STRINGSTRING
STY3244 STY3244 STY3392 STY3392 STY3459 STY3459 secG secG STY3490 STY3490 STY3519 STY3519 STY3639 STY3639 STY3731 STY3731 STY3732 STY3732 STY3738 STY3738 tufB tufB STY3760 STY3760 STY3816 STY3816 STY3902 STY3902 STY3926 STY3926 STY3936 STY3936 STY3948 STY3948 STY3981 STY3981 STY4008 STY4008 rpoZ rpoZ STY4165 STY4165 STY4168 STY4168 STY4169 STY4169 STY4170 STY4170 STY4194 STY4194 STY4230 STY4230 fkpA fkpA tufA tufA bfr bfr prlA prlA rpoA rpoA STY4459 STY4459 STY4489 STY4489 yjfR yjfR fklB fklB msrA msrA STY4874 STY4874 STY0156 STY0156 STY0176 STY0176 STY0278 STY0278 STY0326 STY0326 tinR tinR STY0365 STY0365 STY0387 STY0387 STY0414 STY0414 STY0440 STY0440 STY0445 STY0445 STY0446 STY0446 STY0455 STY0455 STY0475 STY0475 STY0486 STY0486 ybaO ybaO mdlA mdlA STY0504 STY0504 ybbN ybbN STY0556 STY0556 STY0653 STY0653 citA-2 citA-2 STY0780 STY0780 yliB yliB yliC yliC yliD yliD mdfA mdfA STY0956 STY0956 STY0957 STY0957 STY0985 STY0985 STY1002 STY1002 STY1005 STY1005 STY1169 STY1169 STY1191 STY1191 STY1305 STY1305 STY1369 STY1369 STY1381 STY1381 STY1397 STY1397 STY1517 STY1517 hyaE2 hyaE2 STY1538 STY1538 STY1544 STY1544 STY1579 STY1579 STY1604 STY1604 STY1649 STY1649 STY1682 STY1682 STY1691 STY1691 STY1694 STY1694 STY1863 STY1863 STY1864 STY1864 STY1865 STY1865 STY1917 STY1917 STY2056 STY2056 STY2141 STY2141 STY2143 STY2143 ompS1 ompS1 wzb wzb STY2342 STY2342 STY2409 STY2409 STY2443 STY2443 STY2455 STY2455 bcr bcr sspH2 sspH2 ompC ompC STY2509 STY2509 STY2603 STY2603 STY2729 STY2729 STY2771 STY2771 STY2842 STY2842 STY2847 STY2847 iroC iroC STY2928 STY2928 STY2938 STY2938 STY2941 STY2941 STY3036 STY3036 STY3152 STY3152 STY3160 STY3160
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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STY3244Galactose-proton symport (galactose transporter); Fasta hit to XYLE_ECOLI (491 aa), 33% identity in 480 aa overlap; Fasta hit to ARAE_ECOLI (472 aa), 65% identity in 456 aa overlap; Orthologue of E. coli galP (GALP_ECOLI); Fasta hit to GALP_ECOLI (464 aa), 97% identity in 464 aa overlap; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (464 aa)
STY3392Conserved hypothetical protein; Orthologue of E. coli YQJH_ECOLI; Fasta hit to YQJH_ECOLI (254 aa), 72% identity in 253 aa overlap. (255 aa)
STY3459Possible monooxygenase; Similar to Escherichia coli hypothetical protein YhbW SW:YHBW_ECOLI (P45529) (335 aa) fasta scores: E(): 0, 94.9% id in 335 aa and to the N-terminus of several monooxygenases e.g. Photobacterium leiognathi alkanal monooxygenase beta chain luxB SW:LXB2_PHOLE (P29239) (326 aa) fasta scores: E(): 4.1e-05, 26.4% id in 193 aa; Orthologue of E. coli yhbW (YHBW_ECOLI); Fasta hit to YHBW_ECOLI (335 aa), 95% identity in 335 aa overlap. (335 aa)
secGProtein-export membrane protein; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. (110 aa)
STY3490Possible exported protein; Orthologue of E. coli YRBD_ECOLI; Fasta hit to YRBD_ECOLI (183 aa), 87% identity in 183 aa overlap. Contains a possible N-terminal signal sequence. (183 aa)
STY3519Putative sialic acid transporter; Catalyzes the proton-dependent transport of sialic acid. Belongs to the major facilitator superfamily. Sialate:H(+) symporter (SHS) (TC 2.A.1.12) family. (496 aa)
STY3639Thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions; Belongs to the thioredoxin family. (109 aa)
STY3731DNA-directed RNA polymerase, beta'-subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1407 aa)
STY3732DNA-directed RNA polymerase, beta-subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1342 aa)
STY3738Preprotein translocase SecE subunit; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. (127 aa)
tufBElongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (394 aa)
STY3760Catalase (hydroperoxidase I); Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily. (726 aa)
