STRINGSTRING
STY3992 STY3992 STY4514 STY4514 arcA arcA STY4935 STY4935 STY4901 STY4901 STY4900 STY4900 STY4843 STY4843 ecnR ecnR iagA iagA STY3293 STY3293 STY3354 STY3354 STY4197 STY4197 STY4281 STY4281 ompR ompR pmrA pmrA sprB sprB tctD tctD STY2804 STY2804 STY2495 STY2495 STY2472 STY2472 STY2344 STY2344 STY2190 STY2190 STY2158 STY2158 sirA sirA STY1856 STY1856 ssrB ssrB STY1285 STY1285 STY1179 STY1179 copR copR fimW fimW fimZ fimZ STY0381 STY0381 STY0377 STY0377 STY0374 STY0374 STY0038 STY0038 STY0035 STY0035 STY0017 STY0017
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STY3992Two-component system response regulator protein; Fasta hit to NARP_ECOLI (215 aa), 36% identity in 195 aa overlap; Fasta hit to UVRY_ECOLI (218 aa), 36% identity in 202 aa overlap; Fasta hit to NARL_ECOLI (216 aa), 34% identity in 200 aa overlap; Orthologue of E. coli uhpA (UHPA_ECOLI); Fasta hit to UHPA_ECOLI (196 aa), 97% identity in 196 aa overlap. (196 aa)
STY4514Putative GerE family regulatory protein; Similar to the N-terminus of Erwinia amylovora RcsB TR:P96320 (EMBL:Y09848) (215 aa) fasta scores: E(): 0.011, 34.4% id in 64 aa, and to Salmonella typhi capsular synthesis regulator component B RcsB SW:RCSB_SALTI (Q56127) (216 aa) fasta scores: E(): 0.019, 36.4% id in 55 aa. (95 aa)
arcAGlobal response regulator; Similar to Escherichia coli aerobic respiration control protein ArcA SW:ARCA_ECOLI (P03026) (238 aa) fasta scores: E(): 0, 99.6% id in 238 aa, and to Haemophilus influenzae aerobic respiration control protein ArcA homolog ArcA or hi0884 SW:ARCA_HAEIN (P44918) (236 aa) fasta scores: E(): 0, 76.8% id in 237 aa. (238 aa)
STY4935Putative two-component response regulator; Similar to Escherichia coli transcriptional regulatory protein CreB SW:CREB_ECOLI (P08368) (229 aa) fasta scores: E(): 0, 83.4% id in 229 aa, and to Aeromonas jandaei response regulator protein BlrA TR:P97015 (EMBL:U67069) (223 aa) fasta scores: E(): 0, 62.8% id in 226 aa. (229 aa)
STY4901Probable regulatory protein. Divergence in the N-terminal region, other possible translational starts. Similar to Escherichia coli BglJ protein SW:BGLJ_ECOLI (P39404) (175 aa) fasta scores: E(): 0, 67.8% id in 171 aa, and to Salmonella typhi capsular synthesis regulator component b RcsB SW:RCSB_SALTI (Q56127) (216 aa) fasta scores: E(): 4.6e-07, 28.7% id in 171 aa. (208 aa)
STY4900Probable regulatory protein. Contains helix-turn-helix motif, residues 170-191, score 1107 (+2.96 SD). Similar to Escherichia coli hypothetical 27.0 kDa protein in dnaT-bglJ intergenic region YjjQ SW:YJJQ_ECOLI (P39403) (241 aa) fasta scores: E(): 0, 66.5% id in 242 aa, and to Erwinia amylovora response regulator HrpY TR:Q9X3S9 (EMBL:AF083877) (213 aa) fasta scores: E(): 0.00011, 28.8% id in 163 aa. (241 aa)
STY4843Putative gerE-family regulatory protein; Possible regulator, similar to Salmonella typhimurium hypothetical 12.7 kDa protein in pefI 3'region, found on virulence plasmid, TR:Q04825 (EMBL:L08613) (116 aa) fasta scores: E(): 0, 93.1% id in 116 aa. (116 aa)
ecnRSimilar to Citrobacter freundii transcriptional regulatory protein entr ecnR SW:ECNR_CITFR (O69280) (199 aa) fasta scores: E(): 0, 63.8% id in 199 aa. (195 aa)
iagAInvasion protein regulator; The main transcriptional regulator of the Salmonella pathogenicity island 1 (SPI1) gene expression. Activates the expression of invasion genes by a direct action at their promoters and also indirectly by increasing the level of invF. Also binds upstream of prgH and directly activates the expression of prgHIJK operon (By similarity). (553 aa)
