STRINGSTRING
STY0103 STY0103 STY0104 STY0104 STY0105 STY0105 STY0106 STY0106 STY0107 STY0107 STY0108 STY0108 STY0154 STY0154 STY0231 STY0231 yaeT yaeT ompH ompH lpxD lpxD STY0250 STY0250 STY0251 STY0251 STY0252 STY0252 STY0583 STY0583 STY0584 STY0584 STY0698 STY0698 STY0790 STY0790 STY0791 STY0791 STY0792 STY0792 STY0793 STY0793 STY0794 STY0794 STY0795 STY0795 STY0796 STY0796 STY0959 STY0959 STY0985 STY0985 lpxK lpxK STY0990 STY0990 STY1192 STY1192 STY1257 STY1257 STY1258 STY1258 STY1259 STY1259 STY1897 STY1897 STY1904 STY1904 STY2639 STY2639 STY2726 STY2726 STY2765 STY2765 STY2852 STY2852 STY2871 STY2871 STY3494 STY3494 STY3495 STY3495 STY3496 STY3496 STY3497 STY3497 STY3498 STY3498 STY4070 STY4070 fkpA fkpA STY4817 STY4817 STY4818 STY4818
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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STY0103Bis(5'-nucleosyl)-tetraphosphatase; Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP; Belongs to the Ap4A hydrolase family. (282 aa)
STY0104CorD protein; Similar to Salmonella typhimurium ApaG protein SW:APAG_SALTY (Q56017) fasta scores: E(): 0, 97.6% id in 125 aa, and to Escherichia coli ApaG protein APAG SW:APAG_ECOLI (P05636) fasta scores: E(): 0, 92.8% id in 125 aa, and to C-terminus of Homo sapiens f-box protein fbx3 TR:Q9UK99 (EMBL:AF176702) fasta scores: E(): 2.1e-09, 35.8% id in 123 aa. (125 aa)
STY0105Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (273 aa)
STY0106Pyridoxal phosphate biosynthetic protein PdxA; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (329 aa)
STY0107Survival protein SurA precursor; Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation. (428 aa)
STY0108Organic solvent tolerance protein precursor; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Belongs to the LptD family. (784 aa)
STY0154UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (305 aa)
STY0231Protease DO precursor; Fasta hit to DEGQ_ECOLI (455 aa), 57% identity in 478 aa overlap; Orthologue of E. coli htrA (HTRA_ECOLI); Fasta hit to HTRA_ECOLI (474 aa), 92% identity in 475 aa overlap; Belongs to the peptidase S1C family. (475 aa)
yaeTOuter membrane protein precursor; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamD, the core component of the assembly machinery. (803 aa)
ompHOuter membrane protein OmpH precursor; Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm. (161 aa)
lpxDUDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O- (hydroxytetradecanoyl)glucosamine using 3-hydroxytetradecanoyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell; Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (341 aa)
STY0250(3R)-hydroxymyristol acyl carrier protein dehydrase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity). (151 aa)
STY0251acyl-[acyl-carrier-protein]:UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (262 aa)
STY0252lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (382 aa)
STY0583Conserved hypothetical protein; Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (240 aa)
STY0584Peptidyl-prolyl cis-trans isomerase B; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (164 aa)
STY0698Rare lipoprotein B precursor; Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane. (196 aa)
STY0790Conserved hypothetical protein; Orthologue of E. coli ybgC (YBGC_ECOLI); Fasta hit to YBGC_ECOLI (134 aa), 92% identity in 134 aa overlap. (134 aa)
STY0791TolQ protein; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. Required, with TolR, for the proton motive force-dependent activation of TolA and for TolA-Pal interaction. (230 aa)
STY0792tolR protein; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. Required, with TolQ, for the proton motive force-dependent activation of TolA and for TolA-Pal interaction. (142 aa)
STY0793tolA protein; Orthologue of E. coli tolA (TOLA_ECOLI); Fasta hit to TOLA_ECOLI (421 aa), 68% identity in 421 aa overlap. (376 aa)
STY0794tolB protein precursor; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. TolB occupies a key intermediary position in the Tol-Pal system because it communicates directly with both membrane-embedded components, Pal in the outer membrane and TolA in the inner membrane. (430 aa)
STY0795Peptidoglycan-associated lipoprotein precursor; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. (174 aa)
STY0796Putative exported protein; Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division; Belongs to the CpoB family. (262 aa)