STY3816Manganese superoxide dismutase; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the iron/manganese superoxide dismutase family. (206 aa)
STY3902Regulatory protein; Orthologue of E. coli asnC (ASNC_ECOLI); Fasta hit to ASNC_ECOLI (152 aa), 97% identity in 152 aa overlap. (152 aa)
STY3926Periplasmic phosphate-binding protein; Part of the ABC transporter complex PstSACB involved in phosphate import; Belongs to the PstS family. (346 aa)
STY3936Putative membrane transport protein; Similar to Escherichia coli bicyclomycin resistance protein BicR SW:BCR_ECOLI (P28246) (396 aa) fasta scores: E(): 1.5e-20, 25.5% id in 381 aa. Contains multiple possible membrane spanning hydrophobic domains; Orthologue of E. coli yidY (YIDY_ECOLI); Fasta hit to YIDY_ECOLI (391 aa), 78% identity in 393 aa overlap. (395 aa)
STY3948Hypothetical protein. (340 aa)
STY3981Multidrug resistance protein D; Orthologue of E. coli emrD (EMRD_ECOLI); Fasta hit to EMRD_ECOLI (396 aa), 93% identity in 394 aa overlap. (394 aa)
STY4008Putative inner membrane transport protein; Involved in the efflux of purine ribonucleosides, such as guanosine, adenosine and especially inosine. Involved in the resistance to 6-mercaptopurine (By similarity). Required for triggering apoptosis and bacterial survival inside macrophages. (397 aa)
rpoZDNA-directed RNA polymerase omega chain; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity). (91 aa)
STY4165Hypothetical protein; Unknown function. (374 aa)
STY4168Periplasmic dipeptide transport protein precursor; Fasta hit to SAPA_ECOLI (547 aa), 36% identity in 513 aa overlap; Orthologue of E. coli dppA (DPPA_ECOLI); Fasta hit to DPPA_ECOLI (535 aa), 93% identity in 535 aa overlap. (535 aa)
STY4169Dipeptide transport system permease protein DppB; Fasta hit to YDDR_ECOLI (340 aa), 44% identity in 333 aa overlap; Fasta hit to YLIC_ECOLI (306 aa), 42% identity in 342 aa overlap; Fasta hit to NIKB_ECOLI (314 aa), 34% identity in 341 aa overlap; Fasta hit to OPPB_ECOLI (306 aa), 36% identity in 340 aa overlap; Fasta hit to SAPB_ECOLI (321 aa), 35% identity in 343 aa overlap; Orthologue of E. coli dppB (DPPB_ECOLI); Fasta hit to DPPB_ECOLI (339 aa), 98% identity in 339 aa overlap. (339 aa)
STY4170Dipeptide transport system permease protein DppC; Fasta hit to SAPC_ECOLI (296 aa), 40% identity in 288 aa overlap; Fasta hit to YLID_ECOLI (303 aa), 42% identity in 284 aa overlap; Fasta hit to NIKC_ECOLI (277 aa), 37% identity in 280 aa overlap; Fasta hit to YDDQ_ECOLI (298 aa), 44% identity in 275 aa overlap; Fasta hit to OPPC_ECOLI (302 aa), 34% identity in 285 aa overlap; Orthologue of E. coli dppC (DPPC_ECOLI); Fasta hit to DPPC_ECOLI (300 aa), 94% identity in 300 aa overlap. (300 aa)
STY4194Hypothetical metabolite transport protein; Fasta hit to KGTP_ECOLI (432 aa), 32% identity in 434 aa overlap; Fasta hit to PROP_ECOLI (500 aa), 34% identity in 429 aa overlap; Fasta hit to SHIA_ECOLI (438 aa), 35% identity in 443 aa overlap; Orthologue of E. coli yhjE (YHJE_ECOLI); Fasta hit to YHJE_ECOLI (440 aa), 94% identity in 440 aa overlap. (440 aa)
STY4230Putative membrane protein; Similar to Escherichia coli hypothetical 43.8 kDa protein in ftsY-nikA intergenic region YhhS SW:YHHS_ECOLI (P37621) (419 aa) fasta scores: E(): 0, 90.6% id in 405 aa, and to Escherichia coli from bases 2434445 to 2447012 YhhS TR:P77549 (EMBL:AE000321) (392 aa) fasta scores: E(): 0, 42.2% id in 372 aa. Predicted hydrophobic membrane spanning domains, integral membrane protein. (405 aa)
fkpASimilar to Escherichia coli fkbp-type peptidyl-prolyl cis-trans isomerase FkpA precursor fkpA SW:FKBA_ECOLI (P45523) (270 aa) fasta scores: E(): 0, 89.7% id in 272 aa, and to Aeromonas hydrophila fkbp-type peptidyl-prolyl cis-trans isomerase FkpA precursor fkpA SW:FKBA_AERHY (O08437) (268 aa) fasta scores: E(): 0, 44.0% id in 266 aa. (272 aa)
