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| | STY2193 | Conserved hypothetical protein; Orthologue of E. coli YEDP_ECOLI; Fasta hit to YEDP_ECOLI (271 aa), 76% identity in 269 aa overlap. (271 aa) |
| | STY2097 | Lipid A acyltransferase; Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)- lipid A. (323 aa) |
| | STY2089 | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (392 aa) |
| | ftsI2 | Penicillin-binding protein; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum. (581 aa) |
| | STY1906 | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (315 aa) |
| | STY1897 | 2-dehydro-3-deoxyphosphooctonate aldolase; Orthologue of E. coli kdsA (KDSA_ECOLI); Fasta hit to KDSA_ECOLI (284 aa), 94% identity in 282 aa overlap; Belongs to the KdsA family. (284 aa) |
| | rfc | O-antigen polymerase; May link the O-antigen tetrasaccharide units into long chains, giving rise to typical smooth LPS. (407 aa) |
| | ssaN | Putative type III secretion ATP synthase; Similar to Salmonella typhimurium probable secretion system apparatus ATP synthase SsaN SW:SSAN_SALTY (P74857) (433 aa) fasta scores: E(): 0, 99.3% id in 433 aa, and to Yersinia enterocolitica probable ATP synthase YscN SW:YSCN_YEREN (P40290) (439 aa) fasta scores: E(): 0, 56.6% id in 401 aa; Paralogue of E. coli fliI (FLII_ECOLI); Fasta hit to FLII_ECOLI (457 aa), 44% identity in 427 aa overlap. (433 aa) |
| | STY1655 | Mannose-6-phosphate isomerase; Orthologue of E. coli manA (MANA_ECOLI); Fasta hit to MANA_ECOLI (391 aa), 86% identity in 391 aa overlap; Belongs to the mannose-6-phosphate isomerase type 1 family. (391 aa) |
| | STY1513 | Putative isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (359 aa) |
| | STY1344 | orotidine-5'-P decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (245 aa) |
| | STY1294 | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (280 aa) |
| | STY1272 | Adenylosuccinate lyase; Orthologue of E. coli purB (PUR8_ECOLI); Fasta hit to PUR8_ECOLI (456 aa), 94% identity in 456 aa overlap; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (456 aa) |
| | STY1255 | Putative exported protein; Fasta hit to ERFK_ECOLI (310 aa), 52% identity in 254 aa overlap; Fasta hit to YBIS_ECOLI (306 aa), 52% identity in 262 aa overlap; Orthologue of E. coli YCFS_ECOLI; Fasta hit to YCFS_ECOLI (320 aa), 87% identity in 263 aa overlap. Contains a possible N-terminal signal sequence. Short C-terminal truncation relative to E. coli. (263 aa) |
| | STY1249 | Putative glycosyl hydrolase; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. (341 aa) |
| | STY1247 | Putative lipoprotein; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b). Belongs to the LpoB family. (212 aa) |
| | STY1239 | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (213 aa) |
| | STY1238 | Putative secreted protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. (338 aa) |
| | mviN | Virulence factor MviN; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. (497 aa) |
| | STY1201 | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (348 aa) |
| | STY1192 | Lipid A biosynthesis lauroyl acyltransferase (EC 2.3.1.-) (heat shock protein); Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A). (306 aa) |
| | STY1079 | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (336 aa) |
| | ribF | Similar to Escherichia coli riboflavin biosynthesis protein RibF [includes: riboflavin kinase; FMN adenylyltransferase] RIBF SW:RIBF_ECOLI (P08391; P75621) fasta scores: E(): 0, 90.0% id in 309 aa, and to Pseudomonas fluorescens riboflavin biosynthesis protein ribf [includes: riboflavin kinase; FMN adenylyltransferase] RIBF SW:RIBF_PSEFL (P22990) fasta scores: E(): 0, 52.6% id in 304 aa; Orthologue of E. coli yaaC (RIBF_ECOLI); Fasta hit to RIBF_ECOLI (313 aa), 90% identity in 309 aa overlap. (312 aa) |
