Conserved hypothetical protein; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protease targets the host cell ubiquitin pathway by acting as a deubiquitinase in infected host cells (By similarity); Belongs to the peptidase C79 family.

Conserved hypothetical protein; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. Involved in the reorganization of late endosome/lysosome (LE/Lys) compartments in mammalian cells. Necessary and sufficient to link kinesin-1 onto the Salmonella-containing vacuole (SCV) membrane. Required for centrifugal extension of lysosomal glycoprotein-rich membrane tubules, known as Salmonella-induced filaments (Sifs), away from the SCV and toward the cell periphery. Required for virulence, but not for intracellular survival and replication in p [...]

Conserved hypothetical protein; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protease targets the host cell ubiquitin pathway by acting as a deubiquitinase in infected host cells (By similarity); Belongs to the peptidase C79 family.

Conserved hypothetical protein; Similar to Salmonella dublin PipB TR:O85307 (EMBL:AF060858) fasta scores: E(): 0, 97.6% id in 291 aa.

Conserved hypothetical protein; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protease targets the host cell ubiquitin pathway by acting as a deubiquitinase in infected host cells (By similarity); Belongs to the peptidase C79 family.

Putative virulence determinant; Similar to Salmonella typhimurium SifA protein sifA SW:SIFA_SALTY (Q56061) (336 aa) fasta scores: E(): 0, 93.5% id in 336 aa.

Conserved hypothetical protein; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protease targets the host cell ubiquitin pathway by acting as a deubiquitinase in infected host cells (By similarity); Belongs to the peptidase C79 family.

Hypothetical protein; Similar to Salmonella enteritidis virulence effector protein SifB TR:AAF42760 (EMBL:AF128839) (316 aa) fasta scores: E(): 0, 94.1% id in 303 aa. Also similar to Salmonella typhimurium SifA protein SW:SIFA_SALTY () (336 aa) fasta scores: E(): 2.5e-13, 23.9% id in 305 aa; putative virulence effector protein.

Conserved hypothetical protein; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protease targets the host cell ubiquitin pathway by acting as a deubiquitinase in infected host cells (By similarity); Belongs to the peptidase C79 family.

Cell invasion protein; Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns 3-P and prevents the transition of PtdIns 3-P to PtdIns 3,5-P2. It is one of the known effectors injected by Salmonella into the host cell and is required for invasion and for an efficient generation and maintenance of Salmonella-containing vacuole (SVC). Alteration of the phosphoinositide composition of the plasma membrane causes membrane ruffling and actin cytoskeleton rearrangements. The persistence of PtdIns 3-P diverts the SCV from the endocytic pathway resulting in enlarged vesicl [...]

Conserved hypothetical protein; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protease targets the host cell ubiquitin pathway by acting as a deubiquitinase in infected host cells (By similarity); Belongs to the peptidase C79 family.

Pathogenicity island 1 effector protein (function unknown); Actin-binding protein that interferes with host cell actin cytoskeleton. It stimulates actin polymerization and counteracts F- actin destabilizing proteins. Potentiates SipC activity; both are required for an efficient bacterial internalization (By similarity). Belongs to the SipA/IpaA family.

Conserved hypothetical protein; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protease targets the host cell ubiquitin pathway by acting as a deubiquitinase in infected host cells (By similarity); Belongs to the peptidase C79 family.

Pathogenicity island 1 effector protein; Actin-binding protein that interferes with host cell actin cytoskeleton. Nucleates actin polymerization and condensates actin filaments into cables (bundling). SipA potenciates SipC activity and both are required for an efficient bacterial internalization by the host cell (By similarity).

Conserved hypothetical protein; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protease targets the host cell ubiquitin pathway by acting as a deubiquitinase in infected host cells (By similarity); Belongs to the peptidase C79 family.

Possible secreted protein; Similar to several SopD orthologues associated with salmonella virulence: Salmonella dublin secreted protein sopD TR:O52235 (EMBL:AF030589) (317 aa) fasta scores: E(): 0, 100.0% id in 317 aa.

Conserved hypothetical protein; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protease targets the host cell ubiquitin pathway by acting as a deubiquitinase in infected host cells (By similarity); Belongs to the peptidase C79 family.

Putative pathogenicity island 2 secreted effector protein; Putative virulence protein.

Conserved hypothetical protein; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protease targets the host cell ubiquitin pathway by acting as a deubiquitinase in infected host cells (By similarity); Belongs to the peptidase C79 family.

Putative pathogenicity island effector protein; Similar to Salmonella typhimurium SseF TR:O84951 (EMBL:AF020808) (260 aa) fasta scores: E(): 0, 96.5% id in 260 aa.

Conserved hypothetical protein; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protease targets the host cell ubiquitin pathway by acting as a deubiquitinase in infected host cells (By similarity); Belongs to the peptidase C79 family.

Putative pathogenicity island effector protein; Similar to Salmonella typhimurium SseG TR:O84952 (EMBL:AF020808) (229 aa) fasta scores: E(): 0, 98.3% id in 229 aa.

Conserved hypothetical protein; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protease targets the host cell ubiquitin pathway by acting as a deubiquitinase in infected host cells (By similarity); Belongs to the peptidase C79 family.

Similar to Salmonella typhimurium secreted protein SspH2 TR:Q9RPH0 (EMBL:AF160727) (788 aa) fasta scores: E(): 0, 99.6% id in 788 aa and to many secreted, leucine-rich-repeat proteins e.g. Shigella flexneri 65.4 kDa antigen IpaH 4.5 SW:IPA4_SHIFL (P18009) (574 aa) fasta scores: E(): 0, 44.9% id in 515 aa.

Conserved hypothetical protein; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protease targets the host cell ubiquitin pathway by acting as a deubiquitinase in infected host cells (By similarity); Belongs to the peptidase C79 family.

