STRINGSTRING
STY0519 STY0519 STY0520 STY0520 STY0521 STY0521 mdfA mdfA STY0901 STY0901 ybjX ybjX ybjY ybjY ybjZ ybjZ STY1191 STY1191 STY1204 STY1204 STY1539 STY1539 STY1540 STY1540 STY1541 STY1541 STY1542 STY1542 STY1697 STY1697 STY2339 STY2339 STY2340 STY2340 STY2341 STY2341 STY2342 STY2342 STY2343 STY2343 STY2344 STY2344 STY2345 STY2345 STY2346 STY2346 STY2347 STY2347 STY2348 STY2348 STY2349 STY2349 STY2402 STY2402 STY2719 STY2719 STY2939 STY2939 STY2940 STY2940 STY2941 STY2941 tolC tolC STY3981 STY3981 STY4874 STY4874
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STY0519Acriflavin resistance protein B; Fasta hit to ACRF_ECOLI (1034 aa), 78% identity in 1033 aa overlap; Fasta hit to YHIV_ECOLI (1037 aa), 71% identity in 1035 aa overlap; Fasta hit to ACRD_ECOLI (1037 aa), 65% identity in 1036 aa overlap; Orthologue of E. coli acrB (ACRB_ECOLI); Fasta hit to ACRB_ECOLI (1049 aa), 95% identity in 1048 aa overlap. (1049 aa)
STY0520Acriflavin resistance protein A precursor; Fasta hit to YHIU_ECOLI (385 aa), 54% identity in 391 aa overlap; Fasta hit to ACRE_ECOLI (385 aa), 67% identity in 388 aa overlap; Orthologue of E. coli acrA (ACRA_ECOLI); Fasta hit to ACRA_ECOLI (397 aa), 91% identity in 397 aa overlap; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (397 aa)
STY0521Potential acrAB operon repressor; Fasta hit to ENVR_ECOLI (220 aa), 38% identity in 203 aa overlap; Orthologue of E. coli acrR (ACRR_ECOLI); Fasta hit to ACRR_ECOLI (215 aa), 87% identity in 214 aa overlap. (217 aa)
mdfASimilar to Escherichia coli multidrug translocase mdfa SW:MDFA_ECOLI (Q46966) (410 aa) fasta scores: E(): 0, 90.9% id in 406 aa, and to Escherichia coli bicyclomycin resistance protein bcr or bica or bicr or sur or suxA SW:BCR_ECOLI (P28246) (396 aa) fasta scores: E(): 7.9e-15, 23.1% id in 389 aa, and to Klebsiella pneumoniae chloramphenicol transporter Cmla4 cmla4 TR:AAF27726 (EMBL:UNNKOWN ACCESSION) (419 aa) fasta scores: E(): 3.4e-13, 26.8% id in 354 aa; Fasta hit to YJIO_ECOLI (410 aa), 41% identity in 389 aa overlap; Orthologue of E. coli MDFA_ECOLI; Fasta hit to MDFA_ECOLI (410 a [...] (410 aa)
STY0901Putative membrane protein; Similar to Escherichia coli MosC protein mosC TR:P75810 (EMBL:AE000186) (402 aa) fasta scores: E(): 0, 88.1% id in 402 aa, and to Rhizobium meliloti membrane protein MosC mosC SW:MOSC_RHIME (Q07609) (407 aa) fasta scores: E(): 5.3e-07, 25.8% id in 395 aa; Orthologue of E. coli P75810; Fasta hit to P75810 (402 aa), 88% identity in 402 aa overlap. (403 aa)
ybjXPutative virK protein; Similar to Escherichia coli hypothetical 38.4 kDa protein in aqpZ-cspD intergenic region YbjX SW:YBJX_ECOLI (P75829) (330 aa) fasta scores: E(): 0, 57.1% id in 315 aa, and to Salmonella typhi VirK TR:O68287 (EMBL:AF029845) (297 aa) fasta scores: E(): 2.9e-32, 35.6% id in 281 aa, and to Shigella flexneri virulence protein VirK TR:Q52617 (EMBL:D11025) (316 aa) fasta scores: E(): 4.8e-32, 36.6% id in 279 aa. (316 aa)
ybjYPutative exported protein; Similar to Escherichia coli hypothetical 41.7 kDa protein in aqpz-cspd intergenic region ybjY SW:YBJY_ECOLI (P75830) (371 aa) fasta scores: E(): 0, 83.4% id in 368 aa, and to Campylobacter jejuni putative periplasmic protein cj0606 TR:Q9PHR0 (EMBL:AL139075) (390 aa) fasta scores: E(): 2.1e-21, 30.6% id in 386 aa, and to Neisseria meningitidis acra/acre family protein nmb0548 TR:Q9K0N8 (EMBL:AE002410) (392 aa) fasta scores: E(): 1e-20, 36.1% id in 352 aa, and to Escherichia coli acriflavin resistance protein e precursor acre or envC SW:ACRE_ECOLI (P24180) (385 [...] (372 aa)