| | STY0076 | Carbamoyl-phosphate synthase small chain; Orthologue of E. coli carA (CARA_ECOLI); Fasta hit to CARA_ECOLI (382 aa), 93% identity in 382 aa overlap; Belongs to the CarA family. (382 aa) |
| | STY0077 | Carbamoyl-phosphate synthase large chain; Orthologue of E. coli carB (CARB_ECOLI); Fasta hit to CARB_ECOLI (1072 aa), 98% identity in 1072 aa overlap. (1075 aa) |
| | STY0118 | L-ribulose-5-phosphate 4-epimerase; Involved in the degradation of L-arabinose. Catalyzes the interconversion of L-ribulose 5-phosphate (LRu5P) and D-xylulose 5- phosphate (D-Xu5P) via a retroaldol/aldol mechanism (carbon-carbon bond cleavage analogous to a class II aldolase reaction). (231 aa) |
| | STY0119 | L-arabinose isomerase; Catalyzes the conversion of L-arabinose to L-ribulose. (500 aa) |
| | STY0120 | L-ribulokinase; Orthologue of E. coli araB (KIRI_ECOLI); Fasta hit to KIRI_ECOLI (565 aa), 90% identity in 567 aa overlap. (569 aa) |
| | STY0142 | Penicillin-binding protein 3 precursor; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum. (588 aa) |
| | STY0143 | UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-dia minopim ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (495 aa) |
| | STY0144 | UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diami nopimelate--D-alan alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (452 aa) |
| | STY0145 | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (360 aa) |
| | STY0146 | UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (438 aa) |
| | STY0147 | Cell division protein FtsW; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. (414 aa) |
| | STY0148 | Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (355 aa) |
| | STY0149 | UDP-N-acetylmuramate:alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (491 aa) |
| | STY0150 | D-alanine:D-alanine ligase B; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (306 aa) |
| | STY0154 | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (305 aa) |
| | STY0162 | Conserved hypothetical protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (206 aa) |
| | STY0192 | Hypoxanthine phosphoribosyltransferase; Orthologue of E. coli hpt (HPRT_ECOLI); Fasta hit to HPRT_ECOLI (182 aa), 95% identity in 171 aa overlap; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (178 aa) |
| | STY0215 | Penicillin-binding protein 1b; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). (840 aa) |
| | STY0241 | Uridine 5'-monophosphate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (241 aa) |
| | STY0244 | Undecaprenyl pyrophosphate synthetase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. (252 aa) |
| | lpxD | UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O- (hydroxytetradecanoyl)glucosamine using 3-hydroxytetradecanoyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell; Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (341 aa) |
| | STY0250 | (3R)-hydroxymyristol acyl carrier protein dehydrase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity). (151 aa) |
| | STY0251 | acyl-[acyl-carrier-protein]:UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (262 aa) |
| | STY0252 | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (382 aa) |
| | STY0255 | Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (319 aa) |
| | STY0275 | Conserved hypothetical protein; Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate by removing the phosphate group at the C-7 position in vitro. Also catalyzes the dephosphorylation of D-glycero-alpha-D-manno-heptose 1,7- bisphosphate and 2-deoxy-D-manno-2-octoulosonate-8-phosphate in vitro. Belongs to the GmhB family. (188 aa) |
| | STY0355 | Phosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate; Belongs to the SIS family. GmhA subfamily. (192 aa) |
| | STY0357 | Putative exported protein; Orthologue of E. coli yafK (YAFK_ECOLI); Fasta hit to YAFK_ECOLI (246 aa), 91% identity in 246 aa overlap. (246 aa) |
