STRINGSTRING
envZ envZ STY3096 STY3096 tctE tctE STY2811 STY2811 pgtB pgtB rcsC rcsC STY2343 STY2343 STY3951 STY3951 ssrA ssrA STY1651 STY1651 copS copS STY0744 STY0744 STY0433 STY0433 creC creC pmrB pmrB STY3875 STY3875 STY3813 STY3813 STY3712 STY3712 STY3507 STY3507 STY3355 STY3355
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
envZTwo-component sensor kinase EnvZ; Member of the two-component regulatory system EnvZ/OmpR involved in regulating expression of the outer membrane porins OmpC and OmpF as well as other genes. Unlike E.coli or S.typhimurium both porins are expressed constitutively. Involved in regulation of the biosynthesis of Vi polysaccharide, a capsular antigen thought to be involved in the virulence of S.typhi. Vi antigen is synthesized at low NaCl concentrations (under 0.4 M). EnvZ functions as a membrane-associated protein kinase that phosphorylates OmpR in response to environmental signals (By sim [...] (450 aa)
STY3096Sensor protein; Similar to Escherichia coli sensor protein BarA involved in adaptive response SW:BARA_ECOLI (P26607) (918 aa) fasta scores: E(): 0, 90.0% id in 921 aa; Orthologue of E. coli barA (BARA_ECOLI); Fasta hit to BARA_ECOLI (918 aa), 90% identity in 921 aa overlap. (918 aa)
tctEPutative two-component system sensor kinase; Similar to Salmonella typhi TctE TR:O68289 (EMBL:AF029846) (439 aa) fasta scores: E(): 0, 99.8% id in 421 aa, but with a different N-terminus. Similar to e.g. Streptomyces coelicolor and Streptomyces lividans two-component system CutS proteins cutS or SC2E9.04 SW:CUTS_STRCO (Q03757) (414 aa) fasta scores: E(): 1.3e-17, 29.2% id in 346 aa. (471 aa)
STY2811Putative sensor kinase protein; C-terminal half shares similarity with e.g. Mycobacterium tuberculosis MtrB mtrB TR:Q50496 (EMBL:U14909) (567 aa) fasta scores: E(): 5.4e-15, 27.6% id in 301 aa and Pseudomonas aeruginosa alginate biosynthesis sensor protein KinB kinB TR:O34206 (EMBL:U97063) (595 aa) fasta scores: E(): 4.3e-14, 30.0% id in 273 aa; Orthologue of E. coli YFHK_ECOLI; Fasta hit to YFHK_ECOLI (496 aa), 87% identity in 460 aa overlap. (461 aa)
pgtBSimilar to Salmonella typhimurium phosphoglycerate transport system sensor protein PgtB pgtB SW:PGTB_SALTY (P37433) (593 aa) fasta scores: E(): 0, 98.6% id in 513 aa, and to Vibrio cholerae putative phosphoglycerate transport regulatory protein pgtB, vca0705 TR:Q9KLN8 (EMBL:AE004400) (789 aa) fasta scores: E(): 1.4e-26, 25.0% id in 781 aa, and to Rhizobium leguminosarum c4-dicarboxylate transport sensor protein DctB dctB SW:DCTB_RHILE (P10047) (622 aa) fasta scores: E(): 2.7e-21, 35.1% id in 259 aa. (668 aa)
rcsCSensor protein RcsC; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsC functions as a membrane- associated protein kinase that phosphorylates RcsD in response to environmental signals. The phosphoryl group is then transferred to the response regulator RcsB. (948 aa)
STY2343Putative two-component system sensor kinase; Orthologue of E. coli baeS (BAES_ECOLI); Fasta hit to BAES_ECOLI (467 aa), 89% identity in 467 aa overlap. (467 aa)
STY3951Two-component sensor protein histidine protein kinase; Orthologue of E. coli torS (TORS_ECOLI); Fasta hit to TORS_ECOLI (904 aa), 63% identity in 898 aa overlap. (911 aa)
ssrAPutative two-component sensor kinase; Similar to Salmonella typhimurium SpiR TR:P74862 (EMBL:U51927) (823 aa) fasta scores: E(): 0, 98.1% id in 823 aa, and to Escherichia coli sensor protein TorS SW:TORS_ECOLI (P39453; P75887) (904 aa) fasta scores: E(): 1.3e-26, 27.8% id in 598 aa. (920 aa)
STY1651Two component sensor kinase; Orthologue of E. coli rstB (RSTB_ECOLI); Fasta hit to RSTB_ECOLI (433 aa), 82% identity in 433 aa overlap. (434 aa)
copSHistidine kinase; Member of a two-component regulatory system. (454 aa)
STY0744Sensor protein KdpD; Orthologue of E. coli kdpD (KDPD_ECOLI); Fasta hit to KDPD_ECOLI (894 aa), 89% identity in 902 aa overlap. (902 aa)
STY0433Phosphate regulon sensor protein PhoR; Orthologue of E. coli phoR (PHOR_ECOLI); Fasta hit to PHOR_ECOLI (431 aa), 90% identity in 431 aa overlap. (431 aa)
creCPutative two-component sensor kinase; Similar to Escherichia coli sensor protein CreC SW:CREC_ECOLI (P08401) (474 aa) fasta scores: E(): 0, 80.4% id in 474 aa, and to Myxococcus xanthus developmental histidine kinase sensor SasS TR:O52223 (EMBL:AF029787) (497 aa) fasta scores: E(): 1.4e-18, 27.5% id in 483 aa. (474 aa)
pmrBTwo-component sensor kinase; Similar to Salmonella typhimurium sensor protein PmrB or BasS SW:BASS_SALTY (P36557) (356 aa) fasta scores: E(): 0, 98.9% id in 356 aa, and to Escherichia coli sensor protein BasS SW:BASS_ECOLI (P30844) (363 aa) fasta scores: E(): 0, 85.6% id in 355 aa. (359 aa)
STY3875Two-component system sensory histidine kinase; Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Under conditions of nitrogen limitation, NtrB autophosphorylates and transfers the phosphoryl group to NtrC. In the presence of nitrogen, acts as a phosphatase that dephosphorylates and inactivates NtrC. (349 aa)
STY3813Similar to Escherichia coli sensor protein governing extracytoplasmic protein-mediated toxicities CpxA SW:CPXA_ECOLI (P08336) (457 aa) fasta scores: E(): 0, 96.9% id in 457 aa. (457 aa)
STY3712Two-component system sensor protein; Member of the two-component regulatory system ZraS/ZraR. May function as a membrane-associated protein kinase that phosphorylates ZraR in response to high concentrations of zinc or lead in the medium (By similarity). (465 aa)
STY3507Aerobic respiration control sensor protein; Orthologue of E. coli arcB (ARCB_ECOLI); Fasta hit to ARCB_ECOLI (776 aa), 94% identity in 778 aa overlap. (778 aa)
STY3355Probable two-component system sensor histidine kinase; Member of a two-component regulatory system QseB/QseC. Activates the flagella regulon by activating transcription of FlhDC. May activate QseB by phosphorylation (By similarity). (449 aa)
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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