ybjZConserved hypothetical ABC transporter; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. (648 aa)
STY1191Putative membrane transport protein; Similar to Streptococcus pneumoniae multi-drug resistance efflux pump PmraATR:Q9ZEX9 (EMBL:AJ007367) (399 aa) fasta scores: E(): 0, 44.4% id in 390 aa; Orthologue of E. coli yceE (YCEE_ECOLI); Fasta hit to YCEE_ECOLI (408 aa), 90% identity in 403 aa overlap. (404 aa)
STY1204Putative membrane transporter; Orthologue of E. coli YCEL_ECOLI; Fasta hit to YCEL_ECOLI (402 aa), 91% identity in 402 aa overlap. (402 aa)
STY1539Putative membrane protein; Fasta hit to YCHE_ECOLI (215 aa), 30% identity in 202 aa overlap; Orthologue of E. coli ydeB (MARC_ECOLI); Fasta hit to MARC_ECOLI (221 aa), 92% identity in 221 aa overlap. (221 aa)
STY1540Multiple antibiotic resistance protein MarR; Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes. Binds to the marO operator/promoter site (By similarity). (125 aa)
STY1541Multiple antibiotic resistance protein MarA; May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF (By similarity). (144 aa)
STY1542Multiple antibiotic resistance protein MarB; Orthologue of E. coli marB (MARB_ECOLI); Fasta hit to MARB_ECOLI (72 aa), 47% identity in 71 aa overlap. (71 aa)
STY1697Hypothetical integral membrane protein; Multidrug efflux pump that functions probably as a Na(+)/drug antiporter; Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MdtK subfamily. (457 aa)
STY2339Similar to efflux-system proteins e.g. Neisseria gonorrhoeae membrane fusion protein MtrC precursor mtrC SW:MTRC_NEIGO (P43505) (412 aa) fasta scores: E(): 4.8e-26, 32.7% id in 342 aa and Escherichia coli acriflavin resistance protein a precursor acrA or acrE SW:ACRA_ECOLI (P31223) (397 aa) fasta scores: E(): 5.5e-23, 28.9% id in 356 aa. Contains possible N-terminal membrane anchor; Fasta hit to ACRE_ECOLI (385 aa), 31% identity in 331 aa overlap; Orthologue of E. coli YEGM_ECOLI; Fasta hit to YEGM_ECOLI (415 aa), 83% identity in 415 aa overlap; Belongs to the membrane fusion protein ( [...] (413 aa)
STY2340Putative RND-family transporter protein; Fasta hit to YEGO_ECOLI (1025 aa), 50% identity in 1023 aa overlap; Orthologue of E. coli YEGN_ECOLI; Fasta hit to YEGN_ECOLI (1040 aa), 92% identity in 1040 aa overlap; Similar to many. Contains hydrophobic, probable membrane-spanning regions; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtB subfamily. (1040 aa)
STY2341Putative RND-family transporter protein; Fasta hit to YEGN_ECOLI (1040 aa), 50% identity in 1021 aa overlap; Orthologue of E. coli YEGO_ECOLI; Fasta hit to YEGO_ECOLI (1025 aa), 92% identity in 1025 aa overlap; Similar to many. Contains hydrophobic, probable membrane-spanning regions; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtC subfamily. (1026 aa)
STY2342Putative transporter protein; Fasta hit to YIEO_ECOLI (475 aa), 46% identity in 459 aa overlap; Orthologue of E. coli YEGB_ECOLI; Fasta hit to YEGB_ECOLI (471 aa), 86% identity in 469 aa overlap; Similar to many putative major facilitator family transporter proteins. Contains hydrophobic, probable membrane-spanning regions. (470 aa)
STY2343Putative two-component system sensor kinase; Orthologue of E. coli baeS (BAES_ECOLI); Fasta hit to BAES_ECOLI (467 aa), 89% identity in 467 aa overlap. (467 aa)
