STRINGSTRING
glgB glgB STY4182 STY4182 yhjO yhjO rfaD rfaD waaF waaF waaC waaC waaK waaK waaJ waaJ waaI waaI waaB waaB waaP waaP STY4070 STY4070 STY3637 STY3637 STY3636 STY3636 wecB wecB rfaE rfaE STY2960 STY2960 STY2639 STY2639 STY2533 STY2533 STY2532 STY2532 pqaB pqaB STY2530 STY2530 STY2529 STY2529 pmrF pmrF STY2527 STY2527 STY2449 STY2449 wzc wzc STY2308 STY2308 STY2306 STY2306 STY2305 STY2305 rfbF rfbF rfbS rfbS rfbE rfbE rfbX rfbX cld cld STY2194 STY2194 STY2097 STY2097 STY1897 STY1897 rfc rfc STY1442 STY1442 STY1192 STY1192 STY1188 STY1188 STY1187 STY1187 STY1186 STY1186 STY0990 STY0990 STY0355 STY0355 STY0275 STY0275 STY3634 STY3634 STY3632 STY3632 STY3631 STY3631 STY3630 STY3630 STY3629 STY3629 STY3628 STY3628 STY3627 STY3627 STY3626 STY3626 STY3495 STY3495 STY3494 STY3494 mdoB mdoB tviA tviA tviB tviB tviC tviC tviD tviD tviE tviE glgA glgA glgC glgC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
glgB1,4-alpha-glucan branching enzyme; Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position; Belongs to the glycosyl hydrolase 13 family. GlgB subfamily. (728 aa)
STY4182Putative polysaccharide biosynthesis protein subunit B; Binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP); Belongs to the AcsB/BcsB family. (766 aa)
yhjOPutative polysaccharide biosynthesis protein catalytic subunit; Catalytic subunit of cellulose synthase. It polymerizes uridine 5'-diphosphate glucose to cellulose, which is produced as an extracellular component for mechanical and chemical protection at the onset of the stationary phase, when the cells exhibit multicellular behavior (rdar morphotype). Coexpression of cellulose and thin aggregative fimbriae leads to a hydrophobic network with tightly packed cells embedded in a highly inert matrix (By similarity). (874 aa)
rfaDADP-L-Glycero-D-mannoheptose-6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose. (310 aa)
waaFSimilar to Salmonella typhimurium ADP-heptose-LPS heptosyltransferase II rfaF or waaF SW:RFAF_SALTY (P37421) (348 aa) fasta scores: E(): 0, 99.1% id in 348 aa, and to Escherichia coli ADP-heptose-LPS heptosyltransferase II rfaF or waaF SW:RFAF_ECOLI (P37692) (348 aa) fasta scores: E(): 0, 92.2% id in 346 aa. (348 aa)
waaCSimilar to Salmonella typhimurium lipopolysaccharide heptosyltransferase-1 rfaC or waaC SW:RFAC_SALTY (P26469) (317 aa) fasta scores: E(): 0, 98.7% id in 317 aa, and to Escherichia coli lipopolysaccharide heptosyltransferase-1 rfaC or waaC or rfa-2 SW:RFAC_ECOLI (P24173) (319 aa) fasta scores: E(): 0, 84.2% id in 316 aa. (317 aa)
waaKSimilar to Salmonella typhimurium lipopolysaccharide 1,2-N-acetylglucosaminetransferase SW:RFAK_SALTY (P26470) (381 aa) fasta scores: E(): 0, 99.2% id in 381 aa, and to Escherichia coli glcnac transferase waaK TR:O68201 (EMBL:AF019375) (380 aa) fasta scores: E(): 0, 73.6% id in 379 aa. (381 aa)
waaJSimilar to Salmonella typhimurium lipopolysaccharide 1,2-glucosyltransferase SW:RFAJ_SALTY (P19817) (336 aa) fasta scores: E(): 0, 99.1% id in 336 aa, and to Escherichia coli lipopolysaccharide 1,2-glucosyltransferase SW:RFAJ_ECOLI (P27129) (338 aa) fasta scores: E(): 0, 58.4% id in 339 aa. (336 aa)
waaISimilar to Salmonella typhimurium lipopolysaccharide 1,3-galactosyltransferase SW:RFAI_SALTY (P19816) (338 aa) fasta scores: E(): 0, 97.0% id in 338 aa, and to Escherichia coli lipopolysaccharide 1,3-galactosyltransferase SW:RFAI_ECOLI (P27128) (339 aa) fasta scores: E(): 0, 54.9% id in 337 aa. (337 aa)
waaBSimilar to Salmonella typhimurium lipopolysaccharide 1,6-galactosyltransferase rfab or waaB SW:RFAB_SALTY (Q06994) (359 aa) fasta scores: E(): 0, 98.1% id in 359 aa, and to Escherichia coli lipopolysaccharide 1,6-galactosyltransferase rfab or waaB SW:RFAB_ECOLI (P27127) (369 aa) fasta scores: E(): 0, 63.8% id in 359 aa. (359 aa)
