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STY4787 STY4787 STY0183 STY0183 STY0196 STY0196 STY0702 STY0702 STY0723 STY0723 STY0917 STY0917 STY0918 STY0918 STY1242 STY1242 STY1448 STY1448 STY1450 STY1450 STY1451 STY1451 STY1538 STY1538 STY1799 STY1799 celB celB STY1801 STY1801 manX manX STY1960 STY1960 STY1961 STY1961 wza wza STY2439 STY2439 STY2442 STY2442 STY2443 STY2443 STY2572 STY2572 STY2573 STY2573 STY2667 STY2667 STY2670 STY2670 STY2816 STY2816 STY2953 STY2953 STY2954 STY2954 STY2955 STY2955 STY3115 STY3115 STY3144 STY3144 treB treB STY3437 STY3437 STY3438 STY3438 STY3442 STY3442 STY3443 STY3443 ptsN ptsN STY3503 STY3503 STY3823 STY3823 STY3896 STY3896 STY3925 STY3925 STY3990 STY3990 STY3999 STY3999 STY4000 STY4000 STY4013 STY4013 STY4014 STY4014 STY4015 STY4015 STY4016 STY4016 STY4111 STY4111 STY4425 STY4425 STY4426 STY4426 STY4427 STY4427 vexD vexD vexA vexA sgaT sgaT sgaB sgaB sgaA sgaA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
STY4787Putative BglB-family transcriptional antiterminator; Similar to Bacillus subtilis putative cel operon regulator CelR or LicR SW:CELR_BACSU (P46321) (641 aa) fasta scores: E(): 0, 28.0% id in 643 aa. (657 aa)
STY01832-keto-3-deoxygluconate permease; The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity); Belongs to the KdgT transporter family. (317 aa)
STY0196Putative PTS system IIA component; Similar to Vibrio furnissii PTS permease for mannose subunit IIIman N terminal domain manW TR:P96165 (EMBL:U65015) (146 aa) fasta scores: E(): 1.3e-10, 30.7% id in 137 aa, and to Klebsiella pneumoniae PTS system, sorbose-specific IIA component sorF SW:PTRA_KLEPN (P37080) (135 aa) fasta scores: E(): 0.0053, 23.5% id in 132 aa; Orthologue of E. coli yadI (YADI_ECOLI); Fasta hit to YADI_ECOLI (146 aa), 77% identity in 146 aa overlap. (146 aa)
STY0702Probable permease; The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity); Belongs to the KdgT transporter family. (317 aa)
STY0723Pts system, N-acetylglucosamine-specific IIABC component; Orthologue of E. coli nagE (PTAA_ECOLI); Fasta hit to PTAA_ECOLI (648 aa), 93% identity in 648 aa overlap. (650 aa)
STY0917Possible transport protein; Similar to Escherichia coli putative transport protein SgaT sgaT SW:SGAT_ECOLI (P39301) (484 aa) fasta scores: E(): 0, 39.0% id in 431 aa, and to Mycoplasma pneumoniae sgat protein homolog SW:SGAT_MYCPN (P75291) (660 aa) fasta scores: E(): 4e-09, 29.0% id in 428 aa; Paralogue of E. coli yjfS (SGAT_ECOLI); Fasta hit to SGAT_ECOLI (484 aa), 39% identity in 431 aa overlap. (447 aa)
STY0918Similar to Escherichia coli unknown pentitol phosphotransferase enzyme ii, b component sgaB SW:PTXB_ECOLI (P39302) (101 aa) fasta scores: E(): 0.00016, 25.3% id in 99 aa, and to Borrelia burgdorferi pts system, cellobiose-specific iib component bbb06 TR:O50982 (EMBL:AE000792) (105 aa) fasta scores: E(): 0.92, 28.6% id in 105 aa. (106 aa)
STY1242PTS system, glucose-specific IIBC component; Fasta hit to PTOA_ECOLI (530 aa), 37% identity in 513 aa overlap; Orthologue of E. coli ptsG (PTGB_ECOLI); Fasta hit to PTGB_ECOLI (477 aa), 97% identity in 476 aa overlap. (477 aa)
STY1448Putative phosphotransferase enzyme; Fasta hit to PTXA_ECOLI (154 aa), 34% identity in 125 aa overlap; Fasta hit to PTYA_ECOLI (147 aa), 40% identity in 124 aa overlap; Orthologue of E. coli yjhL (SGCA_ECOLI); Fasta hit to SGCA_ECOLI (143 aa), 72% identity in 142 aa overlap. (145 aa)
STY1450Putative phosphotransferase enzyme; Fasta hit to PTKC_ECOLI (451 aa), 42% identity in 431 aa overlap; Orthologue of E. coli yjhN (SGCC_ECOLI); Fasta hit to SGCC_ECOLI (437 aa), 95% identity in 437 aa overlap. (437 aa)
STY1451Putative phosphotransferase enzyme; Paralogue of E. coli gatB (PTKB_ECOLI); Fasta hit to PTKB_ECOLI (94 aa), 35% identity in 92 aa overlap. (93 aa)