| | STY0362 | Xanthine-guanine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (152 aa) |
| | STY0412 | D-alanine:D-alanine ligase A; Cell wall formation. (364 aa) |
| | STY0442 | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (354 aa) |
| | STY0443 | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form th [...] (375 aa) |
| | dxs | 1-deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (620 aa) |
| | ybaX | Conserved hypothetical protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (231 aa) |
| | STY0527 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (183 aa) |
| | STY0532 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (214 aa) |
| | STY0581 | Phosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (355 aa) |
| | STY0582 | Phosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (169 aa) |
| | STY0583 | Conserved hypothetical protein; Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (240 aa) |
| | pagP | Antimicrobial peptide resistance and lipid A acylation protein; Transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors. (190 aa) |
| | STY0688 | D-alanine carboxypeptidase; Fasta hit to DACC_ECOLI (400 aa), 60% identity in 401 aa overlap; Fasta hit to DACD_ECOLI (388 aa), 48% identity in 390 aa overlap; Orthologue of E. coli dacA (DACA_ECOLI); Fasta hit to DACA_ECOLI (403 aa), 95% identity in 403 aa overlap; Belongs to the peptidase S11 family. (403 aa) |
| | STY0690 | Rod shape-determining protein RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. (370 aa) |
| | pbpA | Penicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. (633 aa) |
| | ybiS | Putative exported protein; Similar to Escherichia coli protein YbiS precursor ybiS SW:YBIS_ECOLI (P75789) (306 aa) fasta scores: E(): 0, 92.5% id in 306 aa, and to Escherichia coli protein ErfK/srfk precursor erfK SW:ERFK_ECOLI (P39176) (310 aa) fasta scores: E(): 0, 65.8% id in 295 aa, and to Escherichia coli hypothetical 34.6 kDa protein in ndh-mfd intergenic region precursor ycfS SW:YCFS_ECOLI (P75954) (320 aa) fasta scores: E(): 0, 51.7% id in 302 aa. Contains probable N-terminal signal sequence; Fasta hit to YNHG_ECOLI (334 aa), 47% identity in 305 aa overlap; Fasta hit to YCFS_EC [...] (306 aa) |
| | STY0896 | D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 6 precursor); Fasta hit to DACD_ECOLI (388 aa), 47% identity in 384 aa overlap; Fasta hit to DACA_ECOLI (403 aa), 61% identity in 397 aa overlap; Orthologue of E. coli dacC (DACC_ECOLI); Fasta hit to DACC_ECOLI (400 aa), 92% identity in 400 aa overlap; Belongs to the peptidase S11 family. (400 aa) |
| | STY0905 | Glutaredoxin 1; The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing some disulfides in a coupled system with glutathione reductase (By similarity); Belongs to the glutaredoxin family. (87 aa) |
| | lpxK | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (325 aa) |
| | STY0990 | 3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (248 aa) |
| | STY0997 | Putative exported protein; Orthologue of E. coli ycbB (YCBB_ECOLI); Fasta hit to YCBB_ECOLI (615 aa), 85% identity in 618 aa overlap. (615 aa) |
| | deoB | Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (407 aa) |
| | pyrB | Similar to Salmonella typhimurium aspartate carbamoyltransferase catalytic chain PyrB SW:PYRB_SALTY (P08420) (309 aa) fasta scores: E(): 0, 98.4% id in 310 aa, and to Escherichia coli aspartate carbamoyltransferase catalytic chain PyrB SW:PYRB_ECOLI (P00479) (310 aa) fasta scores: E(): 0, 95.2% id in 310 aa; Fasta hit to OTC2_ECOLI (333 aa), 32% identity in 298 aa overlap; Fasta hit to OTC1_ECOLI (333 aa), 32% identity in 295 aa overlap. (311 aa) |
| | mpl | Murein peptide ligase; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate. Belongs to the MurCDEF family. Mpl subfamily. (457 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (432 aa) |