tufAElongation factor Tu; Identical to Salmonella typhimurium elongation factor Tu tufa and tufB SW:EFTU_SALTY (P21694) (393 aa) fasta scores: E(): 0, 100.0% id in 393 aa, and to Escherichia coli elongation factor tu SW:EFTU_ECOLI (P02990) (393 aa) fasta scores: E(): 0, 99.7% id in 392 aa. (394 aa)
bfrBacterioferritin; Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex; Belongs to the bacterioferritin family. (158 aa)
prlAPreprotein translocase subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (443 aa)
rpoADNA-directed RNA polymerase alpha chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (329 aa)
STY4459Large repetitive protein; Similar to Synechocystis sp. hypothetical 308.8 kDa protein slr0364 TR:Q55582 (EMBL:D63999) (3029 aa) fasta scores:E(): 0, 26.2% id in 2291 aa. Also similar to Salmonella typhimurium SPI-4 hypothetical proteins: TR:O85324 (EMBL:AF060869) (1512 aa) fasta scores: E(): 0, 97.6% id in 1464 aa and TR:O85325 (EMBL:AF060869) (463 aa) fasta scores: E(): 0, 97.4% id in 463 aa. Note product of this CDS is composed of multiple degenerate repeats and is significantly similar to the upstream CDS STY4458 fasta scores: E(): 0 33.24% identity in 2118 aa overlap. (2256 aa)
STY4489ProP; Similar to Escherichia coli ProP TR:P71321 (EMBL:U75904) (500 aa) fasta scores: E(): 0, 95.2% id in 500 aa, and to Erwinia chrysanthemi osmoprotectant uptake system A OusA SW:OUSA_ERWCH (Q47421) (498 aa) fasta scores: E(): 0, 84.0% id in 499 aa; putative proline/betaine transporter. (500 aa)
yjfRConserved hypothetical protein; Probably catalyzes the hydrolysis of L-ascorbate-6-P into 3- keto-L-gulonate-6-P. Is essential for L-ascorbate utilization under anaerobic conditions; Belongs to the UlaG family. (354 aa)
fklBSimilar to Escherichia coli FkbP-type 22 kDa peptidyl-prolyl cis-trans isomerase FklB SW:FKBB_ECOLI (P39311; Q47717; P76801) (205 aa) fasta scores: E(): 0, 96.1% id in 204 aa, and to Legionella israelensis macrophage infectivity potentiator Mip TR:O32767 (EMBL:U92208) (242 aa) fasta scores: E(): 1.5e-26, 40.0% id in 205 aa. (220 aa)
msrAPeptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. (212 aa)
STY4874Putative sugar transport protein; Similar to Escherichia coli hypothetical protein YjiO yjiO SW:YJIO_ECOLI (P39386) (410 aa) fasta scores: E(): 0, 86.0% id in 408 aa and to Escherichia coli multidrug translocase mdfA SW:MDFA_ECOLI (Q46966) (410 aa) fasta scores: E(): 0, 40.2% id in 386 aa. (413 aa)
STY0156Preprotein translocase SecA subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. (901 aa)
STY0176Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (629 aa)
STY0278Putative drug efflux protein; Similar to Bacillus subtilis YtbD TR:O34367 (EMBL:AF008220) (396 aa) fasta scores: E(): 0, 52.8% id in 381 aa, and to Escherichia coli from bases 1733307 to 1744339 TR:P77389 (EMBL:AE000261) (389 aa) fasta scores: E(): 0, 41.8% id in 378 aa, and to Streptomyces violaceus chloramphenicol resistance protein CmlV TR:Q56147 (EMBL:U09991) (436 aa) fasta scores: E(): 0, 37.0% id in 386 aa, and to Corynebacterium striatum chloramphenicol export protein cmx TR:O30996 (EMBL:AF024666) (391 aa) fasta scores: E(): 0, 33.4% id in 389 aa, and to Escherichia coli araJ pr [...] (391 aa)
STY0326Conserved hypothetical protein; Similar to the extreme C-terminus of Neisseria meningitidis filamentous hemagglutinin B-like fhab protein TR:CAB71945 (EMBL:AJ391255) (2015 aa) fasta scores: E(): 1.3e-06, 46.0% id in 63 aa. (86 aa)
tinRTranscriptional regulator; Similar to Salmonella enterica TinR protein TR:Q9RIR7 (EMBL:AJ242964) (151 aa) fasta scores: E(): 0, 99.3% id in 151 aa, Escherichia coli hypothetical transcriptional regulator in mdl-cof intergenic region YbaO SW:YBAO_ECOLI (P54986; P71209; P77575) (152 aa) fasta scores: E(): 1.1e-22, 44.0% id in 150 aa and to Escherichia coli and Enterobacter aerogenes leucine-responsive regulatory protein Lrp or AlsB or LivR or IhB or OppI SW:LRP_ECOLI (P19494) (163 aa) fasta scores: E(): 3.7e-13, 30.7% id in 150 aa. (151 aa)