STY2344Putative two-component system response regulator; Fasta hit to TORR_ECOLI (230 aa), 37% identity in 231 aa overlap; Fasta hit to YLCA_ECOLI (227 aa), 35% identity in 223 aa overlap; Fasta hit to RSTA_ECOLI (242 aa), 33% identity in 228 aa overlap; Fasta hit to YGIX_ECOLI (219 aa), 35% identity in 222 aa overlap; Fasta hit to OMPR_ECOLI (239 aa), 37% identity in 241 aa overlap; Fasta hit to ARCA_ECOLI (238 aa), 32% identity in 233 aa overlap; Fasta hit to CPXR_ECOLI (232 aa), 37% identity in 225 aa overlap; Fasta hit to PHOB_ECOLI (229 aa), 40% identity in 224 aa overlap; Fasta hit to P [...] (240 aa)
STY2345Hypothetical protein; Unknown function. (100 aa)
STY2346Hypothetical protein; Unknown function. (294 aa)
STY2347Hypothetical protein; Unknown function. (235 aa)
STY2348Hypothetical protein; Unknown function. (703 aa)
STY2349Putative exported protein; Unknown function. Contains probable N-terminal signal sequence. (239 aa)
STY2402Putative lipoprotein; Shows weak similarity to e.g. Pseudomonas aeruginosa outer membrane protein OprM precursor oprM or oprK SW:OPRM_PSEAE (Q51487; Q51444) (477 aa) fasta scores: E(): 7.1e-20, 25.5% id in 491 aa. Contains probable N-terminal signal sequence; Fasta hit to YJCP_ECOLI (488 aa), 37% identity in 488 aa overlap; Orthologue of E. coli yohG (YOHG_ECOLI); Fasta hit to YOHG_ECOLI (398 aa), 85% identity in 396 aa overlap. (478 aa)
STY2719Putative efflux pump; Similar to Pseudomonas aeruginosa multidrug resistance protein MexB mexB SW:MEXB_PSEAE (P52002) (1046 aa) fasta scores: E(): 0, 61.7% id in 1032 aa; Fasta hit to ACRF_ECOLI (1034 aa), 63% identity in 1032 aa overlap; Fasta hit to ACRB_ECOLI (1049 aa), 66% identity in 1036 aa overlap; Fasta hit to YHIV_ECOLI (1037 aa), 60% identity in 1032 aa overlap; Orthologue of E. coli acrD (ACRD_ECOLI); Fasta hit to ACRD_ECOLI (1037 aa), 94% identity in 1037 aa overlap. (1037 aa)
STY2939Putative transcriptional regulator; Orthologue of E. coli emrR (MPRA_ECOLI); Fasta hit to MPRA_ECOLI (176 aa), 93% identity in 175 aa overlap. (176 aa)
STY2940Multidrug resistance protein A; Fasta hit to EMRK_ECOLI (387 aa), 50% identity in 377 aa overlap; Orthologue of E. coli emrA (EMRA_ECOLI); Fasta hit to EMRA_ECOLI (390 aa), 90% identity in 390 aa overlap. (390 aa)
STY2941Multidrug resistance protein B; Fasta hit to YIEO_ECOLI (475 aa), 33% identity in 424 aa overlap; Fasta hit to EMRY_ECOLI (512 aa), 63% identity in 506 aa overlap; Orthologue of E. coli emrB (EMRB_ECOLI); Fasta hit to EMRB_ECOLI (512 aa), 96% identity in 512 aa overlap; Belongs to the major facilitator superfamily. (512 aa)
tolCSimilar to Salmonella enteritidis outer membrane protein TolC precursor tolC SW:TOLC_SALEN (Q54001) (491 aa) fasta scores: E(): 0, 99.0% id in 491 aa, and to Escherichia coli outer membrane protein tolc precursor tolc or mtcb or muka or refI SW:TOLC_ECOLI (P02930) (495 aa) fasta scores: E(): 0, 89.7% id in 495 aa; Orthologue of E. coli tolC (TOLC_ECOLI); Fasta hit to TOLC_ECOLI (495 aa), 90% identity in 495 aa overlap. (491 aa)
STY3981Multidrug resistance protein D; Orthologue of E. coli emrD (EMRD_ECOLI); Fasta hit to EMRD_ECOLI (396 aa), 93% identity in 394 aa overlap. (394 aa)
STY4874Putative sugar transport protein; Similar to Escherichia coli hypothetical protein YjiO yjiO SW:YJIO_ECOLI (P39386) (410 aa) fasta scores: E(): 0, 86.0% id in 408 aa and to Escherichia coli multidrug translocase mdfA SW:MDFA_ECOLI (Q46966) (410 aa) fasta scores: E(): 0, 40.2% id in 386 aa. (413 aa)
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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