STY3293LysR-family transcriptional regulator; Similar to Klebsiella aerogenes monoamine regulon transcriptional regulator MoaR SW:MOAR_KLEAE (P54794) (227 aa) fasta scores: E(): 0, 74.9% id in 227 aa, and to Enterobacter aerogenes MoaR-transcriptional positive regulator TR:Q46656 (EMBL:D49928) (227 aa) fasta scores: E(): 0, 74.0% id in 227 aa. (227 aa)
STY3354Probable two-component system response regulator; Member of a two-component regulatory system QseB/QseC. Activates the flagella regulon by activating transcription of flhDC (By similarity). (219 aa)
STY4197Similar to Escherichia coli hypothetical transcriptional regulator in tref-kdgk intergenic region yhjB SW:YHJB_ECOLI (P37640) (200 aa) fasta scores: E(): 0, 72.0% id in 200 aa, and to Hyphomicrobium methylovorum probable transcriptional regulatory protein sgar. probable transcriptional regulatory protein sgar SW:SGAR_HYPME (P56644) (211 aa) fasta scores: E(): 7.7e-09, 27.9% id in 197 aa; Orthologue of E. coli yhjB (YHJB_ECOLI); Fasta hit to YHJB_ECOLI (200 aa), 72% identity in 200 aa overlap. (200 aa)
STY4281MalT regulatory protein; Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto- oligosaccharides. Specifically binds to the promoter region of its target genes, recognizing a short DNA motif called the MalT box. (901 aa)
ompRTwo-component response regulator OmpR; Member of the two-component regulatory system EnvZ/OmpR involved in regulating expression of the outer membrane porins OmpC and OmpF as well as other genes. Unlike E.coli or S.typhimurium both porins are expressed constitutively. Involved in regulation of the biosynthesis of Vi polysaccharide, a capsular antigen thought to be involved in the virulence of S.typhi. Vi antigen is synthesized at low NaCl concentrations (under 0.4 M). Binds to the promoter of both ompC and ompF (By similarity). (239 aa)
pmrATwo-component response regulator; Similar to Salmonella typhimurium transcriptional regulatory protein PmrA or BasR SW:BASR_SALTY (P36556) (222 aa) fasta scores: E(): 0, 98.6% id in 222 aa, and to Escherichia coli transcriptional regulatory protein BasR SW:BASR_ECOLI (P30843) (222 aa) fasta scores: E(): 0, 90.1% id in 222 aa. (222 aa)
sprBSimilar to Salmonella typhimurium transcriptional regulator SprB found on pathogenicity island 1 TR:Q9XC53 (EMBL:AF148689) (251 aa) fasta scores: E(): 0, 99.2% id in 251 aa. (251 aa)
tctDSimilar to Salmonella typhimurium transcriptional regulatory protein TctD SW:TCTD_SALTY (P22104) (224 aa) fasta scores: E(): 0, 99.1% id in 224 aa and Salmonella typhi AJB70 TctD protein TR:O68288 (EMBL:AF029846) (223 aa) fasta scores: E(): 0, 97.3% id in 224 aa; Fasta hit to TORR_ECOLI (230 aa), 31% identity in 226 aa overlap; Fasta hit to BAER_ECOLI (240 aa), 33% identity in 224 aa overlap; Fasta hit to YLCA_ECOLI (227 aa), 38% identity in 226 aa overlap; Fasta hit to YEDW_ECOLI (239 aa), 37% identity in 220 aa overlap; Fasta hit to OMPR_ECOLI (239 aa), 36% identity in 228 aa overlap [...] (224 aa)
STY2804Transcriptional activator cadC; Orthologue of E. coli cadC (CADC_ECOLI); Fasta hit to CADC_ECOLI (512 aa), 58% identity in 519 aa overlap. (514 aa)
STY2495Regulator of capsule synthesis B component; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsB is the response regulator that binds to regulatory DNA regions. Can function both in an RcsA-dependent or RcsA-independent manner. (216 aa)
