STRINGSTRING
STY0484 STY0484 STY0776 STY0776 STY1793 STY1793 ccmF1 ccmF1 ccmE1 ccmE1 ccmC1 ccmC1 STY2481 STY2481 STY2683 STY2683 asrC asrC STY2803 STY2803 corE corE STY3075 STY3075 STY3558 STY3558 STY3760 STY3760 yhjA yhjA ccmC2 ccmC2 ccmE2 ccmE2 ccmF2 ccmF2 nirB nirB STY4475 STY4475 STY4476 STY4476 STY4479 STY4479 STY4778 STY4778
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STY0484Cytochrome o ubiquinol oxidase subunit I; Orthologue of E. coli cyoB (CYOB_ECOLI); Fasta hit to CYOB_ECOLI (663 aa), 96% identity in 663 aa overlap; Belongs to the heme-copper respiratory oxidase family. (663 aa)
STY0776Succinate dehydrogenase hydrophobic membrane anchor protein; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (115 aa)
STY1793Catalase HPII; Serves to protect cells from the toxic effects of hydrogen peroxide. (750 aa)
ccmF1Cytochrome c-type biogenesis protein F1; Fasta hit to NRFE_ECOLI (552 aa), 38% identity in 611 aa overlap; Orthologue of E. coli ccmF (CCMF_ECOLI); Fasta hit to CCMF_ECOLI (647 aa), 85% identity in 646 aa overlap. (643 aa)
ccmE1Cytochrome c-type biogenesis protein E1; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. Belongs to the CcmE/CycJ family. (159 aa)
ccmC1Heme exporter protein C1; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmC/CycZ/HelC family. (245 aa)
STY2481Cytochrome c-type protein NapC; Orthologue of E. coli napC (NAPC_ECOLI); Fasta hit to NAPC_ECOLI (200 aa), 88% identity in 200 aa overlap. (200 aa)
STY2683Similar to hypothetical proteins e.g. Neisseria meningitidis serogroup A hypothetical protein NMA0996 TR:Q9JV47 (EMBL:AL162754) (302 aa) fasta scores: E(): 0, 50.3% id in 302 aa, Neisseria meningitidis serogroup B hypothetical protein NMB0786 TR:Q9K036 (EMBL:AE002432) (302 aa) fasta scores: E(): 0, 50.3% id in 302 aa and Vibrio cholerae TyrA protein VC2145 TR:Q9KQ59 (EMBL:AE004287) (302 aa) fasta scores: E(): 0, 45.6% id in 294 aa; Orthologue of E. coli P76536; Fasta hit to P76536 (308 aa), 94% identity in 299 aa overlap. (299 aa)
asrCAnaerobic sulfite reductase subunit C; This enzyme catalyzes the hydrogen sulfide production from sulfite. It is strictly anaerobic. It is regulated by electron acceptors rather than by cysteine (By similarity). (337 aa)
STY2803Flavohemoprotein (haemoglobin-like protein); Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress; Belongs to the globin family. Two-domain flavohemoproteins subfamily. (396 aa)
corEPutative membrane protein; Similar to Salmonella typhimurium CorE corE TR:Q9X619 (EMBL:AF130857) (288 aa) fasta scores: E(): 0, 98.5% id in 263 aa. Shares a region of similarity with e.g. Chlamydomonas reinhardtii cytochrome C biogenesis protein CcsA ccsA SW:CCSA_CHLRE (P48269) (353 aa) fasta scores: E(): 2.4e-05, 24.2% id in 207 aa. Contains hydrophobic, probable membrane-spanning regions; Orthologue of E. coli P76599; Fasta hit to P76599 (288 aa), 94% identity in 263 aa overlap. (263 aa)
STY3075Sulfite reductase (NADPH) hemoprotein alpha subunit; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (570 aa)
STY3558Putative membrane protein; Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation, including the primary periplasmic chaperone SurA and the lipoprotein Pal. MsrQ prov [...] (199 aa)
STY3760Catalase (hydroperoxidase I); Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily. (726 aa)
yhjASimilar to Escherichia coli probable cytochrome c peroxidase yhjA SW:YHJA_ECOLI (P37197) (465 aa) fasta scores: E(): 0, 82.5% id in 462 aa, and to Pseudomonas aeruginosa cytochrome c551 peroxidase precursor ccpa or pa4587 SW:CCPR_PSEAE (P14532) (346 aa) fasta scores: E(): 0, 42.0% id in 305 aa; Orthologue of E. coli yhjA (YHJA_ECOLI); Fasta hit to YHJA_ECOLI (465 aa), 83% identity in 462 aa overlap. (466 aa)
ccmC2Heme exporter protein C2; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmC/CycZ/HelC family. (248 aa)
ccmE2Cytochrome c-type biogenesis protein E2; Orthologue of E. coli ccmE (CCME_ECOLI); Fasta hit to CCME_ECOLI (159 aa), 84% identity in 159 aa overlap. (159 aa)
ccmF2Similar to Escherichia coli cytochrome c-type biogenesis protein CcmF SW:CCMF_ECOLI (P33927) (647 aa) fasta scores: E(): 0, 85.1% id in 646 aa; Fasta hit to NRFE_ECOLI (552 aa), 38% identity in 611 aa overlap. (643 aa)
nirBSimilar to Escherichia coli nitrite reductase [NAD nirB SW:NIRB_ECOLI (P08201) (847 aa) fasta scores: E(): 0, 95.0% id in 847 aa; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (847 aa)
STY4475Cytochrome c552 precursor; Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process; Belongs to the cytochrome c-552 family. (478 aa)
STY4476Similar to Escherichia coli cytochrome c-type protein NrfB precursor SW:NRFB_ECOLI (P32707) (188 aa) fasta scores: E(): 0, 88.3% id in 188 aa and to Haemophilus influenzae cytochrome c-type protein NrfB precursor HI1068 SW:NRFB_HAEIN (P45016) (226 aa) fasta scores: E(): 6.6e-24, 45.1% id in 153 aa. (188 aa)
STY4479Similar to Escherichia coli cytochrome c-type biogenesis protein CcmF SW:CCMF_ECOLI (P33927) (647 aa) fasta scores: E(): 0, 38.3% id in 637 aa, and to Pseudomonas fluorescens inner membrane or periplasmic protein PFCYT4 TR:Q51753 (EMBL:Z47979) (714 aa) fasta scores: E(): 0, 36.0% id in 702 aa. Predicted hydrophobic membrane spanning domains, integral membrane protein. (578 aa)
STY4778Soluble cytochrome b562; Electron-transport protein of unknown function. (128 aa)
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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