteins, e.g. the N-terminus of Xanthomonas campestris multiphosphoryl transfer protein FruB SW:PTF1_XANCP (P45597) (837 aa) fasta scores: E(): 2.9e-22, 36.0% id in 225 aa; Paralogue of E. coli fruB (PTFA_ECOLI); Fasta hit to PTFA_ECOLI (376 aa), 36% identity in 372 aa overlap. (268 aa)
ptsNSimilar to Escherichia coli nitrogen regulatory IIA protein PtsN or RpoP SW:PTSN_ECOLI (P31222) (163 aa) fasta scores: E(): 0, 95.1% id in 163 aa. (163 aa)
STY3503Phosphocarrier protein (nitrogen related hpr); Fasta hit to PTHP_ECOLI (85 aa), 30% identity in 79 aa overlap; Orthologue of E. coli ptsO (PTSO_ECOLI); Fasta hit to PTSO_ECOLI (90 aa), 97% identity in 90 aa overlap. (90 aa)
STY3925Similar to Escherichia coli PTS system, fructose-specific IIBC component SW:PTFB_ECOLI () (563 aa) fasta scores: E(): 0, 65.5% id in 458 aa. Note the product of this CDS lacks the first of the two E. coli EIIB transferase domains; Fasta hit to PTVB_ECOLI (485 aa), 35% identity in 450 aa overlap; Paralogue of E. coli fruA (PTFB_ECOLI); Fasta hit to PTFB_ECOLI (563 aa), 66% identity in 458 aa overlap. (457 aa)
STY4004Similar to Mycoplasma capricolum phosphocarrier protein ptsH SW:PTHP_MYCCA (P45611) (88 aa) fasta scores: E(): 3.3e-06, 32.9% id in 76 aa, and to Alcaligenes eutrophus phosphocarrier protein SW:PTHP_ALCEU (P23537) (89 aa) fasta scores: E(): 7.5e-06, 33.7% id in 89 aa. (89 aa)
STY4013Similar to Escherichia coli PTS system, mannose-specific IIAB component SW:PTNA_ECOLI (P08186) (322 aa) fasta scores: E(): 0.0015, 35.0% id in 123 aa, and to Streptococcus salivarius mannose-specific phosphotransferase system component IIAB TR:Q9S4L5 (EMBL:AF130465) (330 aa) fasta scores: E(): 0.0035, 25.2% id in 103 aa. (141 aa)
STY4014Similar to Bacillus subtilis PTS system, fructose-specific IIB component SW:PTFB_BACSU (P26380) (163 aa) fasta scores: E(): 6.6e-15, 30.2% id in 159 aa, and to Streptococcus salivarius mannose-specific phosphotransferase system component IIB TR:Q9S4L5 (EMBL:AF130465) (330 aa) fasta scores: E(): 1.6e-14, 31.8% id in 157 aa, and to Escherichia coli PTS system, mannose-specific IIAB component manX or ptsl or gptB SW:PTNA_ECOLI (P08186) (322 aa) fasta scores: E(): 3.5e-13, 29.9% id in 157 aa. (161 aa)
STY4015Putative PTS system protein; Orthologue of E. coli agaC (PTPC_ECOLI); Fasta hit to PTPC_ECOLI (267 aa), 30% identity in 238 aa overlap. (249 aa)
STY4016Similar to Escherichia coli PTS system, mannose-specific IID component SW:PTND_ECOLI (P08188) (286 aa) fasta scores: E(): 0, 39.9% id in 273 aa, and to Klebsiella pneumoniae PTS system, sorbose-specific IID component sorM SW:PTRD_KLEPN (P37083) (274 aa) fasta scores: E(): 3.2e-29, 34.8% id in 276 aa. (285 aa)
STY4017Putative transferase; Weakly similar to Aquifex aeolicus L-seryl-tRNA selA TR:O67140 (EMBL:AE000719) (452 aa) fasta scores: E(): 0.37, 24.6% id in 403 aa, and to Azotobacter vinelandii dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex SW:ODO2_AZOVI (P20708) (398 aa) fasta scores: E(): 0.91, 23.2% id in 285 aa. (369 aa)
STY4018Conserved hypothetical protein; Some similarity to Arabidopsis thaliana putative D-ribulose-5-phosphate 3-epimerase f28j7.18 TR:Q9SGI6 (EMBL:AC010797) (233 aa) fasta scores: E(): 1.1, 24.3% id in 243 aa, and to Haloferax sp predicted 2-dehydro-3-deoxyphosphogluconate aldolase TR:P94802 (EMBL:U70664) (215 aa) fasta scores: E(): 4.8, 29.2% id in 144 aa. (247 aa)
STY4020Similar to Escherichia coli hypothetical 34.2 kDa protein in folX-hispP intergenic region. hypothetical 34.2 kda protein in folX-hispP intergenic region SW:YFCI_ECOLI (P77768) (296 aa) fasta scores: E(): 0, 64.5% id in 313 aa, and to Salmonella typhimurium hypothetical 35.3 kDa protein near tlpA operon SW:YTL2_SALTY (P37415) (313 aa) fasta scores: E(): 0, 56.1% id in 312 aa. (313 aa)
STY4115Putative sugar kinase; Similar to e.g. Bacillus megaterium glucose kinase glk TR:O31392 (EMBL:AJ000005) (324 aa) fasta scores: E(): 1.5e-16, 29.5% id in 319 aa and Streptomyces coelicolor glucokinase SW:GLK_STRCO (P40184) (317 aa) fasta scores: E(): 2.8e-16, 31.4% id in 318 aa. As the N-terminal helix-turn-helix domain of ROK-family tarnscriptional regulators is absent, this is probably a sugar kinase; Paralogue of E. coli yhcI (YHCI_ECOLI); Fasta hit to YHCI_ECOLI (291 aa), 30% identity in 306 aa overlap. (293 aa)
STY41912-dehydro-3-deoxygluconokinase; Orthologue of E. coli kdgK (KDGK_ECOLI); Fasta hit to KDGK_ECOLI (309 aa), 92% identity in 308 aa overlap. (309 aa)
STY4202Putative phosphosugar-binding protein; Similar to the N-terminal regions of Bacillus subtilis yurP protein TR:O32157 (EMBL:Z99120) (328 aa) fasta scores: E(): 0, 44.4% id in 257 aa, and to Agrobacterium tumefaciens mocD protein TR:Q44324 (EMBL:AF242881) (340 aa) fasta scores: E(): 3.3e-24, 32.2% id in 267 aa. Lack of similarity to the C-terminal regions of these proteins. The CDS appears to be a fusion protein, after residue 266 the CDS is similar to L-asparaginase (STY4203). C-terminal deletion of DNA relative to Salmonella typhimurium. Effect on function not known. (284 aa)
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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