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mpl mpl purA purA STY4704 STY4704 STY4064 STY4064 STY3901 STY3901 STY3874 STY3874 STY3741 STY3741 STY3710 STY3710 STY3560 STY3560 STY3470 STY3470 STY3310 STY3310 STY3248 STY3248 STY3217 STY3217 STY3082 STY3082 STY2944 STY2944 STY2812 STY2812 STY2751 STY2751 STY2740 STY2740 STY2725 STY2725 STY2675 STY2675 STY2596 STY2596 cbiA cbiA STY1803 STY1803 STY1575 STY1575 STY1010 STY1010 STY0908 STY0908 STY0830 STY0830 STY0718 STY0718 STY0631 STY0631 STY0626 STY0626 STY0581 STY0581 ybaX ybaX STY0412 STY0412 STY0261 STY0261 STY0199 STY0199 STY0150 STY0150 STY0076 STY0076 STY0077 STY0077 STY0081 STY0081 STY0143 STY0143 STY0144 STY0144 STY0146 STY0146 STY0149 STY0149 lplA lplA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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experimentally determined
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textmining
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mplMurein peptide ligase; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate. Belongs to the MurCDEF family. Mpl subfamily. (457 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (432 aa)
STY4704lysyl-tRNA synthetase; With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF- P) on 'Lys-34'. Catalyzes the ATP-dependent activation of (R)-beta- lysine produced by EpmB, forming a lysyl-adenylate, from which the beta-lysyl moiety is then transferred to the epsilon-amino group of EF- P 'Lys-34'; Belongs to the class-II aminoacyl-tRNA synthetase family. EpmA subfamily. (325 aa)
STY4064Conserved hypothetical protein; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (407 aa)
STY3901Asparagine synthetase A; Orthologue of E. coli asnA (ASNA_ECOLI); Fasta hit to ASNA_ECOLI (330 aa), 95% identity in 330 aa overlap; Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily. (330 aa)
STY3874Glutamine synthetase; Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia; Belongs to the glutamine synthetase family. (469 aa)
STY3741Bifunctional protein: biotin operon repressor and biotin-[acetyl-CoA carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. (320 aa)
STY3710Phosphoribosylglycineamide synthetase; Orthologue of E. coli purD (PUR2_ECOLI); Fasta hit to PUR2_ECOLI (429 aa), 94% identity in 429 aa overlap; Belongs to the GARS family. (429 aa)
STY3560Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa)
STY3470Argininosuccinate synthetase; Orthologue of E. coli argG (ASSY_ECOLI); Fasta hit to ASSY_ECOLI (446 aa), 96% identity in 446 aa overlap; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (469 aa)
STY3310Glutathionylspermidine synthetase/amidase; Orthologue of E. coli gsp (GSP_ECOLI); Fasta hit to GSP_ECOLI (619 aa), 90% identity in 618 aa overlap. (618 aa)
STY3248Glutathione synthetase; Orthologue of E. coli gshB (GSHB_ECOLI); Fasta hit to GSHB_ECOLI (316 aa), 90% identity in 315 aa overlap. (315 aa)
STY3217Conserved hypothetical protein; Orthologue of E. coli ygfA (YGFA_ECOLI); Fasta hit to YGFA_ECOLI (182 aa), 87% identity in 182 aa overlap. Weakly similar to Oryctolagus cuniculus 5-formyltetrahydrofolate cyclo-ligase SW:FTHC_RABIT (P80405) (201 aa) fasta scores: E(): 8.8e-10, 27.8% id in 180 aa. (182 aa)
STY3082CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (545 aa)
STY2944Gamma-glutamylcysteine synthetase; Similar to Salmonella typhimurium LT2 glutamate--cysteine ligase SW:GSH1_SALTY (O68838) (518 aa) fasta scores: E(): 0, 98.6% id in 518 aa; Orthologue of E. coli gshA (GSH1_ECOLI); Fasta hit to GSH1_ECOLI (518 aa), 93% identity in 518 aa overlap; Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily. (518 aa)
STY2812Phosphoribosylformylglycineamide synthetase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1295 aa)
STY2751GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (525 aa)
STY2740Phosphoribosylformylglycinamidine cyclo-ligase; Orthologue of E. coli purM (PUR5_ECOLI); Fasta hit to PUR5_ECOLI (344 aa), 91% identity in 344 aa overlap. (345 aa)