| | yjeS | Putative 4Fe-4S binding protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. (384 aa) |
| | acs | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (652 aa) |
| | alr | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. Provides the D-alanine required for cell wall biosynthesis (By similarity). (359 aa) |
| | mrcA | Similar to Escherichia coli penicillin-binding protein 1A mrca or ponA SW:PBPA_ECOLI (P02918) (850 aa) fasta scores: E(): 0, 92.5% id in 850 aa, and to Pseudomonas aeruginosa penicillin-binding protein 1A ponA TR:Q07806 (EMBL:U73780) (822 aa) fasta scores: E(): 0, 42.1% id in 860 aa. (858 aa) |
| | STY4232 | Putative membrane protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (221 aa) |
| | gpsA | Similar to Escherichia coli glycerol-3-phosphate dehydrogenase [NAD+] gpsA SW:GPDA_ECOLI (P37606) (339 aa) fasta scores: E(): 0, 95.0% id in 339 aa, and to Bacillus subtilis glycerol-3-phosphate dehydrogenase [NAD gpsA or glyC SW:GPDA_BACSU (P46919) (345 aa) fasta scores: E(): 0, 38.4% id in 331 aa; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (339 aa) |
| | STY4093 | Glutaredoxin 3; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. (83 aa) |
| | rfaD | ADP-L-Glycero-D-mannoheptose-6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose. (310 aa) |
| | waaF | Similar to Salmonella typhimurium ADP-heptose-LPS heptosyltransferase II rfaF or waaF SW:RFAF_SALTY (P37421) (348 aa) fasta scores: E(): 0, 99.1% id in 348 aa, and to Escherichia coli ADP-heptose-LPS heptosyltransferase II rfaF or waaF SW:RFAF_ECOLI (P37692) (348 aa) fasta scores: E(): 0, 92.2% id in 346 aa. (348 aa) |
| | waaC | Similar to Salmonella typhimurium lipopolysaccharide heptosyltransferase-1 rfaC or waaC SW:RFAC_SALTY (P26469) (317 aa) fasta scores: E(): 0, 98.7% id in 317 aa, and to Escherichia coli lipopolysaccharide heptosyltransferase-1 rfaC or waaC or rfa-2 SW:RFAC_ECOLI (P24173) (319 aa) fasta scores: E(): 0, 84.2% id in 316 aa. (317 aa) |
| | waaK | Similar to Salmonella typhimurium lipopolysaccharide 1,2-N-acetylglucosaminetransferase SW:RFAK_SALTY (P26470) (381 aa) fasta scores: E(): 0, 99.2% id in 381 aa, and to Escherichia coli glcnac transferase waaK TR:O68201 (EMBL:AF019375) (380 aa) fasta scores: E(): 0, 73.6% id in 379 aa. (381 aa) |
| | waaJ | Similar to Salmonella typhimurium lipopolysaccharide 1,2-glucosyltransferase SW:RFAJ_SALTY (P19817) (336 aa) fasta scores: E(): 0, 99.1% id in 336 aa, and to Escherichia coli lipopolysaccharide 1,2-glucosyltransferase SW:RFAJ_ECOLI (P27129) (338 aa) fasta scores: E(): 0, 58.4% id in 339 aa. (336 aa) |
| | waaI | Similar to Salmonella typhimurium lipopolysaccharide 1,3-galactosyltransferase SW:RFAI_SALTY (P19816) (338 aa) fasta scores: E(): 0, 97.0% id in 338 aa, and to Escherichia coli lipopolysaccharide 1,3-galactosyltransferase SW:RFAI_ECOLI (P27128) (339 aa) fasta scores: E(): 0, 54.9% id in 337 aa. (337 aa) |
| | waaB | Similar to Salmonella typhimurium lipopolysaccharide 1,6-galactosyltransferase rfab or waaB SW:RFAB_SALTY (Q06994) (359 aa) fasta scores: E(): 0, 98.1% id in 359 aa, and to Escherichia coli lipopolysaccharide 1,6-galactosyltransferase rfab or waaB SW:RFAB_ECOLI (P27127) (369 aa) fasta scores: E(): 0, 63.8% id in 359 aa. (359 aa) |
| | waaP | Lipopolysaccharide core biosynthesis protein; Catalyzes the phosphorylation of heptose(I) of the outer membrane lipopolysaccharide core; Belongs to the protein kinase superfamily. KdkA/rfaP family. (265 aa) |
| | STY4070 | 3-deoxy-D-manno-octulosonic-acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (425 aa) |
| | coaD | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (159 aa) |
| | STY4064 | Conserved hypothetical protein; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (407 aa) |