STY0959Outer membrane lipoprotein carrier protein precursor; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane). (204 aa)
STY0985Probable transport ATP-binding protein MsbA; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. (582 aa)
lpxKTetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (325 aa)
STY09903-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (248 aa)
STY1192Lipid A biosynthesis lauroyl acyltransferase (EC 2.3.1.-) (heat shock protein); Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A). (306 aa)
STY1257ABC transporter integral membrane subunit; Orthologue of E. coli YCFU_ECOLI; Fasta hit to YCFU_ECOLI (399 aa), 94% identity in 399 aa overlap. (436 aa)
STY1258ABC transporter ATP-binding subunit; Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner. (233 aa)
STY1259ABC transporter integral membrane subunit; Orthologue of E. coli YCFW_ECOLI; Fasta hit to YCFW_ECOLI (414 aa), 93% identity in 414 aa overlap. (414 aa)
STY18972-dehydro-3-deoxyphosphooctonate aldolase; Orthologue of E. coli kdsA (KDSA_ECOLI); Fasta hit to KDSA_ECOLI (284 aa), 94% identity in 282 aa overlap; Belongs to the KdsA family. (284 aa)
STY1904Outer membrane lipoprotein; Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein. (207 aa)
STY2639Putative acyltransferase; Catalyzes the transfer of palmitoleate from palmitoleoyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (palmitoleoyl)-lipid IV(A); Belongs to the LpxL/LpxM/LpxP family. LpxP subfamily. (306 aa)
STY2726Putative lipoprotein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (344 aa)
STY2765Putative lipoprotein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (392 aa)
STY2852Putative lipoprotein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamA, the core component of the assembly machinery. (245 aa)
STY2871Small protein A; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (112 aa)
STY3494Conserved hypothetical protein; Involved in the biosynthesis of 3-deoxy-D-manno-octulosonate (KDO), a unique 8-carbon sugar component of lipopolysaccharides (LPSs). Catalyzes the reversible aldol-ketol isomerization between D-ribulose 5-phosphate (Ru5P) and D-arabinose 5-phosphate (A5P) (By similarity). (328 aa)
STY3495Conserved hypothetical protein; Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8- phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate in vitro. Also catalyzes the dephosphorylation of phospho- tyrosine in vitro; Belongs to the KdsC family. (188 aa)
STY3496Possible exported protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. Belongs to the LptC family. (191 aa)
STY3497Conserved hypothetical protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm. (172 aa)
STY3498Probable ABC transport protein, ATP-binding component; Fasta hit to ARTP_ECOLI (242 aa), 30% identity in 212 aa overlap; Fasta hit to YCFV_ECOLI (233 aa), 30% identity in 203 aa overlap; Fasta hit to ZNUC_ECOLI (251 aa), 33% identity in 233 aa overlap; Fasta hit to LIVF_ECOLI (237 aa), 35% identity in 229 aa overlap; Fasta hit to FECE_ECOLI (255 aa), 31% identity in 237 aa overlap; Fasta hit to TAUB_ECOLI (255 aa), 32% identity in 238 aa overlap; Fasta hit to LIVG_ECOLI (255 aa), 32% identity in 249 aa overlap; Fasta hit to FTSE_ECOLI (222 aa), 30% identity in 216 aa overlap; Fasta hit [...] (241 aa)
STY40703-deoxy-D-manno-octulosonic-acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (425 aa)
fkpASimilar to Escherichia coli fkbp-type peptidyl-prolyl cis-trans isomerase FkpA precursor fkpA SW:FKBA_ECOLI (P45523) (270 aa) fasta scores: E(): 0, 89.7% id in 272 aa, and to Aeromonas hydrophila fkbp-type peptidyl-prolyl cis-trans isomerase FkpA precursor fkpA SW:FKBA_AERHY (O08437) (268 aa) fasta scores: E(): 0, 44.0% id in 266 aa. (272 aa)
STY4817Probable inner membrane protein. Similar to Escherichia coli hypothetical protein YjgP SW:YJGP_ECOLI (P39340) (366 aa) fasta scores: E(): 0, 95.3% id in 359 aa and to Haemophilus influenzae hypothetical protein HI1704 SW:YJGP_HAEIN (P45333) (372 aa) fasta scores: E(): 0, 47.8% id in 358 aa. (366 aa)
STY4818Probable inner membrane protein. Similar to Escherichia coli hypothetical 39.8 kDa protein in pepA-gntV intergenic region YjgQ SW:YJGQ_ECOLI (P39341) (361 aa) fasta scores: E(): 0, 96.9% id in 360 aa, and to Haemophilus influenzae hypothetical protein HI1703 HI1703 SW:YJGQ_HAEIN (P45332) (358 aa) fasta scores: E(): 0, 53.8% id in 353 aa. (360 aa)
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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