waaPLipopolysaccharide core biosynthesis protein; Catalyzes the phosphorylation of heptose(I) of the outer membrane lipopolysaccharide core; Belongs to the protein kinase superfamily. KdkA/rfaP family. (265 aa)
STY40703-deoxy-D-manno-octulosonic-acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (425 aa)
STY3637Putative undecaprenyl-phosphate alpha-N-acetylglucosaminyltransferase; Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55). (367 aa)
STY3636Lipopolysaccharide biosynthesis protein; Modulates the polysaccharide chain length of enterobacterial common antigen (ECA); Belongs to the WzzB/Cld/Rol family. (348 aa)
wecBUDP-N-acetyl-D-glucosamine 2-epimerase; Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP- N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues. (376 aa)
rfaEADP-heptose synthase; Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7- phosphate at the C-1 position to selectively form D-glycero-beta-D- manno-heptose-1,7-bisphosphate; In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (477 aa)
STY2960Putative phosphosugar binding protein; Catalyzes the reversible aldol-ketol isomerization between D- ribulose 5-phosphate (Ru5P) and D-arabinose 5-phosphate (A5P). It is also able of sustaining the biosynthetic pathway of 3-deoxy-D-manno- octulosonate (KDO), a unique 8-carbon sugar component of lipopolysaccharides (LPSs) (By similarity). (321 aa)
STY2639Putative acyltransferase; Catalyzes the transfer of palmitoleate from palmitoleoyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (palmitoleoyl)-lipid IV(A); Belongs to the LpxL/LpxM/LpxP family. LpxP subfamily. (306 aa)
STY2533Putative membrane protein; Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane; Belongs to the ArnF family. (125 aa)
STY2532Putative membrane protein; Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane; Belongs to the ArnE family. (111 aa)
pqaBMelittin resistance protein PqaB; Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; Belongs to the glycosyltransferase 83 family. (548 aa)
STY2530Conserved hypothetical protein; Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; Belongs to the polysaccharide deacetylase family. ArnD deformylase subfamily. (299 aa)
STY2529Putative lipopolysaccharide modification protein; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; In the C-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily. (660 aa)
pmrFPutative lipopolysaccharide modification protein; Catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. (327 aa)
STY2527Putative lipopolysaccharide biosynthesis protein; Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; Belongs to the DegT/DnrJ/EryC1 family. ArnB subfamily. (385 aa)
STY2449Putative membrane protein; Involved in the modification of the lipid A domain of lipopolysaccharides (LPS). Transfers a phosphate group from undecaprenyl pyrophosphate (C55-PP) to lipid A to form lipid A 1- diphosphate. Contributes to the recycling of undecaprenyl phosphate (C55-P); Belongs to the LpxT phosphotransferase family. (239 aa)
wzcPutative tyrosine-protein kinase; Required for the extracellular polysaccharide colanic acid synthesis. The autophosphorylated form is inactive. Probably involved in the export of colanic acid from the cell to medium (By similarity). Belongs to the etk/wzc family. (719 aa)
STY2308UTP-glucose-1-phosphate uridylyltransferase; May play a role in stationary phase survival; Belongs to the UDPGP type 2 family. (297 aa)