| | STY4063 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (151 aa) |
| | STY4061 | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (213 aa) |
| | spoT | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (703 aa) |
| | STY3917 | Glucosamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (609 aa) |
| | STY3916 | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. (456 aa) |
| | STY3914 | ATP synthase epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (139 aa) |
| | STY3913 | ATP synthase beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (460 aa) |
| | STY3912 | ATP synthase gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (287 aa) |
| | STY3911 | ATP synthase alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (513 aa) |
| | STY3910 | ATP synthase delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (177 aa) |
| | STY3909 | ATP synthase subunit B; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (156 aa) |
| | STY3908 | ATP synthase subunit C; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (79 aa) |
| | STY3907 | ATP synthase A chain; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (271 aa) |
| | STY3849 | Putative acetyltransferase; Orthologue of E. coli yiiD (YIID_ECOLI); Fasta hit to YIID_ECOLI (329 aa), 95% identity in 313 aa overlap. (329 aa) |
| | STY3743 | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (260 aa) |
| | STY3742 | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (342 aa) |
| | STY3740 | Pantothenate kinase; Orthologue of E. coli coaA (COAA_ECOLI); Fasta hit to COAA_ECOLI (316 aa), 96% identity in 316 aa overlap. (316 aa) |
| | STY3710 | Phosphoribosylglycineamide synthetase; Orthologue of E. coli purD (PUR2_ECOLI); Fasta hit to PUR2_ECOLI (429 aa), 94% identity in 429 aa overlap; Belongs to the GARS family. (429 aa) |
| | STY3709 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Orthologue of E. coli purH (PUR9_ECOLI); Fasta hit to PUR9_ECOLI (529 aa), 94% identity in 529 aa overlap. (529 aa) |
| | STY3641 | Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (guanosine pentaphosphatase); Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities. (493 aa) |
| | STY3637 | Putative undecaprenyl-phosphate alpha-N-acetylglucosaminyltransferase; Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55). (367 aa) |
| | STY3636 | Lipopolysaccharide biosynthesis protein; Modulates the polysaccharide chain length of enterobacterial common antigen (ECA); Belongs to the WzzB/Cld/Rol family. (348 aa) |
| | wecB | UDP-N-acetyl-D-glucosamine 2-epimerase; Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP- N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues. (376 aa) |
| | STY3634 | UDP-ManNAc dehydrogenase; Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA); Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. WecC subfamily. (420 aa) |
| | STY3631 | Lipopolysaccharide biosynthesis protein; Catalyzes the acetylation of dTDP-fucosamine (dTDP-4-amino- 4,6-dideoxy-D-galactose) to dTDP-Fuc4NAc, which is utilized in the biosynthesis of the enterobacterial common antigen (ECA). Belongs to the WecD family. (182 aa) |
| | STY3630 | Lipopolysaccharide biosynthesis protein; Catalyzes the synthesis of dTDP-4-amino-4,6-dideoxy-D- galactose (dTDP-Fuc4N) from dTDP-4-keto-6-deoxy-D-glucose (dTDP-D- Glc4O) and L-glutamate; Belongs to the DegT/DnrJ/EryC1 family. (376 aa) |
| | STY3629 | Putative lipopolysaccharide biosynthesis protein; Mediates the transbilayer movement of Und-PP-GlcNAc-ManNAcA- Fuc4NAc (lipid III) from the inner to the outer leaflet of the cytoplasmic membrane during the assembly of enterobacterial common antigen (ECA); Belongs to the polysaccharide transport (PST) (TC 2.A.66.2) family. (416 aa) |
| | STY3628 | Conserved hypothetical protein; Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis; Belongs to the glycosyltransferase 56 family. (359 aa) |
