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pocR pocR pduF pduF pduA pduA pduB pduB pduC pduC pduD pduD pduE pduE pduG pduG pduH pduH pduJ pduJ pduK pduK pduM pduM pduO pduO pduP pduP pduQ pduQ pduS pduS pduT pduT STY2260 STY2260 pduV pduV pduX pduX STY2691 STY2691 eutK eutK eutL eutL eutC eutC eutB eutB eutA eutA STY2697 STY2697 eutG eutG STY2699 STY2699 STY2700 STY2700 eutN eutN STY2703 STY2703 STY2704 STY2704 STY2705 STY2705 eutS eutS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pocRSimilar to Salmonella typhimurium regulatory protein PocR pocR SW:POCR_SALTY (Q05587) (303 aa) fasta scores: E(): 0, 99.3% id in 304 aa. (304 aa)
pduFSimilar to Salmonella typhimurium propanediol diffusion facilitator pduF SW:PDUF_SALTY (P37451) (264 aa) fasta scores: E(): 0, 97.3% id in 264 aa. Contains hydrophobic, probable membrane-spanning regions; Belongs to the MIP/aquaporin (TC 1.A.8) family. (264 aa)
pduASimilar to Salmonella typhimurium propanediol utilization protein PduA pduA SW:PDUA_SALTY (P37448) (97 aa) fasta scores: E(): 5.7e-31, 100.0% id in 90 aa and identical to Salmonella enterica serovar Typhimurium PduA pduA TR:AAB84107 (EMBL:AF026270) (94 aa) fasta scores: E(): 1.1e-32, 100.0% id in 94 aa. S. typhi pduA is probably not essential for propanediol catabolism (by similarity), but may be involved (cf. homologue in the eut operon). The Salmonella enterica homologue has been implicated in polyhedral body formation which may protect the cell from toxic metabolites, or protect the [...] (94 aa)
pduBSimilar to Salmonella typhimurium propanediol utilization protein PduB pduB SW:PDUB_SALTY (P37449) (233 aa) fasta scores: E(): 0, 99.1% id in 233 aa. S. typhi pduB is probably not essential for propanediol catabolism (by similarity), but may be involved (cf. homologue in the eut operon). The Salmonella enterica homologue has been implicated in polyhedral body formation which may protect the cell from toxic metabolites, or protect the dehydratase from oxygen. (233 aa)
pduCSimilar to Salmonella typhimurium glycerol dehydratase large subunit pduC SW:DHAB_SALTY (P37450) (554 aa) fasta scores: E(): 0, 99.6% id in 554 aa and Klebsiella oxytoca diol dehydratase alpha subunit pddA TR:Q59470 (EMBL:D45071) (554 aa) fasta scores: E(): 0, 99.6% id in 554 aa. (554 aa)
pduDSimilar to Salmonella typhimurium diol dehydratase medium subunit pduD TR:O31041 (EMBL:AF026270) (224 aa) fasta scores: E(): 0, 98.2% id in 224 aa and Klebsiella oxytoca diol dehydratase beta subunit pddB TR:Q59471 (EMBL:D45071) (224 aa) fasta scores: E(): 0, 95.1% id in 224 aa. (224 aa)
pduESimilar to Salmonella typhimurium diol dehydratase small subunit pduE TR:O31042 (EMBL:AF026270) (173 aa) fasta scores: E(): 0, 99.4% id in 173 aa, and to Klebsiella oxytoca diol dehydratase gamma pddC TR:Q59472 (EMBL:D45071) (173 aa) fasta scores: E(): 0, 96.5% id in 173 aa. (173 aa)
pduGPduG protein; Similar to Salmonella enterica serovar Typhimurium protein PduG pduG TR:O31043 (EMBL:AF026270) (610 aa) fasta scores: E(): 0, 99.0% id in 610 aa and Klebsiella oxytoca diol dehydratase-reactivating factor large subunit ddrA TR:O68195 (EMBL:AF017781) (610 aa) fasta scores: E(): 0, 95.4% id in 608 aa. May be involved in removing inactive cofactor from the PduCDE dehydratase. Possibly also an adenosyltransferase (experimental). (610 aa)
