STRINGSTRING
pagP pagP STY1270 STY1270 STY1271 STY1271 STY1783 STY1783 STY1970 STY1970 STY2097 STY2097 STY2449 STY2449 pmrD pmrD STY4162 STY4162 STY4485 STY4485 pmrB pmrB pmrA pmrA STY4492 STY4492
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pagPAntimicrobial peptide resistance and lipid A acylation protein; Transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors. (190 aa)
STY1270Sensor protein PhoQ, regulator of virulence determinants; Member of the two-component regulatory system PhoP/PhoQ which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. In low periplasmic Mg(2+), PhoQ functions as a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to PhoP, which results in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2+), acts as a protein phosphatase that dephosphorylates phosph [...] (487 aa)
STY1271Transcriptional regulatory protein PhoP, regulator of virulence determinants; Member of the two-component regulatory system PhoQ/PhoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. Promotes intramacrophage survival of S.typhi. Is required to enhance bacterial resistance to bile in the human intestinal cells. (224 aa)
STY1783Similar to Helicobacter pylori J99 putative outer membrane protein jhp0634 TR:Q9ZLE6 (EMBL:AE001495) (336 aa) fasta scores: E(): 9.3e-05, 17.2% id in 319 aa. (319 aa)
STY1970Putative membrane protein; PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing. MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway. Represses PhoP/PhoQ signaling, possibly by binding to the periplasmic domain of PhoQ, altering its activity and that of downstream effector PhoP. (47 aa)
STY2097Lipid A acyltransferase; Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)- lipid A. (323 aa)
STY2449Putative membrane protein; Involved in the modification of the lipid A domain of lipopolysaccharides (LPS). Transfers a phosphate group from undecaprenyl pyrophosphate (C55-PP) to lipid A to form lipid A 1- diphosphate. Contributes to the recycling of undecaprenyl phosphate (C55-P); Belongs to the LpxT phosphotransferase family. (239 aa)
pmrDIdentical to Salmonella typhimurium polymyxin B resistance protein PmrD SW:PMRD_SALTY (P37589) (85 aa) fasta scores: E(): 0, 100.0% id in 84 aa; Orthologue of E. coli pmrD (PMRD_ECOLI); Fasta hit to PMRD_ECOLI (88 aa), 60% identity in 79 aa overlap. (85 aa)
STY4162Putative membrane protein; Similar to Salmonella typhimurium ATCC 14028 protein (fragment) SW:YHJW_SALTY (P43666) (295 aa) fasta scores: E(): 0, 98.6% id in 277 aa. N-terminus contains hydrophobic, probable membrane-spanning regions; Orthologue of E. coli yhjW (YHJW_ECOLI); Fasta hit to YHJW_ECOLI (574 aa), 85% identity in 562 aa overlap. (543 aa)
STY4485Putative membrane-bound beta-hydroxylase; Similar to C-terminus of Bos taurus aspartyl/asparaginyl beta-hydroxylase aspH SW:ASPH_BOVIN (Q28056) (754 aa) fasta scores: E(): 3.4e-08, 26.1% id in 176 aa, Homo sapiens aspartyl/asparaginyl beta-hydroxylase aspH SW:ASPH_HUMAN (Q12797) (757 aa) fasta scores: E(): 4.7e-08, 26.0% id in 169 aa and to the N-terminus of Streptomyces verticillus beta-hydroxylase TR:Q53792 (EMBL:L26955) (304 aa) fasta scores: E(): 2e-07, 20.6% id in 218 aa. Contains N-terminal and C-terminal hydrophobic regions, probable membrane spanning domains. (302 aa)
pmrBTwo-component sensor kinase; Similar to Salmonella typhimurium sensor protein PmrB or BasS SW:BASS_SALTY (P36557) (356 aa) fasta scores: E(): 0, 98.9% id in 356 aa, and to Escherichia coli sensor protein BasS SW:BASS_ECOLI (P30844) (363 aa) fasta scores: E(): 0, 85.6% id in 355 aa. (359 aa)
pmrATwo-component response regulator; Similar to Salmonella typhimurium transcriptional regulatory protein PmrA or BasR SW:BASR_SALTY (P36556) (222 aa) fasta scores: E(): 0, 98.6% id in 222 aa, and to Escherichia coli transcriptional regulatory protein BasR SW:BASR_ECOLI (P30843) (222 aa) fasta scores: E(): 0, 90.1% id in 222 aa. (222 aa)
STY4492Putative membrane protein; Similar to Salmonella typhimurium hypothetical 61.6 kDa protein in basS/pmrA-adiY intergenic region YjdB SW:YJDB_SALTY (P36555) (547 aa) fasta scores: E(): 0, 99.6% id in 547 aa, and to Escherichia coli hypothetical 61.7 kDa protein in basS-adiY intergenic region YjdB SW:YJDB_ECOLI (P30845) (547 aa) fasta scores: E(): 0, 82.3% id in 547 aa. Predicted hydrophobic membrane spanning domains, integral membrane protein. (547 aa)
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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