STY0365Outer membrane pore protein E precursor; Uptake of inorganic phosphate, phosphorylated compounds, and some other negatively charged solutes; Belongs to the Gram-negative porin family. (350 aa)
STY0387Similar to Escherichia coli hypothetical metabolite transport protein in leux-fece intergenic region yjhB SW:YJHB_ECOLI (P39352) (405 aa) fasta scores: E(): 1.4e-29, 28.7% id in 387 aa, and to Alcaligenes eutrophus probable 4-methylmuconolactone transporter mmlH SW:MMLH_ALCEU (O51798) (428 aa) fasta scores: E(): 2.7e-23, 27.8% id in 424 aa. (417 aa)
STY0414Possible efflux pump; Similar to Escherichia coli hypothetical 43.9 kDa protein in msyb-htrb intergenic region yceE SW:YCEE_ECOLI (P25744) (408 aa) fasta scores: E(): 0, 59.6% id in 396 aa, and to Streptococcus pneumoniae multi-drug resistance efflux pump pmrA TR:Q9ZEX9 (EMBL:AJ007367) (399 aa) fasta scores: E(): 0, 41.4% id in 394 aa, and to Salmonella ordonez tetracycline resistance protein, class d tetA SW:TCR4_SALOR (P33733) (394 aa) fasta scores: E(): 3.7e-19, 29.7% id in 357 aa; Paralogue of E. coli yceE (YCEE_ECOLI); Fasta hit to YCEE_ECOLI (408 aa), 60% identity in 396 aa overlap. (399 aa)
STY0440Probable peroxidase; Similar to Legionella pneumophila predicted alkylhydrogenperoxide reductase tsaA TR:Q48834 (EMBL:L46863) (201 aa) fasta scores: E(): 0, 65.3% id in 199 aa, and to Campylobacter jejuni predicted alkyl hydroperoxide reductase subunit c ahpC TR:Q9ZI13 (EMBL:AF044271) (198 aa) fasta scores: E(): 0, 61.3% id in 199 aa, and to Homo sapiens thioredoxin peroxidase 1 tdpx1 or nkefB SW:TDX1_HUMAN (P32119; P35701; P31945; Q92763) (198 aa) fasta scores: E(): 0, 47.9% id in 194 aa; Paralogue of E. coli ahpC (AHPC_ECOLI); Fasta hit to AHPC_ECOLI (186 aa), 36% identity in 190 aa [...] (200 aa)
STY0445Protein-export membrane protein SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (615 aa)
STY0446Protein-export membrane protein SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (323 aa)
STY0455Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (367 aa)
STY0475Hpothetical major facilitator family transport protein; Orthologue of E. coli YAJR_ECOLI; Fasta hit to YAJR_ECOLI (456 aa), 89% identity in 453 aa overlap. (454 aa)
STY0486AmpG protein; Orthologue of E. coli ampG (AMPG_ECOLI); Fasta hit to AMPG_ECOLI (491 aa), 91% identity in 490 aa overlap. (491 aa)
ybaOSimilar to Escherichia coli hypothetical transcriptional regulator in mdl-cof intergenic region ybaO SW:YBAO_ECOLI (P54986; P71209; P77575) (152 aa) fasta scores: E(): 0, 95.4% id in 152 aa, and to Zymomonas mobilis glutamate uptake regulatory protein grP SW:GRP_ZYMMO (P74996) (164 aa) fasta scores: E(): 9.7e-26, 44.0% id in 150 aa, and to Pseudomonas putida bkd operon transcriptional regulator bkdR SW:BKDR_PSEPU (P42179) (161 aa) fasta scores: E(): 1.2e-17, 35.3% id in 153 aa; Fasta hit to LRP_ECOLI (163 aa), 34% identity in 151 aa overlap; Orthologue of E. coli YBAO_ECOLI; Fasta hit [...] (152 aa)
mdlAPutative ABC transporter ATP-binding membrane protein; Similar to Escherichia coli multidrug resistance-like ATP-binding protein mdla mdla or mdL SW:MDLA_ECOLI (P77265; P30751) (590 aa) fasta scores: E(): 0, 89.0% id in 590 aa, and to many ABC transporters e.g. Bacillus subtilis hypothetical 65.1 kDa protein yheI TR:O07550 (EMBL:Y14080) (585 aa) fasta scores: E(): 0, 39.8% id in 575 aa, and to Thermotoga maritima ABC transporter, ATP-binding protein tm1256 TR:Q9X0Y3 (EMBL:AE001781) (577 aa) fasta scores: E(): 0, 33.3% id in 567 aa; Orthologue of E. coli mdlA (MDLA_ECOLI); Fasta hit to [...] (590 aa)
