STRINGSTRING
STY0111 STY0111 STY0253 STY0253 STY0254 STY0254 STY0284 STY0284 STY0285 STY0285 STY0429 STY0429 STY0430 STY0430 STY0528 STY0528 STY0529 STY0529 STY0530 STY0530 STY0697 STY0697 STY0831 STY0831 STY1240 STY1240 STY1256 STY1256 STY1336 STY1336 STY1406 STY1406 STY1804 STY1804 STY1951 STY1951 STY2082 STY2082 STY2084 STY2084 STY2102 STY2102 ruvA ruvA STY2106 STY2106 STY2154 STY2154 STY2460 STY2460 STY2737 STY2737 STY2949 STY2949 STY2950 STY2950 STY3033 STY3033 STY3111 STY3111 STY3198 STY3198 recQ recQ STY3608 STY3608 STY3881 STY3881 STY3940 STY3940 STY3941 STY3941 STY3942 STY3942 STY4048 STY4048 trmH trmH uvrA uvrA ssb ssb topB topB ssB ssB mutL mutL holC holC holD holD radA radA
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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STY0111Probable ATP-dependent helicase HepA; Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair; Belongs to the SNF2/RAD54 helicase family. RapA subfamily. (968 aa)
STY0253Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (198 aa)
STY0254DNA polymerase III, alpha chain; Orthologue of E. coli dnaE (DP3A_ECOLI); Fasta hit to DP3A_ECOLI (1160 aa), 97% identity in 1160 aa overlap. (1160 aa)
STY0284Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (155 aa)
STY0285DNA polymerase III epsilon subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contains the editing function and is a proofreading 3'- 5' exonuclease (By similarity). (243 aa)
STY0429Exonuclease SbcC; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SMC family. SbcC subfamily. (1034 aa)
STY0430Exonuclease SbcD; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. (400 aa)
STY0528DNA polymerase III subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (642 aa)
STY0529Conserved hypothetical protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. (109 aa)
STY0530Recombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (201 aa)
STY0697DNA polymerase III, delta subunit; Orthologue of E. coli holA (HOLA_ECOLI); Fasta hit to HOLA_ECOLI (343 aa), 90% identity in 343 aa overlap. (343 aa)
STY0831Excision nuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissoc [...] (673 aa)
STY1240DNA polymerase III, delta' subunit; Orthologue of E. coli holB (HOLB_ECOLI); Fasta hit to HOLB_ECOLI (334 aa), 79% identity in 334 aa overlap. (334 aa)
STY1256Transcription-repair coupling factor (TrcF); Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1148 aa)
STY1336DNA topoisomerase I, omega protein I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus [...] (865 aa)
STY1406Conserved hypothetical protein; Orthologue of E. coli YDAL_ECOLI; Fasta hit to YDAL_ECOLI (187 aa), 86% identity in 187 aa overlap. (187 aa)
STY1804Conserved hypothetical protein; Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity). (302 aa)
STY1951Similar to Escherichia coli probable ATP-dependent helicase YoaA SW:YOAA_ECOLI (P76257) (636 aa) fasta scores: E(): 0, 95.1% id in 635 aa, and to Haemophilus influenzae probable ATP-dependent helicase Hi0387 SW:YOAA_HAEIN (P44680) (640 aa) fasta scores: E(): 0, 62.4% id in 633 aa, and to Streptomyces coelicolor putative ATP-dependent helicase SC4H2.23 TR:O69978 (EMBL:AL022268) (664 aa) fasta scores: E(): 2.1e-32, 33.6% id in 660 aa. (636 aa)
STY2082DNA polymerase III, theta subunit; Orthologue of E. coli holE (HOLE_ECOLI); Fasta hit to HOLE_ECOLI (76 aa), 88% identity in 76 aa overlap. (76 aa)
STY2084Orthologue of E. coli EXOX_ECOLI; Fasta hit to EXOX_ECOLI (220 aa), 91% identity in 219 aa overlap. (232 aa)
STY2102Holliday junction DNA helicase; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (336 aa)
ruvAHolliday junction DNA helicase; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (203 aa)
