STRINGSTRING
STY2334 STY2334 STY2506 STY2506 STY2507 STY2507 STY2508 STY2508 STY2771 STY2771 STY2929 STY2929 nrdH nrdH nrdI nrdI STY2932 STY2932 STY2933 STY2933 STY3082 STY3082 STY3083 STY3083 relA relA STY3361 STY3361 STY3620 STY3620 spoT spoT crp crp nrdG nrdG nrdD nrdD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STY2334Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (193 aa)
STY2506Ribonucleoside-diphosphate reductase 1 alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (761 aa)
STY2507Similar to Salmonella typhimurium ribonucleoside-diphosphate reductase 1 beta chain nrdB SW:RIR2_SALTY (P37427) (375 aa) fasta scores: E(): 0, 99.7% id in 375 aa; Orthologue of E. coli nrdB (RIR2_ECOLI); Fasta hit to RIR2_ECOLI (375 aa), 98% identity in 375 aa overlap. (376 aa)
STY2508Putative ferredoxin; Similar to Neisseria meningitidis (serogroup A and B) putative iron-sulphur binding protein NMA1497 or NMB1287 TR:Q9JQU8 (EMBL:AL162756) (96 aa) fasta scores: E(): 5.7e-11, 50.0% id in 66 aa. Similar to the N-termini of some oxidoreductases e.g. Yersinia pseudotuberculosis CDP-6-deoxy-delta-3,4-glucoseen reductase ascD or rfbI SW:ASCD_YERPS (P37911) (328 aa) fasta scores: E(): 5.8e-07, 38.4% id in 86 aa. Also similar to plant ferredoxins e.g. Phytolacca esculenta ferredoxin i SW:FER1_PHYES (P00230) (96 aa) fasta scores: E(): 3.7e-05, 38.6% id in 88 aa; Orthologue o [...] (84 aa)
STY2771Nucleoside diphosphate kinase (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (143 aa)
STY2929Hypothetical protein; Unknown function. (58 aa)
nrdHPutative glutaredoxin; Similar to Salmonella typhimurium LT2 glutaredoxin-like protein NrdH nrdH SW:NRDH_SALTY (Q56108) (81 aa) fasta scores: E(): 5.3e-32, 98.8% id in 81 aa; Orthologue of E. coli NRDH_ECOLI; Fasta hit to NRDH_ECOLI (81 aa), 84% identity in 81 aa overlap. (81 aa)
nrdINrdI protein; Probably involved in ribonucleotide reductase function. (136 aa)
STY2932Ribonucleoside-diphosphate reductase 2 alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (714 aa)
STY2933Ribonucleoside-diphosphate reductase 2 beta chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (319 aa)
STY3082CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (545 aa)
STY3083Conserved hypothetical protein; Orthologue of E. coli mazG (MAZG_ECOLI); Fasta hit to MAZG_ECOLI (263 aa), 94% identity in 262 aa overlap. (266 aa)
relAGTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (744 aa)
STY3361Conserved hypothetical protein; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. (275 aa)
STY3620Adenylate cyclase; Orthologue of E. coli cyaA (CYAA_ECOLI); Fasta hit to CYAA_ECOLI (848 aa), 96% identity in 848 aa overlap; Belongs to the adenylyl cyclase class-1 family. (848 aa)
spoTGuanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (703 aa)
crpCyclic AMP receptor protein,catabolite gene activator; Similar to Salmonella typhimurium, and Klebsiella aerogenes catabolite gene activator crp or cap SW:CRP_SALTY (P06170) (210 aa) fasta scores: E(): 0, 99.5% id in 210 aa, and to Escherichia coli, and Shigella flexneri catabolite gene activator crp or cap or csm SW:CRP_ECOLI (P03020) (210 aa) fasta scores: E(): 0, 99.0% id in 210 aa. (210 aa)
nrdGAnaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (154 aa)
nrdDSimilar to Escherichia coli anaerobic ribonucleoside-triphosphate reductase nrdD SW:NRDD_ECOLI (P28903) (712 aa) fasta scores: E(): 0, 96.2% id in 712 aa. (712 aa)
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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