STY0504Putative ABC transporter ATP-binding membrane protein; Similar to Escherichia coli multidrug resistance-like ATP-binding protein mdlb mdlb or mdL SW:MDLB_ECOLI (P75706; P30751; P77117) (593 aa) fasta scores: E(): 0, 87.7% id in 593 aa, and to many ABC transporters e.g. Mycobacterium tuberculosis hypothetical ABC transporter ATP-binding protein rv1272c rv1272c or mtcy50.10 SW:YC72_MYCTU (Q11047) (631 aa) fasta scores: E(): 0, 35.0% id in 523 aa, and to Rattus norvegicus tap-like ABC transporter tapL TR:Q9QYJ4 (EMBL:AB027520) (762 aa) fasta scores: E(): 0, 33.2% id in 585 aa; Orthologue [...] (593 aa)
ybbNThioredoxin-like protein; Similar to Escherichia coli hypothetical 33.1 kDa protein in usha-tesa intergenic region ybbN SW:YBBN_ECOLI (P77395) (296 aa) fasta scores: E(): 0, 93.8% id in 290 aa, and to Alicyclobacillus acidocaldarius thioredoxin trxA SW:THIO_ALIAC (P80579) (105 aa) fasta scores: E(): 1.5e-07, 35.6% id in 104 aa, and to Escherichia coli thioredoxin 2 trxC SW:THI2_ECOLI (P33636; P76593; P77000; P77001) (139 aa) fasta scores: E(): 1e-06, 29.5% id in 105 aa. Note that the redox-active disulphide pair is not conserved; Orthologue of E. coli YBBN_ECOLI; Fasta hit to YBBN_ECOL [...] (284 aa)
STY0556Outer membrane protein; Previously sequenced as Salmonella enteritidis outer membrane protein omp TR:Q9S4Z2 (EMBL:AF102556) (377 aa) fasta scores: E(): 0, 99.7% id in 377 aa, and weakly similar to Brucella melitensis porin omp2B TR:Q45311 (EMBL:U26440) (375 aa) fasta scores: E(): 0.074, 25.2% id in 313 aa, and to Aeromonas hydrophila outer membrane protein porin ii ompiI TR:Q9RNA1 (EMBL:AF183931) (351 aa) fasta scores: E(): 0.17, 22.6% id in 393 aa, and to Neisseria meningitidis iron-regulated protein FrpC frpC SW:FRPC_NEIME (P55127) (1829 aa) fasta scores: E(): 0.56, 26.4% id in 356 aa. (377 aa)
STY0653Alkyl hydroperoxide reductase c22 protein; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. (187 aa)
citA-2Citrate-proton symporter; Uptake of citrate across the boundary membrane with the concomitant transport of protons into the cell (symport system). (434 aa)
STY0780Dihydrolipoamide succinyltransferase component (E2); E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (402 aa)
yliBPutative ABC transporter periplasmic binding protein; Part of the ABC transporter complex GsiABCD involved in glutathione import. Binds glutathione. (512 aa)
yliCHypothetical ABC transporter permease protein; Part of the ABC transporter complex GsiABCD involved in glutathione import. Probably responsible for the translocation of the substrate across the membrane. (306 aa)
yliDHypothetical ABC transporter permease protein; Part of the ABC transporter complex GsiABCD involved in glutathione import. Probably responsible for the translocation of the substrate across the membrane. (303 aa)
mdfASimilar to Escherichia coli multidrug translocase mdfa SW:MDFA_ECOLI (Q46966) (410 aa) fasta scores: E(): 0, 90.9% id in 406 aa, and to Escherichia coli bicyclomycin resistance protein bcr or bica or bicr or sur or suxA SW:BCR_ECOLI (P28246) (396 aa) fasta scores: E(): 7.9e-15, 23.1% id in 389 aa, and to Klebsiella pneumoniae chloramphenicol transporter Cmla4 cmla4 TR:AAF27726 (EMBL:UNNKOWN ACCESSION) (419 aa) fasta scores: E(): 3.4e-13, 26.8% id in 354 aa; Fasta hit to YJIO_ECOLI (410 aa), 41% identity in 389 aa overlap; Orthologue of E. coli MDFA_ECOLI; Fasta hit to MDFA_ECOLI (410 a [...] (410 aa)
STY0956Thioredoxin reductase; Orthologue of E. coli trxB (TRXB_ECOLI); Fasta hit to TRXB_ECOLI (320 aa), 97% identity in 319 aa overlap. (322 aa)
STY0957Leucine-responsive regulatory protein; Fasta hit to YBAO_ECOLI (152 aa), 33% identity in 151 aa overlap; Orthologue of E. coli lrp (LRP_ECOLI); Fasta hit to LRP_ECOLI (163 aa), 99% identity in 163 aa overlap. (164 aa)
STY0985Probable transport ATP-binding protein MsbA; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. (582 aa)
STY1002Outer membrane protein F precursor; Forms pores that allow passive diffusion of small molecules across the outer membrane; Belongs to the Gram-negative porin family. (363 aa)
