STRINGSTRING
STY0223 STY0223 STY0259 STY0259 phnW phnW STY0647 STY0647 cobD cobD STY0826 STY0826 STY0828 STY0828 ybjU ybjU STY0977 STY0977 STY1000 STY1000 STY1466 STY1466 STY1507 STY1507 STY1750 STY1750 astC astC STY2282 STY2282 rfbH rfbH STY2527 STY2527 STY2561 STY2561 STY2642 STY2642 ptsJ ptsJ STY2789 STY2789 STY2802 STY2802 STY4785 STY4785 adi adi STY4444 STY4444 argD argD STY4221 STY4221 STY4133 STY4133 STY4113 STY4113 STY4086 STY4086 STY4017 STY4017 STY2806 STY2806 STY2912 STY2912 STY3124 STY3124 STY3209 STY3209 STY3333 STY3333 STY3396 STY3396 STY3630 STY3630 STY3762 STY3762 STY3764 STY3764 STY3769 STY3769
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STY0223Glutamate-1-semialdehyde 2,1-aminomutase; Fasta hit to GOAG_ECOLI (421 aa), 33% identity in 354 aa overlap; Fasta hit to GABT_ECOLI (426 aa), 32% identity in 421 aa overlap; Orthologue of E. coli hemL (GSA_ECOLI); Fasta hit to GSA_ECOLI (426 aa), 98% identity in 426 aa overlap. (426 aa)
STY0259Lysine decarboxylase; Fasta hit to ADI_ECOLI (755 aa), 35% identity in 720 aa overlap; Fasta hit to DCOS_ECOLI (732 aa), 32% identity in 694 aa overlap; Fasta hit to DCOR_ECOLI (731 aa), 35% identity in 626 aa overlap; Fasta hit to DCLY_ECOLI (715 aa), 71% identity in 710 aa overlap; Orthologue of E. coli ldcC (DCLZ_ECOLI); Fasta hit to DCLZ_ECOLI (713 aa), 91% identity in 712 aa overlap. (713 aa)
phnW2-aminoethylphosphonate:pyruvate aminotransferase; Involved in phosphonate degradation; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily. (367 aa)
STY0647Putative aminotransferase; Similar to Escherichia coli hypothetical aminotransferase YbdL ybdL SW:YBDL_ECOLI (P77806) (386 aa) fasta scores: E(): 0, 85.2% id in 386 aa, and to Thermus aquaticus aspartate aminotransferase aspC SW:AAT_THETH (Q56232) (385 aa) fasta scores: E(): 3e-31, 32.2% id in 379 aa; Orthologue of E. coli YBDL_ECOLI; Fasta hit to YBDL_ECOLI (386 aa), 85% identity in 386 aa overlap. (386 aa)
cobDPutative aminotransferase CobD; Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin. (364 aa)
STY0826Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (429 aa)
STY08288-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (385 aa)
ybjUSimilar to Escherichia coli L-allo-threonine aldolase ybjU SW:LTAA_ECOLI (P75823) (333 aa) fasta scores: E(): 0, 89.2% id in 333 aa, and to Aeromonas jandaei L-allo-threonine aldolase ltaA SW:LTAA_AERJA (O07051) (338 aa) fasta scores: E(): 0, 53.5% id in 333 aa; Orthologue of E. coli LTAA_ECOLI; Fasta hit to LTAA_ECOLI (333 aa), 89% identity in 333 aa overlap. (333 aa)
STY0977Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (362 aa)
STY1000Aspartate aminotransferase; Fasta hit to TYRB_ECOLI (397 aa), 43% identity in 397 aa overlap; Orthologue of E. coli aspC (AAT_ECOLI); Fasta hit to AAT_ECOLI (396 aa), 96% identity in 396 aa overlap; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. (396 aa)
STY1466Putative regulatory protein; Similar to Salmonella enteritidis hypothetical 53.3 kDa protein TR:AAF42764 (EMBL:AF128839) (475 aa) fasta scores: E(): 0, 99.4% id in 475 aa; Fasta hit to YJIR_ECOLI (470 aa), 36% identity in 472 aa overlap; Orthologue of E. coli P77730; Fasta hit to P77730 (468 aa), 87% identity in 468 aa overlap. (474 aa)
STY1507Putative aminotransferase; Orthologue of E. coli malY (MALY_ECOLI); Fasta hit to MALY_ECOLI (390 aa), 34% identity in 384 aa overlap. (393 aa)
STY1750Putative amintransferase; Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L- selenocysteine. Selenocysteine lyase activity is however unsure in vivo. (406 aa)