STY1538Putative membrane transport protein; Involved in the efflux of sugars. The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites; Belongs to the major facilitator superfamily. SotB (TC 2.A.1.2) family. (396 aa)
STY1799Phosphoenolpyruvate dependent phosphotransferase enzyme III-cellobiose; Orthologue of E. coli celC (PTCA_ECOLI); Fasta hit to PTCA_ECOLI (116 aa), 87% identity in 115 aa overlap. (115 aa)
celBPTS system, cellobiose-specific IIC component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. (452 aa)
STY1801PTS system, cellobiose-specific IIB component; Orthologue of E. coli celA (PTCB_ECOLI); Fasta hit to PTCB_ECOLI (106 aa), 96% identity in 106 aa overlap. (106 aa)
manXSimilar to Escherichia coli PTS system, mannose-specific IIAB component SW:PTNA_ECOLI (P08186) (322 aa) fasta scores: E(): 0, 96.0% id in 322 aa. (322 aa)
STY1960Phosphotransferase enzyme II, C component; Orthologue of E. coli manY (PTNC_ECOLI); Fasta hit to PTNC_ECOLI (266 aa), 94% identity in 266 aa overlap. (266 aa)
STY1961Phosphotransferase enzyme II, D component; Fasta hit to PTPD_ECOLI (263 aa), 35% identity in 274 aa overlap; Orthologue of E. coli manZ (PTND_ECOLI); Fasta hit to PTND_ECOLI (286 aa), 93% identity in 282 aa overlap. (283 aa)
wzaPutative polysaccharide export protein; Probably involved in the export of the extracellular polysaccharide colanic acid from the cell to medium. (379 aa)
STY2439PTS system, fructose-specific IIBC component; Fasta hit to PTVB_ECOLI (485 aa), 34% identity in 478 aa overlap; Orthologue of E. coli fruA (PTFB_ECOLI); Fasta hit to PTFB_ECOLI (563 aa), 94% identity in 507 aa overlap. (562 aa)
STY2442Pts system, fructose-specific IIA/FPR component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FruAB PTS system is involved in fructose transport. (376 aa)
STY2443Sugar efflux transporter; Fasta hit to YABM_ECOLI (392 aa), 53% identity in 376 aa overlap; Fasta hit to YICK_ECOLI (394 aa), 71% identity in 390 aa overlap; Orthologue of E. coli yeiO (YEIO_ECOLI); Fasta hit to YEIO_ECOLI (393 aa), 90% identity in 393 aa overlap. Contains hydrophobic, probable membrane-spanning regions. (393 aa)
STY2572Putative membrane protein; Similar to Streptomyces coelicolor putative integral membrane protein SCJ21.17C TR:Q9S1Z0 (EMBL:AL109747) (516 aa) fasta scores: E(): 0, 47.3% id in 457 aa and Escherichia coli putative transport protein SgaT sgaT SW:SGAT_ECOLI (P39301) (484 aa) fasta scores: E(): 0, 27.6% id in 460 aa. Contains hydrophobic, probable membrane-spanning regions. (463 aa)
STY2573Similar to Escherichia coli unknown pentitol phosphotransferase enzyme II, B component sgaB SW:PTXB_ECOLI (P39302) (101 aa) fasta scores: E(): 0.0058, 28.7% id in 87 aa, and to the C-termini of pts system proteins e.g. Escherichia coli pts system, mannitol cmtA SW:PTYC_ECOLI (P32059) (462 aa) fasta scores: E(): 0.061, 30.9% id in 81 aa. (90 aa)
STY2667Phosphocarrier protein HPr; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain. (85 aa)
STY2670Pts system, glucose-specific IIA component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II complex composed of PtsG and Crr is involved in glucose transport. (169 aa)
STY2816Putative PTS system IIBC component; Similar to Bacillus subtilis negative regulatory protein of SacY sacX or sacS SW:SACX_BACSU (P15400) (459 aa) fasta scores: E(): 0, 33.1% id in 472 aa and putative PTS components e.g. Bacillus halodurans putative PTS system, sucrose phosphotransferase enzyme II BC component BH3574 TR:Q9K700 (EMBL:AP001519) (453 aa) fasta scores: E(): 0, 47.4% id in 454 aa; Orthologue of E. coli P77272; Fasta hit to P77272 (474 aa), 39% identity in 470 aa overlap. (453 aa)
