STRINGSTRING
STY2678 STY2678 STY4817 STY4817 vexB vexB vexC vexC STY4426 STY4426 STY4425 STY4425 STY4424 STY4424 STY4423 STY4423 STY4257 STY4257 STY4256 STY4256 STY4255 STY4255 STY4254 STY4254 STY3896 STY3896 STY3796 STY3796 STY3793 STY3793 STY3498 STY3498 STY3313 STY3313 STY3233 STY3233 STY3232 STY3232 sitD sitD sitC sitC sitB sitB STY2937 STY2937 STY2936 STY2936 iroC iroC STY2680 STY2680 STY2679 STY2679 STY2395 STY2395 STY2393 STY2393 cbiN cbiN cbiQ cbiQ cbiO cbiO STY2100 STY2100 STY1770 STY1770 STY1768 STY1768 STY1573 STY1573 STY1571 STY1571 STY1570 STY1570 STY1266 STY1266 STY1265 STY1265 STY1263 STY1263 STY0985 STY0985 STY0955 STY0955 STY0954 STY0954 STY0913 STY0913 STY0912 STY0912 STY0911 STY0911 STY0811 STY0811 STY4818 STY4818 STY0764 STY0764 sfbC sfbC sfbB sfbB phnT phnT phnU phnU STY0274 STY0274 STY0273 STY0273 STY0272 STY0272 STY0221 STY0221 STY0219 STY0219
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STY2678Sulphate transport ATP-binding protein CysA; Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system. (364 aa)
STY4817Probable inner membrane protein. Similar to Escherichia coli hypothetical protein YjgP SW:YJGP_ECOLI (P39340) (366 aa) fasta scores: E(): 0, 95.3% id in 359 aa and to Haemophilus influenzae hypothetical protein HI1704 SW:YJGP_HAEIN (P45333) (372 aa) fasta scores: E(): 0, 47.8% id in 358 aa. (366 aa)
vexBVi polysaccharide export inner-membrane protein (ABC-2 type transporter); May form an ATP-driven Vi polysaccharide export apparatus, in association with the VexA, VexC and VexD proteins; Belongs to the ABC-2 integral membrane protein family. (264 aa)
vexCVi polysaccharide export ATP-binding protein; May form an ATP-driven Vi polysaccharide export apparatus, in association with the VexA, VexB and VexD proteins; Belongs to the ABC transporter superfamily. (231 aa)
STY4426Maltose/maltodextrin transport ATP-binding protein; Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Maltooligosaccharide importer (TC 3.A.1.1.1) family. (369 aa)
STY4425Periplasmic maltose-binding protein; Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Binds maltose and higher maltodextrins. Belongs to the bacterial solute-binding protein 1 family. (396 aa)
STY4424Maltose transport inner membrane protein; Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane. (514 aa)
STY4423Maltose transport inner membrane protein; Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane. (296 aa)
STY4257sn-Glycerol-3-phosphate transport ATP-binding protein; Part of the ABC transporter complex UgpABCE involved in sn- glycerol-3-phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. sn-glycerol-3- phosphate importer (TC 3.A.1.1.3) family. (356 aa)
STY4256sn-Glycerol-3-phosphate transport system permease protein; Part of the binding-protein-dependent transport system for sn-glycerol-3-phosphate; probably responsible for the translocation of the substrate across the membrane. (281 aa)
STY4255Glycerol-3-phosphate transport system permease protein; Part of the binding-protein-dependent transport system for sn-glycerol-3-phosphate; probably responsible for the translocation of the substrate across the membrane. (295 aa)
STY4254Glycerol-3-phosphate-binding periplasmic protein; sn-glycerol-3-phosphate and glycerophosphoryl diester-binding protein interacts with the binding protein-dependent transport system UgpACE. (438 aa)
