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STY1868 STY1868 fdoG fdoG STY3841 STY3841 STY3842 STY3842 STY4401 STY4401 STY4403 STY4403 STY4475 STY4475 STY4476 STY4476 dmsC dmsC aspA aspA frdB frdB frdA frdA prpD prpD prpC prpC STY0392 STY0392 STY0483 STY0483 STY0484 STY0484 STY0661 STY0661 STY0773 STY0773 STY0775 STY0775 STY0776 STY0776 STY0181 STY0181 STY0777 STY0777 STY0778 STY0778 STY0779 STY0779 STY0780 STY0780 STY0781 STY0781 STY0782 STY0782 STY0786 STY0786 STY0964 STY0964 STY1278 STY1278 STY1339 STY1339 STY1431 STY1431 hyaC2 hyaC2 STY1531 STY1531 STY1568 STY1568 STY1653 STY1653 STY1914 STY1914 STY1915 STY1915 phsC phsC STY2397 STY2397 STY2481 STY2481 STY2482 STY2482 STY2515 STY2515 STY2546 STY2546 STY2547 STY2547 STY2548 STY2548 nuoK nuoK nuoG nuoG STY2556 STY2556 STY2773 STY2773 STY2873 STY2873 STY2971 STY2971 STY3318 STY3318 STY3539 STY3539 ubiE ubiE STY3754 STY3754
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
STY1868Similar to Escherichia coli cytochrome b561 homolog 1 yodB TR:P94749 (EMBL:AE000289) (184 aa) fasta scores: E(): 0, 66.5% id in 173 aa, and to Yersinia pestis probable cytochrome b561 cybB SW:C561_YERPE (Q9X6B2) (176 aa) fasta scores: E(): 3.8e-25, 42.4% id in 172 aa. (176 aa)
fdoGHighly similar to Escherichia coli formate dehydrogenase-O, major subunit fdoG SW:FDOG_ECOLI (P32176; P78131) (1016 aa). Contains a stop codon (codon 196) which is encoded as a selenocysteine by the opal codon UGA. (1016 aa)
STY3841Formate dehydrogenase-O beta subunit; The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers. (300 aa)
STY3842Formate dehydrogenase-O gamma subunit; Fasta hit to FDNI_ECOLI (217 aa), 49% identity in 214 aa overlap; Orthologue of E. coli fdoI (FDOI_ECOLI); Fasta hit to FDOI_ECOLI (211 aa), 96% identity in 211 aa overlap. (211 aa)
STY4401Similar to Escherichia coli malate synthase A AceB SW:MASY_ECOLI (P08997) (533 aa) fasta scores: E(): 0, 90.8% id in 533 aa, and to Myxococcus xanthus malate synthase mls SW:MASY_MYXXA (P95329) (541 aa) fasta scores: E(): 0, 56.2% id in 511 aa. (533 aa)
STY4403Isocitrate dehydrogenase kinase/phosphatase; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation. (593 aa)
STY4475Cytochrome c552 precursor; Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process; Belongs to the cytochrome c-552 family. (478 aa)
STY4476Similar to Escherichia coli cytochrome c-type protein NrfB precursor SW:NRFB_ECOLI (P32707) (188 aa) fasta scores: E(): 0, 88.3% id in 188 aa and to Haemophilus influenzae cytochrome c-type protein NrfB precursor HI1068 SW:NRFB_HAEIN (P45016) (226 aa) fasta scores: E(): 6.6e-24, 45.1% id in 153 aa. (188 aa)
dmsCSimilar to Yersinia pestis dimethyl sulfoxide reductase subunit C DmsC TR:Q9X6B4 (EMBL:AF135170) (286 aa) fasta scores: E(): 3.6e-16, 34.4% id in 273 aa, and to Escherichia coli anaerobic dimethyl sulfoxide reductase chain C SW:DMSC_ECOLI (P18777) (287 aa) fasta scores: E(): 4.2e-16, 34.3% id in 274 aa. Predicted hydrophobic membrane spanning domains, integral membrane protein. (257 aa)
aspASimilar to Escherichia coli Aspartate ammonia-lyase aspA SW:ASPA_ECOLI (P04422) (478 aa) fasta scores: E(): 0, 97.1% id in 478 aa, and to Serratia marcescens Aspartate ammonia-lyase aspA SW:ASPA_SERMA (P33109) (478 aa) fasta scores: E(): 0, 89.7% id in 478 aa. (478 aa)