| | STY3627 | Probable 4-alpha-l-fucosyltransferase; Probably involved in the polymerization of enterobacterial common antigen (ECA) trisaccharide repeat units; Belongs to the WzyE family. (452 aa) |
| | STY3626 | Probable UDP-N-acetyl-D-mannosaminuronic acid transferase; Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II), the second lipid-linked intermediate involved in enterobacterial common antigen (ECA) synthesis. (246 aa) |
| | STY3620 | Adenylate cyclase; Orthologue of E. coli cyaA (CYAA_ECOLI); Fasta hit to CYAA_ECOLI (848 aa), 96% identity in 848 aa overlap; Belongs to the adenylyl cyclase class-1 family. (848 aa) |
| | udp | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity). (253 aa) |
| | STY3560 | Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa) |
| | mtgA | Monofunctional biosynthetic peptidoglycan transglycosylase; Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors; Belongs to the glycosyltransferase 51 family. (242 aa) |
| | STY3495 | Conserved hypothetical protein; Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8- phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate in vitro. Also catalyzes the dephosphorylation of phospho- tyrosine in vitro; Belongs to the KdsC family. (188 aa) |
| | STY3494 | Conserved hypothetical protein; Involved in the biosynthesis of 3-deoxy-D-manno-octulosonate (KDO), a unique 8-carbon sugar component of lipopolysaccharides (LPSs). Catalyzes the reversible aldol-ketol isomerization between D-ribulose 5-phosphate (Ru5P) and D-arabinose 5-phosphate (A5P) (By similarity). (328 aa) |
| | STY3486 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (419 aa) |
| | STY3447 | Possible exported protein; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a). Belongs to the LpoA family. (683 aa) |
| | STY3384 | Bacitracin resistance protein (putative undecaprenol kinase); Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (273 aa) |
| | rfaE | ADP-heptose synthase; Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7- phosphate at the C-1 position to selectively form D-glycero-beta-D- manno-heptose-1,7-bisphosphate; In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (477 aa) |
| | STY3142 | Thymidylate synthetase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa) |
| | STY3107 | Conserved hypothetical protein; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). (282 aa) |
| | STY3082 | CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (545 aa) |
| | STY3080 | Conserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (223 aa) |
| | STY3077 | Highly similar to Escherichia coli putative 6-pyruvoyl tetrahydrobiopterin synthase YgcM SW:PTPS_ECOLI (Q46903) (121 aa) fasta scores: E(): 0, 94.2% id in 120 aa; Orthologue of E. coli PTPS_ECOLI; Fasta hit to PTPS_ECOLI (121 aa), 94% identity in 120 aa overlap. (120 aa) |
| | STY2960 | Putative phosphosugar binding protein; Catalyzes the reversible aldol-ketol isomerization between D- ribulose 5-phosphate (Ru5P) and D-arabinose 5-phosphate (A5P). It is also able of sustaining the biosynthetic pathway of 3-deoxy-D-manno- octulosonate (KDO), a unique 8-carbon sugar component of lipopolysaccharides (LPSs) (By similarity). (321 aa) |
| | STY2933 | Ribonucleoside-diphosphate reductase 2 beta chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (319 aa) |
| | STY2812 | Phosphoribosylformylglycineamide synthetase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1295 aa) |
| | pbpC | Penicillin-binding protein 1C; Orthologue of E. coli PBPC_ECOLI; Fasta hit to PBPC_ECOLI (770 aa), 83% identity in 762 aa overlap. (771 aa) |
| | STY2771 | Nucleoside diphosphate kinase (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (143 aa) |
| | STY2752 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (490 aa) |