STY2106Crossover junction endodeoxyribonuclease; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (173 aa)
STY2154Excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (610 aa)
STY2460Putative helicase; Orthologue of E. coli yejH (YEJH_ECOLI); Fasta hit to YEJH_ECOLI (586 aa), 95% identity in 586 aa overlap. (586 aa)
STY2737Conserved hypothetical protein; Mediates the interaction of DNA replication initiator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinitiation, a process called regulatory inhibition of DnaA or RIDA (By similarity); Belongs to the DnaA family. HdA subfamily. (241 aa)
STY2949Putative regulatory protein RecX; Modulates RecA activity; Belongs to the RecX family. (166 aa)
STY2950RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (353 aa)
STY3033DNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity). (855 aa)
STY31115'-3' exonuclease; Has flap endonuclease activity. During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. (271 aa)
STY3198Single-stranded DNA-specific exonuclease; Orthologue of E. coli recJ (RECJ_ECOLI); Fasta hit to RECJ_ECOLI (577 aa), 91% identity in 577 aa overlap. (577 aa)
recQSimilar to Escherichia coli ATP-dependent DNA helicase RecQ SW:RECQ_ECOLI (P15043; P76762) (607 aa) fasta scores: E(): 0, 94.6% id in 608 aa. (609 aa)
STY3608DNA helicase II; Fasta hit to REP_ECOLI (673 aa), 38% identity in 666 aa overlap; Orthologue of E. coli uvrD (UVRD_ECOLI); Fasta hit to UVRD_ECOLI (720 aa), 98% identity in 720 aa overlap. (720 aa)
STY3881DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (928 aa)
STY3940Chromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. (466 aa)
STY3941DNA polymerase III beta-subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (366 aa)
STY3942recF protein; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity). (357 aa)
STY4048ATP-dependent DNA helicase; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (693 aa)
trmHtRNA (guanosine-2'-O)-methyltransferase; Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (229 aa)
uvrAExcision nuclease subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate; Belongs to the ABC transporter superfamily. UvrA family. (941 aa)
ssbSingle-strand DNA-binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. (176 aa)
topBTopoisomerase B; Previously sequenced Salmonella typhi topoisomerase B TopB TR:Q9RHF5 (EMBL:AF000001) (664 aa) fasta scores: E(): 0, 100.0% id in 664 aa. Also similar to Escherichia coli DNA topoisomerase III TopB SW:TOP3_ECOLI (P14294) (653 aa) fasta scores: E(): 0, 40.7% id in 619 aa. (664 aa)
ssBPreviously sequenced Salmonella typhi single strand binding protein ssB TR:Q9RHF4 (EMBL:AF000001) (178 aa) fasta scores: E(): 0, 100.0% id in 178 aa. Also highly similar to other single-stranded DNA-binding proteins including: Escherichia coli SW:SSB_ECOLI () (177 aa) fasta scores: E(): 0, 71.8% id in 177 aa and Bacteriophage P1 single-stranded DNA-binding protein Ssb-p1 ssb-p1 TR:Q9XJG4 (EMBL:AF125376) (162 aa) fasta scores: E(): 0, 67.7% id in 164 aa. (178 aa)
mutLDNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (618 aa)
holCSimilar to Escherichia coli DNA polymerase III, chi subunit HolC SW:HOLC_ECOLI (P28905) (147 aa) fasta scores: E(): 0, 95.2% id in 147 aa and to Haemophilus influenzae DNA polymerase III, chi subunit HolC SW:HOLC_HAEIN (P43749) (144 aa) fasta scores: E(): 1.4e-26, 48.6% id in 142 aa. (160 aa)
holDDNA polymerase III, psi subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown. (145 aa)
radAPutative DNA repair protein; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (460 aa)
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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