STY2953PTS system, glucitol/sorbitol-specific IIBC component; Orthologue of E. coli srlA (PTHC_ECOLI); Fasta hit to PTHC_ECOLI (187 aa), 97% identity in 187 aa overlap. (187 aa)
STY2954PTS system, glucitol/sorbitol-specific IIBC component; Orthologue of E. coli srlE (PTHB_ECOLI); Fasta hit to PTHB_ECOLI (319 aa), 93% identity in 323 aa overlap. (323 aa)
STY2955PTS system, glucitol/sorbitol-specific IIA component; Orthologue of E. coli srlB (PTHA_ECOLI); Fasta hit to PTHA_ECOLI (123 aa), 81% identity in 118 aa overlap. (120 aa)
STY3115L-fucose permease; Orthologue of E. coli fucP (FUCP_ECOLI); Fasta hit to FUCP_ECOLI (438 aa), 92% identity in 438 aa overlap. (438 aa)
STY3144Phosphoenolpyruvate-protein phosphotransferase; Orthologue of E. coli ptsP (PT1P_ECOLI); Fasta hit to PT1P_ECOLI (748 aa), 95% identity in 748 aa overlap; Belongs to the PEP-utilizing enzyme family. (748 aa)
treBSimilar to Escherichia coli pts system, trehalose-specific IIBC component treB SW:PTTB_ECOLI (P36672) (473 aa) fasta scores: E(): 0, 89.0% id in 472 aa and to Bacillus subtilis probable pts system, trehalose-specific IIBC component TreP treP or treB SW:PTTB_BACSU (P39794) (470 aa) fasta scores: E(): 0, 41.0% id in 463 aa. (472 aa)
STY3437Similar to Escherichia coli PTS system, fructose-like-1 IIBC component FrvB SW:PTVB_ECOLI (P32154) (485 aa) fasta scores: E(): 0, 32.4% id in 475 aa. Note, like the example given, the predicted product of this CDS contains only one hydrophilic IIB domain. Contains possible membrane spanning hydrophobic domains; Fasta hit to PTVB_ECOLI (485 aa), 32% identity in 474 aa overlap; Paralogue of E. coli fruA (PTFB_ECOLI); Fasta hit to PTFB_ECOLI (563 aa), 42% identity in 471 aa overlap. (475 aa)
STY3438This CDS is similar to the phosphotransferase enzyme IIA and HPr (phosphoryl carrier protein) domains of PTF family sugar transport proteins, e.g. the N-terminus of Xanthomonas campestris multiphosphoryl transfer protein FruB SW:PTF1_XANCP (P45597) (837 aa) fasta scores: E(): 2.9e-22, 36.0% id in 225 aa; Paralogue of E. coli fruB (PTFA_ECOLI); Fasta hit to PTFA_ECOLI (376 aa), 36% identity in 372 aa overlap. (268 aa)
STY3442PTS system, galactitol-specific IIB component; Orthologue of E. coli gatB (PTKB_ECOLI); Fasta hit to PTKB_ECOLI (94 aa), 79% identity in 94 aa overlap. (94 aa)
STY3443PTS system, galactitol-specific IIC component; Fasta hit to SGCC_ECOLI (437 aa), 43% identity in 432 aa overlap; Orthologue of E. coli gatC (PTKC_ECOLI); Fasta hit to PTKC_ECOLI (451 aa), 85% identity in 446 aa overlap. Contains possible membrane spanning hydrophobic domains. (457 aa)
ptsNSimilar to Escherichia coli nitrogen regulatory IIA protein PtsN or RpoP SW:PTSN_ECOLI (P31222) (163 aa) fasta scores: E(): 0, 95.1% id in 163 aa. (163 aa)
STY3503Phosphocarrier protein (nitrogen related hpr); Fasta hit to PTHP_ECOLI (85 aa), 30% identity in 79 aa overlap; Orthologue of E. coli ptsO (PTSO_ECOLI); Fasta hit to PTSO_ECOLI (90 aa), 97% identity in 90 aa overlap. (90 aa)
STY3823L rhamnose-proton symporter; Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system). Belongs to the L-rhamnose transporter (TC 2.A.7.6) family. (344 aa)
STY3896High affinity ribose transport protein; Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Ribose importer (TC 3.A.1.2.1) family. (501 aa)
STY3925Similar to Escherichia coli PTS system, fructose-specific IIBC component SW:PTFB_ECOLI () (563 aa) fasta scores: E(): 0, 65.5% id in 458 aa. Note the product of this CDS lacks the first of the two E. coli EIIB transferase domains; Fasta hit to PTVB_ECOLI (485 aa), 35% identity in 450 aa overlap; Paralogue of E. coli fruA (PTFB_ECOLI); Fasta hit to PTFB_ECOLI (563 aa), 66% identity in 458 aa overlap. (457 aa)
