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STY0073 STY0073 STY0083 STY0083 STY0354 STY0354 STY0642 STY0642 STY0775 STY0775 STY0776 STY0776 STY0777 STY0777 STY0778 STY0778 STY1079 STY1079 hpaB hpaB STY1352 STY1352 STY1476 STY1476 STY2404 STY2404 STY2416 STY2416 STY2688 STY2688 STY2856 STY2856 STY3257 STY3257 STY3564 STY3564 STY3573 STY3573 STY3634 STY3634 STY3877 STY3877 cysG cysG STY4439 STY4439 tviB tviB frdD frdD frdC frdC frdB frdB frdA frdA aidB aidB
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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STY0073Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (273 aa)
STY0083Probable carnitine operon oxidoreductase CaiA; Catalyzes the reduction of crotonobetainyl-CoA to gamma- butyrobetainyl-CoA; Belongs to the acyl-CoA dehydrogenase family. (380 aa)
STY0354Possible acyl-CoA dehydrogenase; Catalyzes the dehydrogenation of acyl-coenzymes A (acyl-CoAs) to 2-enoyl-CoAs, the first step of the beta-oxidation cycle of fatty acid degradation. Is required for the utilization of medium- and long- chain fatty acids as sole carbon sources for growth. Is needed for bacterial survival during carbone-source starvation. (814 aa)
STY06422,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Fasta hit to FABG_ECOLI (244 aa), 33% identity in 252 aa overlap; Fasta hit to YOHF_ECOLI (253 aa), 32% identity in 251 aa overlap; Fasta hit to YGFF_ECOLI (247 aa), 32% identity in 250 aa overlap; Fasta hit to UCPA_ECOLI (285 aa), 32% identity in 256 aa overlap; Fasta hit to HDHA_ECOLI (255 aa), 30% identity in 250 aa overlap; Orthologue of E. coli entA (ENTA_ECOLI); Fasta hit to ENTA_ECOLI (248 aa), 90% identity in 247 aa overlap. (251 aa)
STY0775Succinate dehydrogenase cytochrome b-556 subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (129 aa)
STY0776Succinate dehydrogenase hydrophobic membrane anchor protein; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (115 aa)
STY0777Succinate dehydrogenase flavoprotein subunit; Fasta hit to NADB_ECOLI (540 aa), 32% identity in 570 aa overlap; Fasta hit to FRDA_ECOLI (601 aa), 43% identity in 597 aa overlap; Orthologue of E. coli sdhA (DHSA_ECOLI); Fasta hit to DHSA_ECOLI (588 aa), 98% identity in 588 aa overlap; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (588 aa)
STY0778Succinate dehydrogenase iron-sulfur protein; Fasta hit to FRDB_ECOLI (243 aa), 37% identity in 235 aa overlap; Orthologue of E. coli sdhB (DHSB_ECOLI); Fasta hit to DHSB_ECOLI (238 aa), 96% identity in 238 aa overlap; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (239 aa)
STY1079Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (336 aa)
hpaBSimilar to Escherichia coli 4-hydroxyphenylacetate 3-monooxygenase hpaB TR:Q57160 (EMBL:Z37980) fasta scores: E(): 0, 95.6% id in 435 aa. Note discrepency in position of translational start site. (435 aa)
STY1352Enoyl-[acyl-carrier-protein] reductase (NADH); Orthologue of E. coli fabI (FABI_ECOLI); Fasta hit to FABI_ECOLI (261 aa), 98% identity in 261 aa overlap. (262 aa)
STY1476Similar to Escherichia coli putative NADP-dependent oxidoreductase in tehb-rhse intergenic region yncB SW:YNCB_ECOLI (P76113; P78255) (353 aa) fasta scores: E(): 0, 86.3% id in 344 aa, and to Oryctolagus cuniculus NADP-dependent leukotriene b4 12-hydroxydehydrogenase SW:LB4D_RABIT (Q28719) (349 aa) fasta scores: E(): 0, 40.6% id in 335 aa. (345 aa)
STY2404Conserved hypothetical protein; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs. Belongs to the Dus family. DusC subfamily. (312 aa)
STY2416Putative oxidoreductase; Involved in pyrimidine base degradation. Catalyzes physiologically the reduction of uracil to 5,6-dihydrouracil (DHU) by using NADH as a specific cosubstrate. It also catalyzes the reverse reaction and the reduction of thymine to 5,6-dihydrothymine (DHT) (By similarity). (413 aa)
STY2688Coproporphyrinogen III oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. (299 aa)
STY2856Chorismate mutase/prephenate dehydrogenase; Orthologue of E. coli tyrA (TYRA_ECOLI); Fasta hit to TYRA_ECOLI (373 aa), 95% identity in 372 aa overlap. (373 aa)
STY3257Possible oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (378 aa)
STY3564Conserved hypothetical protein; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the Dus family. DusB subfamily. (281 aa)
STY3573Protoporphyrinogen oxidase; Orthologue of E. coli HEMG_ECOLI; Fasta hit to HEMG_ECOLI (181 aa), 88% identity in 181 aa overlap. (181 aa)
STY3634UDP-ManNAc dehydrogenase; Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA); Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. WecC subfamily. (420 aa)
STY3877Oxygen-independent coproporphyrinogen III oxidase; Involved in the heme biosynthesis. Catalyzes the anaerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen III to yield the vinyl groups in protoporphyrinogen IX; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (457 aa)
cysGSiroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. (457 aa)
STY4439Conserved hypothetical protein; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs; Belongs to the Dus family. DusA subfamily. (332 aa)
tviBSimilar to Salmonella typhi Vi polysaccharide biosynthesis protein VipA or TviB SW:VIPA_SALTI (Q04972) (425 aa) fasta scores: E(): 0, 99.8% id in 425 aa, and to Pseudomonas aeruginosa WbpO TR:Q9RHD7 (EMBL:AF035937) (422 aa) fasta scores: E(): 0, 66.8% id in 422 aa; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (425 aa)
frdDFumarate reductase complex subunit D; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. (119 aa)
frdCFumarate reductase complex subunit C; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. (131 aa)
frdBSimilar to Escherichia coli fumarate reductase iron-sulfur protein frdB SW:FRDB_ECOLI (P00364) (243 aa) fasta scores: E(): 0, 95.5% id in 243 aa, and to Proteus vulgaris fumarate reductase iron-sulfur protein frdB SW:FRDB_PROVU (P20921) (244 aa) fasta scores: E(): 0, 83.5% id in 242 aa; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (244 aa)
frdASimilar to Escherichia coli fumarate reductase flavoprotein subunit SW:FRDA_ECOLI (P00363) (601 aa) fasta scores: E(): 0, 95.3% id in 594 aa, and to Proteus vulgaris fumarate reductase flavoprotein subunit frdA SW:FRDA_PROVU (P20922) (598 aa) fasta scores: E(): 0, 85.5% id in 598 aa. (596 aa)
aidBProbable acyl Co-A dehydrogenase; Similar to Escherichia coli AidB protein SW:AIDB_ECOLI (P33224) (546 aa) fasta scores: E(): 0, 85.2% id in 539 aa and to Streptomyces coelicolor putative oxidoreductase 2scg38.05 TR:CAC13064 (EMBL:AL445503) (567 aa) fasta scores: E(): 0, 44.2% id in 545 aa. (540 aa)
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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