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sipB sipB pipB pipB sigD sigD sifA sifA sifB sifB sseG sseG sseF sseF spiC spiC cdtB cdtB sspH2 sspH2 STY2517 STY2517 STY2897 STY2897 STY2960 STY2960 stpA stpA sipA sipA sipC sipC sopD sopD steD steD STY3494 STY3494
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
sipBPathogenicity island 1 effector protein; Required for entry into the host cell through presentation or delivery of SipC at the host cell plasma membrane. Along with SipC, is necessary for the transfer of other effector proteins into the host cell. Induces macrophage apoptosis either by binding and activating the proapoptotic enzyme caspase-1 (caspase-1 dependent), resulting in the release of interleukin-1 beta active form, or by disrupting mitochondria and inducing autophagy (caspase-1 independent). The former is dependent of its membrane-fusion activity. The SipBC complex, in associat [...] (593 aa)
pipBConserved hypothetical protein; Similar to Salmonella dublin PipB TR:O85307 (EMBL:AF060858) fasta scores: E(): 0, 97.6% id in 291 aa. (291 aa)
sigDCell invasion protein; Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns 3-P and prevents the transition of PtdIns 3-P to PtdIns 3,5-P2. It is one of the known effectors injected by Salmonella into the host cell and is required for invasion and for an efficient generation and maintenance of Salmonella-containing vacuole (SVC). Alteration of the phosphoinositide composition of the plasma membrane causes membrane ruffling and actin cytoskeleton rearrangements. The persistence of PtdIns 3-P diverts the SCV from the endocytic pathway resulting in enlarged vesicl [...] (561 aa)
sifAPutative virulence determinant; Similar to Salmonella typhimurium SifA protein sifA SW:SIFA_SALTY (Q56061) (336 aa) fasta scores: E(): 0, 93.5% id in 336 aa. (336 aa)
sifBHypothetical protein; Similar to Salmonella enteritidis virulence effector protein SifB TR:AAF42760 (EMBL:AF128839) (316 aa) fasta scores: E(): 0, 94.1% id in 303 aa. Also similar to Salmonella typhimurium SifA protein SW:SIFA_SALTY () (336 aa) fasta scores: E(): 2.5e-13, 23.9% id in 305 aa; putative virulence effector protein. (316 aa)
sseGPutative pathogenicity island effector protein; Similar to Salmonella typhimurium SseG TR:O84952 (EMBL:AF020808) (229 aa) fasta scores: E(): 0, 98.3% id in 229 aa. (229 aa)
sseFPutative pathogenicity island effector protein; Similar to Salmonella typhimurium SseF TR:O84951 (EMBL:AF020808) (260 aa) fasta scores: E(): 0, 96.5% id in 260 aa. (260 aa)
spiCPutative pathogenicity island 2 secreted effector protein; Putative virulence protein. (127 aa)
cdtBPutative toxin-like protein; Produces a CDT (cytolethal distending toxin) activity, which causes DNA damage in intoxicated cells. This damage induces G2/M cell cycle arrest, chromatin fragmentation, cell distention and nucleus enlargement. (269 aa)
sspH2Similar to Salmonella typhimurium secreted protein SspH2 TR:Q9RPH0 (EMBL:AF160727) (788 aa) fasta scores: E(): 0, 99.6% id in 788 aa and to many secreted, leucine-rich-repeat proteins e.g. Shigella flexneri 65.4 kDa antigen IpaH 4.5 SW:IPA4_SHIFL (P18009) (574 aa) fasta scores: E(): 0, 44.9% id in 515 aa. (788 aa)
STY2517Conserved hypothetical protein; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protease targets the host cell ubiquitin pathway by acting as a deubiquitinase in infected host cells (By similarity); Belongs to the peptidase C79 family. (317 aa)
STY2897Conserved hypothetical protein; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. Involved in the reorganization of late endosome/lysosome (LE/Lys) compartments in mammalian cells. Necessary and sufficient to link kinesin-1 onto the Salmonella-containing vacuole (SCV) membrane. Required for centrifugal extension of lysosomal glycoprotein-rich membrane tubules, known as Salmonella-induced filaments (Sifs), away from the SCV and toward the cell periphery. Required for virulence, but not for intracellular survival and replication in p [...] (350 aa)
STY2960Putative phosphosugar binding protein; Catalyzes the reversible aldol-ketol isomerization between D- ribulose 5-phosphate (Ru5P) and D-arabinose 5-phosphate (A5P). It is also able of sustaining the biosynthetic pathway of 3-deoxy-D-manno- octulosonate (KDO), a unique 8-carbon sugar component of lipopolysaccharides (LPSs) (By similarity). (321 aa)
stpATyrosine phosphatase (associated with virulence); Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein includes tyrosine phosphatase and GTPase activating protein (GAP) activities. After bacterial internalization, GAP mediates the reversal of the cytoskeletal changes induced by SopE. This function is independent of its tyrosine phosphatase activity, which remains unclear (By similarity). (543 aa)
sipAPathogenicity island 1 effector protein (function unknown); Actin-binding protein that interferes with host cell actin cytoskeleton. It stimulates actin polymerization and counteracts F- actin destabilizing proteins. Potentiates SipC activity; both are required for an efficient bacterial internalization (By similarity). Belongs to the SipA/IpaA family. (685 aa)
sipCPathogenicity island 1 effector protein; Actin-binding protein that interferes with host cell actin cytoskeleton. Nucleates actin polymerization and condensates actin filaments into cables (bundling). SipA potenciates SipC activity and both are required for an efficient bacterial internalization by the host cell (By similarity). (409 aa)
sopDPossible secreted protein; Similar to several SopD orthologues associated with salmonella virulence: Salmonella dublin secreted protein sopD TR:O52235 (EMBL:AF030589) (317 aa) fasta scores: E(): 0, 100.0% id in 317 aa. (317 aa)
steDFimbrial subunit; Similar to Salmonella typhimurium minor fimbrial subunit StfE TR:O87660 (EMBL:AF093503) (170 aa) fasta scores: E(): 5.3e-31, 52.9% id in 170 aa and to Escherichia coli hypothetical prtein TR:P76501 (EMBL:AE000322) (170 aa) fasta scores: E(): 2.4e-22, 42.4% id in 158 aa; Fasta hit to P76500 (162 aa), 33% identity in 171 aa overlap; Orthologue of E. coli P76501; Fasta hit to P76501 (170 aa), 42% identity in 158 aa overlap. (168 aa)
STY3494Conserved hypothetical protein; Involved in the biosynthesis of 3-deoxy-D-manno-octulosonate (KDO), a unique 8-carbon sugar component of lipopolysaccharides (LPSs). Catalyzes the reversible aldol-ketol isomerization between D-ribulose 5-phosphate (Ru5P) and D-arabinose 5-phosphate (A5P) (By similarity). (328 aa)
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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