STY3990Probable permease; Similar to Escherichia coli L-fucose permease SW:FUCP_ECOLI () (438 aa) fasta scores: E(): 0, 34.5% id in 423 aa; Paralogue of E. coli fucP (FUCP_ECOLI); Fasta hit to FUCP_ECOLI (438 aa), 35% identity in 423 aa overlap. (438 aa)
STY3999Similar to Escherichia coli PTS system, galactitol-specific IIB component SW:PTKB_ECOLI () (94 aa) fasta scores: E(): 2.9e-09, 37.2% id in 94 aa. (95 aa)
STY4000Putative PTS system IIC component; Similar to Bacillus halodurans PTS system galactitol-specific enzyme IIC component gatC TR:Q9Z9U2 (EMBL:AB011837) (419 aa) fasta scores: E(): 0, 45.0% id in 422 aa, and to Escherichia coli PTS system, galactitol-specific IIC component SW:PTKC_ECOLI () (451 aa) fasta scores: E(): 0, 39.7% id in 443 aa; Fasta hit to SGCC_ECOLI (437 aa), 37% identity in 430 aa overlap. (452 aa)
STY4013Similar to Escherichia coli PTS system, mannose-specific IIAB component SW:PTNA_ECOLI (P08186) (322 aa) fasta scores: E(): 0.0015, 35.0% id in 123 aa, and to Streptococcus salivarius mannose-specific phosphotransferase system component IIAB TR:Q9S4L5 (EMBL:AF130465) (330 aa) fasta scores: E(): 0.0035, 25.2% id in 103 aa. (141 aa)
STY4014Similar to Bacillus subtilis PTS system, fructose-specific IIB component SW:PTFB_BACSU (P26380) (163 aa) fasta scores: E(): 6.6e-15, 30.2% id in 159 aa, and to Streptococcus salivarius mannose-specific phosphotransferase system component IIB TR:Q9S4L5 (EMBL:AF130465) (330 aa) fasta scores: E(): 1.6e-14, 31.8% id in 157 aa, and to Escherichia coli PTS system, mannose-specific IIAB component manX or ptsl or gptB SW:PTNA_ECOLI (P08186) (322 aa) fasta scores: E(): 3.5e-13, 29.9% id in 157 aa. (161 aa)
STY4015Putative PTS system protein; Orthologue of E. coli agaC (PTPC_ECOLI); Fasta hit to PTPC_ECOLI (267 aa), 30% identity in 238 aa overlap. (249 aa)
STY4016Similar to Escherichia coli PTS system, mannose-specific IID component SW:PTND_ECOLI (P08188) (286 aa) fasta scores: E(): 0, 39.9% id in 273 aa, and to Klebsiella pneumoniae PTS system, sorbose-specific IID component sorM SW:PTRD_KLEPN (P37083) (274 aa) fasta scores: E(): 3.2e-29, 34.8% id in 276 aa. (285 aa)
STY4111Mannitol-specific enzyme II of phosphotransferase system; Orthologue of E. coli mtlA (PTMA_ECOLI); Fasta hit to PTMA_ECOLI (637 aa), 96% identity in 637 aa overlap. (638 aa)
STY4425Periplasmic maltose-binding protein; Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Binds maltose and higher maltodextrins. Belongs to the bacterial solute-binding protein 1 family. (396 aa)
STY4426Maltose/maltodextrin transport ATP-binding protein; Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Maltooligosaccharide importer (TC 3.A.1.1.1) family. (369 aa)
STY4427Maltoporin precursor; Involved in the transport of maltose and maltodextrins. Belongs to the porin LamB (TC 1.B.3) family. (452 aa)
vexDVi polysaccharide export inner-membrane protein; May form an ATP-driven capsule polysaccharide export apparatus, in association with the VexA, VexB and VexC proteins; Belongs to the BexC/CtrB/KpsE family. (434 aa)
vexAVi polysaccharide export protein; May form an ATP-driven capsule polysaccharide export apparatus, in association with the VexB, VexC and VexD proteins. May function as a membrane anchor for the polysaccharide. Possible porin properties; Belongs to the BexD/CtrA/VexA family. (355 aa)
sgaTPutative transport protein SgaT; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport. (476 aa)
sgaBPutative PTS system IIB protein; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport. (101 aa)
sgaAProbable sugar phosphotransferase; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport. (154 aa)
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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