frdBSimilar to Escherichia coli fumarate reductase iron-sulfur protein frdB SW:FRDB_ECOLI (P00364) (243 aa) fasta scores: E(): 0, 95.5% id in 243 aa, and to Proteus vulgaris fumarate reductase iron-sulfur protein frdB SW:FRDB_PROVU (P20921) (244 aa) fasta scores: E(): 0, 83.5% id in 242 aa; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (244 aa)
frdASimilar to Escherichia coli fumarate reductase flavoprotein subunit SW:FRDA_ECOLI (P00363) (601 aa) fasta scores: E(): 0, 95.3% id in 594 aa, and to Proteus vulgaris fumarate reductase flavoprotein subunit frdA SW:FRDA_PROVU (P20922) (598 aa) fasta scores: E(): 0, 85.5% id in 598 aa. (596 aa)
prpDPrpD protein; Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the dehydration of 2-methylcitrate (2-MC) to yield the cis isomer of 2- methyl-aconitate. Could also catalyze the dehydration of citrate and the hydration of cis-aconitate; Belongs to the PrpD family. (483 aa)
prpCMethylcitrate synthase; Similar to Salmonella typhimurium methylcitrate synthase SW:CISZ_SALTY () (389 aa) fasta scores: E(): 0, 98.7% id in 389 aa, and to Escherichia coli methylcitrate synthase prpC SW:CISZ_ECOLI (P31660; P77217) (389 aa) fasta scores: E(): 0, 96.1% id in 388 aa; Fasta hit to CISY_ECOLI (427 aa), 32% identity in 369 aa overlap; Orthologue of E. coli CISZ_ECOLI; Fasta hit to CISZ_ECOLI (389 aa), 96% identity in 388 aa overlap. (389 aa)
STY0392Similar to Pseudomonas aeruginosa cyanide insensitive terminal oxidase cioA TR:O07440 (EMBL:Y10528) (488 aa) fasta scores: E(): 0, 73.3% id in 469 aa, and to Bacillus subtilis cytochrome d ubiquinol oxidase subunit i cydA SW:CYDA_BACSU (P94364) (468 aa) fasta scores: E(): 0, 35.3% id in 459 aa; Fasta hit to CYDA_ECOLI (522 aa), 31% identity in 525 aa overlap; Paralogue of E. coli appC (APPC_ECOLI); Fasta hit to APPC_ECOLI (514 aa), 34% identity in 515 aa overlap. (467 aa)
STY0483Cytochrome o ubiquinol oxidase subunit III; Orthologue of E. coli cyoC (CYOC_ECOLI); Fasta hit to CYOC_ECOLI (204 aa), 97% identity in 204 aa overlap. (204 aa)
STY0484Cytochrome o ubiquinol oxidase subunit I; Orthologue of E. coli cyoB (CYOB_ECOLI); Fasta hit to CYOB_ECOLI (663 aa), 96% identity in 663 aa overlap; Belongs to the heme-copper respiratory oxidase family. (663 aa)
STY0661Molybdopterin-containing oxidoreductase membrane anchor subunit; Similar to Escherichia coli anaerobic dimethyl sulfoxide reductase chain c dmsC SW:DMSC_ECOLI (P18777) (287 aa) fasta scores: E(): 4.5e-05, 27.0% id in 274 aa. (255 aa)
STY0773Citrate synthase; Fasta hit to CISZ_ECOLI (389 aa), 31% identity in 369 aa overlap; Orthologue of E. coli gltA (CISY_ECOLI); Fasta hit to CISY_ECOLI (427 aa), 96% identity in 427 aa overlap; Belongs to the citrate synthase family. (427 aa)
STY0775Succinate dehydrogenase cytochrome b-556 subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (129 aa)
STY0776Succinate dehydrogenase hydrophobic membrane anchor protein; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (115 aa)
STY0181Aconitate hydratase 2 (citrate hydro-lyase 2); Orthologue of E. coli acnB (ACO2_ECOLI); Fasta hit to ACO2_ECOLI (865 aa), 96% identity in 865 aa overlap; Belongs to the aconitase/IPM isomerase family. (865 aa)