STY1005Putative transcriptional regulator; Fasta hit to YBAO_ECOLI (152 aa), 30% identity in 155 aa overlap; Paralogue of E. coli lrp (LRP_ECOLI); Fasta hit to LRP_ECOLI (163 aa), 31% identity in 151 aa overlap; Contains helix-turn-helix motif at residue 20-41. (153 aa)
STY1169Putative transporter; Similar to Acinetobacter calcoaceticus cis,cis-muconate transport protein muck SW:MUCK_ACICA (P94131) fasta scores: E(): 4.1e-26, 28.8% id in 382 aa; Orthologue of E. coli yjhB (YJHB_ECOLI); Fasta hit to YJHB_ECOLI (405 aa), 57% identity in 406 aa overlap. (426 aa)
STY1191Putative membrane transport protein; Similar to Streptococcus pneumoniae multi-drug resistance efflux pump PmraATR:Q9ZEX9 (EMBL:AJ007367) (399 aa) fasta scores: E(): 0, 44.4% id in 390 aa; Orthologue of E. coli yceE (YCEE_ECOLI); Fasta hit to YCEE_ECOLI (408 aa), 90% identity in 403 aa overlap. (404 aa)
STY1305Oligopeptide transport system permease protein OppB; Fasta hit to YDDR_ECOLI (340 aa), 32% identity in 332 aa overlap; Fasta hit to YLIC_ECOLI (306 aa), 36% identity in 310 aa overlap; Fasta hit to NIKB_ECOLI (314 aa), 35% identity in 313 aa overlap; Fasta hit to DPPB_ECOLI (339 aa), 35% identity in 340 aa overlap; Orthologue of E. coli oppB (OPPB_ECOLI); Fasta hit to OPPB_ECOLI (306 aa), 96% identity in 306 aa overlap. (306 aa)
STY1369Peptide transport periplasmic protein SapA precursor; Fasta hit to DPPA_ECOLI (535 aa), 37% identity in 516 aa overlap; Orthologue of E. coli sapA (SAPA_ECOLI); Fasta hit to SAPA_ECOLI (547 aa), 90% identity in 549 aa overlap. (549 aa)
STY1381Thiol peroxidase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Tpx subfamily. (168 aa)
STY1397Putative thiol peroxidase; Similar to Streptococcus sanguis probable thiol peroxidase SW:TPX_STRSA (P31308) (162 aa) fasta scores: E(): 1.3e-07, 32.3% id in 155 aa. (185 aa)
STY1517Similar to Salmonella typhi 12-tms multidrug efflux protein homolog TR:Q9RN46 (EMBL:AF188291) (413 aa) fasta scores: E(): 0, 100.0% id in 413 aa, and to Vibrio anguillarum tetracycline resistance protein, class g tetA SW:TCR7_VIBAN (P51563) (393 aa) fasta scores: E(): 2.7e-22, 30.2% id in 394 aa. (413 aa)
hyaE2Similar to Escherichia coli hydrogenase-1 operon protein HyaE hyaE SW:HYAE_ECOLI (P19931) (132 aa) fasta scores: E(): 3e-10, 36.4% id in 99 aa. (136 aa)
STY1538Putative membrane transport protein; Involved in the efflux of sugars. The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites; Belongs to the major facilitator superfamily. SotB (TC 2.A.1.2) family. (396 aa)
STY1544Putative membrane protein; Orthologue of E. coli ydeF (YDEE_ECOLI); Fasta hit to YDEE_ECOLI (395 aa), 77% identity in 395 aa overlap. (395 aa)
STY1579Putative membrane transport protein; Orthologue of E. coli YNFM_ECOLI; Fasta hit to YNFM_ECOLI (417 aa), 91% identity in 417 aa overlap. (417 aa)
STY1604Hypothetical protein; Weakly similar to Pseudomonas spTW3. hypothetical 63.1 kDa protein TR:Q9RBR4 (EMBL:AF043544) (553 aa) fasta scores: E(): 2e-05, 27.0% id in 378 aa. (589 aa)
STY1649Outer membrane protein; Forms pores that allow passive diffusion of small molecules across the outer membrane. (383 aa)
STY1682Copper-zinc superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (173 aa)
STY1691Superoxide dismutase; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (193 aa)
STY1694Putative integral membrane transport protein; Similar to Escherichia coli bicyclomycin resistance protein bcr or bica or bicr or sur or suxA SW:BCR_ECOLI (P28246) (396 aa) fasta scores: E(): 2e-24, 27.8% id in 381 aa; Orthologue of E. coli ydhC (YDHC_ECOLI); Fasta hit to YDHC_ECOLI (403 aa), 85% identity in 406 aa overlap. (401 aa)
STY1863Similar to Salmonella typhimurium putative transmembrane protein oxd-6C TR:O34158 (EMBL:U94729) (270 aa) fasta scores: E(): 0, 100.0% id in 270 aa, and to Streptococcus pyogenes transmembrane transport protein DppC dppC TR:Q9ZAS4 (EMBL:U78968) (274 aa) fasta scores: E(): 0, 37.6% id in 258 aa. (270 aa)