STY3896High affinity ribose transport protein; Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Ribose importer (TC 3.A.1.2.1) family. (501 aa)
STY3796Putative ABC transporter ATP-binding protein; Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Responsible for energy coupling to the transport system (By similarity). (511 aa)
STY3793Putative ABC transport protein, solute-binding component; Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Binds AI-2 and delivers it to the LsrC and LsrD permeases (By similarity). (340 aa)
STY3498Probable ABC transport protein, ATP-binding component; Fasta hit to ARTP_ECOLI (242 aa), 30% identity in 212 aa overlap; Fasta hit to YCFV_ECOLI (233 aa), 30% identity in 203 aa overlap; Fasta hit to ZNUC_ECOLI (251 aa), 33% identity in 233 aa overlap; Fasta hit to LIVF_ECOLI (237 aa), 35% identity in 229 aa overlap; Fasta hit to FECE_ECOLI (255 aa), 31% identity in 237 aa overlap; Fasta hit to TAUB_ECOLI (255 aa), 32% identity in 238 aa overlap; Fasta hit to LIVG_ECOLI (255 aa), 32% identity in 249 aa overlap; Fasta hit to FTSE_ECOLI (222 aa), 30% identity in 216 aa overlap; Fasta hit [...] (241 aa)
STY3313Possible ABC-transport protein, periplasmic-binding component; Similar to several including: Haemophilus influenzae hypothetical protein HI1472 SW:YE72_HAEIN (P44206) (351 aa) fasta scores: E(): 0, 57.7% id in 343 aa and Archaeoglobus fulgidus iron (III) ABC transporter, ATP-binding protein AF0432 TR:O29817 (EMBL:AE001075) (366 aa) fasta scores: E(): 2e-12, 29.0% id in 362 aa. Contains a possible N-terminal signal sequence. (350 aa)
STY3233Possible ABC-transport protein, ATP-binding component; Similar to Methanococcus jannaschii cobalt transport ATP-binding protein TR:Q58488 (EMBL:U67551) (279 aa) fasta scores: E(): 9.6e-20, 31.9% id in 210 aa. (218 aa)
STY3232Possible ABC-transport protein, ATP-binding component; Similar to Pyrococcus abyssi ABC transporter, ATP-binding protein TR:Q9V1Q4 (EMBL:AJ248284) (280 aa) fasta scores: E(): 1.3e-15, 33.6% id in 223 aa. Note the unusual overlap with the upstream CDS. (227 aa)
sitDIron transport protein, inner membrane component; Similar to Salmonella typhimurium SitD an iron transport protein located on centisome 63 pathogenicity island TR:Q9XCR9 (EMBL:AF128999) (282 aa) fasta scores: E(): 0, 99.3% id in 282 aa, and to Yersinia pestis chelated iron transport system membrane protein YfeD SW:YFED_YERPE (Q56955) (297 aa) fasta scores: E(): 0, 52.6% id in 266 aa. Contains multiple possible membrane spanning hydrophobic domains. (282 aa)
sitCIron transport protein, inner membrane component; Similar to Salmonella typhimurium SitC an iron transport protein located on centisome 63 pathogenicity island TR:Q9XCS0 (EMBL:AF128999) (286 aa) fasta scores: E(): 0, 99.7% id in 286 aa and to Yersinia pestis chelated iron transport system membrane protein YfeC SW:YFEC_YERPE (Q56954) (294 aa) fasta scores: E(): 0, 66.5% id in 281 aa. Contains multiple possible membrane spanning hydrophobic domains. (286 aa)