STY2306dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (299 aa)
STY2305TDP-glucose pyrophosphorylase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. (292 aa)
rfbFGlucose-1-phosphate cytidylyltransferase; Involved in the biosynthesis of the tyvelose, a 3,6- dideoxyhexose found in the O-antigen of the surface lipopolysaccharides. It catalyzes the transfer of a CMP moiety from CTP to glucose 1-phosphate. This enzyme can utilize either CTP or UTP as the nucleotide donor; Belongs to the glucose-1-phosphate cytidylyltransferase family. (257 aa)
rfbSParatose synthase; Catalyzes synthesis of paratose and tyvelose, unusual 3,6- dideoxyhexose sugars that form part of the O-antigen in the lipopolysaccharides of several enteric bacteria; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (279 aa)
rfbECDP-tyvelose-2-epimerase; Catalyzes the isomeration of CDP-paratose to CDP-tyvelose. (338 aa)
rfbXPutative O-antigen transporter; May be involved in the translocation process of the nascent O-polysaccharide molecules and/or its ligation to lipid A core units. (432 aa)
cldSimilar to Salmonella typhimurium chain length determinant protein wzzB or cld or rol SW:WZZB_SALTY (Q04866) (327 aa) fasta scores: E(): 0, 99.1% id in 327 aa. Contains hydrophobic, probable membrane-spanning regions; Orthologue of E. coli WZB1_ECOLI; Fasta hit to WZB1_ECOLI (326 aa), 72% identity in 326 aa overlap. (327 aa)
STY2194Putative membrane protein; Catalyzes the synthesis of cyclic-di-GMP (c-di-GMP) via the condensation of 2 GTP molecules (By similarity). Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria. Involved in the regulation of cellulose production (By similarity). (567 aa)
STY2097Lipid A acyltransferase; Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)- lipid A. (323 aa)
STY18972-dehydro-3-deoxyphosphooctonate aldolase; Orthologue of E. coli kdsA (KDSA_ECOLI); Fasta hit to KDSA_ECOLI (284 aa), 94% identity in 282 aa overlap; Belongs to the KdsA family. (284 aa)
rfcO-antigen polymerase; May link the O-antigen tetrasaccharide units into long chains, giving rise to typical smooth LPS. (407 aa)
STY1442Putative exported protein; Probably involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans (OPGs); Belongs to the OpgD/OpgG family. (541 aa)
STY1192Lipid A biosynthesis lauroyl acyltransferase (EC 2.3.1.-) (heat shock protein); Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A). (306 aa)
STY1188Periplasmic glucans biosynthesis protein MdoH; Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs). (847 aa)
STY1187Periplasmic glucans biosynthesis protein MdoG precursor; Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs). (511 aa)
STY1186Glucans biosynthesis protein; Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane. (384 aa)
STY09903-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (248 aa)
STY0355Phosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate; Belongs to the SIS family. GmhA subfamily. (192 aa)
STY0275Conserved hypothetical protein; Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate by removing the phosphate group at the C-7 position in vitro. Also catalyzes the dephosphorylation of D-glycero-alpha-D-manno-heptose 1,7- bisphosphate and 2-deoxy-D-manno-2-octoulosonate-8-phosphate in vitro. Belongs to the GmhB family. (188 aa)
STY3634UDP-ManNAc dehydrogenase; Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA); Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. WecC subfamily. (420 aa)
STY3632Glucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. (293 aa)