STY2725Phosphoribosylaminoimidazole-succinocarboxamide synthase; Orthologue of E. coli purC (PUR7_ECOLI); Fasta hit to PUR7_ECOLI (237 aa), 95% identity in 237 aa overlap; Belongs to the SAICAR synthetase family. (237 aa)
STY2675Putative amidotransferase; Similar, in part, to Salmonella typhimurium LT2 hypothetical protein yfeJ SW:YFEJ_SALTY (P40194) (170 aa) fasta scores: E(): 0, 89.0% id in 155 aa. The similarity ends due to a deletion in S. typhimurium with respect to S. typhi. Similar to Zymomonas mobilis hypothetical protein TR:Q9RQD2 (EMBL:AF117351) (251 aa) fasta scores: E(): 0, 53.1% id in 239 aa and Pseudomonas aeruginosa probable glutamine amidotransferase PA0531 TR:AAG03920 (EMBL:AE004489) (238 aa) fasta scores: E(): 2.1e-16, 31.9% id in 238 aa. (239 aa)
STY2596Folylpolyglutamate synthase; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. (422 aa)
cbiACobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (474 aa)
STY1803NH3-dependent NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (275 aa)
STY1575Putative dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. Belongs to the dethiobiotin synthetase family. (231 aa)
STY1010Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (400 aa)
STY0908Ribosomal protein S6 modification protein; Is an L-glutamate ligase that catalyzes the ATP-dependent post-translational addition of glutamate residues to the C-terminus of ribosomal protein S6 (RpsF). Is also able to catalyze the synthesis of poly-alpha-glutamate in vitro, via ATP hydrolysis from unprotected glutamate as substrate. The number of glutamate residues added to either RpsF or to poly-alpha-glutamate changes with pH. Belongs to the RimK family. (300 aa)
STY0830Dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. Belongs to the dethiobiotin synthetase family. (228 aa)
STY0718Asparagine synthetase B; Orthologue of E. coli asnB (ASNB_ECOLI); Fasta hit to ASNB_ECOLI (553 aa), 95% identity in 553 aa overlap. (554 aa)
STY0631Enterobactin synthetase component F; Orthologue of E. coli entF (ENTF_ECOLI); Fasta hit to ENTF_ECOLI (1293 aa), 79% identity in 1294 aa overlap. (1294 aa)
STY0626Conserved hypothetical protein; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity. (372 aa)
STY0581Phosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (355 aa)
ybaXConserved hypothetical protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (231 aa)
STY0412D-alanine:D-alanine ligase A; Cell wall formation. (364 aa)
STY0261Cell cycle protein MesJ; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (430 aa)
STY0199Pantoate:beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (284 aa)
STY0150D-alanine:D-alanine ligase B; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (306 aa)
STY0076Carbamoyl-phosphate synthase small chain; Orthologue of E. coli carA (CARA_ECOLI); Fasta hit to CARA_ECOLI (382 aa), 93% identity in 382 aa overlap; Belongs to the CarA family. (382 aa)
STY0077Carbamoyl-phosphate synthase large chain; Orthologue of E. coli carB (CARB_ECOLI); Fasta hit to CARB_ECOLI (1072 aa), 98% identity in 1072 aa overlap. (1075 aa)
STY0081Probable crotonobetaine/carnitine-CoA ligase; Catalyzes the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle. Also has activity toward crotonobetaine and gamma-butyrobetaine. (517 aa)
STY0143UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-dia minopim ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (495 aa)
STY0144UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diami nopimelate--D-alan alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (452 aa)
STY0146UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (438 aa)
STY0149UDP-N-acetylmuramate:alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (491 aa)
lplALipoate-protein ligase A; Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes. (338 aa)
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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