STRINGSTRING
STY1089 STY1089 STY1364 STY1364 STY1498 STY1498 STY1499 STY1499 STY1819 STY1819 cdtB cdtB STY1887 STY1887 STY1889 STY1889 STY1890 STY1890 STY1891 STY1891 tldD tldD pmbA pmbA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STY1089Conserved hypothetical protein; Similar to Haemophilus influenzae protease la homolog LON-B OR HI1324 SW:LONH_HAEIN (P43865) fasta scores: E(): 0, 41.1% id in 584 aa; Orthologue of E. coli P75867; Fasta hit to P75867 (586 aa), 86% identity in 586 aa overlap. (586 aa)
STY1364Hypothetical periplasmic protein; No significant database matches. Contains N-terminal signal sequence. (141 aa)
STY1498Haemolysin HlyE; Toxin, which has some hemolytic activity towards mammalian cells. Acts by forming a pore-like structure upon contact with mammalian cells (By similarity); Belongs to the hemolysin E family. (305 aa)
STY1499Hypothetical protein; No significant database matches. (234 aa)
STY1819Protease IV; Digests cleaved signal peptides in vitro, its in vivo function is unknown. This activity is necessary to maintain proper secretion of mature proteins across the membrane (By similarity). (618 aa)
cdtBPutative toxin-like protein; Produces a CDT (cytolethal distending toxin) activity, which causes DNA damage in intoxicated cells. This damage induces G2/M cell cycle arrest, chromatin fragmentation, cell distention and nucleus enlargement. (269 aa)
STY1887Hypothetical protein; No significant database matches. (125 aa)
STY1889Conserved hypothetical protein; Similar to Neisseria meningitidis (serogroup A), and hypothetical protein NMA1230 (167 aa) fasta scores: E(): 6.2e-12, 34.3% id in 172 aa, and to Rhodobacter capsulatus hypothetical 14.3 kDa protein TR:AAF26222 (137 aa) fasta scores: E(): 0.00087, 33.1% id in 133 aa. (180 aa)
STY1890Similar to Bordetella pertussis pertussis toxin subunit 1 precursor ptxA SW:TOX1_BORPE (P04977) (269 aa) fasta scores: E(): 0.0001, 28.9% id in 232 aa. (242 aa)
STY1891Similar to Bordetella pertussis pertussis toxin subunit 2 precursor ptxB SW:TOX2_BORPE (P04978) (226 aa) fasta scores: E(): 0.0089, 30.7% id in 101 aa, and to Bordetella pertussis pertussis toxin subunit 3 precursor ptxC SW:TOX3_BORPE (P04979) (227 aa) fasta scores: E(): 0.14, 29.6% id in 108 aa. (137 aa)
tldDTldD protein; Similar to Escherichia coli protein TldD which suppresses the inhibitory activity of the carbon storage regulator CsrA SW:TLDD_ECOLI (P46473) (481 aa) fasta scores: E(): 0, 94.4% id in 481 aa. (481 aa)
pmbASimilar to Escherichia coli protein PmbA or TldE SW:PMBA_ECOLI (P24231) (450 aa) fasta scores: E(): 0, 95.8% id in 450 aa. (450 aa)
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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