| | STY2751 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (525 aa) |
| | STY2741 | Phosphoribosylglycinamidine myltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (212 aa) |
| | STY2740 | Phosphoribosylformylglycinamidine cyclo-ligase; Orthologue of E. coli purM (PUR5_ECOLI); Fasta hit to PUR5_ECOLI (344 aa), 91% identity in 344 aa overlap. (345 aa) |
| | STY2739 | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (208 aa) |
| | STY2725 | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Orthologue of E. coli purC (PUR7_ECOLI); Fasta hit to PUR7_ECOLI (237 aa), 95% identity in 237 aa overlap; Belongs to the SAICAR synthetase family. (237 aa) |
| | STY2675 | Putative amidotransferase; Similar, in part, to Salmonella typhimurium LT2 hypothetical protein yfeJ SW:YFEJ_SALTY (P40194) (170 aa) fasta scores: E(): 0, 89.0% id in 155 aa. The similarity ends due to a deletion in S. typhimurium with respect to S. typhi. Similar to Zymomonas mobilis hypothetical protein TR:Q9RQD2 (EMBL:AF117351) (251 aa) fasta scores: E(): 0, 53.1% id in 239 aa and Pseudomonas aeruginosa probable glutamine amidotransferase PA0531 TR:AAG03920 (EMBL:AE004489) (238 aa) fasta scores: E(): 2.1e-16, 31.9% id in 238 aa. (239 aa) |
| | STY2639 | Putative acyltransferase; Catalyzes the transfer of palmitoleate from palmitoleoyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (palmitoleoyl)-lipid IV(A); Belongs to the LpxL/LpxM/LpxP family. LpxP subfamily. (306 aa) |
| | STY2597 | acetyl-CoA carboxylase beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (304 aa) |
| | STY2592 | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (505 aa) |
| | STY2568 | Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (714 aa) |
| | STY2567 | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (400 aa) |
| | STY2533 | Putative membrane protein; Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane; Belongs to the ArnF family. (125 aa) |
| | STY2532 | Putative membrane protein; Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane; Belongs to the ArnE family. (111 aa) |
| | pqaB | Melittin resistance protein PqaB; Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; Belongs to the glycosyltransferase 83 family. (548 aa) |
| | STY2530 | Conserved hypothetical protein; Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; Belongs to the polysaccharide deacetylase family. ArnD deformylase subfamily. (299 aa) |
| | STY2529 | Putative lipopolysaccharide modification protein; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; In the C-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily. (660 aa) |
| | pmrF | Putative lipopolysaccharide modification protein; Catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. (327 aa) |
| | STY2527 | Putative lipopolysaccharide biosynthesis protein; Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; Belongs to the DegT/DnrJ/EryC1 family. ArnB subfamily. (385 aa) |
| | STY2507 | Similar to Salmonella typhimurium ribonucleoside-diphosphate reductase 1 beta chain nrdB SW:RIR2_SALTY (P37427) (375 aa) fasta scores: E(): 0, 99.7% id in 375 aa; Orthologue of E. coli nrdB (RIR2_ECOLI); Fasta hit to RIR2_ECOLI (375 aa), 98% identity in 375 aa overlap. (376 aa) |
| | STY2449 | Putative membrane protein; Involved in the modification of the lipid A domain of lipopolysaccharides (LPS). Transfers a phosphate group from undecaprenyl pyrophosphate (C55-PP) to lipid A to form lipid A 1- diphosphate. Contributes to the recycling of undecaprenyl phosphate (C55-P); Belongs to the LpxT phosphotransferase family. (239 aa) |
| | STY2335 | Uridine kinase; Orthologue of E. coli udk (URK_ECOLI); Fasta hit to URK_ECOLI (213 aa), 96% identity in 213 aa overlap. (213 aa) |
| | STY2334 | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (193 aa) |