STY1864Similar to Salmonella typhimurium putative transmembrane protein oxd-6 TR:O34157 (EMBL:U94729) (323 aa) fasta scores: E(): 0, 97.2% id in 324 aa, and to Streptococcus pyogenes transmembrane transport protein DppB dppB TR:Q9ZAS5 (EMBL:U78968) (325 aa) fasta scores: E(): 0, 42.0% id in 312 aa. (325 aa)
STY1865Similar to Salmonella typhimurium putative substrate-binding protein oxd-6A TR:O34156 (EMBL:U94729) (528 aa) fasta scores: E(): 0, 98.9% id in 528 aa, and to Escherichia coli hypothetical 36.5 kDa protein in ureR 3'region TR:Q05633 (EMBL:L12007) (336 aa) fasta scores: E(): 0, 63.0% id in 319 aa, and to Streptomyces coelicolor putative substrate binding protein SC9B5.18 TR:Q9ZBG2 (EMBL:AL035206) (542 aa) fasta scores: E(): 6.1e-28, 30.7% id in 515 aa. (544 aa)
STY1917Hydrogenase-1 operon protein HyaE; Orthologue of E. coli hyaE (HYAE_ECOLI); Fasta hit to HYAE_ECOLI (132 aa), 71% identity in 133 aa overlap. (134 aa)
STY2056Similar to many Tn10 transposases e.g. Escherichia coli plasmid R100 transposase of Tn10 YdgA TR:Q9WTF5 (EMBL:AP000342) (402 aa) fasta scores: E(): 0, 100.0% id in 402 aa. (402 aa)
STY2141Ferritin-like protein; Iron-storage protein. (167 aa)
STY2143Ferritin; Iron-storage protein. (165 aa)
ompS1Outer membrane protein S1; Forms pores that allow passive diffusion of small molecules across the outer membrane. (394 aa)
wzbPutative protein-tyrosine phosphatase; Dephosphorylates Wzc. Required for the extracellular polysaccharide colanic acid synthesis. Probably involved in the export of colanic acid from the cell to medium. Involved in protection of cells against contact-dependent growth inhibition (CDI). (149 aa)
STY2342Putative transporter protein; Fasta hit to YIEO_ECOLI (475 aa), 46% identity in 459 aa overlap; Orthologue of E. coli YEGB_ECOLI; Fasta hit to YEGB_ECOLI (471 aa), 86% identity in 469 aa overlap; Similar to many putative major facilitator family transporter proteins. Contains hydrophobic, probable membrane-spanning regions. (470 aa)
STY2409Putative n-hydroxybenzoate transporter; Similar to e.g. Pseudomonas putida 4-hydroxybenzoate transporter pcaK SW:PCAK_PSEPU (Q51955) (448 aa) fasta scores: E(): 0, 43.8% id in 422 aa and Acinetobacter calcoaceticus 4-hydroxybenzoate transporter pcaK SW:PCAK_ACICA (Q43975) (457 aa) fasta scores: E(): 0, 43.2% id in 438 aa. (452 aa)
STY2443Sugar efflux transporter; Fasta hit to YABM_ECOLI (392 aa), 53% identity in 376 aa overlap; Fasta hit to YICK_ECOLI (394 aa), 71% identity in 390 aa overlap; Orthologue of E. coli yeiO (YEIO_ECOLI); Fasta hit to YEIO_ECOLI (393 aa), 90% identity in 393 aa overlap. Contains hydrophobic, probable membrane-spanning regions. (393 aa)
STY2455Putative ABC-transporter ATP-binding protein; Fasta hit to YLIA_ECOLI (612 aa), 49% identity in 555 aa overlap; Orthologue of E. coli yejF (YEJF_ECOLI); Fasta hit to YEJF_ECOLI (529 aa), 87% identity in 529 aa overlap; Belongs to the ABC transporter superfamily. (529 aa)
bcrSimilar to Escherichia coli bicyclomycin resistance protein bcr or bicA or bicR or sur or suxA SW:BCR_ECOLI (P28246) (396 aa) fasta scores: E(): 0, 93.2% id in 396 aa. Contains hydrophobic, probable membrane-spannign regions. (396 aa)
sspH2Similar to Salmonella typhimurium secreted protein SspH2 TR:Q9RPH0 (EMBL:AF160727) (788 aa) fasta scores: E(): 0, 99.6% id in 788 aa and to many secreted, leucine-rich-repeat proteins e.g. Shigella flexneri 65.4 kDa antigen IpaH 4.5 SW:IPA4_SHIFL (P18009) (574 aa) fasta scores: E(): 0, 44.9% id in 515 aa. (788 aa)
ompCOuter membrane protein C; Forms pores that allow passive diffusion of small molecules across the outer membrane; Belongs to the Gram-negative porin family. (378 aa)
