STRINGSTRING
STY0501 STY0501 STY1337 STY1337 STY1351 STY1351 STY1507 STY1507 ttrR ttrR ttrB ttrB ttrC ttrC ttrA ttrA STY1755 STY1755 STY2161 STY2161 phsC phsC phsB phsB phsA phsA STY2666 STY2666 STY2677 STY2677 STY2678 STY2678 STY2679 STY2679 STY2680 STY2680 STY2681 STY2681 STY2779 STY2779 STY2780 STY2780 asrA asrA asrB asrB asrC asrC cysC cysC cysN cysN cysD cysD STY3074 STY3074 STY3075 STY3075 STY3076 STY3076 STY3808 STY3808 cysE cysE glpE glpE cysQ cysQ
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STY0501Putative lyase; Similar to Mycobacterium tuberculosis putative lyase rv3684 or mtv025.032 TR:O69652 (EMBL:AL022121) (346 aa) fasta scores: E(): 0, 61.5% id in 338 aa, and to Cyanidioschyzon merolae O-acetylserine cmoastl2 TR:Q9SSV8 (EMBL:AB031004) (390 aa) fasta scores: E(): 2.3e-16, 27.4% id in 329 aa, and to Emericella nidulans cysteine synthase cysB SW:CYSK_EMENI (P50867) (371 aa) fasta scores: E(): 1.7e-14, 25.6% id in 332 aa. (351 aa)
STY1337Cys regulon transcriptional activator; Fasta hit to CBL_ECOLI (316 aa), 42% identity in 313 aa overlap; Orthologue of E. coli cysB (CYSB_ECOLI); Fasta hit to CYSB_ECOLI (324 aa), 95% identity in 324 aa overlap; Belongs to the LysR transcriptional regulatory family. (324 aa)
STY1351Similar to Escherichia coli hypothetical 45.1 kDa protein in rnb-fabI intergenic region YciW SW:YCIW_ECOLI (P76035) (401 aa) fasta scores: E(): 0, 52.3% id in 306 aa. (306 aa)
STY1507Putative aminotransferase; Orthologue of E. coli malY (MALY_ECOLI); Fasta hit to MALY_ECOLI (390 aa), 34% identity in 384 aa overlap. (393 aa)
ttrRPutative two-component response regulator; Similar to Salmonella typhimurium TtrR TR:Q9Z4T0 (EMBL:AJ224978) (206 aa) fasta scores: E(): 0, 100.0% id in 206 aa, and to Rhodobacter capsulatus c4-dicarboxylate transport transcriptional regulatory protein DctR SW:DCTR_RHOCA (P37740) (197 aa) fasta scores: E(): 2.1e-22, 39.1% id in 192 aa; Fasta hit to NARL_ECOLI (216 aa), 30% identity in 200 aa overlap; Paralogue of E. coli uhpA (UHPA_ECOLI); Fasta hit to UHPA_ECOLI (196 aa), 34% identity in 196 aa overlap. (206 aa)
ttrBSimilar to Salmonella typhimurium tetrathionate reductase subunit B TtrB TR:Q9Z4S8 (EMBL:AJ224978) (250 aa) fasta scores: E(): 0, 100.0% id in 250 aa and to Salmonella typhimurium thiosulfate reductase electron transport protein PhsB SW:PHSB_SALTY (P37601) (192 aa) fasta scores: E(): 1.1e-25, 46.4% id in 151 aa; Fasta hit to P77375 (239 aa), 33% identity in 228 aa overlap; Paralogue of E. coli nrfC (NRFC_ECOLI); Fasta hit to NRFC_ECOLI (223 aa), 41% identity in 222 aa overlap. (250 aa)
ttrCSimilar to Salmonella typhimurium tetrathionate reductase subunit C TtrC TR:Q9Z4S7 (EMBL:AJ224978) (340 aa) fasta scores: E(): 0, 98.2% id in 340 aa. (340 aa)
ttrASimilar to Salmonella typhimurium tetrathionate reductase subunit A TtrA TR:Q9Z4S6 (EMBL:AJ224978) (1020 aa) fasta scores: E(): 0, 99.7% id in 1020 aa and to Archaeoglobus fulgidus molybdopterin oxidoreductase, molybdopterin binding subunit, putative af0159 TR:O30078 (EMBL:AE001095) (1134 aa) fasta scores: E(): 6.4e-33, 31.1% id in 1000 aa; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1020 aa)
STY1755Putative transporter; Similar to Haemophilus influenzae hypothetical symporter Hi1154 hi1154 SW:YB54_HAEIN (P45079) (440 aa) fasta scores: E(): 0, 41.3% id in 438 aa; Paralogue of E. coli P77529; Fasta hit to P77529 (463 aa), 46% identity in 439 aa overlap; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. (448 aa)
STY2161Putative deaminase; Catalyzes the alpha,beta-elimination reaction of D-cysteine and of several D-cysteine derivatives. It could be a defense mechanism against D-cysteine; Belongs to the ACC deaminase/D-cysteine desulfhydrase family. (328 aa)
phsCSimilar to Salmonella typhimurium thiosulfate reductase cytochrome b subunit phsC SW:PHSC_SALTY (P37602; P37603; Q56120) (254 aa) fasta scores: E(): 0, 99.6% id in 254 aa; Orthologue of E. coli PHSC_ECOLI; Fasta hit to PHSC_ECOLI (261 aa), 57% identity in 242 aa overlap. Contains hydrophobic, probable membrane-spanning regions. (254 aa)
phsBThiosulfate reductase electron transport protein PhsB; Component of the PhsABC thiosulfate reductase that catalyzes the reduction of thiosulfate to sulfite and hydrogen sulfide, with menaquinol as the sole electron donor. Proton motive force (PMF) is required to drive transmembrane electron transfer within the reductase. The PhsB subunit transfers electrons between PhsC and PhsA. (192 aa)