STY3631Lipopolysaccharide biosynthesis protein; Catalyzes the acetylation of dTDP-fucosamine (dTDP-4-amino- 4,6-dideoxy-D-galactose) to dTDP-Fuc4NAc, which is utilized in the biosynthesis of the enterobacterial common antigen (ECA). Belongs to the WecD family. (182 aa)
STY3630Lipopolysaccharide biosynthesis protein; Catalyzes the synthesis of dTDP-4-amino-4,6-dideoxy-D- galactose (dTDP-Fuc4N) from dTDP-4-keto-6-deoxy-D-glucose (dTDP-D- Glc4O) and L-glutamate; Belongs to the DegT/DnrJ/EryC1 family. (376 aa)
STY3629Putative lipopolysaccharide biosynthesis protein; Mediates the transbilayer movement of Und-PP-GlcNAc-ManNAcA- Fuc4NAc (lipid III) from the inner to the outer leaflet of the cytoplasmic membrane during the assembly of enterobacterial common antigen (ECA); Belongs to the polysaccharide transport (PST) (TC 2.A.66.2) family. (416 aa)
STY3628Conserved hypothetical protein; Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis; Belongs to the glycosyltransferase 56 family. (359 aa)
STY3627Probable 4-alpha-l-fucosyltransferase; Probably involved in the polymerization of enterobacterial common antigen (ECA) trisaccharide repeat units; Belongs to the WzyE family. (452 aa)
STY3626Probable UDP-N-acetyl-D-mannosaminuronic acid transferase; Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II), the second lipid-linked intermediate involved in enterobacterial common antigen (ECA) synthesis. (246 aa)
STY3495Conserved hypothetical protein; Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8- phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate in vitro. Also catalyzes the dephosphorylation of phospho- tyrosine in vitro; Belongs to the KdsC family. (188 aa)
STY3494Conserved hypothetical protein; Involved in the biosynthesis of 3-deoxy-D-manno-octulosonate (KDO), a unique 8-carbon sugar component of lipopolysaccharides (LPSs). Catalyzes the reversible aldol-ketol isomerization between D-ribulose 5-phosphate (Ru5P) and D-arabinose 5-phosphate (A5P) (By similarity). (328 aa)
mdoBPutative phosphoglycerol transferase; Transfers a phosphoglycerol residue from phosphatidylglycerol to the membrane-bound nascent glucan backbones; Belongs to the OpgB family. (763 aa)
tviASimilar to Salmonella typhi Vi polysaccharide biosynthesis protein TviA SW:TVIA_SALTI (Q04971) (179 aa) fasta scores: E(): 0, 100.0% id in 179 aa and to Salmonella paratyphi C VipR protein TR:BAA24231 (EMBL:AB006131) (179 aa) fasta scores: E(): 0, 100.0% id in 179 aa. (179 aa)
tviBSimilar to Salmonella typhi Vi polysaccharide biosynthesis protein VipA or TviB SW:VIPA_SALTI (Q04972) (425 aa) fasta scores: E(): 0, 99.8% id in 425 aa, and to Pseudomonas aeruginosa WbpO TR:Q9RHD7 (EMBL:AF035937) (422 aa) fasta scores: E(): 0, 66.8% id in 422 aa; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (425 aa)
tviCSimilar to Salmonella typhi Vi polysaccharide biosynthesis protein VipB or TviC SW:VIPB_SALTI (Q04973) (348 aa) fasta scores: E(): 0, 100.0% id in 348 aa, and to Pseudomonas aeruginosa WbpP TR:Q9RHD6 (EMBL:AF035937) (341 aa) fasta scores: E(): 0, 66.6% id in 338 aa; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (348 aa)
tviDVi polysaccharide biosynthesis protein; May be required for maturation of the Vi polysaccharide. (831 aa)
tviEVi polysaccharide biosynthesis protein TviE, Glycosyl transferases group 1; Similar to Salmonella typhi Vi polysaccharide biosynthesis protein VipC or TviE SW:VIPC_SALTI (Q04975) (578 aa) fasta scores: E(): 0, 99.5% id in 578 aa. (578 aa)
glgAGlycogen synthase; Synthesizes alpha-1,4-glucan chains using ADP-glucose. (477 aa)
glgCGlucose-1-phosphate adenylyltransferase; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc. (431 aa)
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.