astCSuccinylornithine transaminase; Catalyzes the transamination of N(2)-succinylornithine and alpha-ketoglutarate into N(2)-succinylglutamate semialdehyde and glutamate. Can also act as an acetylornithine aminotransferase. Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. AstC subfamily. (408 aa)
STY2282Similar to Salmonella typhimurium histidinol-phosphate aminotransferase hisC SW:HIS8_SALTY (P10369) (359 aa) fasta scores: E(): 0, 98.6% id in 359 aa; Orthologue of E. coli hisC (HIS8_ECOLI); Fasta hit to HIS8_ECOLI (356 aa), 89% identity in 355 aa overlap; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (359 aa)
rfbHPutative dehydratase RfbH; Similar to many e.g. Salmonella typhimurium strain LT2, group B, lipopolysaccharide biosynthesis protein RfbH rfbH SW:RFBH_SALTY (P26398) (437 aa) fasta scores: E(): 0, 99.5% id in 437 aa and Yersinia pseudotuberculosis CDP-4-keto-6-deoxy-D-glucose-3-dehydrase ddhC TR:Q05341 (EMBL:L01777) (437 aa) fasta scores: E(): 0, 87.4% id in 437 aa; Belongs to the DegT/DnrJ/EryC1 family. (437 aa)
STY2527Putative lipopolysaccharide biosynthesis protein; Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; Belongs to the DegT/DnrJ/EryC1 family. ArnB subfamily. (385 aa)
STY2561Putative aminotransferase; Similar to Methylobacillus flagellatum aspartate aminotransferase aat TR:Q9RAN0 (EMBL:L78665) (429 aa) fasta scores: E(): 0, 62.1% id in 404 aa and to many putative aminotransferases; Orthologue of E. coli YFBQ_ECOLI; Fasta hit to YFBQ_ECOLI (405 aa), 97% identity in 404 aa overlap. (404 aa)
STY2642Putative aminotransferase; Orthologue of E. coli YFDZ_ECOLI; Fasta hit to YFDZ_ECOLI (412 aa), 95% identity in 412 aa overlap; Similar to Lactococcus lactis aromatic amino acid aminotransferase araT TR:Q9RAT0 (EMBL:AF146529) (391 aa) fasta scores: E(): 2e-31, 30.5% id in 354 aa and to many putative aminotransferases. (412 aa)
ptsJSimilar to Salmonella typhimurium putative transcriptional regulatory protein PtsJ ptsJ SW:PTSJ_SALTY (P40193) (430 aa) fasta scores: E(): 0, 97.9% id in 430 aa. (430 aa)
STY2789Putative L-cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur and selenium atoms from cysteine and selenocysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. Also functions as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate; Belongs to the class-V pyridoxal-phosphate-dependent am [...] (404 aa)
STY2802Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa)
STY4785Hypothetical protein; No database matches. (372 aa)
adiArginine decarboxylase; Similar to Escherichia coli biodegradative arginine decarboxylase SW:ADI_ECOLI (P28629) (755 aa) fasta scores: E(): 0, 93.1% id in 755 aa, and to Escherichia coli lysine decarboxylase, constitutive SW:DCLZ_ECOLI (P52095) (713 aa) fasta scores: E(): 0, 36.2% id in 737 aa. (756 aa)
STY4444Similar to Salmonella typhimurium aromatic-amino-acid aminotransferase SW:TYRB_SALTY (P74861) (397 aa) fasta scores: E(): 0, 98.0% id in 397 aa, and to Escherichia coli aromatic-amino-acid aminotransferase tyrB SW:TYRB_ECOLI (P04693) (397 aa) fasta scores: E(): 0, 88.9% id in 397 aa. (397 aa)
argDAcetylornithine aminotransferase; Involved in both the arginine and lysine biosynthetic pathways. (405 aa)
STY4221Putative aminotransferase; Similar to Treponema denticola hemolysin hly TR:Q56257 (EMBL:U30249) (399 aa) fasta scores: E(): 0, 32.9% id in 392 aa and to Escherichia coli probable aminotransferase MalY SW:MALY_ECOLI (P23256) (390 aa) fasta scores: E(): 9.9e-31, 25.3% id in 387 aa. The T. denticola hemolysin has been experimentally characterised. (388 aa)