Fimbrial subunit; Similar to Salmonella typhimurium minor fimbrial subunit StfE TR:O87660 (EMBL:AF093503) (170 aa) fasta scores: E(): 5.3e-31, 52.9% id in 170 aa and to Escherichia coli hypothetical prtein TR:P76501 (EMBL:AE000322) (170 aa) fasta scores: E(): 2.4e-22, 42.4% id in 158 aa; Fasta hit to P76500 (162 aa), 33% identity in 171 aa overlap; Orthologue of E. coli P76501; Fasta hit to P76501 (170 aa), 42% identity in 158 aa overlap.

Conserved hypothetical protein; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protease targets the host cell ubiquitin pathway by acting as a deubiquitinase in infected host cells (By similarity); Belongs to the peptidase C79 family.

Tyrosine phosphatase (associated with virulence); Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein includes tyrosine phosphatase and GTPase activating protein (GAP) activities. After bacterial internalization, GAP mediates the reversal of the cytoskeletal changes induced by SopE. This function is independent of its tyrosine phosphatase activity, which remains unclear (By similarity).

Conserved hypothetical protein; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. Involved in the reorganization of late endosome/lysosome (LE/Lys) compartments in mammalian cells. Necessary and sufficient to link kinesin-1 onto the Salmonella-containing vacuole (SCV) membrane. Required for centrifugal extension of lysosomal glycoprotein-rich membrane tubules, known as Salmonella-induced filaments (Sifs), away from the SCV and toward the cell periphery. Required for virulence, but not for intracellular survival and replication in p [...]

Conserved hypothetical protein; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protease targets the host cell ubiquitin pathway by acting as a deubiquitinase in infected host cells (By similarity); Belongs to the peptidase C79 family.

Conserved hypothetical protein; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. Involved in the reorganization of late endosome/lysosome (LE/Lys) compartments in mammalian cells. Necessary and sufficient to link kinesin-1 onto the Salmonella-containing vacuole (SCV) membrane. Required for centrifugal extension of lysosomal glycoprotein-rich membrane tubules, known as Salmonella-induced filaments (Sifs), away from the SCV and toward the cell periphery. Required for virulence, but not for intracellular survival and replication in p [...]

Conserved hypothetical protein; Similar to Salmonella dublin PipB TR:O85307 (EMBL:AF060858) fasta scores: E(): 0, 97.6% id in 291 aa.

Conserved hypothetical protein; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. Involved in the reorganization of late endosome/lysosome (LE/Lys) compartments in mammalian cells. Necessary and sufficient to link kinesin-1 onto the Salmonella-containing vacuole (SCV) membrane. Required for centrifugal extension of lysosomal glycoprotein-rich membrane tubules, known as Salmonella-induced filaments (Sifs), away from the SCV and toward the cell periphery. Required for virulence, but not for intracellular survival and replication in p [...]

Putative virulence determinant; Similar to Salmonella typhimurium SifA protein sifA SW:SIFA_SALTY (Q56061) (336 aa) fasta scores: E(): 0, 93.5% id in 336 aa.

Conserved hypothetical protein; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. Involved in the reorganization of late endosome/lysosome (LE/Lys) compartments in mammalian cells. Necessary and sufficient to link kinesin-1 onto the Salmonella-containing vacuole (SCV) membrane. Required for centrifugal extension of lysosomal glycoprotein-rich membrane tubules, known as Salmonella-induced filaments (Sifs), away from the SCV and toward the cell periphery. Required for virulence, but not for intracellular survival and replication in p [...]

Hypothetical protein; Similar to Salmonella enteritidis virulence effector protein SifB TR:AAF42760 (EMBL:AF128839) (316 aa) fasta scores: E(): 0, 94.1% id in 303 aa. Also similar to Salmonella typhimurium SifA protein SW:SIFA_SALTY () (336 aa) fasta scores: E(): 2.5e-13, 23.9% id in 305 aa; putative virulence effector protein.

Conserved hypothetical protein; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. Involved in the reorganization of late endosome/lysosome (LE/Lys) compartments in mammalian cells. Necessary and sufficient to link kinesin-1 onto the Salmonella-containing vacuole (SCV) membrane. Required for centrifugal extension of lysosomal glycoprotein-rich membrane tubules, known as Salmonella-induced filaments (Sifs), away from the SCV and toward the cell periphery. Required for virulence, but not for intracellular survival and replication in p [...]

Cell invasion protein; Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns 3-P and prevents the transition of PtdIns 3-P to PtdIns 3,5-P2. It is one of the known effectors injected by Salmonella into the host cell and is required for invasion and for an efficient generation and maintenance of Salmonella-containing vacuole (SVC). Alteration of the phosphoinositide composition of the plasma membrane causes membrane ruffling and actin cytoskeleton rearrangements. The persistence of PtdIns 3-P diverts the SCV from the endocytic pathway resulting in enlarged vesicl [...]

Conserved hypothetical protein; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. Involved in the reorganization of late endosome/lysosome (LE/Lys) compartments in mammalian cells. Necessary and sufficient to link kinesin-1 onto the Salmonella-containing vacuole (SCV) membrane. Required for centrifugal extension of lysosomal glycoprotein-rich membrane tubules, known as Salmonella-induced filaments (Sifs), away from the SCV and toward the cell periphery. Required for virulence, but not for intracellular survival and replication in p [...]

Pathogenicity island 1 effector protein (function unknown); Actin-binding protein that interferes with host cell actin cytoskeleton. It stimulates actin polymerization and counteracts F- actin destabilizing proteins. Potentiates SipC activity; both are required for an efficient bacterial internalization (By similarity). Belongs to the SipA/IpaA family.