STY2472Nitrate/nitrite response regulator protein NarP; Fasta hit to UHPA_ECOLI (196 aa), 37% identity in 195 aa overlap; Fasta hit to FIMZ_ECOLI (210 aa), 30% identity in 200 aa overlap; Fasta hit to CPXR_ECOLI (232 aa), 31% identity in 229 aa overlap; Fasta hit to NARL_ECOLI (216 aa), 43% identity in 214 aa overlap; Fasta hit to UVRY_ECOLI (218 aa), 34% identity in 200 aa overlap; Orthologue of E. coli narP (NARP_ECOLI); Fasta hit to NARP_ECOLI (215 aa), 88% identity in 215 aa overlap. (215 aa)
STY2344Putative two-component system response regulator; Fasta hit to TORR_ECOLI (230 aa), 37% identity in 231 aa overlap; Fasta hit to YLCA_ECOLI (227 aa), 35% identity in 223 aa overlap; Fasta hit to RSTA_ECOLI (242 aa), 33% identity in 228 aa overlap; Fasta hit to YGIX_ECOLI (219 aa), 35% identity in 222 aa overlap; Fasta hit to OMPR_ECOLI (239 aa), 37% identity in 241 aa overlap; Fasta hit to ARCA_ECOLI (238 aa), 32% identity in 233 aa overlap; Fasta hit to CPXR_ECOLI (232 aa), 37% identity in 225 aa overlap; Fasta hit to PHOB_ECOLI (229 aa), 40% identity in 224 aa overlap; Fasta hit to P [...] (240 aa)
STY2190Colanic acid capsullar biosynthesis activation protein A; Component of the Rcs signaling system, which controls transcription of numerous genes. Binds, with RcsB, to the RcsAB box to regulate expression of genes. (207 aa)
STY2158Cell-division regulatory protein; Similar to Salmonella typhimurium regulator of cell division (suppresses division inhibition A) SdiA TR:O66040 (EMBL:U88651) (240 aa) fasta scores: E(): 0, 98.8% id in 240 aa; Orthologue of E. coli sdiA (SDIA_ECOLI); Fasta hit to SDIA_ECOLI (240 aa), 72% identity in 240 aa overlap. (240 aa)
sirAInvasion response-regulator; Similar to many response regulators e.g. Salmonella typhimurium quorum-sensor response-regulator controlling virulence functions SirA sirA TR:P96058 (EMBL:U67869) (218 aa) fasta scores: E(): 0, 99.5% id in 218 aa and Pseudomonas aeruginosa response regulator GacA gacA SW:GACA_PSEAE (Q51373; O06649) (214 aa) fasta scores: E(): 0, 59.8% id in 214 aa; Fasta hit to UHPA_ECOLI (196 aa), 35% identity in 188 aa overlap; Fasta hit to NARP_ECOLI (215 aa), 31% identity in 195 aa overlap; Orthologue of E. coli uvrY (UVRY_ECOLI); Fasta hit to UVRY_ECOLI (218 aa), 97% i [...] (218 aa)
STY1856Putative regulatory protein; Similar to Salmonella cholerae-suis hypothetical 21.3 kDa protein in aada 3'region TR:Q02882 (EMBL:X68089) (186 aa) fasta scores: E(): 0, 99.4% id in 175 aa. (197 aa)
ssrBPutative two-component response regulator; Similar to Salmonella typhimurium SsrB TR:O54305 (EMBL:Z95891) (193 aa) fasta scores: E(): 0, 100.0% id in 193 aa, and to Streptococcus pneumoniae response regulator rr03 TR:Q9S1J7 (EMBL:AJ006393) (210 aa) fasta scores: E(): 1.4e-19, 34.5% id in 206 aa; Fasta hit to UHPA_ECOLI (196 aa), 33% identity in 202 aa overlap; Fasta hit to NARL_ECOLI (216 aa), 32% identity in 198 aa overlap; Paralogue of E. coli uvrY (UVRY_ECOLI); Fasta hit to UVRY_ECOLI (218 aa), 31% identity in 206 aa overlap. (212 aa)
STY1285Nitrate/nitrite response regulator protein NarL; Fasta hit to UHPA_ECOLI (196 aa), 34% identity in 203 aa overlap; Fasta hit to NARP_ECOLI (215 aa), 44% identity in 214 aa overlap; Orthologue of E. coli narL (NARL_ECOLI); Fasta hit to NARL_ECOLI (216 aa), 95% identity in 216 aa overlap. (216 aa)
STY1179Putative regulatory protein; Orthologue of E. coli csgD (CSGD_ECOLI); Fasta hit to CSGD_ECOLI (216 aa), 92% identity in 208 aa overlap. (208 aa)
copRResponse regulator; Fasta hit to TORR_ECOLI (230 aa), 34% identity in 229 aa overlap; Fasta hit to BAER_ECOLI (240 aa), 32% identity in 224 aa overlap; Fasta hit to YLCA_ECOLI (227 aa), 52% identity in 227 aa overlap; Fasta hit to RSTA_ECOLI (242 aa), 34% identity in 228 aa overlap; Fasta hit to OMPR_ECOLI (239 aa), 34% identity in 233 aa overlap; Fasta hit to YGIX_ECOLI (219 aa), 38% identity in 220 aa overlap; Fasta hit to ARCA_ECOLI (238 aa), 33% identity in 228 aa overlap; Fasta hit to CPXR_ECOLI (232 aa), 39% identity in 227 aa overlap; Fasta hit to PHOB_ECOLI (229 aa), 37% identi [...] (248 aa)