sitBIron transport protein, ATP-binding component; Similar to Salmonella typhimurium SitB an iron transport protein located on centisome 63 pathogenicity island TR:Q9XCS1 (EMBL:AF128999) (273 aa) fasta scores: E(): 0, 98.9% id in 273 aa, and to Yersinia pestis YfeB TR:Q56953 (EMBL:U50597) (296 aa) fasta scores: E(): 0, 63.2% id in 266 aa; Fasta hit to ZNUC_ECOLI (251 aa), 31% identity in 223 aa overlap; Fasta hit to FHUC_ECOLI (265 aa), 30% identity in 253 aa overlap; Fasta hit to GLTL_ECOLI (241 aa), 30% identity in 232 aa overlap; Fasta hit to TAUB_ECOLI (255 aa), 30% identity in 220 aa [...] (273 aa)
STY2937Glycine betaine-binding periplasmic protein precursor; Orthologue of E. coli proX (PROX_ECOLI); Fasta hit to PROX_ECOLI (330 aa), 83% identity in 331 aa overlap. (331 aa)
STY2936Glycine betaine/L-proline transport system permease protein P; Orthologue of E. coli proW (PROW_ECOLI); Fasta hit to PROW_ECOLI (354 aa), 91% identity in 354 aa overlap. (354 aa)
iroCPutative ABC transporter protein; Similar to many e.g. Salmonella typhi AJB70 ATP binding cassette protein iroC TR:P96057 (EMBL:U62129) (1218 aa) fasta scores: E(): 0, 95.3% id in 1223 aa and Mycobacterium tuberculosis putative ABC transporter Rv0194 or MTV033.02 TR:O53645 (EMBL:AL021928) (1194 aa) fasta scores: E(): 0, 37.8% id in 1203 aa. Conatins hydrophobic, probable membrane spanning regions. (1218 aa)
STY2680Sulphate transport system permease protein CysT; Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. (277 aa)
STY2679Sulphate transport system permease protein CysW; Fasta hit to CYST_ECOLI (277 aa), 37% identity in 259 aa overlap; Orthologue of E. coli cysW (CYSW_ECOLI); Fasta hit to CYSW_ECOLI (291 aa), 97% identity in 291 aa overlap. (291 aa)
STY2395Putative periplasmic protein; Similar to e.g. Deinococcus radiodurans ABC transporter, periplasmic substrate-binding protein, putative DRA0135 TR:Q9RZ18 (EMBL:AE001862) (369 aa) fasta scores: E(): 0, 51.7% id in 296 aa and Streptomyces coelicolor probable permease binding protein proXL or SCE19A.33 TR:Q9X4J2 (EMBL:AF112365) (322 aa) fasta scores: E(): 1.3e-22, 31.4% id in 287 aa. Contains probable N-terminal signal sequence; Orthologue of E. coli yehZ (YEHZ_ECOLI); Fasta hit to YEHZ_ECOLI (305 aa), 88% identity in 305 aa overlap. (305 aa)
STY2393ABC transporter ATP-binding protein; Similar to e.g. Bacillus subtilis choline transport ATP-binding protein opuBA or proV SW:OPBA_BACSU (Q45460; O34332) (381 aa) fasta scores: E(): 0, 45.3% id in 296 aa; Fasta hit to AFUC_ECOLI (348 aa), 32% identity in 297 aa overlap; Orthologue of E. coli yehX (YEHX_ECOLI); Fasta hit to YEHX_ECOLI (308 aa), 88% identity in 307 aa overlap. (315 aa)
cbiNPutative cobalt transport protein CbiN; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import; Belongs to the CbiN family. (93 aa)
cbiQSimilar to Salmonella typhimurium cobalt transport protein CbiQ cbiQ SW:CBIQ_SALTY (Q05598) (225 aa) fasta scores: E(): 0, 99.1% id in 225 aa. Contains hydrophobic, possible membrane-spanning regions. (225 aa)
cbiOPutative cobalt transport ATP-binding protein CbiO; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. Presumably responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Cobalt importer (TC 3.A.1.18.1) family. (271 aa)
STY2100High-affinity zinc uptake system ATP-binding protein; Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Zinc importer (TC 3.A.1.15.5) family. (251 aa)
STY1770Vitamin B12 transport system permease; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane. (326 aa)