STY0777Succinate dehydrogenase flavoprotein subunit; Fasta hit to NADB_ECOLI (540 aa), 32% identity in 570 aa overlap; Fasta hit to FRDA_ECOLI (601 aa), 43% identity in 597 aa overlap; Orthologue of E. coli sdhA (DHSA_ECOLI); Fasta hit to DHSA_ECOLI (588 aa), 98% identity in 588 aa overlap; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (588 aa)
STY0778Succinate dehydrogenase iron-sulfur protein; Fasta hit to FRDB_ECOLI (243 aa), 37% identity in 235 aa overlap; Orthologue of E. coli sdhB (DHSB_ECOLI); Fasta hit to DHSB_ECOLI (238 aa), 96% identity in 238 aa overlap; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (239 aa)
STY07792-oxoglutarate dehydrogenase E1 component; Orthologue of E. coli sucA (ODO1_ECOLI); Fasta hit to ODO1_ECOLI (933 aa), 95% identity in 933 aa overlap. (933 aa)
STY0780Dihydrolipoamide succinyltransferase component (E2); E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (402 aa)
STY0781succinyl-CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa)
STY0782succinyl-CoA synthetase alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (289 aa)
STY0786Cytochrome d ubiquinol oxidase subunit I; Fasta hit to APPC_ECOLI (514 aa), 62% identity in 506 aa overlap; Orthologue of E. coli cydA (CYDA_ECOLI); Fasta hit to CYDA_ECOLI (522 aa), 96% identity in 522 aa overlap. (522 aa)
STY0964Anaerobic dimethyl sulfoxide reductase chain C; Fasta hit to P76173 (284 aa), 58% identity in 286 aa overlap; Orthologue of E. coli dmsC (DMSC_ECOLI); Fasta hit to DMSC_ECOLI (287 aa), 90% identity in 287 aa overlap. (287 aa)
STY1278Isocitrate dehydrogenase; Orthologue of E. coli icdA (IDH_ECOLI); Fasta hit to IDH_ECOLI (416 aa), 97% identity in 416 aa overlap. (416 aa)
STY1339Aconitate hydratase 1 (citrate hydro-lyase 1); Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (891 aa)
STY1431Similar to Escherichia coli cytochrome b561 SW:C561_ECOLI () (176 aa) fasta scores: E(): 0, 86.6% id in 134 aa. (134 aa)
hyaC2Similar to Escherichia coli probable ni/fe-hydrogenase 1 b-type cytochrome subunit hyaC SW:CYBH_ECOLI (P19929) (235 aa) fasta scores: E(): 0, 54.4% id in 226 aa. (242 aa)
STY1531Putative ATP/GTP-binding protein; Similar to Alcaligenes eutrophus hydrogenase expression/formation protein HoxV hoxV SW:HOXV_ALCEU (P31914) (383 aa) fasta scores: E(): 0.061, 25.8% id in 236 aa. Contains C-terminal deletion. (256 aa)
STY1568Putative dimethyl sulphoxide reductase subunit; Fasta hit to DMSC_ECOLI (287 aa), 59% identity in 288 aa overlap; Orthologue of E. coli P76173; Fasta hit to P76173 (284 aa), 76% identity in 284 aa overlap. (284 aa)
STY1653Fumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (467 aa)
STY1914Hydrogenase-1 large chain (nifE hydrogenase); Fasta hit to MBHM_ECOLI (566 aa), 42% identity in 593 aa overlap; Orthlogue of E. coli hyaB (MBHL_ECOLI); Fasta hit to MBHL_ECOLI (597 aa), 91% identity in 597 aa overlap; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (597 aa)
STY1915Probable Ni/Fe-hydrogenase 1 b-type cytochrome subunit; Orthologue of E. coli hyaC (CYBH_ECOLI); Fasta hit to CYBH_ECOLI (235 aa), 83% identity in 230 aa overlap. (243 aa)