pduHPduH protein; Similar to Salmonella enterica serovar Typhimurium protein PduH pduH TR:Q9XDN8 (EMBL:AF026270) (123 aa) fasta scores: E(): 0, 99.1% id in 111 aa and Klebsiella oxytoca diol dehydratase-reactivating factor small subunit ddrB TR:O68196 (EMBL:AF017781) (125 aa) fasta scores: E(): 0, 88.8% id in 116 aa. May be involved in removing inactive cofactor from the PduCDE dehydratase (in combination with pduG). A frameshift at codon 112 alters its C-terminus with respect to the homologues described above. (116 aa)
pduJPutative propanediol utilization protein PduJ; Similar to Salmonella enterica serovar Typhimurium protein PduJ pduJ TR:Q9XDN7 (EMBL:AF026270) (91 aa) fasta scores: E(): 4.2e-31, 100.0% id in 91 aa, Salmonella typhimurium propanediol utilization protein PduA pduA SW:PDUA_SALTY (P37448) (97 aa) fasta scores: E(): 6.7e-24, 84.9% id in 86 aa and Salmonella typhimurium ethanolamine utilization protein EutM precursor eutM or cchA SW:EUTM_SALTY (P41791) (96 aa) fasta scores: E(): 4.1e-18, 64.4% id in 87 aa. The Salmonella enterica homologue has been implicated in polyhedral body formation whi [...] (91 aa)
pduKPutative propanediol utilization protein PduK; Similar to Salmonella enterica serovar Typhimurium protein PduK pduK TR:Q9XDN6 (EMBL:AF026270) (160 aa) fasta scores: E(): 0, 98.1% id in 160 aa. The Salmonella enterica homologue has been implicated in polyhedral body formation which may protect the cell from toxic metabolites, or protect the dehydratase from oxygen. (160 aa)
pduMConserved hypothetical protein; Similar to Salmonella enterica serovar Typhimurium protein PduM pduM TR:Q9XDN4 (EMBL:AF026270) (163 aa) fasta scores: E(): 0, 96.3% id in 163 aa. (163 aa)
pduOConserved hypothetical protein; Similar to Salmonella enterica serovar Typhimurium protein PduO pduO TR:Q9XDN2 (EMBL:AF026270) (337 aa) fasta scores: E(): 0, 92.6% id in 337 aa. N-terminal half is similar to many e.g. Clostridium pasteurianum hypothetical protein TR:O30452 (EMBL:AF006034) (173 aa) fasta scores: E(): 2.3e-21, 43.7% id in 167 aa and Citrobacter freundii hypothetical protein SW:YDHW_CITFR (P45515) (176 aa) fasta scores: E(): 3.2e-25, 47.9% id in 167 aa. C-terminal half is similar to many e.g. Clostridium pasteurianum hypothetical protein TR:O30453 (EMBL:AF006034) (143 aa) [...] (336 aa)
pduPPutative CoA-dependent proprionaldehyde dehydrogenase; Similar to Salmonella enterica serovar Typhimurium protein PduP pduP TR:Q9XDN1 (EMBL:AF026270) (464 aa) fasta scores: E(): 0, 99.1% id in 464 aa and Salmonella typhimurium ethanolamine utilization protein EutE eutE SW:EUTE_SALTY (P41793) (467 aa) fasta scores: E(): 0, 45.7% id in 473 aa; Paralogue of E. coli eutE (EUTE_ECOLI); Fasta hit to EUTE_ECOLI (467 aa), 45% identity in 470 aa overlap. (464 aa)
pduQPutative propanol dehydrogenase; Similar to Salmonella enterica serovar Typhimurium protein PduQ pduQ TR:Q9XDN0 (EMBL:AF026270) (370 aa) fasta scores: E(): 0, 97.8% id in 370 aa and Clostridium acetobutylicum NADPH-dependent butanol dehydrogenase adh1 SW:ADH1_CLOAB (P13604) (388 aa) fasta scores: E(): 7e-32, 35.6% id in 385 aa; Fasta hit to EUTG_ECOLI (395 aa), 38% identity in 380 aa overlap; Fasta hit to FUCO_ECOLI (383 aa), 32% identity in 383 aa overlap; Paralogue of E. coli yiaY (ADH2_ECOLI); Fasta hit to ADH2_ECOLI (383 aa), 37% identity in 346 aa overlap. (370 aa)
