STRINGSTRING
pagC pagC STY2897 STY2897 sipB sipB sopD sopD STY3179 STY3179 ompX ompX STY0380 STY0380 pipB pipB STY1498 STY1498
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pagCSimilar to Salmonella typhimurium virulence membrane protein pagc precursor. virulence membrane protein pagc precursor SW:PAGC_SALTY (P23988) (188 aa) fasta scores: E(): 0, 95.2% id in 188 aa, and to Salmonella typhimurium RcK protein precursor rcK TR:Q04817 (EMBL:L08613) (185 aa) fasta scores: E(): 0, 51.6% id in 186 aa, and to Yersinia enterocolitica attachment invasion locus protein precursor aiL SW:AIL_YEREN (P16454) (178 aa) fasta scores: E(): 3.7e-14, 36.6% id in 191 aa. (185 aa)
STY2897Conserved hypothetical protein; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. Involved in the reorganization of late endosome/lysosome (LE/Lys) compartments in mammalian cells. Necessary and sufficient to link kinesin-1 onto the Salmonella-containing vacuole (SCV) membrane. Required for centrifugal extension of lysosomal glycoprotein-rich membrane tubules, known as Salmonella-induced filaments (Sifs), away from the SCV and toward the cell periphery. Required for virulence, but not for intracellular survival and replication in p [...] (350 aa)
sipBPathogenicity island 1 effector protein; Required for entry into the host cell through presentation or delivery of SipC at the host cell plasma membrane. Along with SipC, is necessary for the transfer of other effector proteins into the host cell. Induces macrophage apoptosis either by binding and activating the proapoptotic enzyme caspase-1 (caspase-1 dependent), resulting in the release of interleukin-1 beta active form, or by disrupting mitochondria and inducing autophagy (caspase-1 independent). The former is dependent of its membrane-fusion activity. The SipBC complex, in associat [...] (593 aa)
sopDPossible secreted protein; Similar to several SopD orthologues associated with salmonella virulence: Salmonella dublin secreted protein sopD TR:O52235 (EMBL:AF030589) (317 aa) fasta scores: E(): 0, 100.0% id in 317 aa. (317 aa)
STY3179Similar to many members of the AiL/OmpX/PagC/LoM family of outer membrane proteins strongly associated with virulence e.g. Yersinia enterocolitica attachment invasion locus protein precursor AiL SW:AIL_YEREN (P16454) (178 aa) fasta scores: E(): 1.9e-13, 36.0% id in 186 aa and Escherichia coli outer membrane protein OmpX SW:OMPX_ECOLI (P36546) (171 aa) fasta scores: E(): 2.9e-07, 29.9% id in 184 aa. Contains a possible N-terminal signal sequence. (178 aa)
ompXSimilar to Escherichia coli outer membrane protein x precursor ompX SW:OMPX_ECOLI (P36546) (171 aa) fasta scores: E(): 0, 91.2% id in 171 aa, and to Yersinia enterocolitica attachment invasion locus protein precursor aiL SW:AIL_YEREN (P16454) (178 aa) fasta scores: E(): 6.1e-22, 43.3% id in 180 aa; Orthologue of E. coli ompX (OMPX_ECOLI); Fasta hit to OMPX_ECOLI (171 aa), 91% identity in 171 aa overlap. (171 aa)
STY0380Possible outer membrane protein; Similar to Salmonella typhimurium hypothetical 19.7 kDa protein TR:Q9RFV4 (EMBL:AF166275) (174 aa) fasta scores: E(): 0, 98.9% id in 174 aa, and to Yersinia enterocolitica attachment invasion locus protein precursor aiL SW:AIL_YEREN (P16454) (178 aa) fasta scores: E(): 4.3e-20, 40.2% id in 169 aa, and to Escherichia coli outer membrane protein x precursor ompX SW:OMPX_ECOLI (P36546) (171 aa) fasta scores: E(): 3.3e-15, 39.5% id in 157 aa, and to Salmonella typhimurium virulence membrane protein pagc precursor. virulence membrane protein pagc precursor S [...] (174 aa)
pipBConserved hypothetical protein; Similar to Salmonella dublin PipB TR:O85307 (EMBL:AF060858) fasta scores: E(): 0, 97.6% id in 291 aa. (291 aa)
STY1498Haemolysin HlyE; Toxin, which has some hemolytic activity towards mammalian cells. Acts by forming a pore-like structure upon contact with mammalian cells (By similarity); Belongs to the hemolysin E family. (305 aa)
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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