STY1768Vitamin B12 ABC transport ATP-binding protein; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system. (249 aa)
STY1573Putative ABC transporter ATP/GTP-binding protein; Similar to Streptomyces coelicolor ProvL TR:Q9X4J1 (EMBL:AF112365) (429 aa) fasta scores: E(): 0, 46.6% id in 367 aa, and to Bacillus subtilis choline transport ATP-binding protein ProV SW:OPBA_BACSU (Q45460; O34332) (381 aa) fasta scores: E(): 0, 45.9% id in 379 aa; Fasta hit to POTA_ECOLI (378 aa), 34% identity in 320 aa overlap; Paralogue of E. coli proV (PROV_ECOLI); Fasta hit to PROV_ECOLI (400 aa), 34% identity in 371 aa overlap. (382 aa)
STY1571Putative ABC transporter periplasmic binding protein; Similar to Streptomyces coelicolor proxl or sce19a.33 TR:Q9X4J2 (EMBL:AF112365) (322 aa) fasta scores: E(): 1e-32, 39.1% id in 279 aa, and to Bacillus subtilis glycine betaine/carnitine/choline-binding protein precursor opucC SW:OPCC_BACSU (O32243; O31407) (303 aa) fasta scores: E(): 1.4e-14, 30.9% id in 272 aa. (300 aa)
STY1570Putative ABC transporter membrane protein; Similar to Bacillus subtilis glycine betaine/carnitine/choline transport system permease protein OpucB SW:OPCB_BACSU (O34878) (217 aa) fasta scores: E(): 3.3e-25, 40.8% id in 196 aa; Paralogue of E. coli YehW (YEHW_ECOLI); Fasta hit to YEHW_ECOLI (243 aa), 43% identity in 200 aa overlap. (236 aa)
STY1266Spermidine/putrescine transport ATP-binding protein PotA (ABC superfamily); Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family. (378 aa)
STY1265Spermidine/putrescine transport system permease protein PotB; Required for the activity of the bacterial periplasmic transport system of putrescine and spermidine; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. (287 aa)
STY1263Spermidine/putrescine transport system permease protein PotC; Fasta hit to POTI_ECOLI (281 aa), 41% identity in 255 aa overlap; Orthologue of E. coli potC (POTC_ECOLI); Fasta hit to POTC_ECOLI (264 aa), 97% identity in 258 aa overlap. (259 aa)
STY0985Probable transport ATP-binding protein MsbA; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. (582 aa)
STY0955Transport ATP-binding protein CydD; Orthologue of E. coli cydD (CYDD_ECOLI); Fasta hit to CYDD_ECOLI (588 aa), 91% identity in 588 aa overlap. (588 aa)
STY0954Transport ATP-binding protein CydC; Orthologue of E. coli cydC (CYDC_ECOLI); Fasta hit to CYDC_ECOLI (573 aa), 86% identity in 573 aa overlap. (573 aa)
STY0913Putrescine transport system permease protein PotI; Fasta hit to POTC_ECOLI (264 aa), 41% identity in 248 aa overlap; Fasta hit to YDCV_ECOLI (264 aa), 33% identity in 260 aa overlap; Orthologue of E. coli potI (POTI_ECOLI); Fasta hit to POTI_ECOLI (281 aa), 94% identity in 281 aa overlap. (281 aa)
STY0912Putrescine transport system permease protein PotH; Fasta hit to POTB_ECOLI (275 aa), 42% identity in 268 aa overlap; Orthologue of E. coli potH (POTH_ECOLI); Fasta hit to POTH_ECOLI (317 aa), 92% identity in 317 aa overlap. (317 aa)
STY0911Putrescine transport ATP-binding protein PotG; Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system. (377 aa)
STY0811Putative molybdenum transport ATP-binding protein ModF (photorepair protein PhrA); Orthologue of E. coli modF (MODF_ECOLI); Fasta hit to MODF_ECOLI (490 aa), 89% identity in 485 aa overlap. (491 aa)