pduSPutative ferredoxin; Similar to Salmonella enterica serovar Typhimurium protein PduS pduS TR:Q9XDM9 (EMBL:AF026270) (451 aa) fasta scores: E(): 0, 97.7% id in 442 aa and Clostridium sticklandii electron transfer protein from the D-proline reductase cluster prdC TR:Q9L4Q5 (EMBL:AJ130879) (402 aa) fasta scores: E(): 1.5e-24, 32.3% id in 337 aa. The N-terminus is truncated by 9 amino acids with respect to the Salmonella enterica homologue (by a stop codon). The putative start codon indicated here is at codon 10 of the Salmonella enterica homologue. (442 aa)
pduTPutative propanediol utilization protein PduT; Similar to Salmonella enterica serovar Typhimurium protein PduT pduT TR:Q9XDM8 (EMBL:AF026270) (184 aa) fasta scores: E(): 0, 98.9% id in 184 aa and to part of Salmonella typhimurium ethanolamine utilization protein EutM precursor eutM or cchA SW:EUTM_SALTY (P41791) (96 aa) fasta scores: E(): 0.00067, 40.0% id in 80 aa. The Salmonella enterica homologue has been implicated in polyhedral body formation which may protect the cell from toxic metabolites, or protect the dehydratase from oxygen. (184 aa)
STY2260Identical to Salmonella typhimurium propanediol utilization protein pduU SW:PDUU_SALTY (Q9XDM7) (116 aa) fasta scores: E(): 0, 100.0% id in 116 aa and Salmonella typhimurium ethanolamine utilization protein eutS SW:EUTS_SALTY (P76557) (111 aa) fasta scores: E(): 3.4e-22, 57.8% id in 109 aa. The Salmonella enterica homologue has been implicated in polyhedral body formation which may protect the cell from toxic metabolites, or protect the dehydratase from oxygen. (116 aa)
pduVSimilar to Salmonella typhimurium propanediol utilization protein pduV SW:PDUV_SALTY (Q9XDM6) (150 aa) fasta scores: E(): 0, 97.3% id in 150 aa and Salmonella typhimurium ethanolamine utilization protein eutP SW:EUTP_SALTY (Q9ZFV6) (159 aa) fasta scores: E(): 2.7e-08, 32.2% id in 143 aa; Belongs to the EutP/PduV family. (150 aa)
pduXConserved hypothetical protein; Similar to Salmonella enterica serovar Typhimurium PduX TR:Q9XDM4 (EMBL:AF026270) (300 aa) fasta scores: E(): 0, 99.3% id in 300 aa. (300 aa)
STY2691Similar to Salmonella typhimurium LT2 ethanolamine operon regulatory protein. ethanolamine operon regulatory protein SW:EUTR_SALTY (Q9ZFU7) (350 aa) fasta scores: E(): 0, 99.1% id in 350 aa; Orthologue of E. coli yfeG (EUTR_ECOLI); Fasta hit to EUTR_ECOLI (350 aa), 91% identity in 349 aa overlap. (350 aa)
eutKSimilar to Escherichia coli ethanolamine utilization protein EutK precursor eutK SW:EUTK_ECOLI (P76540) (166 aa) fasta scores: E(): 0, 79.9% id in 164 aa and Salmonella typhimurium ethanolamine utilization protein EutK precursor eutK SW:EUTK_SALTY (Q9ZFU8) (164 aa) fasta scores: E(): 0, 97.6% id in 164 aa. The N-terminal approx 100 aa is similar to Salmonella typhimurium propanediol utilization protein PduA which has been implicated in polyhedral body formation which may protect the cell from toxic metabolites. (164 aa)
eutLEthanolamine utilization protein EutL; May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place; Belongs to the EutL/PduB family. (219 aa)
eutCSimilar to Salmonella typhimurium ethanolamine ammonia-lyase light chain eutC SW:EUTC_SALTY (P19265) (298 aa) fasta scores: E(): 0, 99.3% id in 298 aa; Orthologue of E. coli eutC (EUTC_ECOLI); Fasta hit to EUTC_ECOLI (295 aa), 91% identity in 298 aa overlap; Belongs to the EutC family. (298 aa)
eutBSimilar to Salmonella typhimurium ethanolamine ammonia-lyase heavy chain SW:EUTB_SALTY (P19264) (453 aa) fasta scores: E(): 0, 99.8% id in 453 aa; Orthologue of E. coli eutB (EUTB_ECOLI); Fasta hit to EUTB_ECOLI (453 aa), 98% identity in 453 aa overlap. (453 aa)