| | wzc | Putative tyrosine-protein kinase; Required for the extracellular polysaccharide colanic acid synthesis. The autophosphorylated form is inactive. Probably involved in the export of colanic acid from the cell to medium (By similarity). Belongs to the etk/wzc family. (719 aa) |
| | STY2320 | GDP-fucose synthetase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. (321 aa) |
| | manC | Similar to Salmonella typhimurium mannose-1-phosphate guanylyltransferase manC or cpsB or rfbM SW:MANC_SALTY (P26340) (480 aa) fasta scores: E(): 0, 99.8% id in 480 aa; Orthologue of E. coli cpsB (MANC_ECOLI); Fasta hit to MANC_ECOLI (478 aa), 91% identity in 478 aa overlap; Belongs to the mannose-6-phosphate isomerase type 2 family. (480 aa) |
| | STY2308 | UTP-glucose-1-phosphate uridylyltransferase; May play a role in stationary phase survival; Belongs to the UDPGP type 2 family. (297 aa) |
| | STY2306 | dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (299 aa) |
| | STY2304 | dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (183 aa) |
| | rfbF | Glucose-1-phosphate cytidylyltransferase; Involved in the biosynthesis of the tyvelose, a 3,6- dideoxyhexose found in the O-antigen of the surface lipopolysaccharides. It catalyzes the transfer of a CMP moiety from CTP to glucose 1-phosphate. This enzyme can utilize either CTP or UTP as the nucleotide donor; Belongs to the glucose-1-phosphate cytidylyltransferase family. (257 aa) |
| | rfbS | Paratose synthase; Catalyzes synthesis of paratose and tyvelose, unusual 3,6- dideoxyhexose sugars that form part of the O-antigen in the lipopolysaccharides of several enteric bacteria; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (279 aa) |
| | rfbE | CDP-tyvelose-2-epimerase; Catalyzes the isomeration of CDP-paratose to CDP-tyvelose. (338 aa) |
| | rfbX | Putative O-antigen transporter; May be involved in the translocation process of the nascent O-polysaccharide molecules and/or its ligation to lipid A core units. (432 aa) |
| | STY2293 | Similar to many e.g. Salmonella typhimurium mannose-1-phosphate guanylyltransferase SW:RFBM_SALTY (P26404) (479 aa) fasta scores: E(): 0, 98.7% id in 479 aa; Paralogue of E. coli cpsB (MANC_ECOLI); Fasta hit to MANC_ECOLI (478 aa), 59% identity in 469 aa overlap; Belongs to the mannose-6-phosphate isomerase type 2 family. (479 aa) |
| | ugd | Identical to Salmonella typhimurium UDP-glucose 6-dehydrogenase Ugd or Udg SW:UDG_SALTY (Q04873) (388 aa) fasta scores: E(): 0, 98.5% id in 388 aa; Orthologue of E. coli UDG_ECOLI; Fasta hit to UDG_ECOLI (388 aa), 88% identity in 388 aa overlap. (388 aa) |
| | cld | Similar to Salmonella typhimurium chain length determinant protein wzzB or cld or rol SW:WZZB_SALTY (Q04866) (327 aa) fasta scores: E(): 0, 99.1% id in 327 aa. Contains hydrophobic, probable membrane-spanning regions; Orthologue of E. coli WZB1_ECOLI; Fasta hit to WZB1_ECOLI (326 aa), 72% identity in 326 aa overlap. (327 aa) |
| | STY2218 | Putative exported protein; Similar to Salmonella typhimurium protein erfK/srfK precursor SW:ERFK_SALTY (P40680) (309 aa) fasta scores: E(): 0, 99.0% id in 309 aa. Contains probable N-terminal signal sequence; Fasta hit to YNHG_ECOLI (334 aa), 47% identity in 288 aa overlap; Fasta hit to YCFS_ECOLI (320 aa), 48% identity in 307 aa overlap; Fasta hit to YBIS_ECOLI (306 aa), 66% identity in 283 aa overlap; Orthologue of E. coli erfK (ERFK_ECOLI); Fasta hit to ERFK_ECOLI (310 aa), 79% identity in 305 aa overlap. (309 aa) |
| | STY2211 | AMP nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations. (484 aa) |
| | STY2180 | Similar to Salmonella typhimurium flagellum-specific ATP synthase fliI or flaC SW:FLII_SALTY (P26465) (456 aa) fasta scores: E(): 0, 99.6% id in 456 aa; Fasta hit to ATPB_ECOLI (459 aa), 30% identity in 416 aa overlap; Orthologue of E. coli fliI (FLII_ECOLI); Fasta hit to FLII_ECOLI (457 aa), 93% identity in 456 aa overlap. (456 aa) |