fimWFimbriae w protein; Similar to Salmonella typhimurium fimbriae w protein fimW SW:FIMW_SALTY (P37928) (198 aa) fasta scores: E(): 0, 98.5% id in 198 aa. (198 aa)
fimZProbable transcriptional regulator (FimXZ protein); Similar to Salmonella typhimurium fimbriae z protein fimZ SW:FIMZ_SALTY (P26319) (210 aa) fasta scores: E(): 0, 99.0% id in 210 aa, and to Escherichia coli fimbriae z protein fimZ SW:FIMZ_ECOLI (P21502) (210 aa) fasta scores: E(): 0, 71.4% id in 210 aa, and to Bordetella pertussis, Bordetella bronchiseptica, and virulence factors putative positive transcription regulator BvgA bvgA SW:BVGA_BORPE (P16574) (209 aa) fasta scores: E(): 7.7e-28, 39.5% id in 205 aa, and to Escherichia coli putative positive transcription regulator EvgA evgA [...] (210 aa)
STY0381Possible transcriptionl regulator; Similar to Salmonella typhimurium hypothetical 24.8 kDa protein TR:Q9RFV5 (EMBL:AF166275) (213 aa) fasta scores: E(): 0, 99.4% id in 175 aa, and to Klebsiella pneumoniae Rmpa2 rmpa2 TR:Q53343 (EMBL:S64176) (212 aa) fasta scores: E(): 1.7e-12, 31.9% id in 160 aa, and weakly to the C-terminus of Corynebacterium diphtheriae response regulator CstA cstA TR:Q9RPE7 (EMBL:AF161328) (233 aa) fasta scores: E(): 0.33, 34.3% id in 67 aa, and Salmonella typhimurium transcriptional regulatory protein UhpA uhpA SW:UHPA_SALTY (P27667) (196 aa) fasta scores: E(): 0.7 [...] (175 aa)
STY0377Similar to Vibrio hollisae transmembrane regulatory protein ToxR toxR TR:Q9RHQ9 (EMBL:AB027503) (292 aa) fasta scores: E(): 0.0019, 26.8% id in 153 aa, and to Vibrio parahaemolyticus cholera toxin homolog transcriptional activator toxR SW:TOXR_VIBPA (Q05938) (292 aa) fasta scores: E(): 0.042, 25.2% id in 143 aa. (247 aa)
STY0374Possible transmembrane regulator; Similar to Vibrio parahaemolyticus cholera toxin homolog transcriptional activator toxR SW:TOXR_VIBPA (Q05938) (292 aa) fasta scores: E(): 0.007, 25.6% id in 125 aa, and weakly to Salmonella typhimurium putative transcriptional regulator MarT marT TR:Q9Z623 (EMBL:AF106566) (285 aa) fasta scores: E(): 0.1, 20.6% id in 214 aa, and to Vibrio cholerae cholera toxin transcriptional activator toxR SW:TOXR_VIBCH (P15795) (294 aa) fasta scores: E(): 0.73, 23.9% id in 109 aa. (244 aa)
STY0038Putative transcriptional regulator; Similar to Vibrio parahaemolyticus cholera toxin homolog transcriptional activator TOXR SW:TOXR_VIBPA (Q05938) fasta scores: E(): 0.015, 23.5% id in 98 aa. (101 aa)
STY0035Putative membrane protein; Similar to Salmonella typhimurium putative transcriptional regulator mart MART TR:Q9Z623 (EMBL:AF106566) fasta scores: E(): 0.00018, 30.8% id in 104 aa, and to Escherichia coli hypothetical 30.9 kda protein in kdui-lyss intergenic region YQEI SW:YQEI_ECOLI (Q46942) fasta scores: E(): 0.00029, 28.0% id in 132 aa. Contains transmembrane domain at C-term. (149 aa)
STY0017Putative membrane protein; Similar to Escherichia coli hypothetical 30.9 kda protein in kdui-lyss intergenic region YQEI SW:YQEI_ECOLI (Q46942) fasta scores: E(): 4.4e-06, 30.6% id in 108 aa, and to Salmonella typhimurium putative transcriptional regulator mart MART TR:Q9Z623 (EMBL:AF106566) fasta scores: E(): 1.8e-05, 28.4% id in 109 aa. Contains transmembrane domain at C-term. (147 aa)
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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