phsASimilar to Salmonella typhimurium thiosulfate reductase precursor phsA SW:PHSA_SALTY (P37600) (758 aa) fasta scores: E(): 0, 99.6% id in 758 aa. Contains a probable N-terminal signal sequence; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (758 aa)
STY2666Cysteine synthase A; Two cysteine synthase enzymes are found. Both catalyze the same reaction. Cysteine synthase B can also use thiosulfate in place of sulfide to give cysteine thiosulfonate as a product (By similarity). (323 aa)
STY2677Cysteine synthase B; Similar to Salmonella typhimurium LT2 cysteine synthase B cysM SW:CYSM_SALTY (P29848) (303 aa) fasta scores: E(): 0, 98.7% id in 303 aa; Fasta hit to CYSK_ECOLI (322 aa), 44% identity in 307 aa overlap; Orthologue of E. coli cysM (CYSM_ECOLI); Fasta hit to CYSM_ECOLI (303 aa), 93% identity in 303 aa overlap; Belongs to the cysteine synthase/cystathionine beta- synthase family. (303 aa)
STY2678Sulphate transport ATP-binding protein CysA; Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system. (364 aa)
STY2679Sulphate transport system permease protein CysW; Fasta hit to CYST_ECOLI (277 aa), 37% identity in 259 aa overlap; Orthologue of E. coli cysW (CYSW_ECOLI); Fasta hit to CYSW_ECOLI (291 aa), 97% identity in 291 aa overlap. (291 aa)
STY2680Sulphate transport system permease protein CysT; Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. (277 aa)
STY2681Similar to Salmonella typhimurium thiosulphate-binding protein precursor cysP SW:CYSP_SALTY (P41031) (338 aa) fasta scores: E(): 0, 97.3% id in 338 aa; Fasta hit to SUBI_ECOLI (329 aa), 47% identity in 320 aa overlap; Orthologue of E. coli cysP (CYSP_ECOLI); Fasta hit to CYSP_ECOLI (338 aa), 94% identity in 337 aa overlap. (338 aa)
STY2779Putative thiosulfate sulfurtransferase; Similar to many eukaryotic proteins e.g. Homo sapiens 3-mercaptopyruvate sulfurtransferase mpsT or tst2 SW:THTM_HUMAN (P25325) (296 aa) fasta scores: E(): 0, 41.1% id in 280 aa; Orthologue of E. coli sseA (THTR_ECOLI); Fasta hit to THTR_ECOLI (280 aa), 81% identity in 278 aa overlap. (280 aa)
STY2780Hypothetical protein; No significant database matches. Unknown function. (222 aa)
asrASimilar to Salmonella typhimurium anaerobic sulfite reductase subunit A asrA SW:ASRA_SALTY (P26474) (347 aa) fasta scores: E(): 0, 99.1% id in 347 aa. (347 aa)
asrBSimilar to Salmonella typhimurium anaerobic sulfite reductase subunit B SW:ASRB_SALTY (P26475) (272 aa) fasta scores: E(): 0, 99.3% id in 272 aa. (272 aa)
asrCAnaerobic sulfite reductase subunit C; This enzyme catalyzes the hydrogen sulfide production from sulfite. It is strictly anaerobic. It is regulated by electron acceptors rather than by cysteine (By similarity). (337 aa)
cysCAdenosine 5-phosphosulfate kinase; Catalyzes the synthesis of activated sulfate. (201 aa)
cysNATP sulfurylase (ATP:sulfate adenyltransferase) subunit; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (479 aa)
cysDATP sulfurylase (ATP:sulfate adenyltransferase); Orthologue of E. coli cysD (CYSD_ECOLI); Fasta hit to CYSD_ECOLI (302 aa), 97% identity in 302 aa overlap. (302 aa)
STY30743'-phosphoadenosine 5'-phosphosulfate sulfotransferase; Reduction of activated sulfate into sulfite. (244 aa)
STY3075Sulfite reductase (NADPH) hemoprotein alpha subunit; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (570 aa)
STY3076Sulfite reductase (NADPH) flavoprotein beta subunit; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component; Belongs to the NADPH-dependent sulphite reductase flavoprotein subunit CysJ family. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (599 aa)
STY3808Periplasmic sulphate binding protein; Fasta hit to CYSP_ECOLI (338 aa), 46% identity in 323 aa overlap; Orthologue of E. coli sbp (SUBI_ECOLI); Fasta hit to SUBI_ECOLI (329 aa), 94% identity in 329 aa overlap. (329 aa)
cysESimilar to Escherichia coli serine acetyltransferase cysE SW:CYSE_ECOLI (P05796) (273 aa) fasta scores: E(): 0, 95.6% id in 273 aa; Belongs to the transferase hexapeptide repeat family. (273 aa)
glpEConserved hypothetical protein; Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide. (108 aa)
cysQcysQ protein; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family. (246 aa)
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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