STY4818Probable inner membrane protein. Similar to Escherichia coli hypothetical 39.8 kDa protein in pepA-gntV intergenic region YjgQ SW:YJGQ_ECOLI (P39341) (361 aa) fasta scores: E(): 0, 96.9% id in 360 aa, and to Haemophilus influenzae hypothetical protein HI1703 HI1703 SW:YJGQ_HAEIN (P45332) (358 aa) fasta scores: E(): 0, 53.8% id in 353 aa. (360 aa)
STY0764Putative polysaccharide export ABC transporter ATP-binding protein; Similar to Mycobacterium tuberculosis hypothetical 30.0 kDa protein cy13d12.15 rv3781 or mtcy13d12.15 TR:P72047 (EMBL:Z80343) (273 aa) fasta scores: E(): 0, 43.8% id in 233 aa, and to Yersinia enterocolitica O-antigen export system ATP-binding protein RfbE rfbE SW:RFBE_YEREN (Q56903) (239 aa) fasta scores: E(): 0, 45.3% id in 225 aa. (236 aa)
sfbCSimilar to Salmonella enteritidis integral membrane protein sfbC TR:Q9S4Y9 (EMBL:AF102556) (202 aa) fasta scores: E(): 0, 99.5% id in 202 aa, and to Helicobacter pylori ABC transporter, permease protein hp1577 TR:O26097 (EMBL:AE000655) (215 aa) fasta scores: E(): 7.8e-31, 44.7% id in 208 aa; Paralogue of E. coli yaeE (YAEE_ECOLI); Fasta hit to YAEE_ECOLI (217 aa), 45% identity in 203 aa overlap. (219 aa)
sfbBABC transporter ATP-binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. (338 aa)
phnTProbable ATP-binding component of 2-aminoethylphosphonate transporter; Probably part of the PhnSTUV complex (TC 3.A.1.11.5) involved in 2-aminoethylphosphonate import. Probably responsible for energy coupling to the transport system (By similarity). (369 aa)
phnUProbable membrane component of 2-aminoethylphosphonate transporter; Probably part of the PhnSTUV complex (TC 3.A.1.11.5) involved in 2-aminoethylphosphonate import. Probably responsible for the translocation of the substrate across the membrane (By similarity). Belongs to the binding-protein-dependent transport system permease family. (289 aa)
STY0274Putative ABC transporter ATP-binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. (343 aa)
STY0273Putative ABC transporter permease protein; Part of the binding-protein-dependent transport system for D- methionine and the toxic methionine analog alpha-methyl-methionine. Probably responsible for the translocation of the substrate across the membrane (By similarity). (212 aa)
STY0272Putative lipoprotein precursor; This protein is a component of a D-methionine permease, a binding protein-dependent, ATP-driven transport system. (271 aa)
STY0221Ferrichrome transport protein FhuB precursor; Orthologue of E. coli fhuB (FHUB_ECOLI); Fasta hit to FHUB_ECOLI (660 aa), 90% identity in 652 aa overlap; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily. (685 aa)
STY0219Ferrichrome transport ATP-binding protein FhuC; Fasta hit to FEPC_ECOLI (271 aa), 44% identity in 237 aa overlap; Fasta hit to FECE_ECOLI (255 aa), 44% identity in 239 aa overlap; Fasta hit to LIVF_ECOLI (237 aa), 30% identity in 225 aa overlap; Fasta hit to PHNK_ECOLI (252 aa), 30% identity in 217 aa overlap; Fasta hit to HISP_ECOLI (257 aa), 32% identity in 224 aa overlap; Fasta hit to BTUD_ECOLI (249 aa), 35% identity in 232 aa overlap; Fasta hit to PHNL_ECOLI (226 aa), 33% identity in 216 aa overlap; Fasta hit to PHNC_ECOLI (262 aa), 32% identity in 232 aa overlap; Fasta hit to NIK [...] (265 aa)
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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