eutASimilar to Salmonella typhimurium ethanolamine utilization protein EutA eutA SW:EUTA_SALTY (Q9ZFV2) (467 aa) fasta scores: E(): 0, 99.1% id in 467 aa; Orthologue of E. coli EUTA_ECOLI; Fasta hit to EUTA_ECOLI (467 aa), 90% identity in 467 aa overlap. Shares a region of similarity with EutJ and DnaK/FtsA. (467 aa)
STY2697Putative membrane protein; Similar to Salmonella typhimurium ethanolamine utilization protein EutH eutH SW:EUTH_SALTY (P41796) (415 aa) fasta scores: E(): 0, 96.6% id in 416 aa. Contains hydrophobic, probable membrane-spanning regions; Orthologue of E. coli eutH (EUTH_ECOLI); Fasta hit to EUTH_ECOLI (408 aa), 97% identity in 408 aa overlap. (408 aa)
eutGPutative alchohol dehydrogenase; Similar to Escherichia coli ethanolamine utilization protein EutG eutG SW:EUTG_ECOLI (P76553) (395 aa) fasta scores: E(): 0, 86.0% id in 394 aa and Salmonella typhimurium ethanolamine utilization protein EutG eutG SW:EUTG_SALTY (P41795) (391 aa) fasta scores: E(): 0, 93.4% id in 395 aa. (395 aa)
STY2699Putative ethanolamine utilization protein EutJ; Identical to Salmonella typhimurium eutJ SW:EUTJ_SALTY (P41794) (279 aa) fasta scores: E(): 0, 100.0% id in 279 aa; Orthologue of E. coli eutJ (EUTJ_ECOLI); Fasta hit to EUTJ_ECOLI (278 aa), 89% identity in 278 aa overlap. Shares a region of similarity with EutA and DnaK/FtsA. (279 aa)
STY2700Putative aldehyde dehydrogenase; Similar to Salmonella typhimurium ethanolamine utilization protein EutE eutE SW:EUTE_SALTY (P41793) (467 aa) fasta scores: E(): 0, 99.4% id in 467 aa; Orthologue of E. coli eutE (EUTE_ECOLI); Fasta hit to EUTE_ECOLI (467 aa), 94% identity in 467 aa overlap. (467 aa)
eutNIdentical, at the C-terminus, to Salmonella typhimurium ethanolamine utilization protein EutN eutN or cchB SW:EUTN_SALTY (P41792) (99 aa) fasta scores: E(): 0, 100.0% id in 99 aa. Similar, at the C-terminus, to Escherichia coli ethanolamine utilization protein EutN eutN SW:EUTN_ECOLI (P77633) (95 aa) fasta scores: E(): 1.4e-31, 91.6% id in 95 aa. (229 aa)
STY2703Putative cobalamin adenosyltransferase; Similar to Salmonella typhimurium ethanolamine utilization cobalamin adenosyltransferase SW:EUTT_SALTY (Q9ZFV4) (267 aa) fasta scores: E(): 0, 98.9% id in 267 aa; Orthologue of E. coli EUTT_ECOLI; Fasta hit to EUTT_ECOLI (267 aa), 88% identity in 265 aa overlap. (265 aa)
STY2704Similar to Salmonella typhimurium LT2 ethanolamine utilization protein EutQ eutQ SW:EUTQ_SALTY (Q9ZFV5) (229 aa) fasta scores: E(): 0, 99.1% id in 229 aa; Orthologue of E. coli EUTQ_ECOLI; Fasta hit to EUTQ_ECOLI (233 aa), 87% identity in 233 aa overlap. (229 aa)
STY2705Similar to Salmonella typhimurium LT2 ethanolamine utilization protein EutP eutP SW:EUTP_SALTY (Q9ZFV6) (159 aa) fasta scores: E(): 0, 100.0% id in 159 aa and to Salmonella typhimurium propanediol utilization protein PduV pduV SW:PDUV_SALTY (Q9XDM6) (150 aa) fasta scores: E(): 4.1e-07, 30.1% id in 143 aa; Orthologue of E. coli EUTP_ECOLI; Fasta hit to EUTP_ECOLI (159 aa), 85% identity in 159 aa overlap. (159 aa)
eutSPutative ethanolamine utilization protein EutS; May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place; Belongs to the EutS/PduU family. (111 aa)
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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