STY2509Putative transmembrane transport protein; Similar to Bacillus subtilis hypothetical protein ywoG TR:P94577 (EMBL:Z82987) (396 aa) fasta scores: E(): 0, 37.5% id in 381 aa. Similar to Staphylococcus aureus quinolone resistance protein norA SW:NORA_STAAU (P21191) (388 aa) fasta scores: E(): 1.9e-14, 25.1% id in 394 aa and Bacillus subtilis multidrug resistance protein 1 bmr or bmr1 SW:BMR1_BACSU (P33449) (389 aa) fasta scores: E(): 4.7e-14, 23.5% id in 371 aa. Contains hydrophobic, probable membrane-spanning regions. (396 aa)
STY2603Putative transmembrane transporter; Fasta hit to YHHS_ECOLI (419 aa), 42% identity in 372 aa overlap; Orthologue of E. coli P77549; Fasta hit to P77549 (392 aa), 88% identity in 392 aa overlap; Shows weak similarity to many transporters e.g. Erwinia chrysanthemi sugar efflux transporter sotA SW:SOTA_ERWCH (Q9S3K0) (393 aa) fasta scores: E(): 1.6e-08, 25.7% id in 409 aa overlap. Contains hydrophobic, probable membrane-spanning regions. (392 aa)
STY2729Bacterioferritin comigratory protein; Orthologue of E. coli bcp (BCP_ECOLI); Fasta hit to BCP_ECOLI (156 aa), 98% identity in 156 aa overlap. (156 aa)
STY2771Nucleoside diphosphate kinase (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (143 aa)
STY2842Thioredoxin 2; Orthologue of E. coli yfiG (THI2_ECOLI); Fasta hit to THI2_ECOLI (139 aa), 94% identity in 139 aa overlap; Belongs to the thioredoxin family. (139 aa)
STY2847Alpha-ketoglutarate permease; Fasta hit to PROP_ECOLI (500 aa), 32% identity in 418 aa overlap; Fasta hit to YDFJ_ECOLI (427 aa), 32% identity in 396 aa overlap; Fasta hit to YHJE_ECOLI (440 aa), 32% identity in 434 aa overlap; Fasta hit to SHIA_ECOLI (438 aa), 31% identity in 431 aa overlap; Orthologue of E. coli kgtP (KGTP_ECOLI); Fasta hit to KGTP_ECOLI (432 aa), 88% identity in 433 aa overlap. (433 aa)
iroCPutative ABC transporter protein; Similar to many e.g. Salmonella typhi AJB70 ATP binding cassette protein iroC TR:P96057 (EMBL:U62129) (1218 aa) fasta scores: E(): 0, 95.3% id in 1223 aa and Mycobacterium tuberculosis putative ABC transporter Rv0194 or MTV033.02 TR:O53645 (EMBL:AL021928) (1194 aa) fasta scores: E(): 0, 37.8% id in 1203 aa. Conatins hydrophobic, probable membrane spanning regions. (1218 aa)
STY2928Conserved hypothetical protein; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. Belongs to the AhpD family. (143 aa)
STY2938Putative transmembrane transport protein; Similar to Bacillus subtilis YdeR protein ydeR TR:P96675 (EMBL:AB001488) (395 aa) fasta scores: E(): 0, 39.3% id in 379 aa and to many transport proteins e.g. Erwinia chrysanthemi sugar efflux transpoter sotB TR:Q9S3J9 (EMBL:AJ249181) (395 aa) fasta scores: E(): 5.3e-14, 24.9% id in 382 aa. Contains hydrophobic, probable membrane-spannign regions. (394 aa)
STY2941Multidrug resistance protein B; Fasta hit to YIEO_ECOLI (475 aa), 33% identity in 424 aa overlap; Fasta hit to EMRY_ECOLI (512 aa), 63% identity in 506 aa overlap; Orthologue of E. coli emrB (EMRB_ECOLI); Fasta hit to EMRB_ECOLI (512 aa), 96% identity in 512 aa overlap; Belongs to the major facilitator superfamily. (512 aa)
STY3036Weakly similar to a number of putative membrane transport and drug efflux proteins e.g. Propionibacterium freudenreichii membrane-bound transport protein HemX TR:P72184 (EMBL:U51164) (487 aa) fasta scores: E(): 3.6e-19, 24.2% id in 446 aa. Contains multiple possible membrane spanning hydrophobic domains. (402 aa)
STY3152Putative membrane protein; Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell; Belongs to the major facilitator superfamily. LplT (TC 2.A.1.42) family. (400 aa)
STY3160L-arabinose isomerase; Fasta hit to GALP_ECOLI (464 aa), 66% identity in 456 aa overlap; Fasta hit to XYLE_ECOLI (491 aa), 32% identity in 480 aa overlap; Orthologue of E. coli araE (ARAE_ECOLI); Fasta hit to ARAE_ECOLI (472 aa), 97% identity in 472 aa overlap; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (471 aa)
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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