STRINGSTRING
STY2665 STY2665 STY2677 STY2677 STY3075 STY3075 STY3076 STY3076 STY2327 STY2327 cysE cysE STY2666 STY2666
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
STY2665Putative sulfate transport protein CysZ; High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway; Belongs to the CysZ family. (253 aa)
STY2677Cysteine synthase B; Similar to Salmonella typhimurium LT2 cysteine synthase B cysM SW:CYSM_SALTY (P29848) (303 aa) fasta scores: E(): 0, 98.7% id in 303 aa; Fasta hit to CYSK_ECOLI (322 aa), 44% identity in 307 aa overlap; Orthologue of E. coli cysM (CYSM_ECOLI); Fasta hit to CYSM_ECOLI (303 aa), 93% identity in 303 aa overlap; Belongs to the cysteine synthase/cystathionine beta- synthase family. (303 aa)
STY3075Sulfite reductase (NADPH) hemoprotein alpha subunit; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (570 aa)
STY3076Sulfite reductase (NADPH) flavoprotein beta subunit; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component; Belongs to the NADPH-dependent sulphite reductase flavoprotein subunit CysJ family. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (599 aa)
STY2327Similar to acetyltransferases e.g. Staphylococcus xylosus serine acetyltransferase cysE SW:CYSE_STAXY (P77985) (216 aa) fasta scores: E(): 8.2e-12, 39.7% id in 141 aa and to part of Arabidopsis thaliana serine acetyltransferase TR:Q43297 (EMBL:Z34888) (314 aa) fasta scores: E(): 9.4e-12, 39.3% id in 140 aa; Orthologue of E. coli wcaB (WCAB_ECOLI); Fasta hit to WCAB_ECOLI (162 aa), 91% identity in 160 aa overlap; Belongs to the transferase hexapeptide repeat family. (162 aa)
cysESimilar to Escherichia coli serine acetyltransferase cysE SW:CYSE_ECOLI (P05796) (273 aa) fasta scores: E(): 0, 95.6% id in 273 aa; Belongs to the transferase hexapeptide repeat family. (273 aa)
STY2666Cysteine synthase A; Two cysteine synthase enzymes are found. Both catalyze the same reaction. Cysteine synthase B can also use thiosulfate in place of sulfide to give cysteine thiosulfonate as a product (By similarity). (323 aa)
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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