phsCSimilar to Salmonella typhimurium thiosulfate reductase cytochrome b subunit phsC SW:PHSC_SALTY (P37602; P37603; Q56120) (254 aa) fasta scores: E(): 0, 99.6% id in 254 aa; Orthologue of E. coli PHSC_ECOLI; Fasta hit to PHSC_ECOLI (261 aa), 57% identity in 242 aa overlap. Contains hydrophobic, probable membrane-spanning regions. (254 aa)
STY2397D-lactate dehydrogenase; Catalyzes the oxidation of D-lactate to pyruvate. Belongs to the quinone-dependent D-lactate dehydrogenase family. (576 aa)
STY2481Cytochrome c-type protein NapC; Orthologue of E. coli napC (NAPC_ECOLI); Fasta hit to NAPC_ECOLI (200 aa), 88% identity in 200 aa overlap. (200 aa)
STY2482Cytochrome c-type protein NapB precursor; Electron transfer subunit of the periplasmic nitrate reductase complex NapAB; Belongs to the NapB family. (149 aa)
STY2515Anaerobic glycerol-3-phosphate dehydrogenase subunit C; Orthologue of E. coli glpC (GLPC_ECOLI); Fasta hit to GLPC_ECOLI (396 aa), 94% identity in 395 aa overlap. (396 aa)
STY2546NADH dehydrogenase I chain N; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 2 family. (425 aa)
STY2547NADH dehydrogenase I chain M; Orthologue of E. coli nuoM (NUOM_ECOLI); Fasta hit to NUOM_ECOLI (509 aa), 96% identity in 509 aa overlap. (509 aa)
STY2548NADH dehydrogenase I chain L; Fasta hit to HYFD_ECOLI (479 aa), 33% identity in 494 aa overlap; Orthologue of E. coli nuoL (NUOL_ECOLI); Fasta hit to NUOL_ECOLI (613 aa), 95% identity in 613 aa overlap. (613 aa)
nuoKNADH dehydrogenase I chain k; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 4L family. (100 aa)
nuoGNADH dehydrogenase I chain G; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity). (910 aa)
STY2556NADH dehydrogenase I chain C; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; In the N-terminal section; belongs to the complex I 30 kDa subunit family. (600 aa)
STY2773Similar to Haemophilus influenzae anaerobic dimethyl sulfoxide reductase chain C dmsC or HI1045 SW:DMSC_HAEIN (P45002) (279 aa) fasta scores: E(): 1.5e-08, 25.4% id in 283 aa; Paralogue of E. coli dmsC (DMSC_ECOLI); Fasta hit to DMSC_ECOLI (287 aa), 33% identity in 285 aa overlap. Contains hydrophobic, probable membrane-spanning regions. (269 aa)
STY2873Conserved hypothetical protein; Orthologue of E. coli YFJG_ECOLI; Fasta hit to YFJG_ECOLI (158 aa), 89% identity in 157 aa overlap. (158 aa)
STY2971Formate hydrogenlyase subunit 5; Fasta hit to HYFG_ECOLI (555 aa), 72% identity in 563 aa overlap; Orthologue of E. coli hycE (HYCE_ECOLI); Fasta hit to HYCE_ECOLI (569 aa), 97% identity in 569 aa overlap. (569 aa)
STY3318Hydrogenase-2 large subunit; Fasta hit to MBHL_ECOLI (597 aa), 43% identity in 595 aa overlap; Orthologue of E. coli hybC (MBHM_ECOLI); Fasta hit to MBHM_ECOLI (566 aa), 94% identity in 566 aa overlap; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (567 aa)
STY3539Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. (312 aa)
ubiEUbiquinone/menaquinone biosynthesis methyltransferase UbiE; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). (251 aa)
STY3754Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (883 aa)
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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