STY4133Valine--pyruvate aminotransferase; Orthologue of E. coli avtA (AVTA_ECOLI); Fasta hit to AVTA_ECOLI (417 aa), 92% identity in 415 aa overlap. (416 aa)
STY4113L-seryl-tRNA(Ser) selenium transferase; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis; Belongs to the SelA family. (463 aa)
STY40862-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (398 aa)
STY4017Putative transferase; Weakly similar to Aquifex aeolicus L-seryl-tRNA selA TR:O67140 (EMBL:AE000719) (452 aa) fasta scores: E(): 0.37, 24.6% id in 403 aa, and to Azotobacter vinelandii dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex SW:ODO2_AZOVI (P20708) (398 aa) fasta scores: E(): 0.91, 23.2% id in 285 aa. (369 aa)
STY2806Similar to Salmonella typhimurium lysine decarboxylase, inducible SW:DCLY_SALTY (Q60002) (715 aa) fasta scores: E(): 0, 97.5% id in 715 aa; Fasta hit to DCOS_ECOLI (732 aa), 33% identity in 623 aa overlap; Fasta hit to ADI_ECOLI (755 aa), 36% identity in 740 aa overlap; Fasta hit to DCLZ_ECOLI (713 aa), 70% identity in 710 aa overlap; Fasta hit to DCOR_ECOLI (731 aa), 34% identity in 616 aa overlap; Orthologue of E. coli cadA (DCLY_ECOLI); Fasta hit to DCLY_ECOLI (715 aa), 92% identity in 714 aa overlap; Belongs to the Orn/Lys/Arg decarboxylase class-I family. (714 aa)
STY29124-aminobutyrate aminotransferase; Fasta hit to GSA_ECOLI (426 aa), 32% identity in 421 aa overlap; Fasta hit to ARGM_ECOLI (406 aa), 34% identity in 404 aa overlap; Fasta hit to ARGD_ECOLI (405 aa), 36% identity in 411 aa overlap; Fasta hit to BIOA_ECOLI (429 aa), 32% identity in 353 aa overlap; Fasta hit to GOAG_ECOLI (421 aa), 53% identity in 421 aa overlap; Orthologue of E. coli gabT (GABT_ECOLI); Fasta hit to GABT_ECOLI (426 aa), 89% identity in 426 aa overlap; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (427 aa)
STY3124Similar to many NifS-like aminotransferases e.g. Synechocystis sp NifS TR:Q55793 (EMBL:D64004) (420 aa) fasta scores: E(): 0, 40.4% id in 403 aa; Fasta hit to P77444 (406 aa), 44% identity in 404 aa overlap; Orthologue of E. coli Q46925; Fasta hit to Q46925 (401 aa), 89% identity in 401 aa overlap. (401 aa)
STY3209Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (957 aa)
STY3333Beta-cystathionase; Fasta hit to METB_ECOLI (386 aa), 32% identity in 398 aa overlap; Orthologue of E. coli metC (METC_ECOLI); Fasta hit to METC_ECOLI (395 aa), 87% identity in 395 aa overlap. (395 aa)
STY3396Probable aminotransferase; Catalyzes the aminotransferase reaction from putrescine to 2- oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline. This is the first step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate (gamma-aminobutyrate or GABA) via 4- aminobutanal. Also functions as a cadaverine transaminase in a a L- lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. (429 aa)
STY3630Lipopolysaccharide biosynthesis protein; Catalyzes the synthesis of dTDP-4-amino-4,6-dideoxy-D- galactose (dTDP-Fuc4N) from dTDP-4-keto-6-deoxy-D-glucose (dTDP-D- Glc4O) and L-glutamate; Belongs to the DegT/DnrJ/EryC1 family. (376 aa)
STY3762Similar to Rhizobium meliloti probable rhizopine catabolism regulatory protein MocR mocR SW:MOCR_RHIME (P49309) (493 aa) fasta scores: E(): 0, 33.9% id in 492 aa. (493 aa)
STY3764Putative serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (419 aa)
STY3769Cystathionine gamma-synthase; Fasta hit to METC_ECOLI (395 aa), 31% identity in 394 aa overlap; Orthologue of E. coli metB (METB_ECOLI); Fasta hit to METB_ECOLI (386 aa), 96% identity in 386 aa overlap. (386 aa)
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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