STRINGSTRING
STY1271 STY1271 STY1270 STY1270 STY3238 STY3238 rpoS rpoS STY3045 STY3045 spaS spaS virK virK pagP pagP STY0351 STY0351 fliC fliC STY0188 STY0188 slyA slyA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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STY1271Transcriptional regulatory protein PhoP, regulator of virulence determinants; Member of the two-component regulatory system PhoQ/PhoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. Promotes intramacrophage survival of S.typhi. Is required to enhance bacterial resistance to bile in the human intestinal cells. (224 aa)
STY1270Sensor protein PhoQ, regulator of virulence determinants; Member of the two-component regulatory system PhoP/PhoQ which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. In low periplasmic Mg(2+), PhoQ functions as a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to PhoP, which results in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2+), acts as a protein phosphatase that dephosphorylates phosph [...] (487 aa)
STY3238Agmatine ureohydrolase; Catalyzes the formation of putrescine from agmatine. Belongs to the arginase family. Agmatinase subfamily. (306 aa)
rpoSRNA polymerase sigma subunit RpoS (sigma-38); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. (330 aa)
STY3045Putative regulatory protein; Similar to several MarR-family proteins including: Escherichia coli SlyA-like transcriptional regulatory protein TR:Q9X729 (EMBL:AJ006210) (135 aa) fasta scores: E(): 0, 80.5% id in 133 aa, and to Serratia sp. ATCC39006 Rap regulator of antibiotic and pigment production TR:Q9RA96 (EMBL:AF168597) (145 aa) fasta scores: E(): 0.0053, 25.6% id in 125 aa. Also weakly similar to STY1678 28.0% identity in 125 aa overlap. (134 aa)
spaSSecretory protein (associated with virulence); Similar to Salmonella typhimurium surface presentation of antigens protein SpaS SW:SPAS_SALTY (P40702) (356 aa) fasta scores: E(): 0, 99.4% id in 356 aa. Contains possible membrane spanning hydrophobic domains. (356 aa)
virKVirulence protein; Identical to Salmonella typhi AJB70 VirK protein TR:O68287 (EMBL:AF029845) (297 aa) fasta scores: E(): 0, 100.0% id in 297 aa. Similar to Salmonella typhimurium SL1344 protein VirK TR:AAB80743 (EMBL:AF020810) (294 aa) fasta scores: E(): 0, 99.3% id in 294 aa; Paralogue of E. coli YBJX_ECOLI; Fasta hit to YBJX_ECOLI (330 aa), 37% identity in 318 aa overlap. (309 aa)
pagPAntimicrobial peptide resistance and lipid A acylation protein; Transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors. (190 aa)
STY0351Possible outer membrane adhesin; Similar to Escherichia coli heat resistant agglutinin 1 TR:Q46680 (EMBL:U07174) (247 aa) fasta scores: E(): 1.6e-18, 38.1% id in 257 aa, and to Escherichia coli tia invasion determinant precursor TR:Q46760 (EMBL:U20318) (251 aa) fasta scores: E(): 3.5e-14, 38.3% id in 256 aa, and to Salmonella typhimurium virulence membrane protein PagC precursor. virulence membrane protein pagc precursor SW:PAGC_SALTY () (188 aa) fasta scores: E(): 0.001, 25.5% id in 141 aa. (239 aa)
fliCFlagellin; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. (506 aa)
STY0188Spermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine. (286 aa)
slyATranscriptional regulator; Transcription regulator that can specifically activate or repress expression of target genes; Belongs to the SlyA family. (144 aa)
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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